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The map label for this gene is ald [H]

Identifier: 78222317

GI number: 78222317

Start: 1222406

End: 1223503

Strand: Direct

Name: ald [H]

Synonym: Gmet_1099

Alternate gene names: 78222317

Gene position: 1222406-1223503 (Clockwise)

Preceding gene: 78222313

Following gene: 78222318

Centisome position: 30.58

GC content: 68.67

Gene sequence:

>1098_bases
ATGATCGTCGGAGTGCCGCGGGAGATCAAGACCCACGAGTACCGGGTCGGCATGACGCCGGCCGGTATTGCAGAGTTGGC
GCGGGGGGGACACACGGTTCTCGTGGAAACCGGAGCCGGAGAGGGGAGCGGTTTTGCCGACGGGGAATACCTGCGGGTTG
GAGCCCGGGTCTGCGGCAGGGAAGAGGTCTTCGGCCCGGCGGAGCTCCTCGTGAAGGTGAAGGAGCCGCTTCCGTCCGAG
TACGGCCTGCTGAGACAAGGGCAGGCCCTTTTCACCTACCTGCACCTGGCCCCCAACCGTCCCCTCGCGGAGCTGCTCCT
GGAGAGGGGGGTCACGGGAATCGGTTACGAGACCTTCGAGAAGGGAGGGACGCTGCCGCTTCTGGCCCCCATGAGCGAGG
TGGCGGGCCGCATGGCGCCGCTGGTGGGGGGATACCATCTCCAGCGGGTTCTCGGGGGGACGGGGGTCCTTCCCTCGGGG
GTGCCGGGGGTGCCCGCCGCCCGCGCCCTCATCCTGGGGGCCGGCGTGGTGGGGAGCGGCGCTGCGAGGGTCTGCGCCGG
CCTCGGCATGGAAACGGTGGTTATGAACCGGGGGATCGATCGGCTTCAGCGGCTCGACGAAATTCTGGCCGGAAGGGCCC
GGACCGTGGCCCTGAACCGGGAGTCCCTGGCGGAGGAACTTTCGCGGGCAGACTTGGTGGTCGGCGCAGTGCTCGTGCCG
GGGGGGCGGACCCCTCTTCTCATCGACCGGTCGGCCCTCGGCACTATGAAGCGCGGGTCAGTCATTGTCGACGTCTCCAT
CGACCAGGGGGGCTGCGCCGAGACGAGCCGCCCCACCACTCACGACGACCCGGTCTACATTGTGGACGGCGTCATCCACT
ATACCGTGGCGAACATGCCCGGCGCCTATCCTCGTACCTCGACCCTGGCCCTCACCAATGCAACGCTCCCCTGCGTGAAG
GCCCTGGCCGACCGGGGAATCGAGGATGCGCTTCGGGCCGATCCGGCCCTGGCCGGCGCCCTCAATACCTGGCGCGGCGC
CGTGGTCCACCGTGCCCTGGCCCAGGCGCTGGATCTGCCGTTTTCACTTTTTTCCTGA

Upstream 100 bases:

>100_bases
TTTGCCGAATCCGCGCGGTACCCCGGTGGACGACGATGCCCGGGCGGGTATACTTGCATCTAATGCATCAATCCTAATGC
CATGCGCGGAGGGTAACACC

Downstream 100 bases:

>100_bases
CAAAGGGGGATCCCATGGCGAGCGGTCGAATCGAGGTGATTGCCTATGCGGGCTATCGGGGCGAGGAGTGCCCGCGGGCC
TTTGTGGTGGGCGGGGTGCA

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MIVGVPREIKTHEYRVGMTPAGIAELARGGHTVLVETGAGEGSGFADGEYLRVGARVCGREEVFGPAELLVKVKEPLPSE
YGLLRQGQALFTYLHLAPNRPLAELLLERGVTGIGYETFEKGGTLPLLAPMSEVAGRMAPLVGGYHLQRVLGGTGVLPSG
VPGVPAARALILGAGVVGSGAARVCAGLGMETVVMNRGIDRLQRLDEILAGRARTVALNRESLAEELSRADLVVGAVLVP
GGRTPLLIDRSALGTMKRGSVIVDVSIDQGGCAETSRPTTHDDPVYIVDGVIHYTVANMPGAYPRTSTLALTNATLPCVK
ALADRGIEDALRADPALAGALNTWRGAVVHRALAQALDLPFSLFS

Sequences:

>Translated_365_residues
MIVGVPREIKTHEYRVGMTPAGIAELARGGHTVLVETGAGEGSGFADGEYLRVGARVCGREEVFGPAELLVKVKEPLPSE
YGLLRQGQALFTYLHLAPNRPLAELLLERGVTGIGYETFEKGGTLPLLAPMSEVAGRMAPLVGGYHLQRVLGGTGVLPSG
VPGVPAARALILGAGVVGSGAARVCAGLGMETVVMNRGIDRLQRLDEILAGRARTVALNRESLAEELSRADLVVGAVLVP
GGRTPLLIDRSALGTMKRGSVIVDVSIDQGGCAETSRPTTHDDPVYIVDGVIHYTVANMPGAYPRTSTLALTNATLPCVK
ALADRGIEDALRADPALAGALNTWRGAVVHRALAQALDLPFSLFS
>Mature_365_residues
MIVGVPREIKTHEYRVGMTPAGIAELARGGHTVLVETGAGEGSGFADGEYLRVGARVCGREEVFGPAELLVKVKEPLPSE
YGLLRQGQALFTYLHLAPNRPLAELLLERGVTGIGYETFEKGGTLPLLAPMSEVAGRMAPLVGGYHLQRVLGGTGVLPSG
VPGVPAARALILGAGVVGSGAARVCAGLGMETVVMNRGIDRLQRLDEILAGRARTVALNRESLAEELSRADLVVGAVLVP
GGRTPLLIDRSALGTMKRGSVIVDVSIDQGGCAETSRPTTHDDPVYIVDGVIHYTVANMPGAYPRTSTLALTNATLPCVK
ALADRGIEDALRADPALAGALNTWRGAVVHRALAQALDLPFSLFS

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=358, Percent_Identity=28.4916201117318, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI122939153, Length=358, Percent_Identity=28.4916201117318, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1787887, Length=334, Percent_Identity=30.2395209580838, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17550456, Length=338, Percent_Identity=28.9940828402367, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38144; Mature: 38144

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGVPREIKTHEYRVGMTPAGIAELARGGHTVLVETGAGEGSGFADGEYLRVGARVCGR
CCCCCCCCCCCCEEEECCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHEEEHHHHCCC
EEVFGPAELLVKVKEPLPSEYGLLRQGQALFTYLHLAPNRPLAELLLERGVTGIGYETFE
HHCCCHHHHHHHHHCCCCCHHHHHHCCHHHEEEEEECCCCCHHHHHHHCCCCCCCHHHHH
KGGTLPLLAPMSEVAGRMAPLVGGYHLQRVLGGTGVLPSGVPGVPAARALILGAGVVGSG
CCCCCEEECCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
AARVCAGLGMETVVMNRGIDRLQRLDEILAGRARTVALNRESLAEELSRADLVVGAVLVP
HHHHHHHCCHHHHHHHCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHEEEEEEEEC
GGRTPLLIDRSALGTMKRGSVIVDVSIDQGGCAETSRPTTHDDPVYIVDGVIHYTVANMP
CCCCCEEEEHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEHHHHCCC
GAYPRTSTLALTNATLPCVKALADRGIEDALRADPALAGALNTWRGAVVHRALAQALDLP
CCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
FSLFS
HHHCC
>Mature Secondary Structure
MIVGVPREIKTHEYRVGMTPAGIAELARGGHTVLVETGAGEGSGFADGEYLRVGARVCGR
CCCCCCCCCCCCEEEECCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHEEEHHHHCCC
EEVFGPAELLVKVKEPLPSEYGLLRQGQALFTYLHLAPNRPLAELLLERGVTGIGYETFE
HHCCCHHHHHHHHHCCCCCHHHHHHCCHHHEEEEEECCCCCHHHHHHHCCCCCCCHHHHH
KGGTLPLLAPMSEVAGRMAPLVGGYHLQRVLGGTGVLPSGVPGVPAARALILGAGVVGSG
CCCCCEEECCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
AARVCAGLGMETVVMNRGIDRLQRLDEILAGRARTVALNRESLAEELSRADLVVGAVLVP
HHHHHHHCCHHHHHHHCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHEEEEEEEEC
GGRTPLLIDRSALGTMKRGSVIVDVSIDQGGCAETSRPTTHDDPVYIVDGVIHYTVANMP
CCCCCEEEEHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEHHHHCCC
GAYPRTSTLALTNATLPCVKALADRGIEDALRADPALAGALNTWRGAVVHRALAQALDLP
CCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
FSLFS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]