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The map label for this gene is nudG [H]

Identifier: 78222999

GI number: 78222999

Start: 2005109

End: 2005573

Strand: Direct

Name: nudG [H]

Synonym: Gmet_1790

Alternate gene names: 78222999

Gene position: 2005109-2005573 (Clockwise)

Preceding gene: 78222996

Following gene: 78223000

Centisome position: 50.16

GC content: 58.06

Gene sequence:

>465_bases
GTGGGTCAATTTTCAATTTCCGAGGTGGGTCATTTTTACATTGCCGCTAACACCTCGTTGAAGCATATCCACGTCACCTG
CGCCATCATCGAGCGAGACGGTCTCGTCCTTGCCGCCCAGCGGAGCGCCGTCATGAGCCTGCCGCTCAAGTGGGAGTTTC
CCGGTGGTAAGATCGACCCCGGTGAATCGCCCGAAGAATGCCTCCGACGGGAGTTGGTGGAGGAGATGGCGGTTCACGTG
CGCGTGGGACAGAGTCTTCCCGTCAGCACCCATCAATACCCGACGTTCTCGGTCACGCTTTATCCCTTTCTCTGCACCAT
CGAATCGGGAGAGATCGTCCTCCACGAACACGTTGCCGTAACCTGGCTTCCTCCCGATGAACTCCACACCCTCGACTGGG
CCGAGGCCGATCTGCCGGTGATTAAGTCTTATCAGCAGGGATGCCGGATGAGGGACCATAGCTGA

Upstream 100 bases:

>100_bases
TCCCGGATGCTTTTGCCCTGTTTCTTGAGAATTCTGACTTCCATACACTCTTCCTTTCCGATCATGCCGACCCTCCAGGT
CGGCTAGGTTATCAGGAAGA

Downstream 100 bases:

>100_bases
GAACACTGAGTGTAAAATGGTGCTTAATGGCCCATGTGAAGCGGTGGCCTACCTGAATGCGGCCATTGAGGAAGTGATCG
AGAGGTCTTTCTTATGTTCT

Product: NUDIX hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MGQFSISEVGHFYIAANTSLKHIHVTCAIIERDGLVLAAQRSAVMSLPLKWEFPGGKIDPGESPEECLRRELVEEMAVHV
RVGQSLPVSTHQYPTFSVTLYPFLCTIESGEIVLHEHVAVTWLPPDELHTLDWAEADLPVIKSYQQGCRMRDHS

Sequences:

>Translated_154_residues
MGQFSISEVGHFYIAANTSLKHIHVTCAIIERDGLVLAAQRSAVMSLPLKWEFPGGKIDPGESPEECLRRELVEEMAVHV
RVGQSLPVSTHQYPTFSVTLYPFLCTIESGEIVLHEHVAVTWLPPDELHTLDWAEADLPVIKSYQQGCRMRDHS
>Mature_153_residues
GQFSISEVGHFYIAANTSLKHIHVTCAIIERDGLVLAAQRSAVMSLPLKWEFPGGKIDPGESPEECLRRELVEEMAVHVR
VGQSLPVSTHQYPTFSVTLYPFLCTIESGEIVLHEHVAVTWLPPDELHTLDWAEADLPVIKSYQQGCRMRDHS

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=125, Percent_Identity=36, Blast_Score=81, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 17277; Mature: 17146

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQFSISEVGHFYIAANTSLKHIHVTCAIIERDGLVLAAQRSAVMSLPLKWEFPGGKIDP
CCCCCCCCCCEEEEEECCCEEEEEEEEEEEECCCEEEEECCCEEEECCEEEECCCCCCCC
GESPEECLRRELVEEMAVHVRVGQSLPVSTHQYPTFSVTLYPFLCTIESGEIVLHEHVAV
CCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEEEECCCCEEEEEEEEE
TWLPPDELHTLDWAEADLPVIKSYQQGCRMRDHS
EECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GQFSISEVGHFYIAANTSLKHIHVTCAIIERDGLVLAAQRSAVMSLPLKWEFPGGKIDP
CCCCCCCCCEEEEEECCCEEEEEEEEEEEECCCEEEEECCCEEEECCEEEECCCCCCCC
GESPEECLRRELVEEMAVHVRVGQSLPVSTHQYPTFSVTLYPFLCTIESGEIVLHEHVAV
CCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEEEECCCCEEEEEEEEE
TWLPPDELHTLDWAEADLPVIKSYQQGCRMRDHS
EECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]