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The map label for this gene is thlA [H]

Identifier: 78222928

GI number: 78222928

Start: 1932264

End: 1933439

Strand: Reverse

Name: thlA [H]

Synonym: Gmet_1719

Alternate gene names: 78222928

Gene position: 1933439-1932264 (Counterclockwise)

Preceding gene: 78222929

Following gene: 78222926

Centisome position: 48.37

GC content: 65.14

Gene sequence:

>1176_bases
ATGCAAGACGTGTTTGTGGTTGATGCTCTAAGAACACCGTTTGGTTCATTTTCCGGCATGCTGGCCGATGTGGAGGCCCC
AAAGCTGGCCGCCACCGTCATGAAAGAGCTTCTGGCAAAGGCCGGCCTCGCCCCCGACACGGTGAATGAAGTCATTGTGG
GGCAGGTCCTCTCCGGCGGCTGTGGCCAAGCCCCGGCCCGCCAAGCCATGCGCGGGGCGGGAATCCCTGACTCGGCCCAT
GCCCTGACCATCAACAAGGTCTGCGGCAGCGGCCTGAAGGCAATCATGCTCGGCGCCGACAGCATTCGTCTCGGTGAGTC
CCAAATTGTCATCGCCGGCGGCATGGAGAACATGTCCCTGGCGCCCTTTTTCCTCAAGAAGGCCCGCGCCGGCTACCGCA
TGGGGCACAGTGAACTGCTGGACCTGCTGATCTACGACGGTCTCCAGGATCCCTATACGGGCCGTCACATGGGAGAGATC
GGTGAGGTGAGCGCGGAGCGCGGTGGCCTCACCCGCAAGGAGCAGGACGCGTTCGCCCGGCGCTCCTACGAACTGGCCCA
GGCGGCGGTGACCGGCGGCATCTTTGCCGACGAGATCGTGCCGGTGGTGAAGAAGGGGAAAAAGGGAGACGAAACCATTG
GCACGGACGAAGAGCCCTTCAAGGGTGATCCGAGCAAGCTGCCATCCCTGCGGGCCGCCTTCAAGAAGGACGGCACCATC
ACCGCCGGCAACGCCTCCACTATCAACGACGGCGCGGCCCTGGCCCTGCTGACCGATGCCGACGGCCTAAAGAAGCACAA
CCTCACCCCCAAGGCCCGGATCGTTGCCTCGGCCACGGAAAGCCGTCATCCCGACAACTTCCCCGAGGCCCCCATCGGCG
CCATCGAGAAGGCCTGCGCCAAGGCCGGCCTGACGGTGTCCGACATCGACCTCTTCGAGATCAACGAGGCCTTTGCCTCG
GTGGCCCTCCTGGCCATCAAGGGTCTCGGCCTCCCCCTGGACAAGGTGAACGTCAACGGCGGCGCCTGCGCCATCGGCCA
CCCCATCGGCGCCAGCGGCGGCCGGCTTGCAGCCACGGTCATCCGGGAACTCCATCGGCGGCAGAAACGCTACGGCCTCG
CCACCCTCTGCATCGGCGGCGGCGAGGCGGTGGCAGTCATCTTCGAACGGGTTTGA

Upstream 100 bases:

>100_bases
TAAAGATTCACACACATCTATAAAGCCGTTCTAAATATGGTTGACATGCACGTGAAGTAGATATATGCTTACACCAAATC
TGCAACCCGGAGGGAAAGCG

Downstream 100 bases:

>100_bases
AAACAAATTTGAAACACGGAGCAACCGTGTTCTCAGTCAACAAATTAGTGCAGAAGTGGAGTGAATTTCGAGTGATCCCA
CTTCTGGTTGTTTTTCACCA

Product: thiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQDVFVVDALRTPFGSFSGMLADVEAPKLAATVMKELLAKAGLAPDTVNEVIVGQVLSGGCGQAPARQAMRGAGIPDSAH
ALTINKVCGSGLKAIMLGADSIRLGESQIVIAGGMENMSLAPFFLKKARAGYRMGHSELLDLLIYDGLQDPYTGRHMGEI
GEVSAERGGLTRKEQDAFARRSYELAQAAVTGGIFADEIVPVVKKGKKGDETIGTDEEPFKGDPSKLPSLRAAFKKDGTI
TAGNASTINDGAALALLTDADGLKKHNLTPKARIVASATESRHPDNFPEAPIGAIEKACAKAGLTVSDIDLFEINEAFAS
VALLAIKGLGLPLDKVNVNGGACAIGHPIGASGGRLAATVIRELHRRQKRYGLATLCIGGGEAVAVIFERV

Sequences:

>Translated_391_residues
MQDVFVVDALRTPFGSFSGMLADVEAPKLAATVMKELLAKAGLAPDTVNEVIVGQVLSGGCGQAPARQAMRGAGIPDSAH
ALTINKVCGSGLKAIMLGADSIRLGESQIVIAGGMENMSLAPFFLKKARAGYRMGHSELLDLLIYDGLQDPYTGRHMGEI
GEVSAERGGLTRKEQDAFARRSYELAQAAVTGGIFADEIVPVVKKGKKGDETIGTDEEPFKGDPSKLPSLRAAFKKDGTI
TAGNASTINDGAALALLTDADGLKKHNLTPKARIVASATESRHPDNFPEAPIGAIEKACAKAGLTVSDIDLFEINEAFAS
VALLAIKGLGLPLDKVNVNGGACAIGHPIGASGGRLAATVIRELHRRQKRYGLATLCIGGGEAVAVIFERV
>Mature_391_residues
MQDVFVVDALRTPFGSFSGMLADVEAPKLAATVMKELLAKAGLAPDTVNEVIVGQVLSGGCGQAPARQAMRGAGIPDSAH
ALTINKVCGSGLKAIMLGADSIRLGESQIVIAGGMENMSLAPFFLKKARAGYRMGHSELLDLLIYDGLQDPYTGRHMGEI
GEVSAERGGLTRKEQDAFARRSYELAQAAVTGGIFADEIVPVVKKGKKGDETIGTDEEPFKGDPSKLPSLRAAFKKDGTI
TAGNASTINDGAALALLTDADGLKKHNLTPKARIVASATESRHPDNFPEAPIGAIEKACAKAGLTVSDIDLFEINEAFAS
VALLAIKGLGLPLDKVNVNGGACAIGHPIGASGGRLAATVIRELHRRQKRYGLATLCIGGGEAVAVIFERV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.0203562340967, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=45.6410256410256, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=40.4092071611253, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=38.9873417721519, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=30.9133489461358, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=32.133676092545, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=45.9183673469388, Blast_Score=323, Evalue=8e-90,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=46.3104325699746, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=41.5422885572139, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI48994986, Length=409, Percent_Identity=36.919315403423, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=28.8135593220339, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=41.9023136246787, Blast_Score=313, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.8940568475452, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=39.030612244898, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17535917, Length=399, Percent_Identity=33.0827067669173, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=32.5471698113208, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=43.4343434343434, Blast_Score=298, Evalue=9e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=36.6583541147132, Blast_Score=193, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=45.4081632653061, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=44.2455242966752, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=37.8172588832487, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=31.6037735849057, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40723; Mature: 40723

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDVFVVDALRTPFGSFSGMLADVEAPKLAATVMKELLAKAGLAPDTVNEVIVGQVLSGG
CCCEEEEHHHHCCCCHHCCCEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
CGQAPARQAMRGAGIPDSAHALTINKVCGSGLKAIMLGADSIRLGESQIVIAGGMENMSL
CCCCHHHHHHHCCCCCCCCCEEEEHHHHCCCCEEEEECCCCEEECCCEEEEECCCCCCCH
APFFLKKARAGYRMGHSELLDLLIYDGLQDPYTGRHMGEIGEVSAERGGLTRKEQDAFAR
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
RSYELAQAAVTGGIFADEIVPVVKKGKKGDETIGTDEEPFKGDPSKLPSLRAAFKKDGTI
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCHHHHHHHHCCCCE
TAGNASTINDGAALALLTDADGLKKHNLTPKARIVASATESRHPDNFPEAPIGAIEKACA
ECCCCCCCCCCEEEEEEECCCCCHHCCCCCHHHEEEECHHCCCCCCCCCCCHHHHHHHHH
KAGLTVSDIDLFEINEAFASVALLAIKGLGLPLDKVNVNGGACAIGHPIGASGGRLAATV
HCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEECCCCCCCCCHHHHHH
IRELHRRQKRYGLATLCIGGGEAVAVIFERV
HHHHHHHHHHCCEEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MQDVFVVDALRTPFGSFSGMLADVEAPKLAATVMKELLAKAGLAPDTVNEVIVGQVLSGG
CCCEEEEHHHHCCCCHHCCCEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
CGQAPARQAMRGAGIPDSAHALTINKVCGSGLKAIMLGADSIRLGESQIVIAGGMENMSL
CCCCHHHHHHHCCCCCCCCCEEEEHHHHCCCCEEEEECCCCEEECCCEEEEECCCCCCCH
APFFLKKARAGYRMGHSELLDLLIYDGLQDPYTGRHMGEIGEVSAERGGLTRKEQDAFAR
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
RSYELAQAAVTGGIFADEIVPVVKKGKKGDETIGTDEEPFKGDPSKLPSLRAAFKKDGTI
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCHHHHHHHHCCCCE
TAGNASTINDGAALALLTDADGLKKHNLTPKARIVASATESRHPDNFPEAPIGAIEKACA
ECCCCCCCCCCEEEEEEECCCCCHHCCCCCHHHEEEECHHCCCCCCCCCCCHHHHHHHHH
KAGLTVSDIDLFEINEAFASVALLAIKGLGLPLDKVNVNGGACAIGHPIGASGGRLAATV
HCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEECCCCCCCCCHHHHHH
IRELHRRQKRYGLATLCIGGGEAVAVIFERV
HHHHHHHHHHCCEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]