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The map label for this gene is maeB [H]

Identifier: 78222846

GI number: 78222846

Start: 1835829

End: 1838087

Strand: Reverse

Name: maeB [H]

Synonym: Gmet_1637

Alternate gene names: 78222846

Gene position: 1838087-1835829 (Counterclockwise)

Preceding gene: 78222858

Following gene: 78222845

Centisome position: 45.98

GC content: 58.26

Gene sequence:

>2259_bases
ATGAGCAAAAAACAGGATGCCCTGGAATACCATTCGAGCGGACGCAAAGGAAAGATAGAAGTCGTCGCCTCGAAGCCTTG
CCTTACCCAGCGGGACCTCTCTCTTGCCTACTCCCCGGGCGTTGCCGAACCGTGCCTGGAAATCGAGAAAAACCCTGAGG
ATGCTTATAAGTACACCGCGAAAGGAAACCTGGTCGCCGTAGTCTCCAACGGCACCGCGGTCCTGGGGCTCGGGAACATC
GGCGCCCTTGCCGGCAAACCGGTCATGGAAGGGAAAGGCGTCCTCTTCAAGCGCTTTGCCGACATCGACGTCTTTGACAT
CGAACTGAACACCGAGAACCCCGATGAGGTGATCAAAGCCTGCCAACTCCTCGAGCCCACGTTCGGCGGCATCAACCTGG
AGGATATCAAGGCCCCCGAGTGCTTCTATATCGAGGAAGAGCTCAAGAAGACCATGAACATCCCGGTCTTCCACGACGAC
CAACACGGCACCGCCATCATCTCCGCCGCCGCCCTCACCAATGCGCTGGAGATCATCGACAAGAAGATCGAGGATATTCG
CATCGTGGTGAACGGGGCCGGGGCCTCGGCCATCGCCTGCGCCAACCTCGCCATCTCGTTGGGGGTGAAGAAGGAAAACC
TCGTCATGTGCGATACCAAGGGTGTCATCTACAAGGGACGCACCGAGGGGATGAACAAGTATAAGGAACGCTTCGCCGTG
GACACCCCTCTGCGCACCCTGGAAGAGGCCGCGACAGGGGCCGACGTCCTCTACGGCCTCTCCTCCAAGGGGGCATTCAC
GCCGGAGATTGTGCGCAAGCTGGCCAAGAATCCCATTATCTTCGCCATGGCCAACCCGGACCCGGAAATATCGCCGGAAG
AGGCCCATGCCGTGCGGGGCGATGTCCTCATCGCCACCGGCCGTTCCGATTATCCGAACCAGGTGAACAACGTCCTCGGC
TTCCCCTTCATCTTCCGGGGAGCCCTCGATGTCCGGGCCACTACCATTAACGAGGAGATGAAGAAGGCTGCTGTTTTCGC
CCTTGCCGAGCTTGCCCGTGAGGAATGCCCCGACTCGGTCTGCCGCGCTTACGGCAACGTGAAGTTTTCCTTTGGCCGCG
ACTACATCATTCCGAAACCCTTTGACCCCCGTGCCCTCCTGCGGGTGGCACCGGCAGTTGCCAAAGCGGCCATGGAATCG
GGGGTGGCCCGCCAGCCCATCGAGGATATGGAGAAGTACGTTGAGCATCTTGAGTCGTTGCAGGGTAAAGCAAAGGAAGC
CCTGCGGATGATCATTAACAAGGCCAAAGCCGATCCCAGGAAGCTCGTCTTCCCCGAGGGAGATAACGAAAAAATCCTCA
GGGCGACTCAGATTCTCATTGAAGAAGAGATTGCCAAACCGATCCTCATCGGCAACCAGGACAAGATCCGGGAAAAGATG
GCGGAACTGGGACTCGACTTCAACGGCAGTGTCCAGATCATTGACCCGGCCACCTTTGAGCGTTCCGAAGAATATGCCCA
GGAACTCTTCAGCCTGCGGCAGCGCAAGGGACTGACCCTCACTGAAGCACGCCGGATCATGACCCGCAAATCCCGCACCC
ATTTCGGCTGTATGATGGTACACATGGGGGATGCGGACTGCCTCCTCTCCGGCATCGACACCCATTACCCCGAGACCATC
CGTCCGGCCCTTGAGGTCATCGGCAGACAGCCGGGTCTGTCCAGCGTGCACGGTCTCTACATGATGGTCTTCAAGAAGGG
GATTTATTTCATGGCCGATACCACGGTCTGCATCGAGCCGACTCCGGAAGAACTGGCGGAAACCGCCATTCTTGCGGCGG
AAAAAGTCCGCATGCTCGACATCGAGCCGACAATCGCCATGCTCTCCTTCTCCAACTTCGGCTCCGTCAACCATCCCCAG
GCCCAGAAGGTCAGGCGTGCCGTCGAGATCGTCAAACAAAAGGCTCCCGATCTTATCGTCGACGGTGAAATGCAGTCGGA
CACCGCAGTCGTCTCGGAGATGCTGCAGAAGAGCTTCTCCTTTGCCTCCCTCAAGGAGGCGGCCAACGTCCTGATTTTCC
CCGACCTGAACTCCGGAAACATCTGCTACAAACTCCTCCACCATCTAGGCGGGGCTGAAGCGATCGGTCCGATTCTTATG
GGAATGCAGAAACCGGTTCACGTCCTCCAGCGGGGTGACGATGTGAGCGACATCGTGAACATGGCGGCGCTTGCAGTGGT
GGATGCCCAGAATTCGTAA

Upstream 100 bases:

>100_bases
AGAAATCAGCAAAATAAAACCGTGTAACACGGCTGAATTAAAGCGAAGCAATTTTTATTATGACTGAAATTTGTCCACAA
AGAAAGGAGCAAGGAATCAC

Downstream 100 bases:

>100_bases
TAGCTTCACATAAGAAATGCAGAACAACGAAGGGGGCCATGAGCCCCCTTTCTCTTGCCATCCGTCTGGATACTTTGATA
AAATTCCGTCTTAATCATAT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MSKKQDALEYHSSGRKGKIEVVASKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTAKGNLVAVVSNGTAVLGLGNI
GALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEVIKACQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDD
QHGTAIISAAALTNALEIIDKKIEDIRIVVNGAGASAIACANLAISLGVKKENLVMCDTKGVIYKGRTEGMNKYKERFAV
DTPLRTLEEAATGADVLYGLSSKGAFTPEIVRKLAKNPIIFAMANPDPEISPEEAHAVRGDVLIATGRSDYPNQVNNVLG
FPFIFRGALDVRATTINEEMKKAAVFALAELAREECPDSVCRAYGNVKFSFGRDYIIPKPFDPRALLRVAPAVAKAAMES
GVARQPIEDMEKYVEHLESLQGKAKEALRMIINKAKADPRKLVFPEGDNEKILRATQILIEEEIAKPILIGNQDKIREKM
AELGLDFNGSVQIIDPATFERSEEYAQELFSLRQRKGLTLTEARRIMTRKSRTHFGCMMVHMGDADCLLSGIDTHYPETI
RPALEVIGRQPGLSSVHGLYMMVFKKGIYFMADTTVCIEPTPEELAETAILAAEKVRMLDIEPTIAMLSFSNFGSVNHPQ
AQKVRRAVEIVKQKAPDLIVDGEMQSDTAVVSEMLQKSFSFASLKEAANVLIFPDLNSGNICYKLLHHLGGAEAIGPILM
GMQKPVHVLQRGDDVSDIVNMAALAVVDAQNS

Sequences:

>Translated_752_residues
MSKKQDALEYHSSGRKGKIEVVASKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTAKGNLVAVVSNGTAVLGLGNI
GALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEVIKACQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDD
QHGTAIISAAALTNALEIIDKKIEDIRIVVNGAGASAIACANLAISLGVKKENLVMCDTKGVIYKGRTEGMNKYKERFAV
DTPLRTLEEAATGADVLYGLSSKGAFTPEIVRKLAKNPIIFAMANPDPEISPEEAHAVRGDVLIATGRSDYPNQVNNVLG
FPFIFRGALDVRATTINEEMKKAAVFALAELAREECPDSVCRAYGNVKFSFGRDYIIPKPFDPRALLRVAPAVAKAAMES
GVARQPIEDMEKYVEHLESLQGKAKEALRMIINKAKADPRKLVFPEGDNEKILRATQILIEEEIAKPILIGNQDKIREKM
AELGLDFNGSVQIIDPATFERSEEYAQELFSLRQRKGLTLTEARRIMTRKSRTHFGCMMVHMGDADCLLSGIDTHYPETI
RPALEVIGRQPGLSSVHGLYMMVFKKGIYFMADTTVCIEPTPEELAETAILAAEKVRMLDIEPTIAMLSFSNFGSVNHPQ
AQKVRRAVEIVKQKAPDLIVDGEMQSDTAVVSEMLQKSFSFASLKEAANVLIFPDLNSGNICYKLLHHLGGAEAIGPILM
GMQKPVHVLQRGDDVSDIVNMAALAVVDAQNS
>Mature_751_residues
SKKQDALEYHSSGRKGKIEVVASKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTAKGNLVAVVSNGTAVLGLGNIG
ALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEVIKACQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDDQ
HGTAIISAAALTNALEIIDKKIEDIRIVVNGAGASAIACANLAISLGVKKENLVMCDTKGVIYKGRTEGMNKYKERFAVD
TPLRTLEEAATGADVLYGLSSKGAFTPEIVRKLAKNPIIFAMANPDPEISPEEAHAVRGDVLIATGRSDYPNQVNNVLGF
PFIFRGALDVRATTINEEMKKAAVFALAELAREECPDSVCRAYGNVKFSFGRDYIIPKPFDPRALLRVAPAVAKAAMESG
VARQPIEDMEKYVEHLESLQGKAKEALRMIINKAKADPRKLVFPEGDNEKILRATQILIEEEIAKPILIGNQDKIREKMA
ELGLDFNGSVQIIDPATFERSEEYAQELFSLRQRKGLTLTEARRIMTRKSRTHFGCMMVHMGDADCLLSGIDTHYPETIR
PALEVIGRQPGLSSVHGLYMMVFKKGIYFMADTTVCIEPTPEELAETAILAAEKVRMLDIEPTIAMLSFSNFGSVNHPQA
QKVRRAVEIVKQKAPDLIVDGEMQSDTAVVSEMLQKSFSFASLKEAANVLIFPDLNSGNICYKLLHHLGGAEAIGPILMG
MQKPVHVLQRGDDVSDIVNMAALAVVDAQNS

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=343, Percent_Identity=28.2798833819242, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI62420880, Length=343, Percent_Identity=28.2798833819242, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI239049447, Length=343, Percent_Identity=28.2798833819242, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4505143, Length=363, Percent_Identity=28.099173553719, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI4505145, Length=352, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=8e-14,
Organism=Homo sapiens, GI270265879, Length=318, Percent_Identity=27.9874213836478, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1788806, Length=753, Percent_Identity=52.9880478087649, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=357, Percent_Identity=33.6134453781513, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788800, Length=330, Percent_Identity=34.8484848484849, Blast_Score=195, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17537199, Length=422, Percent_Identity=25.1184834123223, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322823, Length=270, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=30, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=30, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281362674, Length=463, Percent_Identity=26.133909287257, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281362672, Length=463, Percent_Identity=26.133909287257, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356279, Length=463, Percent_Identity=26.133909287257, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78707242, Length=407, Percent_Identity=26.7813267813268, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI78707238, Length=407, Percent_Identity=26.7813267813268, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI78707240, Length=345, Percent_Identity=26.9565217391304, Blast_Score=78, Evalue=3e-14,
Organism=Drosophila melanogaster, GI78707232, Length=370, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363505, Length=370, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78707236, Length=370, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363503, Length=370, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82340; Mature: 82209

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKQDALEYHSSGRKGKIEVVASKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTA
CCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCHHHHCCCCCHHHEEEEE
KGNLVAVVSNGTAVLGLGNIGALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEVIKA
CCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDDQHGTAIISAAALTNALEIID
HHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHH
KKIEDIRIVVNGAGASAIACANLAISLGVKKENLVMCDTKGVIYKGRTEGMNKYKERFAV
HHCCEEEEEEECCCCCHHHHHHHHEEECCCCCCEEEEECCCEEEECCHHHHHHHHHHHCC
DTPLRTLEEAATGADVLYGLSSKGAFTPEIVRKLAKNPIIFAMANPDPEISPEEAHAVRG
CCHHHHHHHHCCCCHHEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHCCC
DVLIATGRSDYPNQVNNVLGFPFIFRGALDVRATTINEEMKKAAVFALAELAREECPDSV
CEEEEECCCCCCHHHHHHCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHH
CRAYGNVKFSFGRDYIIPKPFDPRALLRVAPAVAKAAMESGVARQPIEDMEKYVEHLESL
HHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QGKAKEALRMIINKAKADPRKLVFPEGDNEKILRATQILIEEEIAKPILIGNQDKIREKM
HHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
AELGLDFNGSVQIIDPATFERSEEYAQELFSLRQRKGLTLTEARRIMTRKSRTHFGCMMV
HHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEE
HMGDADCLLSGIDTHYPETIRPALEVIGRQPGLSSVHGLYMMVFKKGIYFMADTTVCIEP
EECCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCEEEECC
TPEELAETAILAAEKVRMLDIEPTIAMLSFSNFGSVNHPQAQKVRRAVEIVKQKAPDLIV
CHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
DGEMQSDTAVVSEMLQKSFSFASLKEAANVLIFPDLNSGNICYKLLHHLGGAEAIGPILM
CCCCCCHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHH
GMQKPVHVLQRGDDVSDIVNMAALAVVDAQNS
HCHHHHHHHHCCCCHHHHHHHHHHHEEECCCC
>Mature Secondary Structure 
SKKQDALEYHSSGRKGKIEVVASKPCLTQRDLSLAYSPGVAEPCLEIEKNPEDAYKYTA
CCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCHHHHCCCCCHHHEEEEE
KGNLVAVVSNGTAVLGLGNIGALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEVIKA
CCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDDQHGTAIISAAALTNALEIID
HHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHH
KKIEDIRIVVNGAGASAIACANLAISLGVKKENLVMCDTKGVIYKGRTEGMNKYKERFAV
HHCCEEEEEEECCCCCHHHHHHHHEEECCCCCCEEEEECCCEEEECCHHHHHHHHHHHCC
DTPLRTLEEAATGADVLYGLSSKGAFTPEIVRKLAKNPIIFAMANPDPEISPEEAHAVRG
CCHHHHHHHHCCCCHHEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHCCC
DVLIATGRSDYPNQVNNVLGFPFIFRGALDVRATTINEEMKKAAVFALAELAREECPDSV
CEEEEECCCCCCHHHHHHCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHH
CRAYGNVKFSFGRDYIIPKPFDPRALLRVAPAVAKAAMESGVARQPIEDMEKYVEHLESL
HHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QGKAKEALRMIINKAKADPRKLVFPEGDNEKILRATQILIEEEIAKPILIGNQDKIREKM
HHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
AELGLDFNGSVQIIDPATFERSEEYAQELFSLRQRKGLTLTEARRIMTRKSRTHFGCMMV
HHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEE
HMGDADCLLSGIDTHYPETIRPALEVIGRQPGLSSVHGLYMMVFKKGIYFMADTTVCIEP
EECCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCEEEECC
TPEELAETAILAAEKVRMLDIEPTIAMLSFSNFGSVNHPQAQKVRRAVEIVKQKAPDLIV
CHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
DGEMQSDTAVVSEMLQKSFSFASLKEAANVLIFPDLNSGNICYKLLHHLGGAEAIGPILM
CCCCCCHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHH
GMQKPVHVLQRGDDVSDIVNMAALAVVDAQNS
HCHHHHHHHHCCCCHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]