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The map label for this gene is cusB [H]

Identifier: 78222760

GI number: 78222760

Start: 1754572

End: 1755972

Strand: Reverse

Name: cusB [H]

Synonym: Gmet_1548

Alternate gene names: 78222760

Gene position: 1755972-1754572 (Counterclockwise)

Preceding gene: 78222761

Following gene: 78222759

Centisome position: 43.93

GC content: 61.96

Gene sequence:

>1401_bases
ATGAAATTGAGTGCAAAGGTAGCAGTTCCGGTGGCAGTGGTTCTCCTGGCCGCGGCAGGCGGCGGGGGGTACTACCTGTG
GCACAACCAGAAGGCGGAGACCGCAACAGGAGCAAAACAGGGGGAAAAGGCCGCCCAGGGGAAGGTGCTCTACACCTGCG
CCATGCATCCCTTCATCATCAAGGACAAGCCCGGTACCTGCCCCATTTGCGGGATGGAGCTCATCAAAAAAGTGGAAGGC
GCCCAGGCAGATGCCAAGGAAATGGCCATGCTCGAGCATGTTTCCCTCTCGCCTTCCCAGCAGGTGATGGCCAATGTTGC
CACCGTTGAGGCAAAGACGATGCCCCTCACCAAGGAGGTGAATGCTGTCGGCATCGTGCAGTACGACCAGTCCCGGCAGG
CGAAGGTCACCGCGTGGGTGGCGGGCCGCATTGACAGGCTCTACGTCAACACCGTTGGCGCCTATGTGTCCAAGGGAAAA
CCGGTGGCCGAGGTCTATTCGCCCGATCTCGTCTCCGCTCAGCAGGAATACCTCCTGGCACTGAAGAGCCGCGACCGGTT
CAAGGACTCCCCCATTGCCTCCATCTCCCAGGGGGGAGAGGGGCTCGTGGCCTCGGCCCGGCAGCGGCTCCTCCTCATGG
GGGTAAAGGAGCACCAGATCGCAGGGCTTCAGAAGGCCGGTCGTCCCAATATCCGTCTTCCTATTTACACCCCCCTCTCG
GGGGTGGTGATCGAGAAGATCGCCATTGAGGGGCAGTACGTGAACACGGGGGATCCCCTCTTCAACATCGCCGACCTCTC
CACCGTCTGGGTGGACGTGGAGGTCTACGAAAACGAATTCTCCTTCATAAAGCTCGGCCAGCGGGTCGACATCGTTTCCC
AGTCTTATCCCGGTAAGACCTTCTCGGGTCGGGTGTCGTTCGTCTACCCCTTCCTCGACCCCAAGACCCGGACGGTCAAG
GTGCGGGTCCAACTTCCCAATCCAGGCCTGAAGCTCAAGCCGGACATGTTCGTGAACGCGTCGGTCAAGGTGCCGCTCGG
CACCGCCGTGACCGTGCCGGTGGCCGCAGTGATGGACACCGGTAAGCGGCAGGTAGCATGGGTTGAGATGAAGCCGGGAA
TGTTCGAGCCCCGGGACGTGAAGGTGGGCGCCCGGGTGGGGGACATGCTCCAGGTGCTCTCCGGGGTGAAGGCAGGCGAA
AAGGTTGCGGCATCGGGCGGGTACCTGATCGACTCCGAAGCGCAGCTGAAAGGGACTGGCGGCGGCCATGCCGGCATGCC
GGGGATGAAGATGGAGGAGAAAGGCGCTCCGGCTCCCCCGGCCGGTCATGAAGGGCACACGCCGTCCGCTCCTCCCCAGA
AGAAGGGGGGCGGCATGGATATGGGTGATATGAAAATGTAA

Upstream 100 bases:

>100_bases
CTGGTCGGCAAGGAATTGCAGGAGTAGTGGGCTTTCCCGGCGTGCGCGCCCTGTAGATGCTATGCATTGAACTATTCTCC
ATAAACCGCGAGGTACGATC

Downstream 100 bases:

>100_bases
TTTGATCAGGGACCGGACGCCGGTCCCGGAGGTTCACTGTGATTGAGAAAATCATCGACTACTCCGCGAGAAATCGCATC
ATTATCATCATGATCTTCGC

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKLSAKVAVPVAVVLLAAAGGGGYYLWHNQKAETATGAKQGEKAAQGKVLYTCAMHPFIIKDKPGTCPICGMELIKKVEG
AQADAKEMAMLEHVSLSPSQQVMANVATVEAKTMPLTKEVNAVGIVQYDQSRQAKVTAWVAGRIDRLYVNTVGAYVSKGK
PVAEVYSPDLVSAQQEYLLALKSRDRFKDSPIASISQGGEGLVASARQRLLLMGVKEHQIAGLQKAGRPNIRLPIYTPLS
GVVIEKIAIEGQYVNTGDPLFNIADLSTVWVDVEVYENEFSFIKLGQRVDIVSQSYPGKTFSGRVSFVYPFLDPKTRTVK
VRVQLPNPGLKLKPDMFVNASVKVPLGTAVTVPVAAVMDTGKRQVAWVEMKPGMFEPRDVKVGARVGDMLQVLSGVKAGE
KVAASGGYLIDSEAQLKGTGGGHAGMPGMKMEEKGAPAPPAGHEGHTPSAPPQKKGGGMDMGDMKM

Sequences:

>Translated_466_residues
MKLSAKVAVPVAVVLLAAAGGGGYYLWHNQKAETATGAKQGEKAAQGKVLYTCAMHPFIIKDKPGTCPICGMELIKKVEG
AQADAKEMAMLEHVSLSPSQQVMANVATVEAKTMPLTKEVNAVGIVQYDQSRQAKVTAWVAGRIDRLYVNTVGAYVSKGK
PVAEVYSPDLVSAQQEYLLALKSRDRFKDSPIASISQGGEGLVASARQRLLLMGVKEHQIAGLQKAGRPNIRLPIYTPLS
GVVIEKIAIEGQYVNTGDPLFNIADLSTVWVDVEVYENEFSFIKLGQRVDIVSQSYPGKTFSGRVSFVYPFLDPKTRTVK
VRVQLPNPGLKLKPDMFVNASVKVPLGTAVTVPVAAVMDTGKRQVAWVEMKPGMFEPRDVKVGARVGDMLQVLSGVKAGE
KVAASGGYLIDSEAQLKGTGGGHAGMPGMKMEEKGAPAPPAGHEGHTPSAPPQKKGGGMDMGDMKM
>Mature_466_residues
MKLSAKVAVPVAVVLLAAAGGGGYYLWHNQKAETATGAKQGEKAAQGKVLYTCAMHPFIIKDKPGTCPICGMELIKKVEG
AQADAKEMAMLEHVSLSPSQQVMANVATVEAKTMPLTKEVNAVGIVQYDQSRQAKVTAWVAGRIDRLYVNTVGAYVSKGK
PVAEVYSPDLVSAQQEYLLALKSRDRFKDSPIASISQGGEGLVASARQRLLLMGVKEHQIAGLQKAGRPNIRLPIYTPLS
GVVIEKIAIEGQYVNTGDPLFNIADLSTVWVDVEVYENEFSFIKLGQRVDIVSQSYPGKTFSGRVSFVYPFLDPKTRTVK
VRVQLPNPGLKLKPDMFVNASVKVPLGTAVTVPVAAVMDTGKRQVAWVEMKPGMFEPRDVKVGARVGDMLQVLSGVKAGE
KVAASGGYLIDSEAQLKGTGGGHAGMPGMKMEEKGAPAPPAGHEGHTPSAPPQKKGGGMDMGDMKM

Specific function: Part of a cation efflux system that mediates resistance to copper and silver [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786787, Length=375, Percent_Identity=29.3333333333333, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 49700; Mature: 49700

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSAKVAVPVAVVLLAAAGGGGYYLWHNQKAETATGAKQGEKAAQGKVLYTCAMHPFII
CCCCCCHHHHHEEEHHEECCCCEEEEEECCCCCCCCCCCCCCHHHCCCEEEEEECCCEEE
KDKPGTCPICGMELIKKVEGAQADAKEMAMLEHVSLSPSQQVMANVATVEAKTMPLTKEV
ECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCCCCC
NAVGIVQYDQSRQAKVTAWVAGRIDRLYVNTVGAYVSKGKPVAEVYSPDLVSAQQEYLLA
CEEEEEEECCCCCEEEEEEEECCCEEEEEEHHHHHHHCCCCHHHHCCCCHHHHHHHHHHH
LKSRDRFKDSPIASISQGGEGLVASARQRLLLMGVKEHQIAGLQKAGRPNIRLPIYTPLS
HHCCCCCCCCCCHHHHCCCCHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEEEEECCCC
GVVIEKIAIEGQYVNTGDPLFNIADLSTVWVDVEVYENEFSFIKLGQRVDIVSQSYPGKT
CCEEEEEEECCEEECCCCCCEEEECCEEEEEEEEEECCCCCEEECCCEEEEEECCCCCCC
FSGRVSFVYPFLDPKTRTVKVRVQLPNPGLKLKPDMFVNASVKVPLGTAVTVPVAAVMDT
CCCEEEEEEECCCCCCEEEEEEEECCCCCCEECCCEEEEEEEEECCCCCHHHHHHHHHCC
GKRQVAWVEMKPGMFEPRDVKVGARVGDMLQVLSGVKAGEKVAASGGYLIDSEAQLKGTG
CCCEEEEEEECCCCCCCCCEEECCHHHHHHHHHHCCCCCCEEECCCCEEECCCCEEEECC
GGHAGMPGMKMEEKGAPAPPAGHEGHTPSAPPQKKGGGMDMGDMKM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLSAKVAVPVAVVLLAAAGGGGYYLWHNQKAETATGAKQGEKAAQGKVLYTCAMHPFII
CCCCCCHHHHHEEEHHEECCCCEEEEEECCCCCCCCCCCCCCHHHCCCEEEEEECCCEEE
KDKPGTCPICGMELIKKVEGAQADAKEMAMLEHVSLSPSQQVMANVATVEAKTMPLTKEV
ECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCCCCC
NAVGIVQYDQSRQAKVTAWVAGRIDRLYVNTVGAYVSKGKPVAEVYSPDLVSAQQEYLLA
CEEEEEEECCCCCEEEEEEEECCCEEEEEEHHHHHHHCCCCHHHHCCCCHHHHHHHHHHH
LKSRDRFKDSPIASISQGGEGLVASARQRLLLMGVKEHQIAGLQKAGRPNIRLPIYTPLS
HHCCCCCCCCCCHHHHCCCCHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEEEEECCCC
GVVIEKIAIEGQYVNTGDPLFNIADLSTVWVDVEVYENEFSFIKLGQRVDIVSQSYPGKT
CCEEEEEEECCEEECCCCCCEEEECCEEEEEEEEEECCCCCEEECCCEEEEEECCCCCCC
FSGRVSFVYPFLDPKTRTVKVRVQLPNPGLKLKPDMFVNASVKVPLGTAVTVPVAAVMDT
CCCEEEEEEECCCCCCEEEEEEEECCCCCCEECCCEEEEEEEEECCCCCHHHHHHHHHCC
GKRQVAWVEMKPGMFEPRDVKVGARVGDMLQVLSGVKAGEKVAASGGYLIDSEAQLKGTG
CCCEEEEEEECCCCCCCCCEEECCHHHHHHHHHHCCCCCCEEECCCCEEECCCCEEEECC
GGHAGMPGMKMEEKGAPAPPAGHEGHTPSAPPQKKGGGMDMGDMKM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]