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The map label for this gene is thrC [H]

Identifier: 78222840

GI number: 78222840

Start: 1827511

End: 1828896

Strand: Reverse

Name: thrC [H]

Synonym: Gmet_1631

Alternate gene names: 78222840

Gene position: 1828896-1827511 (Counterclockwise)

Preceding gene: 78222845

Following gene: 78222839

Centisome position: 45.75

GC content: 62.27

Gene sequence:

>1386_bases
ATGAACTATATCAGTACCCGGGGTGCCATCGCCCCCATCGGATTCAAGGACGCGGTCATGATGGGACTCGCCACCGACGG
CGGGCTTCTGCTGCCGGAGACCATCCCGGCCCTTGGCCGCAACACGCTCGAATCGTGGCAAAGCCTCTCCTACCAGGATC
TGGCGTTCAACGTGATATCCCTCTTCGCCGATGACATTCCCGCGCAGGACCTCAAGGATCTCATCGACCGCTCCTACGCC
ACCTTCTCCCATCCGGAGATTACACCGGTGGTGGAAAAGGACGGTGTGTACATCCTGGAACTCTTCCACGGGCCGACCCT
TGCCTTCAAAGACGTGGCGCTGCAGCTCCTCGGCAACCTCTTCGAGTACCTGCTGAAGGAGCGCGGGGAAAAGATGAACA
TCGTCGGCGCCACCTCGGGCGACACCGGCAGTGCCGCCATCTACGGCGTCCGGGGAAAGGACAAGATCAACATCTTCATC
CTCCATCCCCACGGCAAGACCTCGCCGGTGCAGGCCCTGCAGATGACCACGGTGCTCGATCCGAACGTGCACAACATCGC
CGCGCGGGGGACCTTTGACGACTGCCAGAACATCGTGAAGAGCCTCTTCAGCGATCTCCCCTTCAAGGAAAAGTACTCCT
TGGGCGCCGTCAACTCCATCAACTGGGCCCGGGTCCTGGCCCAGGTGGTCTACTACTTCTACGCCTACTTCCGGGTTGCC
GCGCTCTTCGGCCAGGAGGTGGTCTTCTCGGTTCCGACCGGCAATTTCGGCGATATTTTCGCCGGCTACGTGGCAAAGCG
GATGGGTCTGCCGATCAGACGGTTGATCCTGGCCACCAACGAGAACAATATCCTCTCCCGGTTCATCAACGGGGGTGACT
ATTCCCTCGGAGACGTGGTGGCGACCGTATCCCCGTCCATGGATATCCAGCTGGCCTCCAACTTCGAGCGGTATGTCTAC
TACCTCTTCGGCGAGAACCCCGCCCGGGTCCGCGAGGCGTTCGCCGCCCTCCCCACGAAGGGGCGGATCGACTTCACCGA
GGCCGAAATGGAGAAGGTGCGGGATGAGTTCCTCTCCCGCTCGGTGAACGAGGATGAGACCATCGCGACCATCGCCGCCT
TTCACCGGGAGACCGGCTACATCCTCGACCCCCACACGGCGGTCGGCGTCAAGGCGGCCCTGGAACTGGTGCAGGACGGC
ACTCCCGCCGTCTGCCTCGCCACGGCTCACCCGGCCAAGTTCGCCGAGGCGGTGGTCCGTGCCGTGGGTTTCGAGCCTTC
CCGACCGACCTCCCTGGAAGGAATCGAAGCCCTTCCGAGCCGATGCGACGTGCTCGATGCGGACCGCGACGCCATAAAGG
CATTCATCGAGAAAAAGGCCCTGTAG

Upstream 100 bases:

>100_bases
AAAGGCCCACGGCCGGAGCGGTCCGTCCCCTTCCCTTTTCGCGGGATTACTGTTAAGATGCTTCGTCTTTTACACAAAAA
ACAGCGGAGATTTGATCACT

Downstream 100 bases:

>100_bases
GGCCTTTTCCTTTTAAACCGATCCCCATGACTATTGACTGGAATCAGATCGATACGGTGCTCCTCGACATGGACGGCACC
CTCCTGGACCGCCATTTCGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNYISTRGAIAPIGFKDAVMMGLATDGGLLLPETIPALGRNTLESWQSLSYQDLAFNVISLFADDIPAQDLKDLIDRSYA
TFSHPEITPVVEKDGVYILELFHGPTLAFKDVALQLLGNLFEYLLKERGEKMNIVGATSGDTGSAAIYGVRGKDKINIFI
LHPHGKTSPVQALQMTTVLDPNVHNIAARGTFDDCQNIVKSLFSDLPFKEKYSLGAVNSINWARVLAQVVYYFYAYFRVA
ALFGQEVVFSVPTGNFGDIFAGYVAKRMGLPIRRLILATNENNILSRFINGGDYSLGDVVATVSPSMDIQLASNFERYVY
YLFGENPARVREAFAALPTKGRIDFTEAEMEKVRDEFLSRSVNEDETIATIAAFHRETGYILDPHTAVGVKAALELVQDG
TPAVCLATAHPAKFAEAVVRAVGFEPSRPTSLEGIEALPSRCDVLDADRDAIKAFIEKKAL

Sequences:

>Translated_461_residues
MNYISTRGAIAPIGFKDAVMMGLATDGGLLLPETIPALGRNTLESWQSLSYQDLAFNVISLFADDIPAQDLKDLIDRSYA
TFSHPEITPVVEKDGVYILELFHGPTLAFKDVALQLLGNLFEYLLKERGEKMNIVGATSGDTGSAAIYGVRGKDKINIFI
LHPHGKTSPVQALQMTTVLDPNVHNIAARGTFDDCQNIVKSLFSDLPFKEKYSLGAVNSINWARVLAQVVYYFYAYFRVA
ALFGQEVVFSVPTGNFGDIFAGYVAKRMGLPIRRLILATNENNILSRFINGGDYSLGDVVATVSPSMDIQLASNFERYVY
YLFGENPARVREAFAALPTKGRIDFTEAEMEKVRDEFLSRSVNEDETIATIAAFHRETGYILDPHTAVGVKAALELVQDG
TPAVCLATAHPAKFAEAVVRAVGFEPSRPTSLEGIEALPSRCDVLDADRDAIKAFIEKKAL
>Mature_461_residues
MNYISTRGAIAPIGFKDAVMMGLATDGGLLLPETIPALGRNTLESWQSLSYQDLAFNVISLFADDIPAQDLKDLIDRSYA
TFSHPEITPVVEKDGVYILELFHGPTLAFKDVALQLLGNLFEYLLKERGEKMNIVGATSGDTGSAAIYGVRGKDKINIFI
LHPHGKTSPVQALQMTTVLDPNVHNIAARGTFDDCQNIVKSLFSDLPFKEKYSLGAVNSINWARVLAQVVYYFYAYFRVA
ALFGQEVVFSVPTGNFGDIFAGYVAKRMGLPIRRLILATNENNILSRFINGGDYSLGDVVATVSPSMDIQLASNFERYVY
YLFGENPARVREAFAALPTKGRIDFTEAEMEKVRDEFLSRSVNEDETIATIAAFHRETGYILDPHTAVGVKAALELVQDG
TPAVCLATAHPAKFAEAVVRAVGFEPSRPTSLEGIEALPSRCDVLDADRDAIKAFIEKKAL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=456, Percent_Identity=37.719298245614, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI153792148, Length=440, Percent_Identity=36.3636363636364, Blast_Score=253, Evalue=4e-67,
Organism=Escherichia coli, GI1786185, Length=445, Percent_Identity=33.7078651685393, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6319901, Length=459, Percent_Identity=50.3267973856209, Blast_Score=423, Evalue=1e-119,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50556; Mature: 50556

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISTRGAIAPIGFKDAVMMGLATDGGLLLPETIPALGRNTLESWQSLSYQDLAFNVIS
CCCCCCCCCCCCCCHHHHHHEEEECCCCEECCHHHHHHCHHHHHHHHCCCHHHHHHHHHH
LFADDIPAQDLKDLIDRSYATFSHPEITPVVEKDGVYILELFHGPTLAFKDVALQLLGNL
HHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHH
FEYLLKERGEKMNIVGATSGDTGSAAIYGVRGKDKINIFILHPHGKTSPVQALQMTTVLD
HHHHHHHCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHEEC
PNVHNIAARGTFDDCQNIVKSLFSDLPFKEKYSLGAVNSINWARVLAQVVYYFYAYFRVA
CCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALFGQEVVFSVPTGNFGDIFAGYVAKRMGLPIRRLILATNENNILSRFINGGDYSLGDVV
HHHCCCEEEECCCCCCHHHHHHHHHHHHCCCEEHEEEECCCCHHHHHHHCCCCCCHHHHH
ATVSPSMDIQLASNFERYVYYLFGENPARVREAFAALPTKGRIDFTEAEMEKVRDEFLSR
EECCCCCCEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
SVNEDETIATIAAFHRETGYILDPHTAVGVKAALELVQDGTPAVCLATAHPAKFAEAVVR
CCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
AVGFEPSRPTSLEGIEALPSRCDVLDADRDAIKAFIEKKAL
HHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNYISTRGAIAPIGFKDAVMMGLATDGGLLLPETIPALGRNTLESWQSLSYQDLAFNVIS
CCCCCCCCCCCCCCHHHHHHEEEECCCCEECCHHHHHHCHHHHHHHHCCCHHHHHHHHHH
LFADDIPAQDLKDLIDRSYATFSHPEITPVVEKDGVYILELFHGPTLAFKDVALQLLGNL
HHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHH
FEYLLKERGEKMNIVGATSGDTGSAAIYGVRGKDKINIFILHPHGKTSPVQALQMTTVLD
HHHHHHHCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHEEC
PNVHNIAARGTFDDCQNIVKSLFSDLPFKEKYSLGAVNSINWARVLAQVVYYFYAYFRVA
CCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALFGQEVVFSVPTGNFGDIFAGYVAKRMGLPIRRLILATNENNILSRFINGGDYSLGDVV
HHHCCCEEEECCCCCCHHHHHHHHHHHHCCCEEHEEEECCCCHHHHHHHCCCCCCHHHHH
ATVSPSMDIQLASNFERYVYYLFGENPARVREAFAALPTKGRIDFTEAEMEKVRDEFLSR
EECCCCCCEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
SVNEDETIATIAAFHRETGYILDPHTAVGVKAALELVQDGTPAVCLATAHPAKFAEAVVR
CCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
AVGFEPSRPTSLEGIEALPSRCDVLDADRDAIKAFIEKKAL
HHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]