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The map label for this gene is paaJ [C]

Identifier: 78222741

GI number: 78222741

Start: 1732058

End: 1733230

Strand: Direct

Name: paaJ [C]

Synonym: Gmet_1529

Alternate gene names: 78222741

Gene position: 1732058-1733230 (Clockwise)

Preceding gene: 78222740

Following gene: 78222742

Centisome position: 43.33

GC content: 59.93

Gene sequence:

>1173_bases
ATGAAATTACAGCGTGAAGTATACATAGCAGGGGTGGGGGAAACGAAATTCGGCAAGCATACGGTCGATTTCGATGTGTT
GGGGAGGGAGGCTGCTCTGCAGGCGATGAATGGATCGAACATCGACCGACCGGACATGATCCAGAGCGCCTATGTGGGAA
ACGGAATGAACGACATGACGACCGGCCAGGCTGTTTTCAGGGGGCTGGGGATGTGCGGGCCCAATCTGCCGATTATCAAT
GTGCAGAGCGCCTGTTCAGCCGGCGCCATGGCAGTCTTCTGCGCCATTAAGGATGTGGCCACCGGAGTTACCGACCTCTC
CATCGGAGTCGGCACTGAGAACCACACCATGCACAGACAGAGCGGAGCCGCGTTCAGTGCGGCCAGGTCAGACATAGAAA
CCATGCACGGGGCGGTCATGACCGGCAAATACGCCATGCGGGCGACCCGCTATATGCATGAGACCGGCGCCACCATCGAG
GATCTGGCGATGATCACGGTGAAAAACCGCAAGCACGCCACCCACAACCCCTATGCCTGGTTCAAGGGGGCGATCACGGT
GGAAGAAGTGGTCAATTCCCGGATGGTTGCCTATCCCATGACCCTGCAGCAGTGTTGCGGCATTGCCGACGGCGCTGCCG
CCGTGGTGGTCGGTTCCAAGGAGATGATGAAGAAACTGGGGATTGCCAAGCCGGTCAAGGTGGCGGGTGTGGTGGTGGAG
TCGGGTCCGTACCATAACCGGCCGCGGGACATTACCGGCGACGATATCACCGAGACCACTTCGGAAAAGTTGTACGAGGA
GTCGGGGATCGGCCCGAAAGAGGTCAATATTCTCGAATTGCACGACGCCTTCACCATTGCCGAGCTTCTCTATTACGAAT
GCATGGGGCTTTGCAAAAAGGGAGATGGCCTCAAGTTCCTGAGGGACGGCCAGTCCACCTATGGCGGCCAGTGCGTGGTG
AGTCCACGGGGTGGGCTGCTCTCCTACGGCCACCCGATCGGCGCTTCCGGTGCGGCCCAGATCGCCCAGAACGTGAAGCA
GCTGCGGGGGGAATGCGGCGGTTACCAGGTCGGTCCGACTCCGAAGGTTGCCATGTCCCACGTCACCGGCGGCGGGCTCT
CCGGCACCGAGCATGCGGCGTGCACCATGCACATGCTGGTAAAGGGGTGGTAA

Upstream 100 bases:

>100_bases
CTGACTCTGGGGCCGATCAGGATGAACAACGATAACCTGCCGATCATCAGCTACAAGTTCAAGAAGATTGCCTAACTATT
GAAAGAAACGGGAGAAGGTT

Downstream 100 bases:

>100_bases
GCGAGGCATCTGACCAATAAATCCTCAACGGGTAAGGAGAGGCAGTCATGAAAGACAGAACAGCACTGATAGTGGGAGCG
GCAAACGATATAGGAGGGGC

Product: thiolase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKLQREVYIAGVGETKFGKHTVDFDVLGREAALQAMNGSNIDRPDMIQSAYVGNGMNDMTTGQAVFRGLGMCGPNLPIIN
VQSACSAGAMAVFCAIKDVATGVTDLSIGVGTENHTMHRQSGAAFSAARSDIETMHGAVMTGKYAMRATRYMHETGATIE
DLAMITVKNRKHATHNPYAWFKGAITVEEVVNSRMVAYPMTLQQCCGIADGAAAVVVGSKEMMKKLGIAKPVKVAGVVVE
SGPYHNRPRDITGDDITETTSEKLYEESGIGPKEVNILELHDAFTIAELLYYECMGLCKKGDGLKFLRDGQSTYGGQCVV
SPRGGLLSYGHPIGASGAAQIAQNVKQLRGECGGYQVGPTPKVAMSHVTGGGLSGTEHAACTMHMLVKGW

Sequences:

>Translated_390_residues
MKLQREVYIAGVGETKFGKHTVDFDVLGREAALQAMNGSNIDRPDMIQSAYVGNGMNDMTTGQAVFRGLGMCGPNLPIIN
VQSACSAGAMAVFCAIKDVATGVTDLSIGVGTENHTMHRQSGAAFSAARSDIETMHGAVMTGKYAMRATRYMHETGATIE
DLAMITVKNRKHATHNPYAWFKGAITVEEVVNSRMVAYPMTLQQCCGIADGAAAVVVGSKEMMKKLGIAKPVKVAGVVVE
SGPYHNRPRDITGDDITETTSEKLYEESGIGPKEVNILELHDAFTIAELLYYECMGLCKKGDGLKFLRDGQSTYGGQCVV
SPRGGLLSYGHPIGASGAAQIAQNVKQLRGECGGYQVGPTPKVAMSHVTGGGLSGTEHAACTMHMLVKGW
>Mature_390_residues
MKLQREVYIAGVGETKFGKHTVDFDVLGREAALQAMNGSNIDRPDMIQSAYVGNGMNDMTTGQAVFRGLGMCGPNLPIIN
VQSACSAGAMAVFCAIKDVATGVTDLSIGVGTENHTMHRQSGAAFSAARSDIETMHGAVMTGKYAMRATRYMHETGATIE
DLAMITVKNRKHATHNPYAWFKGAITVEEVVNSRMVAYPMTLQQCCGIADGAAAVVVGSKEMMKKLGIAKPVKVAGVVVE
SGPYHNRPRDITGDDITETTSEKLYEESGIGPKEVNILELHDAFTIAELLYYECMGLCKKGDGLKFLRDGQSTYGGQCVV
SPRGGLLSYGHPIGASGAAQIAQNVKQLRGECGGYQVGPTPKVAMSHVTGGGLSGTEHAACTMHMLVKGW

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=390, Percent_Identity=36.1538461538462, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI302344760, Length=386, Percent_Identity=35.2331606217617, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI302344767, Length=314, Percent_Identity=36.3057324840764, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI302344762, Length=386, Percent_Identity=33.160621761658, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI55956775, Length=350, Percent_Identity=30.5714285714286, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17537653, Length=385, Percent_Identity=33.2467532467532, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24585051, Length=388, Percent_Identity=33.5051546391753, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19921506, Length=388, Percent_Identity=33.2474226804124, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41433; Mature: 41433

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQREVYIAGVGETKFGKHTVDFDVLGREAALQAMNGSNIDRPDMIQSAYVGNGMNDMT
CCCCEEEEEEECCCCCCCCEECCHHHCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCH
TGQAVFRGLGMCGPNLPIINVQSACSAGAMAVFCAIKDVATGVTDLSIGVGTENHTMHRQ
HHHHHHHHHCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHC
SGAAFSAARSDIETMHGAVMTGKYAMRATRYMHETGATIEDLAMITVKNRKHATHNPYAW
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCEE
FKGAITVEEVVNSRMVAYPMTLQQCCGIADGAAAVVVGSKEMMKKLGIAKPVKVAGVVVE
EECCEEHHHHHCCCEEEECCCHHHHCCCCCCCEEEEECCHHHHHHCCCCCCEEEEEEEEE
SGPYHNRPRDITGDDITETTSEKLYEESGIGPKEVNILELHDAFTIAELLYYECMGLCKK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
GDGLKFLRDGQSTYGGQCVVSPRGGLLSYGHPIGASGAAQIAQNVKQLRGECGGYQVGPT
CCCCCEEECCCCCCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
PKVAMSHVTGGGLSGTEHAACTMHMLVKGW
CHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKLQREVYIAGVGETKFGKHTVDFDVLGREAALQAMNGSNIDRPDMIQSAYVGNGMNDMT
CCCCEEEEEEECCCCCCCCEECCHHHCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCH
TGQAVFRGLGMCGPNLPIINVQSACSAGAMAVFCAIKDVATGVTDLSIGVGTENHTMHRQ
HHHHHHHHHCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHC
SGAAFSAARSDIETMHGAVMTGKYAMRATRYMHETGATIEDLAMITVKNRKHATHNPYAW
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCEE
FKGAITVEEVVNSRMVAYPMTLQQCCGIADGAAAVVVGSKEMMKKLGIAKPVKVAGVVVE
EECCEEHHHHHCCCEEEECCCHHHHCCCCCCCEEEEECCHHHHHHCCCCCCEEEEEEEEE
SGPYHNRPRDITGDDITETTSEKLYEESGIGPKEVNILELHDAFTIAELLYYECMGLCKK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
GDGLKFLRDGQSTYGGQCVVSPRGGLLSYGHPIGASGAAQIAQNVKQLRGECGGYQVGPT
CCCCCEEECCCCCCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
PKVAMSHVTGGGLSGTEHAACTMHMLVKGW
CHHHHHHCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]