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The map label for this gene is ymxG [H]

Identifier: 78222802

GI number: 78222802

Start: 1794651

End: 1795907

Strand: Direct

Name: ymxG [H]

Synonym: Gmet_1592

Alternate gene names: 78222802

Gene position: 1794651-1795907 (Clockwise)

Preceding gene: 78222801

Following gene: 78222803

Centisome position: 44.9

GC content: 52.82

Gene sequence:

>1257_bases
ATGGTCAGTAAAACAATCCTCGATAATGGCGTGCGGGTCATATCCGAGTATATGCCCCACGCCCACTCGGTATCCATCGG
GATATGGGTCGCCAATGGCTCCCGTCATGAACGGCGGGAGCACAATGGCGTCGCCCATTTCATCGAGCATCTCCTCTTCA
AGGGGACTGTGCGCCGAAGTGCACTTGACATTGCCCGCGAGATTGATTCTGTAGGGGGAGTGCTCAACGCATTCACCAGC
CGTGAGTACGTCTGCTACTACGCCAAGGTCCTCGATAAAAATCTTCCACAAGCCGTAGACCTCCTTACTGACATCTTCCT
TAATTCGACTTTTGACCCGGAAGAGATTGAGAAGGAGCGGAAGGTGGTCCTCCAGGAAATCAGCATGCTGGAGGATTCTC
CGGACGACTATGTTCACGACCTCTTTCATCGCAGTTTCTGGAGAGGGCACCCCCTCGGCATGTCGATCCTTGGAAGTGCT
GAGAGCGTCAGTAATCTTTCCCGTGATGCTATCGTTGCACACCGGGATGCGATGTACCGTTCCGAGGACATCATTGTGGC
GGTGGCGGGCAACGTGCGCCACGATGAGCTTCTGAAACTCATAAGCGGCTCTTTTGACAGTGTTCCAGAGGGGACCGGAC
GCAACTGCTGCCATCTGCCCGTTTATGACCAGAAGCTGGAGATAGTCGAGAAGGATCTGGAGCAACTTCATATCTGTCTT
GGGACCAAGTCTCTGCCCCATAATCATCCCCGACGGTTTGAAGCATATCTCATGAACACCATTCTCGGTGGCAGCATGAG
CTCACGCCTTTTTCAGGAGATTCGAGAGCATCTCGGCCTTGCTTACACGGTCTATTCCTATGTTGTTTCACACACCGATG
CAGGGTCACTCGTGGTCTATGCCGGAACGAGCCCTGAAAAGCTCAGTGATGTTCTTGAGATAACCTGTTCCGAGCTAAGA
CGGCTGAAGTTTGAACCTGTTCCCGCCACTGAGCTTGAGGCGGCCCGGGAACAACTCAAGGGAAACATTCTTCTCTCGCT
TGAGAGTTCAGACAACCGGATGACCAAGCTTGCAAAGAATGAAATATATTTTGGCCGTTACCTTTCCCTTGCCGAGCTGA
CTGGAGGCTTTGACAGCGCTACGGCAGACGGCATTGCTGAACTGGCCAACGATTTCTTCTCGGGCGATTATGTCACCCTT
GCCCTTACGGGGAAGATATCAGGACAGATTCCGGACCTCTCGCATCTCGTACTATAG

Upstream 100 bases:

>100_bases
AAAACTGTCCCGTAAAGAAGCTCTGGGTGCAGTACTGCCCGAGTAGTGTCCGGCGGGAATCCTGCTGGTAAACTCACCGG
TCCGCGGTATAGTTTTATTC

Downstream 100 bases:

>100_bases
GTGACTGATGGAACGCTGCGTAGTCAAGGTTCGACGGGTGCGTGGGGGGGACCAGAATCTCCCCTGCTACATGACAGTCC
ACGCAGCAGGCATGGATCTC

Product: peptidase M16-like

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MVSKTILDNGVRVISEYMPHAHSVSIGIWVANGSRHERREHNGVAHFIEHLLFKGTVRRSALDIAREIDSVGGVLNAFTS
REYVCYYAKVLDKNLPQAVDLLTDIFLNSTFDPEEIEKERKVVLQEISMLEDSPDDYVHDLFHRSFWRGHPLGMSILGSA
ESVSNLSRDAIVAHRDAMYRSEDIIVAVAGNVRHDELLKLISGSFDSVPEGTGRNCCHLPVYDQKLEIVEKDLEQLHICL
GTKSLPHNHPRRFEAYLMNTILGGSMSSRLFQEIREHLGLAYTVYSYVVSHTDAGSLVVYAGTSPEKLSDVLEITCSELR
RLKFEPVPATELEAAREQLKGNILLSLESSDNRMTKLAKNEIYFGRYLSLAELTGGFDSATADGIAELANDFFSGDYVTL
ALTGKISGQIPDLSHLVL

Sequences:

>Translated_418_residues
MVSKTILDNGVRVISEYMPHAHSVSIGIWVANGSRHERREHNGVAHFIEHLLFKGTVRRSALDIAREIDSVGGVLNAFTS
REYVCYYAKVLDKNLPQAVDLLTDIFLNSTFDPEEIEKERKVVLQEISMLEDSPDDYVHDLFHRSFWRGHPLGMSILGSA
ESVSNLSRDAIVAHRDAMYRSEDIIVAVAGNVRHDELLKLISGSFDSVPEGTGRNCCHLPVYDQKLEIVEKDLEQLHICL
GTKSLPHNHPRRFEAYLMNTILGGSMSSRLFQEIREHLGLAYTVYSYVVSHTDAGSLVVYAGTSPEKLSDVLEITCSELR
RLKFEPVPATELEAAREQLKGNILLSLESSDNRMTKLAKNEIYFGRYLSLAELTGGFDSATADGIAELANDFFSGDYVTL
ALTGKISGQIPDLSHLVL
>Mature_418_residues
MVSKTILDNGVRVISEYMPHAHSVSIGIWVANGSRHERREHNGVAHFIEHLLFKGTVRRSALDIAREIDSVGGVLNAFTS
REYVCYYAKVLDKNLPQAVDLLTDIFLNSTFDPEEIEKERKVVLQEISMLEDSPDDYVHDLFHRSFWRGHPLGMSILGSA
ESVSNLSRDAIVAHRDAMYRSEDIIVAVAGNVRHDELLKLISGSFDSVPEGTGRNCCHLPVYDQKLEIVEKDLEQLHICL
GTKSLPHNHPRRFEAYLMNTILGGSMSSRLFQEIREHLGLAYTVYSYVVSHTDAGSLVVYAGTSPEKLSDVLEITCSELR
RLKFEPVPATELEAAREQLKGNILLSLESSDNRMTKLAKNEIYFGRYLSLAELTGGFDSATADGIAELANDFFSGDYVTL
ALTGKISGQIPDLSHLVL

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=424, Percent_Identity=33.2547169811321, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI46593007, Length=436, Percent_Identity=27.0642201834862, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI24308013, Length=379, Percent_Identity=25.8575197889182, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1787770, Length=217, Percent_Identity=25.8064516129032, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI2367164, Length=208, Percent_Identity=25.9615384615385, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=412, Percent_Identity=27.4271844660194, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17553678, Length=401, Percent_Identity=25.6857855361596, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323192, Length=427, Percent_Identity=30.6791569086651, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6321813, Length=426, Percent_Identity=23.0046948356808, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319426, Length=428, Percent_Identity=24.2990654205607, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325449, Length=190, Percent_Identity=28.4210526315789, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357875, Length=427, Percent_Identity=28.5714285714286, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24646943, Length=427, Percent_Identity=28.5714285714286, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921772, Length=452, Percent_Identity=23.6725663716814, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46622; Mature: 46622

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKTILDNGVRVISEYMPHAHSVSIGIWVANGSRHERREHNGVAHFIEHLLFKGTVRRS
CCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHH
ALDIAREIDSVGGVLNAFTSREYVCYYAKVLDKNLPQAVDLLTDIFLNSTFDPEEIEKER
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KVVLQEISMLEDSPDDYVHDLFHRSFWRGHPLGMSILGSAESVSNLSRDAIVAHRDAMYR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHC
SEDIIVAVAGNVRHDELLKLISGSFDSVPEGTGRNCCHLPVYDQKLEIVEKDLEQLHICL
CCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHH
GTKSLPHNHPRRFEAYLMNTILGGSMSSRLFQEIREHLGLAYTVYSYVVSHTDAGSLVVY
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEE
AGTSPEKLSDVLEITCSELRRLKFEPVPATELEAAREQLKGNILLSLESSDNRMTKLAKN
ECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
EIYFGRYLSLAELTGGFDSATADGIAELANDFFSGDYVTLALTGKISGQIPDLSHLVL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MVSKTILDNGVRVISEYMPHAHSVSIGIWVANGSRHERREHNGVAHFIEHLLFKGTVRRS
CCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHH
ALDIAREIDSVGGVLNAFTSREYVCYYAKVLDKNLPQAVDLLTDIFLNSTFDPEEIEKER
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KVVLQEISMLEDSPDDYVHDLFHRSFWRGHPLGMSILGSAESVSNLSRDAIVAHRDAMYR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHC
SEDIIVAVAGNVRHDELLKLISGSFDSVPEGTGRNCCHLPVYDQKLEIVEKDLEQLHICL
CCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHH
GTKSLPHNHPRRFEAYLMNTILGGSMSSRLFQEIREHLGLAYTVYSYVVSHTDAGSLVVY
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEE
AGTSPEKLSDVLEITCSELRRLKFEPVPATELEAAREQLKGNILLSLESSDNRMTKLAKN
ECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
EIYFGRYLSLAELTGGFDSATADGIAELANDFFSGDYVTLALTGKISGQIPDLSHLVL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]