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The map label for this gene is fabF [H]

Identifier: 78222813

GI number: 78222813

Start: 1803205

End: 1804437

Strand: Direct

Name: fabF [H]

Synonym: Gmet_1603

Alternate gene names: 78222813

Gene position: 1803205-1804437 (Clockwise)

Preceding gene: 78222812

Following gene: 78222814

Centisome position: 45.11

GC content: 53.69

Gene sequence:

>1233_bases
ATGAGAAGAGTTGTTGTGACGGGAGTTGGAGCCATTTCTCCCCTGGGGACCGGCAATGGCAAGAACTGGGATGCACTCGT
CGCGGGACGGTCAGGAATCGATCTGATTACCCGTTTCGACGCCTCGGAGCTTCCTGTAAAGATTGCCGGCGAAGTTAAGG
ATTTCACTCCTGAGGATTTCATTGAAAAAAAAGAGGTCAAGAAAATGGACCTCTTTATTCAGTATGCCCTTGCGGCTGCC
CAGTTTGCCATGGAGGATTCGGGGCTTCAGATTACCGATGAGAACGCTGAACGCGTCGGGGTGATTGTCGGAGCTGGTCT
CGGCGGACTGCCGACCATTGAGAAATATCATGCGGCAATGCTGGAAGGGGGCTACAAGAAGATCTCTCCTTTCTTTATTC
CGATGCTCATTATCAACCTGGCTCCGGGGCATATTTCCATCAAGTACGGGGCAAAAGGACCAAACCTTTCGTCAGTTTCA
GCCTGCGCGACCGGTACCCACTCAATCGGTGATGCCTATCACATGATCAAGCGGGGAGATGCGGATGCCATGATTGCCGG
CGGTACCGAGTCGACGGTGACACCTCTCGGCATAGGTGGTTTTGCCGTGATGAAGGCCCTCTCTACCCGTAATGACGACC
CGAAAGGGGCATCGCGCCCCTTCGAGAAGAGCCGTGACGGATTCGTCCTCGCTGAAGGCGCCGGAATCGTGATTCTTGAG
GAGTATGAGTCTGCCAAGAAGCGCGGAGCGAAGATTTATGCCGAGGTAGTCGGTTATGGCCTCTCGGGCGATGCCTATCA
CCTGACAGCGCCTGCCCCGGAAGGAGAAGGGGCCGCCCGCTGCATCAAGATGGCGCTCAACAACGCCGGCATCAATGCTG
ATCAGGTTGACTACATCAATGCTCATGGTACTTCAACTCATTTTAATGATTACTATGAGACGCTTGCCATCAAAAAAGTC
TTCGGAGACCACGCAAAGAAAATCATGGTCTCTTCCACCAAATCGATGACCGGTCACCTTCTCGGGGCAGCAGGCGGTGT
CGAGGCGGTATTCAGCCTCATGGCGATGGACAAGGGTGTTGTTCCTCCGACCATCAACTACCAGGAGCAGGATTCTGAGT
GCGATCTCGATTATGTCCCCAACACTGCCCGGGATGCAAAGATCACCTATGCCATGAGCAACAACTTCGGTTTCGGCGGC
ACCAATGCCTCGCTTCTCTTCAAGAAGATATAG

Upstream 100 bases:

>100_bases
ATACCTAAACACGAGGGGGAAGGGGAACCTTCCCCCTTTTCACACAGAGCGGCACTGCCGCTATCTCTGCACGATTCCAG
AACATCGGGAGCACGCCATT

Downstream 100 bases:

>100_bases
CGAGGTGATGCAGTGATACTCGTCGGAAGCGATCATGGAGGCCTTGAACTGAAGGAGGCAATTAAGCTTCTCCTGACTGA
GCGGGGCATTACTGTTGAGG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRRVVVTGVGAISPLGTGNGKNWDALVAGRSGIDLITRFDASELPVKIAGEVKDFTPEDFIEKKEVKKMDLFIQYALAAA
QFAMEDSGLQITDENAERVGVIVGAGLGGLPTIEKYHAAMLEGGYKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVS
ACATGTHSIGDAYHMIKRGDADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPKGASRPFEKSRDGFVLAEGAGIVILE
EYESAKKRGAKIYAEVVGYGLSGDAYHLTAPAPEGEGAARCIKMALNNAGINADQVDYINAHGTSTHFNDYYETLAIKKV
FGDHAKKIMVSSTKSMTGHLLGAAGGVEAVFSLMAMDKGVVPPTINYQEQDSECDLDYVPNTARDAKITYAMSNNFGFGG
TNASLLFKKI

Sequences:

>Translated_410_residues
MRRVVVTGVGAISPLGTGNGKNWDALVAGRSGIDLITRFDASELPVKIAGEVKDFTPEDFIEKKEVKKMDLFIQYALAAA
QFAMEDSGLQITDENAERVGVIVGAGLGGLPTIEKYHAAMLEGGYKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVS
ACATGTHSIGDAYHMIKRGDADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPKGASRPFEKSRDGFVLAEGAGIVILE
EYESAKKRGAKIYAEVVGYGLSGDAYHLTAPAPEGEGAARCIKMALNNAGINADQVDYINAHGTSTHFNDYYETLAIKKV
FGDHAKKIMVSSTKSMTGHLLGAAGGVEAVFSLMAMDKGVVPPTINYQEQDSECDLDYVPNTARDAKITYAMSNNFGFGG
TNASLLFKKI
>Mature_410_residues
MRRVVVTGVGAISPLGTGNGKNWDALVAGRSGIDLITRFDASELPVKIAGEVKDFTPEDFIEKKEVKKMDLFIQYALAAA
QFAMEDSGLQITDENAERVGVIVGAGLGGLPTIEKYHAAMLEGGYKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVS
ACATGTHSIGDAYHMIKRGDADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPKGASRPFEKSRDGFVLAEGAGIVILE
EYESAKKRGAKIYAEVVGYGLSGDAYHLTAPAPEGEGAARCIKMALNNAGINADQVDYINAHGTSTHFNDYYETLAIKKV
FGDHAKKIMVSSTKSMTGHLLGAAGGVEAVFSLMAMDKGVVPPTINYQEQDSECDLDYVPNTARDAKITYAMSNNFGFGG
TNASLLFKKI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=47.4698795180723, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=52.7397260273973, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=23.8317757009346, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=56.5853658536585, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=40.4819277108434, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=37.410071942446, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=42.0849420849421, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=428, Percent_Identity=26.1682242990654, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17550940, Length=271, Percent_Identity=26.5682656826568, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=36.0178970917226, Blast_Score=281, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24644341, Length=414, Percent_Identity=45.1690821256039, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI19920632, Length=381, Percent_Identity=24.4094488188976, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221330659, Length=381, Percent_Identity=24.4094488188976, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24581345, Length=408, Percent_Identity=22.3039215686275, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43422; Mature: 43422

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGVGAISPLGTGNGKNWDALVAGRSGIDLITRFDASELPVKIAGEVKDFTPEDF
CCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCHHH
IEKKEVKKMDLFIQYALAAAQFAMEDSGLQITDENAERVGVIVGAGLGGLPTIEKYHAAM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHH
LEGGYKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVSACATGTHSIGDAYHMIKRGD
HHCCCHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHCCC
ADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPKGASRPFEKSRDGFVLAEGAGIVILE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEC
EYESAKKRGAKIYAEVVGYGLSGDAYHLTAPAPEGEGAARCIKMALNNAGINADQVDYIN
CHHHHHHHCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
AHGTSTHFNDYYETLAIKKVFGDHAKKIMVSSTKSMTGHLLGAAGGVEAVFSLMAMDKGV
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHEEECCCCHHHHHHHHHHCCCC
VPPTINYQEQDSECDLDYVPNTARDAKITYAMSNNFGFGGTNASLLFKKI
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECC
>Mature Secondary Structure
MRRVVVTGVGAISPLGTGNGKNWDALVAGRSGIDLITRFDASELPVKIAGEVKDFTPEDF
CCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCHHH
IEKKEVKKMDLFIQYALAAAQFAMEDSGLQITDENAERVGVIVGAGLGGLPTIEKYHAAM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHH
LEGGYKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVSACATGTHSIGDAYHMIKRGD
HHCCCHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHCCC
ADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPKGASRPFEKSRDGFVLAEGAGIVILE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEC
EYESAKKRGAKIYAEVVGYGLSGDAYHLTAPAPEGEGAARCIKMALNNAGINADQVDYIN
CHHHHHHHCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
AHGTSTHFNDYYETLAIKKVFGDHAKKIMVSSTKSMTGHLLGAAGGVEAVFSLMAMDKGV
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHEEECCCCHHHHHHHHHHCCCC
VPPTINYQEQDSECDLDYVPNTARDAKITYAMSNNFGFGGTNASLLFKKI
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]