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The map label for this gene is moeZ [H]

Identifier: 78222778

GI number: 78222778

Start: 1770296

End: 1771105

Strand: Direct

Name: moeZ [H]

Synonym: Gmet_1568

Alternate gene names: 78222778

Gene position: 1770296-1771105 (Clockwise)

Preceding gene: 78222777

Following gene: 78222779

Centisome position: 44.29

GC content: 61.11

Gene sequence:

>810_bases
ATGTTCACTGAAGAGCAGATCGAACGCTACTCCCGCCACATCATCCTGAAAGAGGTGGGAGGAAAGGGACAGAAGAAACT
CCTGGAGGGGAAGGTGATGGTGATCGGCGCCGGCGGCCTCGGTGCCCCCATCGCACTTTATCTGGCCGCAGCCGGGGTTG
GCACCATCGGCATTGCCGACGCCGACGTGGTGGATCTTTCCAATCTCCAGCGCCAGGTGATCCACTTCACCCCCGACGTG
GGTAAGCCGAAAGTGGAGTCGGCCCGGGAGAAGATGGAGGCCATCAACCCCGACGTGACGGTGCGGACCTACCAGGAGTG
GATCTCCGCCGCCAACATCGCCCGGATCATCGCCGACTATGATTTCGTCATCGACGGCACCGACAACTTTGCCGCCAAGT
TCCTCATCAACGACGCCTGCGTCATGGCGGGGAAACCGTACTCCCACGGCGGCATCCTCCAGTTCGTGGGCCAGACAATG
ACCATTAAGCCAGGGGAATCCCCCTGCTACCGCTGCATCTTCCCGGCTCCGCCGCCAAAGGACGCCATTCCCACCTGCTC
CCAGGCCGGTGTCATCGGCGTCCTGCCAGGAGTTATCGGCACTATCCAGGCCACCGAGGCGATCAAGTACCTGCTCGGAA
AAGGTGCGCTGCTGACCGGTCACATCATGATGTATGACGCCCTGGAGATGAACTTCCGGAAGGTGAAGCTCAACCGGAAC
CGCAAGTGCCCCGTATGCGGCGATAACCCCACCGTGACGGAACTGGTGGACGAACTCGACGCCCTGAACGTCTGCGACCT
GGAGAAGTGA

Upstream 100 bases:

>100_bases
AGCTGAACGGCGAGGTGCTGGAGCGGGAGGCGTTCGATGCCACAACGGTAAAAGATGGCGATGCGGTGGAATTCCTCTAC
TTTATGGGCGGAGGTAAGTA

Downstream 100 bases:

>100_bases
CCATGCTGACGATTCCCCGCGCGATCCACGCAGAGCTCATCGCTCATGCCCAAGCCGACGCCCCCATTGAGGCGTGCGGC
ATCCTCGGCGGTATTGACGG

Product: UBA/THIF-type NAD/FAD binding fold:MoeZ/MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MFTEEQIERYSRHIILKEVGGKGQKKLLEGKVMVIGAGGLGAPIALYLAAAGVGTIGIADADVVDLSNLQRQVIHFTPDV
GKPKVESAREKMEAINPDVTVRTYQEWISAANIARIIADYDFVIDGTDNFAAKFLINDACVMAGKPYSHGGILQFVGQTM
TIKPGESPCYRCIFPAPPPKDAIPTCSQAGVIGVLPGVIGTIQATEAIKYLLGKGALLTGHIMMYDALEMNFRKVKLNRN
RKCPVCGDNPTVTELVDELDALNVCDLEK

Sequences:

>Translated_269_residues
MFTEEQIERYSRHIILKEVGGKGQKKLLEGKVMVIGAGGLGAPIALYLAAAGVGTIGIADADVVDLSNLQRQVIHFTPDV
GKPKVESAREKMEAINPDVTVRTYQEWISAANIARIIADYDFVIDGTDNFAAKFLINDACVMAGKPYSHGGILQFVGQTM
TIKPGESPCYRCIFPAPPPKDAIPTCSQAGVIGVLPGVIGTIQATEAIKYLLGKGALLTGHIMMYDALEMNFRKVKLNRN
RKCPVCGDNPTVTELVDELDALNVCDLEK
>Mature_269_residues
MFTEEQIERYSRHIILKEVGGKGQKKLLEGKVMVIGAGGLGAPIALYLAAAGVGTIGIADADVVDLSNLQRQVIHFTPDV
GKPKVESAREKMEAINPDVTVRTYQEWISAANIARIIADYDFVIDGTDNFAAKFLINDACVMAGKPYSHGGILQFVGQTM
TIKPGESPCYRCIFPAPPPKDAIPTCSQAGVIGVLPGVIGTIQATEAIKYLLGKGALLTGHIMMYDALEMNFRKVKLNRN
RKCPVCGDNPTVTELVDELDALNVCDLEK

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=257, Percent_Identity=41.2451361867704, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4885649, Length=159, Percent_Identity=31.4465408805031, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI38045942, Length=173, Percent_Identity=30.635838150289, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI38045944, Length=173, Percent_Identity=30.635838150289, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI13376212, Length=258, Percent_Identity=29.4573643410853, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI38327032, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI23510338, Length=178, Percent_Identity=28.6516853932584, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510340, Length=178, Percent_Identity=28.6516853932584, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=248, Percent_Identity=42.741935483871, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI87082356, Length=242, Percent_Identity=41.7355371900826, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1789177, Length=115, Percent_Identity=31.304347826087, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540406, Length=251, Percent_Identity=40.6374501992032, Blast_Score=213, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI193203301, Length=165, Percent_Identity=28.4848484848485, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71984476, Length=185, Percent_Identity=30.8108108108108, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI86565433, Length=178, Percent_Identity=29.2134831460674, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=178, Percent_Identity=29.2134831460674, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508819, Length=228, Percent_Identity=25.4385964912281, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=265, Percent_Identity=39.622641509434, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6325323, Length=207, Percent_Identity=28.5024154589372, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322639, Length=190, Percent_Identity=31.0526315789474, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320598, Length=176, Percent_Identity=27.8409090909091, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24582879, Length=257, Percent_Identity=41.2451361867704, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24660640, Length=168, Percent_Identity=33.9285714285714, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573937, Length=187, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641311, Length=262, Percent_Identity=28.2442748091603, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129973, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 29035; Mature: 29035

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTEEQIERYSRHIILKEVGGKGQKKLLEGKVMVIGAGGLGAPIALYLAAAGVGTIGIAD
CCCHHHHHHHHHEEEEECCCCCCHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCEEECCC
ADVVDLSNLQRQVIHFTPDVGKPKVESAREKMEAINPDVTVRTYQEWISAANIARIIADY
CCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
DFVIDGTDNFAAKFLINDACVMAGKPYSHGGILQFVGQTMTIKPGESPCYRCIFPAPPPK
EEEEECCCCCEEHHEECCHHEECCCCCCCCCHHHHCCCEEEECCCCCCCEEEECCCCCCC
DAIPTCSQAGVIGVLPGVIGTIQATEAIKYLLGKGALLTGHIMMYDALEMNFRKVKLNRN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHCCEEEEEECCC
RKCPVCGDNPTVTELVDELDALNVCDLEK
CCCCCCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFTEEQIERYSRHIILKEVGGKGQKKLLEGKVMVIGAGGLGAPIALYLAAAGVGTIGIAD
CCCHHHHHHHHHEEEEECCCCCCHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCEEECCC
ADVVDLSNLQRQVIHFTPDVGKPKVESAREKMEAINPDVTVRTYQEWISAANIARIIADY
CCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
DFVIDGTDNFAAKFLINDACVMAGKPYSHGGILQFVGQTMTIKPGESPCYRCIFPAPPPK
EEEEECCCCCEEHHEECCHHEECCCCCCCCCHHHHCCCEEEECCCCCCCEEEECCCCCCC
DAIPTCSQAGVIGVLPGVIGTIQATEAIKYLLGKGALLTGHIMMYDALEMNFRKVKLNRN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHCCEEEEEECCC
RKCPVCGDNPTVTELVDELDALNVCDLEK
CCCCCCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]