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The map label for this gene is fabF [H]

Identifier: 78222904

GI number: 78222904

Start: 1901665

End: 1902870

Strand: Direct

Name: fabF [H]

Synonym: Gmet_1695

Alternate gene names: 78222904

Gene position: 1901665-1902870 (Clockwise)

Preceding gene: 78222903

Following gene: 78222905

Centisome position: 47.57

GC content: 66.5

Gene sequence:

>1206_bases
GTGAGCGCCGGCGTTGTCGCCATAACCGGACTCGGCATCTTCTGTGGCGCAGGGAAGGATATCCCTTCCTTCACCGATGC
CCTTATGAACGGGAAGAGCGGGGTCGCCCCTCTGGACCTCTTCGATGTCTCTGATTTCCCCTCCAAAATTGGCGTCCAGG
TGAAGGAATACGATCCCCTTGACCACTTCGACCGGAAAGCTGTCTCCCGGCTCTCCCGGGCGGATCAGTTCGGCGTGATC
GCCGCCGGCGAGGCCCTCCGGGCCAGCGGCATCGGCAAGCACTGCTCCCCCTATGACATGGGGGTCGTGGTGGGGGGAGG
CGCAGCCGGGATGTTCCAGTCGGAGCAGTGGCTCAAGGAGCGCATTGCTGGCCGCAAGGGGCGGCCGAGTCTGCTCCGGG
GTCTCCTTCCCGACAAGGCCTCCACGGTCATCGCCGAAACCTTCGGGCTTGCCGGCTACCAGGGGACCATAACCACCGCT
TGCTCGTCGTCGGCCACCGCCATCGGCTGGGGGGCCGACCTGGTATCCTCCGGTCGCCTCAAGGCCGTGGTCTGCGGGGG
GACGGACACTCTCTCCCTCCTCACCTTTGCGGGCTTCAACTCCCTGCGGGTCGTGGATCCCGAGCCCTGCTCCCCCTTCA
GCCTTGGTCGCCAGGGGATTTCCCTCGGTGAAGGTGCGGCCTTCATGGTACTGGAGGACGCGGATGCCGCCCGGCAGCGC
GGCGCAACGGTCTATGGCCACGTGCGAGGGTACGCGGCAGCCGGGGAAGCCTACCATATGACCGCCCCGGAGCCGTCGGG
AACGGCGGCGGCCCGGGTGATGACCGAGGCCATGCGGATCGCGGGGATCGATGCTGGCGCGGTGGGGTGGGTCAATGCCC
ACGGCACCGGAACGCCGTTGAACGATGCGGTCGAATCGAAGGCGATGAAGCTGGTCTTCGGCGAGGGGGTCGCCAACGTC
CCACTCGTCTCCACCAAAGCGCTTACCGGTCACTGCCTGGGTGCCGCCGGGGCCGTCGAAGGGGTGGCGACTGTCATCGC
CCTGAACGAGGGGATCATCCCTCAGACGTTGCACTTCCGGGGACGCGACCCCGAATGCGACCTGGATTACTGCCACGACG
GCCCACGCGCCAGCGGGGCAACCGTCGCGCTCTCCAACTCGTTTGCCTTTGGCGGCAACATCACCACCCTGGTGTTATCC
CGATGA

Upstream 100 bases:

>100_bases
TCGGCACCACCTGCGAGGTGGCCGATGCGGTGGCGTTTCTGGCATCGGATCGGGCCACCTATATCACTGGCCAGAGCCTG
GTGGTTGATGGAGGGATCCT

Downstream 100 bases:

>100_bases
AACCTGTGACCCATGACATAGTCGTCACCGGCCTCGCTGCCATCTCTGCGGCCGGGGTTGGCCTCGAAACCCTTGCCGCT
GCGATCAGCGACGGACAGAG

Product: Beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSAGVVAITGLGIFCGAGKDIPSFTDALMNGKSGVAPLDLFDVSDFPSKIGVQVKEYDPLDHFDRKAVSRLSRADQFGVI
AAGEALRASGIGKHCSPYDMGVVVGGGAAGMFQSEQWLKERIAGRKGRPSLLRGLLPDKASTVIAETFGLAGYQGTITTA
CSSSATAIGWGADLVSSGRLKAVVCGGTDTLSLLTFAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFMVLEDADAARQR
GATVYGHVRGYAAAGEAYHMTAPEPSGTAAARVMTEAMRIAGIDAGAVGWVNAHGTGTPLNDAVESKAMKLVFGEGVANV
PLVSTKALTGHCLGAAGAVEGVATVIALNEGIIPQTLHFRGRDPECDLDYCHDGPRASGATVALSNSFAFGGNITTLVLS
R

Sequences:

>Translated_401_residues
MSAGVVAITGLGIFCGAGKDIPSFTDALMNGKSGVAPLDLFDVSDFPSKIGVQVKEYDPLDHFDRKAVSRLSRADQFGVI
AAGEALRASGIGKHCSPYDMGVVVGGGAAGMFQSEQWLKERIAGRKGRPSLLRGLLPDKASTVIAETFGLAGYQGTITTA
CSSSATAIGWGADLVSSGRLKAVVCGGTDTLSLLTFAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFMVLEDADAARQR
GATVYGHVRGYAAAGEAYHMTAPEPSGTAAARVMTEAMRIAGIDAGAVGWVNAHGTGTPLNDAVESKAMKLVFGEGVANV
PLVSTKALTGHCLGAAGAVEGVATVIALNEGIIPQTLHFRGRDPECDLDYCHDGPRASGATVALSNSFAFGGNITTLVLS
R
>Mature_400_residues
SAGVVAITGLGIFCGAGKDIPSFTDALMNGKSGVAPLDLFDVSDFPSKIGVQVKEYDPLDHFDRKAVSRLSRADQFGVIA
AGEALRASGIGKHCSPYDMGVVVGGGAAGMFQSEQWLKERIAGRKGRPSLLRGLLPDKASTVIAETFGLAGYQGTITTAC
SSSATAIGWGADLVSSGRLKAVVCGGTDTLSLLTFAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFMVLEDADAARQRG
ATVYGHVRGYAAAGEAYHMTAPEPSGTAAARVMTEAMRIAGIDAGAVGWVNAHGTGTPLNDAVESKAMKLVFGEGVANVP
LVSTKALTGHCLGAAGAVEGVATVIALNEGIIPQTLHFRGRDPECDLDYCHDGPRASGATVALSNSFAFGGNITTLVLSR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=414, Percent_Identity=32.8502415458937, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI223972627, Length=163, Percent_Identity=39.8773006134969, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI41872631, Length=265, Percent_Identity=27.9245283018868, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=34.4660194174757, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1788663, Length=410, Percent_Identity=29.5121951219512, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=26.7639902676399, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=30.46875, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI212642053, Length=280, Percent_Identity=29.6428571428571, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=206, Percent_Identity=31.5533980582524, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=434, Percent_Identity=27.6497695852535, Blast_Score=135, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=32.0665083135392, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24581345, Length=270, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221330659, Length=261, Percent_Identity=27.9693486590038, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920632, Length=261, Percent_Identity=27.9693486590038, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 41082; Mature: 40951

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGVVAITGLGIFCGAGKDIPSFTDALMNGKSGVAPLDLFDVSDFPSKIGVQVKEYDPL
CCCCEEEEECCEEEECCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCHHHCCEEEECCCH
DHFDRKAVSRLSRADQFGVIAAGEALRASGIGKHCSPYDMGVVVGGGAAGMFQSEQWLKE
HHHHHHHHHHHHHCCCCCEEECCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHH
RIAGRKGRPSLLRGLLPDKASTVIAETFGLAGYQGTITTACSSSATAIGWGADLVSSGRL
HHCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCEEECCHHHHCCCCE
KAVVCGGTDTLSLLTFAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFMVLEDADAARQR
EEEEECCCCHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECCHHHHHC
GATVYGHVRGYAAAGEAYHMTAPEPSGTAAARVMTEAMRIAGIDAGAVGWVNAHGTGTPL
CCEEEEEECCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
NDAVESKAMKLVFGEGVANVPLVSTKALTGHCLGAAGAVEGVATVIALNEGIIPQTLHFR
HHHHHHHHEEEEECCCCCCCCEEEECCHHCHHCCCHHHHHHHEEEEEECCCCCCCEEEEC
GRDPECDLDYCHDGPRASGATVALSNSFAFGGNITTLVLSR
CCCCCCCCHHCCCCCCCCCCEEEEECCEEECCCEEEEEEEC
>Mature Secondary Structure 
SAGVVAITGLGIFCGAGKDIPSFTDALMNGKSGVAPLDLFDVSDFPSKIGVQVKEYDPL
CCCEEEEECCEEEECCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCHHHCCEEEECCCH
DHFDRKAVSRLSRADQFGVIAAGEALRASGIGKHCSPYDMGVVVGGGAAGMFQSEQWLKE
HHHHHHHHHHHHHCCCCCEEECCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHH
RIAGRKGRPSLLRGLLPDKASTVIAETFGLAGYQGTITTACSSSATAIGWGADLVSSGRL
HHCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCEEECCHHHHCCCCE
KAVVCGGTDTLSLLTFAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFMVLEDADAARQR
EEEEECCCCHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECCHHHHHC
GATVYGHVRGYAAAGEAYHMTAPEPSGTAAARVMTEAMRIAGIDAGAVGWVNAHGTGTPL
CCEEEEEECCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
NDAVESKAMKLVFGEGVANVPLVSTKALTGHCLGAAGAVEGVATVIALNEGIIPQTLHFR
HHHHHHHHEEEEECCCCCCCCEEEECCHHCHHCCCHHHHHHHEEEEEECCCCCCCEEEEC
GRDPECDLDYCHDGPRASGATVALSNSFAFGGNITTLVLSR
CCCCCCCCHHCCCCCCCCCCEEEEECCEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]