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The map label for this gene is ubiE [H]

Identifier: 78222383

GI number: 78222383

Start: 1290213

End: 1290992

Strand: Reverse

Name: ubiE [H]

Synonym: Gmet_1167

Alternate gene names: 78222383

Gene position: 1290992-1290213 (Counterclockwise)

Preceding gene: 78222388

Following gene: 78222382

Centisome position: 32.3

GC content: 58.33

Gene sequence:

>780_bases
ATGCCCAGAAAGAATCAGGATTTATACCACCATTACCCGCAAAAGGATAGAAAATTTACGATGTATAAACTGAGCGAAAA
AGGCGAGCAGATCCGGGAGATGTTCTCCGACATTGCCCCCCGGTACGACTTCCTCAACCGGCTCCTGAGCTTCGGCATCG
ACCGGCGCTGGCGGCGCATCGCCGTACAATGCGCCCGATGGAGCGAGGGGGGAAAAATCCTCGACGTTGCCACCGGAACC
GGCGACGTGGCGCTGGAAATCGCCCGCCAAACCCCCGACTCAGTCTCCATCATCGGCATCGACATCACGGAAGGGATGGT
GGTGCTCGGCCGCGAAAAGGTTGCGCAATCCCCCTATGCCCGCCGGATCACCCTGGAAATCGCCCCCTGCGAGGCGATCC
CCTTTCCCGACAATACGTTTGACTCGGTCACCATCGCCTTCGGCATCCGCAACGTGGTCGACCGGCGCCAGGGGCTGGCG
GAAATGCAGCGCATCCTGAAGCCCGGCGGCCGGGCCGTCATCCTCGAGTTCTCCACTCCCCGCTCACAGTTCTTCAAACG
GGTCTATTATTTCTACTTTCTCCGGTTGCTGCCGGCGATCGGCGGACTTTTCTCCAACTTCAGCGCCTACAAGTACCTCC
CCGATTCCGTGCTGGAGTTTCCGTCGCAAGAGGAATTCAAGACTCTCATGCGATCCGTGGGTTTCCATTCCACCACCCAT
CGTGATCTCACCTTTGGAATCGCGACGATCTACACCGGGGAAAAAGCCGCTCAAAACTGA

Upstream 100 bases:

>100_bases
TCCATACAGGGGACGTCCCCGGGAAACCTGCACCACCACGCTCCGAAAATCCGTTTTTTCTGGCATGGAGTGAGGTTTTG
TGCTAAAAATATCGGTCTGT

Downstream 100 bases:

>100_bases
CGCTTTCTTGACACTTGGCTGCTGTTTCCTGTATAACGCGACAGTCGTTCATCCACCACCAAGGGGCACACCATGTTCGT
GCTTGCCAACTTTCTCCTGG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MPRKNQDLYHHYPQKDRKFTMYKLSEKGEQIREMFSDIAPRYDFLNRLLSFGIDRRWRRIAVQCARWSEGGKILDVATGT
GDVALEIARQTPDSVSIIGIDITEGMVVLGREKVAQSPYARRITLEIAPCEAIPFPDNTFDSVTIAFGIRNVVDRRQGLA
EMQRILKPGGRAVILEFSTPRSQFFKRVYYFYFLRLLPAIGGLFSNFSAYKYLPDSVLEFPSQEEFKTLMRSVGFHSTTH
RDLTFGIATIYTGEKAAQN

Sequences:

>Translated_259_residues
MPRKNQDLYHHYPQKDRKFTMYKLSEKGEQIREMFSDIAPRYDFLNRLLSFGIDRRWRRIAVQCARWSEGGKILDVATGT
GDVALEIARQTPDSVSIIGIDITEGMVVLGREKVAQSPYARRITLEIAPCEAIPFPDNTFDSVTIAFGIRNVVDRRQGLA
EMQRILKPGGRAVILEFSTPRSQFFKRVYYFYFLRLLPAIGGLFSNFSAYKYLPDSVLEFPSQEEFKTLMRSVGFHSTTH
RDLTFGIATIYTGEKAAQN
>Mature_258_residues
PRKNQDLYHHYPQKDRKFTMYKLSEKGEQIREMFSDIAPRYDFLNRLLSFGIDRRWRRIAVQCARWSEGGKILDVATGTG
DVALEIARQTPDSVSIIGIDITEGMVVLGREKVAQSPYARRITLEIAPCEAIPFPDNTFDSVTIAFGIRNVVDRRQGLAE
MQRILKPGGRAVILEFSTPRSQFFKRVYYFYFLRLLPAIGGLFSNFSAYKYLPDSVLEFPSQEEFKTLMRSVGFHSTTHR
DLTFGIATIYTGEKAAQN

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=264, Percent_Identity=34.0909090909091, Blast_Score=164, Evalue=7e-41,
Organism=Escherichia coli, GI48994983, Length=231, Percent_Identity=38.5281385281385, Blast_Score=190, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17557039, Length=240, Percent_Identity=34.1666666666667, Blast_Score=153, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI25143945, Length=139, Percent_Identity=25.1798561151079, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323526, Length=266, Percent_Identity=32.3308270676692, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24641702, Length=259, Percent_Identity=33.976833976834, Blast_Score=157, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 29698; Mature: 29567

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRKNQDLYHHYPQKDRKFTMYKLSEKGEQIREMFSDIAPRYDFLNRLLSFGIDRRWRRI
CCCCCCCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
AVQCARWSEGGKILDVATGTGDVALEIARQTPDSVSIIGIDITEGMVVLGREKVAQSPYA
HHHHHHCCCCCEEEEEECCCCHHEEEEECCCCCCEEEEEEECCCCEEEECHHHHHCCCCC
RRITLEIAPCEAIPFPDNTFDSVTIAFGIRNVVDRRQGLAEMQRILKPGGRAVILEFSTP
EEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
RSQFFKRVYYFYFLRLLPAIGGLFSNFSAYKYLPDSVLEFPSQEEFKTLMRSVGFHSTTH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCCC
RDLTFGIATIYTGEKAAQN
CHHHEEHEEEEECCHHCCC
>Mature Secondary Structure 
PRKNQDLYHHYPQKDRKFTMYKLSEKGEQIREMFSDIAPRYDFLNRLLSFGIDRRWRRI
CCCCCCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
AVQCARWSEGGKILDVATGTGDVALEIARQTPDSVSIIGIDITEGMVVLGREKVAQSPYA
HHHHHHCCCCCEEEEEECCCCHHEEEEECCCCCCEEEEEEECCCCEEEECHHHHHCCCCC
RRITLEIAPCEAIPFPDNTFDSVTIAFGIRNVVDRRQGLAEMQRILKPGGRAVILEFSTP
EEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
RSQFFKRVYYFYFLRLLPAIGGLFSNFSAYKYLPDSVLEFPSQEEFKTLMRSVGFHSTTH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCCC
RDLTFGIATIYTGEKAAQN
CHHHEEHEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA