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The map label for this gene is atoS [H]

Identifier: 78222272

GI number: 78222272

Start: 1169529

End: 1171187

Strand: Direct

Name: atoS [H]

Synonym: Gmet_1054

Alternate gene names: 78222272

Gene position: 1169529-1171187 (Clockwise)

Preceding gene: 78222271

Following gene: 78222273

Centisome position: 29.26

GC content: 60.22

Gene sequence:

>1659_bases
ATGGAAAACCGGGAAAAACTCCTTGAGCAGCTGACCGGGGTCGACTCCTCCAAGCTCAACTACTATATCGAGCTGAAAAA
GCGCAACCAGGAGATCCTCAAGCAGAACAGCCGCCTGGAGATCCTCCAGCAGTTGACGCGCGACATCAATATCGACATGT
CCATGGAGGATATCCTCGAACGGGCGTTCACCAAGTTTCCCCAGACCCTTCCCTGCGATTTTCTCGGTCTCGTGAGGGTC
CGTGACGGCGAGTTGCGGCTCATGGCCCTGATGCCGCGGGATTTCTGCAGAATCGACAATTTCCCTGCCCACTCACCGAC
GCTCAACGTCATCAGTAACAGGAAGGCCGGGATTTACAACCTGACTCCGGAAGAACTCAGCCATGTCCAGATAAACCCCC
ATTACCCGGGGCCGCTCCGGTCCCTGGCGATTGCGCCGATGTTCCAGCGCGACGAGGTGATCGGCGCCCTCATTGTCGCC
AGCATTATCGACGGCGCCTACAACGAGGCGGATCTCAGCTTTGTCCAGCATCTGGCCGACCAGCTCTCCATCAGCATCCA
GAACGCCCGGCTCTACAAGCAGGTCTCGCGGGCCAAGAAGGAGTGGGAGGAGACCTTCCTGGCGGTTACCGACCCGATTT
TCCTGGTTGACACCGACTACAACGTCCTGCTTCACAACAACCGGCTTTCTCCGGCAATGAGCGGGTTCTGGAACCAGGCG
GTGAGCAACAAGTGCTTTGCCAGGCTCCACGGCCGCACCCATCCCTGCGAGAACTGCCCCATCAAGGAGGTCCAGCGGAC
CGGCAAGCCGGTTTTCCAGCGCTGGCAGACCGACGCGGGGCTGCTCCTCGATATTTCCTACTACCCGGTGTTCAACGAAG
AGAAGCAGCTGTCGGCCGTGACGATCATCATCAAGGATGTCACCGACAAGACCAAGATGGAGGCGCAGCTGGTCCAGACG
GCAAAGCTGGCGGCCCTCGGAGAGATGGCGGCCGGGGTGGCCCACGAGCTGAACAGCCCCATGACCGTCATCATCGGCAC
GGCGCAGCTGCTCCTCAGGGAGCTCCAGCAGGATGCCCAGTACGACCGGGCCGAGGTGCTGGAAGACATAGTCAATTCGG
GCCTGCGCTGCAAGCGGATCATCCAGAACCTGCTGACCTTCTCCCGGCAGAATCAGCCGCCGGTAACGGACATCGACTTG
AATGTCGAGGTGGAGCGGGTTCTGAGCATGATCCAGTACCAGATCAACCGGAACCAGATCAAAATTGTCGAGCAGCTTGC
CCCTTTCCTGCCGCGGCTTACCGCCAACGGCTCCCAGATCCAGCAGGTGCTGACCAACCTGCTGATCAACGCCCGGGATG
CACTCGGCGAGGTCGACCGCAAGGAGAAGGTCATTACGGTGGCGACGGCGCTGCTGGTGAGGGACCGGAAGAAGTGGGCC
GTCCTCAGTGTGAGAGACAACGGCACCGGCATCGCCCCGGAGAACCTGTCGAAGATTTTTACCCCCTTTTACACGAGCAA
GGAGGCGACCAAGGGGACCGGCCTCGGCCTCTCGGTCAGCCTGGGGATTGCCGAGTCCCATAATGGCACCATCGAGGTGG
AGAGCCGCCTTGGGGAGGGGAGCACCTTTTCGCTGCTCCTCCCCATAGAGCATCAGTGA

Upstream 100 bases:

>100_bases
CCCATAATCCTCGACGTAGTGCTGCTACGCCTGCGGTTATGCTCAATCGGCCAGGCCAAATCCGCCCCAAATTCGAACGC
GGCATGACAGGGGAAGAATA

Downstream 100 bases:

>100_bases
GAAGATCACAGCCGGAGCGAAAATGTCACAGATCAAGGTATTGATTATCGATGACGAGGCGGATGTCTGCACCTTTTTCC
GCCGCCTGCTGACCAGAAAA

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MENREKLLEQLTGVDSSKLNYYIELKKRNQEILKQNSRLEILQQLTRDINIDMSMEDILERAFTKFPQTLPCDFLGLVRV
RDGELRLMALMPRDFCRIDNFPAHSPTLNVISNRKAGIYNLTPEELSHVQINPHYPGPLRSLAIAPMFQRDEVIGALIVA
SIIDGAYNEADLSFVQHLADQLSISIQNARLYKQVSRAKKEWEETFLAVTDPIFLVDTDYNVLLHNNRLSPAMSGFWNQA
VSNKCFARLHGRTHPCENCPIKEVQRTGKPVFQRWQTDAGLLLDISYYPVFNEEKQLSAVTIIIKDVTDKTKMEAQLVQT
AKLAALGEMAAGVAHELNSPMTVIIGTAQLLLRELQQDAQYDRAEVLEDIVNSGLRCKRIIQNLLTFSRQNQPPVTDIDL
NVEVERVLSMIQYQINRNQIKIVEQLAPFLPRLTANGSQIQQVLTNLLINARDALGEVDRKEKVITVATALLVRDRKKWA
VLSVRDNGTGIAPENLSKIFTPFYTSKEATKGTGLGLSVSLGIAESHNGTIEVESRLGEGSTFSLLLPIEHQ

Sequences:

>Translated_552_residues
MENREKLLEQLTGVDSSKLNYYIELKKRNQEILKQNSRLEILQQLTRDINIDMSMEDILERAFTKFPQTLPCDFLGLVRV
RDGELRLMALMPRDFCRIDNFPAHSPTLNVISNRKAGIYNLTPEELSHVQINPHYPGPLRSLAIAPMFQRDEVIGALIVA
SIIDGAYNEADLSFVQHLADQLSISIQNARLYKQVSRAKKEWEETFLAVTDPIFLVDTDYNVLLHNNRLSPAMSGFWNQA
VSNKCFARLHGRTHPCENCPIKEVQRTGKPVFQRWQTDAGLLLDISYYPVFNEEKQLSAVTIIIKDVTDKTKMEAQLVQT
AKLAALGEMAAGVAHELNSPMTVIIGTAQLLLRELQQDAQYDRAEVLEDIVNSGLRCKRIIQNLLTFSRQNQPPVTDIDL
NVEVERVLSMIQYQINRNQIKIVEQLAPFLPRLTANGSQIQQVLTNLLINARDALGEVDRKEKVITVATALLVRDRKKWA
VLSVRDNGTGIAPENLSKIFTPFYTSKEATKGTGLGLSVSLGIAESHNGTIEVESRLGEGSTFSLLLPIEHQ
>Mature_552_residues
MENREKLLEQLTGVDSSKLNYYIELKKRNQEILKQNSRLEILQQLTRDINIDMSMEDILERAFTKFPQTLPCDFLGLVRV
RDGELRLMALMPRDFCRIDNFPAHSPTLNVISNRKAGIYNLTPEELSHVQINPHYPGPLRSLAIAPMFQRDEVIGALIVA
SIIDGAYNEADLSFVQHLADQLSISIQNARLYKQVSRAKKEWEETFLAVTDPIFLVDTDYNVLLHNNRLSPAMSGFWNQA
VSNKCFARLHGRTHPCENCPIKEVQRTGKPVFQRWQTDAGLLLDISYYPVFNEEKQLSAVTIIIKDVTDKTKMEAQLVQT
AKLAALGEMAAGVAHELNSPMTVIIGTAQLLLRELQQDAQYDRAEVLEDIVNSGLRCKRIIQNLLTFSRQNQPPVTDIDL
NVEVERVLSMIQYQINRNQIKIVEQLAPFLPRLTANGSQIQQVLTNLLINARDALGEVDRKEKVITVATALLVRDRKKWA
VLSVRDNGTGIAPENLSKIFTPFYTSKEATKGTGLGLSVSLGIAESHNGTIEVESRLGEGSTFSLLLPIEHQ

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=275, Percent_Identity=32.7272727272727, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790300, Length=247, Percent_Identity=30.3643724696356, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=247, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1786600, Length=280, Percent_Identity=25.7142857142857, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=282, Percent_Identity=27.6595744680851, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994928, Length=280, Percent_Identity=24.6428571428571, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=28.3333333333333, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=27.1111111111111, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789808, Length=224, Percent_Identity=26.3392857142857, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62221; Mature: 62221

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENREKLLEQLTGVDSSKLNYYIELKKRNQEILKQNSRLEILQQLTRDINIDMSMEDILE
CCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHH
RAFTKFPQTLPCDFLGLVRVRDGELRLMALMPRDFCRIDNFPAHSPTLNVISNRKAGIYN
HHHHHCCCCCCCCHHEEEEEECCCEEEEEECCHHHHHCCCCCCCCCCCHHHCCCCCCEEE
LTPEELSHVQINPHYPGPLRSLAIAPMFQRDEVIGALIVASIIDGAYNEADLSFVQHLAD
CCHHHCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QLSISIQNARLYKQVSRAKKEWEETFLAVTDPIFLVDTDYNVLLHNNRLSPAMSGFWNQA
HHEEEHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCEEEEECCCCCHHHHHHHHHH
VSNKCFARLHGRTHPCENCPIKEVQRTGKPVFQRWQTDAGLLLDISYYPVFNEEKQLSAV
HHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCEEE
TIIIKDVTDKTKMEAQLVQTAKLAALGEMAAGVAHELNSPMTVIIGTAQLLLRELQQDAQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHC
YDRAEVLEDIVNSGLRCKRIIQNLLTFSRQNQPPVTDIDLNVEVERVLSMIQYQINRNQI
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCHHH
KIVEQLAPFLPRLTANGSQIQQVLTNLLINARDALGEVDRKEKVITVATALLVRDRKKWA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
VLSVRDNGTGIAPENLSKIFTPFYTSKEATKGTGLGLSVSLGIAESHNGTIEVESRLGEG
EEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCCC
STFSLLLPIEHQ
CEEEEEEECCCC
>Mature Secondary Structure
MENREKLLEQLTGVDSSKLNYYIELKKRNQEILKQNSRLEILQQLTRDINIDMSMEDILE
CCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHH
RAFTKFPQTLPCDFLGLVRVRDGELRLMALMPRDFCRIDNFPAHSPTLNVISNRKAGIYN
HHHHHCCCCCCCCHHEEEEEECCCEEEEEECCHHHHHCCCCCCCCCCCHHHCCCCCCEEE
LTPEELSHVQINPHYPGPLRSLAIAPMFQRDEVIGALIVASIIDGAYNEADLSFVQHLAD
CCHHHCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QLSISIQNARLYKQVSRAKKEWEETFLAVTDPIFLVDTDYNVLLHNNRLSPAMSGFWNQA
HHEEEHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCEEEEECCCCCHHHHHHHHHH
VSNKCFARLHGRTHPCENCPIKEVQRTGKPVFQRWQTDAGLLLDISYYPVFNEEKQLSAV
HHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCEEE
TIIIKDVTDKTKMEAQLVQTAKLAALGEMAAGVAHELNSPMTVIIGTAQLLLRELQQDAQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHC
YDRAEVLEDIVNSGLRCKRIIQNLLTFSRQNQPPVTDIDLNVEVERVLSMIQYQINRNQI
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCHHH
KIVEQLAPFLPRLTANGSQIQQVLTNLLINARDALGEVDRKEKVITVATALLVRDRKKWA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
VLSVRDNGTGIAPENLSKIFTPFYTSKEATKGTGLGLSVSLGIAESHNGTIEVESRLGEG
EEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCCC
STFSLLLPIEHQ
CEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]