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The map label for this gene is mdh [H]

Identifier: 78222271

GI number: 78222271

Start: 1168240

End: 1169388

Strand: Direct

Name: mdh [H]

Synonym: Gmet_1053

Alternate gene names: 78222271

Gene position: 1168240-1169388 (Clockwise)

Preceding gene: 78222265

Following gene: 78222272

Centisome position: 29.22

GC content: 65.01

Gene sequence:

>1149_bases
GTGAACATCAGCAAGTTTGTGGCGCCGGAGATCATCTTCGGCCAGGGCTCCCTGAGCCAGATCGGCGAGAGCGCCGCCCG
CATCGGCGCCTCCAAGGTGTTCTTGGTCAGCGACGAGGATGTCATCAGCGCCGGCTGGGTAGACAAGGCGCTCCACTACC
TCCATGCCGTCGGCCTGGAAACGGAAATCTACTCGTCCCTCACCTCCAATCCGAAGGATTTCGAGGTGTTGGAGGGTGCC
CGTCACTACGTGGCCTCGGGGTGTGACGCCATCGTCGCCGTGGGTGGGGGGAGCCCCACCGACGTGGCCAAGGCGGTGGC
CATCCTTGCCAGCAACGGGGGGGAGCTGCGCGACTACGAGGGGATCAACAGGATTTCCCGGCCGCTCCCGCCGATGGTGA
TCGCCCCCTCTACCGCCGGAGCCGGTTCCGAGGTGAGCCCGTTCGCCATCATAGTCGACACCGAGCGGAAGCTGAAGATG
TCCATCATCTCCAAATCCCTGGTGCCGGATATCGCCATCGTCGACCCGGAGCTTCTCAGGACCAAGGATGCGAAGCTGGC
GGCCGCCACCGGCATGGATGCCCTCACCCACGGCATCGAGTCCTACGTCTCCCTGGCGGCTACCCCCCTGACCGACATCC
ACGCCTGCAAGGCGATCCAGCTCATCGCGGCCAACCTGCGCCGGGCGGTGGCCGACCGGGGTGACATGGAGGCCAACACC
AACATGGCCATGGCAAGCCTCACGGCGGGCATCGCCTTCTCCAACGCCATCCTTGGCGCCACCCATGCCATGACCCATCA
GGTGGACGGCCTCCTGGACCAGCACCACGGCGAGGCCAACGCCTCGATCCTCCCCCACGTCATGGAGTTCAACCTCTCGG
CCTGCCCGGAGCGGTTCAAGCATATCGCCTGGTCCCTGGGGAAGGACGTGCGCAACACCGGCCAAGAGGAGGGGGCCCGG
CTGGCCATCGAGGGGATCCGGGAACTGATTGCCGACATCGGTCTCGCCAAGGGGCTTGGCGCCATGGGGCTGCGGGAGGA
GTTCATACCTCTCCTCAGCCGCAACGCCTTGAACGATGCCTGTCTGGTGACCAATCCGCGCAATGCGACTGTCGACGACA
TTGAAGCCATCTTCCGCAAGGCGATGTAG

Upstream 100 bases:

>100_bases
TTGTGGCGCAAAACGCCGTAAACGCTCGTTCGACGCCTTGTGCACGGGAATTGCACATGTATACGGCTGTATACGGCATC
ATTCCCTTGAAGGAGACACT

Downstream 100 bases:

>100_bases
GCCGCGTCCGCCTTCGGGGCATCTTCGACCCGGCCTCAATCCCATAATCCTCGACGTAGTGCTGCTACGCCTGCGGTTAT
GCTCAATCGGCCAGGCCAAA

Product: Iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNISKFVAPEIIFGQGSLSQIGESAARIGASKVFLVSDEDVISAGWVDKALHYLHAVGLETEIYSSLTSNPKDFEVLEGA
RHYVASGCDAIVAVGGGSPTDVAKAVAILASNGGELRDYEGINRISRPLPPMVIAPSTAGAGSEVSPFAIIVDTERKLKM
SIISKSLVPDIAIVDPELLRTKDAKLAAATGMDALTHGIESYVSLAATPLTDIHACKAIQLIAANLRRAVADRGDMEANT
NMAMASLTAGIAFSNAILGATHAMTHQVDGLLDQHHGEANASILPHVMEFNLSACPERFKHIAWSLGKDVRNTGQEEGAR
LAIEGIRELIADIGLAKGLGAMGLREEFIPLLSRNALNDACLVTNPRNATVDDIEAIFRKAM

Sequences:

>Translated_382_residues
MNISKFVAPEIIFGQGSLSQIGESAARIGASKVFLVSDEDVISAGWVDKALHYLHAVGLETEIYSSLTSNPKDFEVLEGA
RHYVASGCDAIVAVGGGSPTDVAKAVAILASNGGELRDYEGINRISRPLPPMVIAPSTAGAGSEVSPFAIIVDTERKLKM
SIISKSLVPDIAIVDPELLRTKDAKLAAATGMDALTHGIESYVSLAATPLTDIHACKAIQLIAANLRRAVADRGDMEANT
NMAMASLTAGIAFSNAILGATHAMTHQVDGLLDQHHGEANASILPHVMEFNLSACPERFKHIAWSLGKDVRNTGQEEGAR
LAIEGIRELIADIGLAKGLGAMGLREEFIPLLSRNALNDACLVTNPRNATVDDIEAIFRKAM
>Mature_382_residues
MNISKFVAPEIIFGQGSLSQIGESAARIGASKVFLVSDEDVISAGWVDKALHYLHAVGLETEIYSSLTSNPKDFEVLEGA
RHYVASGCDAIVAVGGGSPTDVAKAVAILASNGGELRDYEGINRISRPLPPMVIAPSTAGAGSEVSPFAIIVDTERKLKM
SIISKSLVPDIAIVDPELLRTKDAKLAAATGMDALTHGIESYVSLAATPLTDIHACKAIQLIAANLRRAVADRGDMEANT
NMAMASLTAGIAFSNAILGATHAMTHQVDGLLDQHHGEANASILPHVMEFNLSACPERFKHIAWSLGKDVRNTGQEEGAR
LAIEGIRELIADIGLAKGLGAMGLREEFIPLLSRNALNDACLVTNPRNATVDDIEAIFRKAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=411, Percent_Identity=27.9805352798054, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI48994951, Length=383, Percent_Identity=40.2088772845953, Blast_Score=281, Evalue=4e-77,
Organism=Escherichia coli, GI1789163, Length=371, Percent_Identity=36.6576819407008, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87082107, Length=375, Percent_Identity=36.8, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1787493, Length=402, Percent_Identity=29.3532338308458, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537053, Length=420, Percent_Identity=27.8571428571429, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321181, Length=379, Percent_Identity=36.1477572559367, Blast_Score=239, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24657991, Length=414, Percent_Identity=28.5024154589372, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40367; Mature: 40367

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISKFVAPEIIFGQGSLSQIGESAARIGASKVFLVSDEDVISAGWVDKALHYLHAVGLE
CCCHHHCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCH
TEIYSSLTSNPKDFEVLEGARHYVASGCDAIVAVGGGSPTDVAKAVAILASNGGELRDYE
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHH
GINRISRPLPPMVIAPSTAGAGSEVSPFAIIVDTERKLKMSIISKSLVPDIAIVDPELLR
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEECCHHHHH
TKDAKLAAATGMDALTHGIESYVSLAATPLTDIHACKAIQLIAANLRRAVADRGDMEANT
CCCCHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NMAMASLTAGIAFSNAILGATHAMTHQVDGLLDQHHGEANASILPHVMEFNLSACPERFK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHH
HIAWSLGKDVRNTGQEEGARLAIEGIRELIADIGLAKGLGAMGLREEFIPLLSRNALNDA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
CLVTNPRNATVDDIEAIFRKAM
EEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNISKFVAPEIIFGQGSLSQIGESAARIGASKVFLVSDEDVISAGWVDKALHYLHAVGLE
CCCHHHCCCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCH
TEIYSSLTSNPKDFEVLEGARHYVASGCDAIVAVGGGSPTDVAKAVAILASNGGELRDYE
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHH
GINRISRPLPPMVIAPSTAGAGSEVSPFAIIVDTERKLKMSIISKSLVPDIAIVDPELLR
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEECCHHHHH
TKDAKLAAATGMDALTHGIESYVSLAATPLTDIHACKAIQLIAANLRRAVADRGDMEANT
CCCCHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NMAMASLTAGIAFSNAILGATHAMTHQVDGLLDQHHGEANASILPHVMEFNLSACPERFK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHH
HIAWSLGKDVRNTGQEEGARLAIEGIRELIADIGLAKGLGAMGLREEFIPLLSRNALNDA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
CLVTNPRNATVDDIEAIFRKAM
EEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]