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The map label for this gene is gpmA

Identifier: 78222862

GI number: 78222862

Start: 1858881

End: 1859624

Strand: Direct

Name: gpmA

Synonym: Gmet_1653

Alternate gene names: 78222862

Gene position: 1858881-1859624 (Clockwise)

Preceding gene: 78222861

Following gene: 78222866

Centisome position: 46.5

GC content: 57.66

Gene sequence:

>744_bases
ATGAAAAAGCTCGTTTTGCTTCGTCACGGCGAAAGCGTCTGGAACAGGGAGAACCGTTTCACCGGCTGGACCGATGTGGG
GCTCAGCGAGAAGGGGATCGAGGAGGCAATCAGTGCCGGGCGCACCCTGAAAGAAGAAGGGTTTGTTTTCGACGTGGCCT
ACACGTCGGTCCTCAAGCGGGCCATCAAGACCCTCTGGCTCGTCCTGGAAGAGATGGATCTCATGTGGATCCCGGAATAC
CGCCACTGGAGGCTCAACGAGCGTCACTACGGAGCGCTCCAGGGGCTCAACAAGGCGGAGACCGCCGAACGGCACGGCAT
GGAGCAGGTCATGATCTGGCGCCGCAGTTACGATATCCCGCCGCCTCCCCTGACCCCCGACGATCAGCGGTTTCCGGGAA
GCGATCCTCGCTATGCATCACTTTTACCCGAGGAGTTACCACTCACCGAATCCCTCAAGGACACGGTCGCCCGTTTTCTT
CCCTACTGGCATGAAACCATCGCCCCCGCCGTAAAAGAAGGGAAACGGGTTCTCGTCACCGCCCACGGCAACAGCCTGCG
GGCCCTTGTAAAATACCTGGATCTGGTCTCTGACTCCGAAATCGTCAACCTCAATATTCCCACCGGCATTCCCCTTGTCT
ACGAACTAACGGATAACATGACACCCATCAGGAGCTACTATCTCGGTGATCCGGATGACGTGGCCAGGGCAAGCAGGATG
GTGGCGGATCAGATAAAGAAGTAA

Upstream 100 bases:

>100_bases
GTCGGCAGGGTAGGAAGGTTGCGCGCGGCGGACGCCTGTATATACTTACCCTGCGTGTGGGGTTGGTTGCCGACCCCGAT
TTTCTGAAAGGGGCCATGCC

Downstream 100 bases:

>100_bases
GTATCGCTCTGAACTCCTGGCGCCGGCGTCAAGCGATAAAGAGTCGTCCCTTCCTCTTCGCGATAAACCCTTCTGCTTCC
ATCTGCTTCAGGTTGCTCAG

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKKLVLLRHGESVWNRENRFTGWTDVGLSEKGIEEAISAGRTLKEEGFVFDVAYTSVLKRAIKTLWLVLEEMDLMWIPEY
RHWRLNERHYGALQGLNKAETAERHGMEQVMIWRRSYDIPPPPLTPDDQRFPGSDPRYASLLPEELPLTESLKDTVARFL
PYWHETIAPAVKEGKRVLVTAHGNSLRALVKYLDLVSDSEIVNLNIPTGIPLVYELTDNMTPIRSYYLGDPDDVARASRM
VADQIKK

Sequences:

>Translated_247_residues
MKKLVLLRHGESVWNRENRFTGWTDVGLSEKGIEEAISAGRTLKEEGFVFDVAYTSVLKRAIKTLWLVLEEMDLMWIPEY
RHWRLNERHYGALQGLNKAETAERHGMEQVMIWRRSYDIPPPPLTPDDQRFPGSDPRYASLLPEELPLTESLKDTVARFL
PYWHETIAPAVKEGKRVLVTAHGNSLRALVKYLDLVSDSEIVNLNIPTGIPLVYELTDNMTPIRSYYLGDPDDVARASRM
VADQIKK
>Mature_247_residues
MKKLVLLRHGESVWNRENRFTGWTDVGLSEKGIEEAISAGRTLKEEGFVFDVAYTSVLKRAIKTLWLVLEEMDLMWIPEY
RHWRLNERHYGALQGLNKAETAERHGMEQVMIWRRSYDIPPPPLTPDDQRFPGSDPRYASLLPEELPLTESLKDTVARFL
PYWHETIAPAVKEGKRVLVTAHGNSLRALVKYLDLVSDSEIVNLNIPTGIPLVYELTDNMTPIRSYYLGDPDDVARASRM
VADQIKK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=250, Percent_Identity=57.2, Blast_Score=295, Evalue=2e-80,
Organism=Homo sapiens, GI4505753, Length=247, Percent_Identity=58.2995951417004, Blast_Score=280, Evalue=7e-76,
Organism=Homo sapiens, GI71274132, Length=247, Percent_Identity=55.8704453441296, Blast_Score=266, Evalue=1e-71,
Organism=Homo sapiens, GI4502445, Length=249, Percent_Identity=48.1927710843374, Blast_Score=249, Evalue=1e-66,
Organism=Homo sapiens, GI40353764, Length=249, Percent_Identity=48.1927710843374, Blast_Score=249, Evalue=1e-66,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=60.8695652173913, Blast_Score=189, Evalue=2e-48,
Organism=Escherichia coli, GI1786970, Length=244, Percent_Identity=64.7540983606557, Blast_Score=331, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6322697, Length=247, Percent_Identity=52.2267206477733, Blast_Score=248, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6324516, Length=291, Percent_Identity=32.9896907216495, Blast_Score=141, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320183, Length=295, Percent_Identity=32.2033898305085, Blast_Score=135, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646216, Length=248, Percent_Identity=53.6290322580645, Blast_Score=273, Evalue=7e-74,
Organism=Drosophila melanogaster, GI85725270, Length=248, Percent_Identity=54.8387096774194, Blast_Score=253, Evalue=8e-68,
Organism=Drosophila melanogaster, GI85725272, Length=248, Percent_Identity=54.8387096774194, Blast_Score=253, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24650981, Length=248, Percent_Identity=54.8387096774194, Blast_Score=253, Evalue=8e-68,
Organism=Drosophila melanogaster, GI28571815, Length=245, Percent_Identity=40.8163265306122, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI28571817, Length=246, Percent_Identity=40.650406504065, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24648979, Length=246, Percent_Identity=40.650406504065, Blast_Score=178, Evalue=4e-45,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_GEOMG (Q39V40)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384609.1
- ProteinModelPortal:   Q39V40
- SMR:   Q39V40
- STRING:   Q39V40
- GeneID:   3740503
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1653
- NMPDR:   fig|269799.3.peg.1970
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   Q39V40
- ProtClustDB:   PRK14115
- BioCyc:   GMET269799:GMET_1653-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28389; Mature: 28389

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVLLRHGESVWNRENRFTGWTDVGLSEKGIEEAISAGRTLKEEGFVFDVAYTSVLKR
CCCEEEEECCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHCCCEEHHHHHHHHHH
AIKTLWLVLEEMDLMWIPEYRHWRLNERHYGALQGLNKAETAERHGMEQVMIWRRSYDIP
HHHHHHHHHHHCCCEECCCHHCCCCCCCHHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCC
PPPLTPDDQRFPGSDPRYASLLPEELPLTESLKDTVARFLPYWHETIAPAVKEGKRVLVT
CCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSLRALVKYLDLVSDSEIVNLNIPTGIPLVYELTDNMTPIRSYYLGDPDDVARASRM
ECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHH
VADQIKK
HHHHHCC
>Mature Secondary Structure
MKKLVLLRHGESVWNRENRFTGWTDVGLSEKGIEEAISAGRTLKEEGFVFDVAYTSVLKR
CCCEEEEECCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHCCCEEHHHHHHHHHH
AIKTLWLVLEEMDLMWIPEYRHWRLNERHYGALQGLNKAETAERHGMEQVMIWRRSYDIP
HHHHHHHHHHHCCCEECCCHHCCCCCCCHHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCC
PPPLTPDDQRFPGSDPRYASLLPEELPLTESLKDTVARFLPYWHETIAPAVKEGKRVLVT
CCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSLRALVKYLDLVSDSEIVNLNIPTGIPLVYELTDNMTPIRSYYLGDPDDVARASRM
ECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHH
VADQIKK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA