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The map label for this gene is yiaY [H]

Identifier: 78222264

GI number: 78222264

Start: 1161195

End: 1162358

Strand: Reverse

Name: yiaY [H]

Synonym: Gmet_1046

Alternate gene names: 78222264

Gene position: 1162358-1161195 (Counterclockwise)

Preceding gene: 78222266

Following gene: 78222263

Centisome position: 29.08

GC content: 65.21

Gene sequence:

>1164_bases
ATGGCACTGGCAGATCAGACTTTCGGATTCTTCATTCCCACCGTTACGCTCATGGGGGTCGGCTCCTCCAAGGAGACCGG
CGCGCAGGTAAAGGCGCTGGGCGCCCGGAAGGCGCTCCTGGTGACCGACAAGGGGATCTCGGCCATGGGGATGGCCGACC
AGATCAAACAGCAGGTTGAGGCTGCCGGCGTCGCGGTCGTCATCTTCGACGGCGCCGAGCCGAACCCCACCGACACCAAC
GTCCACGACGGCGTCAAGGTCTATCAGGAGAACGGCTGCGACTCCATCATCTCCCTCGGCGGCGGCAGCTCCCACGACTG
CGCCAAGGGGGTGGGCCTCGTGATCGGCAACGGCGGCCACATCCGCGATTTCGAAGGGGTTAACAAATCCACGAAGCCGA
TGCCCCCCTTCGTCGCCATCAACACCACTGCCGGCACCGCCTCGGAGATGACCCGCTTCTGCATCATCACCAACACTGAC
ACCCACGTGAAGATGGCCATTGTCGACTGGCGCTGCACCCCGAACATCGCCATCAACGACCCGGTCCTCATGCTCGGCAA
GCCCGCGCCCCTCACCGCCGCCACCGGCATGGACGCCCTCACCCACGCGGTCGAGGCCTACGTCTCCACCATCGCCACCC
CCATCACCGACGCCTGCGCCCTCCAGGCCATCAAGCTGATCGCCGAGTACCTGAGCCCGGCCGTGGCTAACGGCGACAAC
CTGGAAGCCCGGGACCGGATGGCCTACGCCGAGTACCTGGCCGGCATGGCATTCAACAACGCGAGCCTCGGCTACGTCCA
CTCCATGGCCCACCAGTTGGGGGGCTTCTACAACCTCCCCCACGGGGTCTGCAACGCCATCCTGCTGCCGGCGGTTTCCG
AATTCAACGCCATCGCCTGCCCGAAGCGGTACGCCGACATTGCCGTGGCCCTGGGCGAAGACATCACCGGCCTTGCCCCC
CTGGATGCCGCCGCCAAGGCCATTGCCGCCATCCGCAAGCTCTCGGCGGCCATCGGCATCCCGGCCGGCCTCAAGGAGCT
GAACGTGAAAGAAGAGGACCTGAAGGTCATGGCCGAGAACGCCAAGAAAGACGCCTGCCAGCTGACCAACCCGCGCAAGG
CGACCTTGGAGCAAGTGATCGGCATCTTCAAAGCGGCGATGTAG

Upstream 100 bases:

>100_bases
AACAGCCGTTCTAAAAAACCGTATGACAACTGGCAGGTTGAACAGAGAAAGTTTCCACCGCAGTGGCAGAACGCCACACA
CCAACAAGGAGGAAGTACAC

Downstream 100 bases:

>100_bases
ACGGCTGCCGCTTTCGCGCAATCCCGGCGTTGCCCTTCGCGATGCTCTTGTGCGGCGTAGCGCTGCTACGCCTCCGCGGC
ATCACTCGGACGCCTTGGCC

Product: Iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MALADQTFGFFIPTVTLMGVGSSKETGAQVKALGARKALLVTDKGISAMGMADQIKQQVEAAGVAVVIFDGAEPNPTDTN
VHDGVKVYQENGCDSIISLGGGSSHDCAKGVGLVIGNGGHIRDFEGVNKSTKPMPPFVAINTTAGTASEMTRFCIITNTD
THVKMAIVDWRCTPNIAINDPVLMLGKPAPLTAATGMDALTHAVEAYVSTIATPITDACALQAIKLIAEYLSPAVANGDN
LEARDRMAYAEYLAGMAFNNASLGYVHSMAHQLGGFYNLPHGVCNAILLPAVSEFNAIACPKRYADIAVALGEDITGLAP
LDAAAKAIAAIRKLSAAIGIPAGLKELNVKEEDLKVMAENAKKDACQLTNPRKATLEQVIGIFKAAM

Sequences:

>Translated_387_residues
MALADQTFGFFIPTVTLMGVGSSKETGAQVKALGARKALLVTDKGISAMGMADQIKQQVEAAGVAVVIFDGAEPNPTDTN
VHDGVKVYQENGCDSIISLGGGSSHDCAKGVGLVIGNGGHIRDFEGVNKSTKPMPPFVAINTTAGTASEMTRFCIITNTD
THVKMAIVDWRCTPNIAINDPVLMLGKPAPLTAATGMDALTHAVEAYVSTIATPITDACALQAIKLIAEYLSPAVANGDN
LEARDRMAYAEYLAGMAFNNASLGYVHSMAHQLGGFYNLPHGVCNAILLPAVSEFNAIACPKRYADIAVALGEDITGLAP
LDAAAKAIAAIRKLSAAIGIPAGLKELNVKEEDLKVMAENAKKDACQLTNPRKATLEQVIGIFKAAM
>Mature_386_residues
ALADQTFGFFIPTVTLMGVGSSKETGAQVKALGARKALLVTDKGISAMGMADQIKQQVEAAGVAVVIFDGAEPNPTDTNV
HDGVKVYQENGCDSIISLGGGSSHDCAKGVGLVIGNGGHIRDFEGVNKSTKPMPPFVAINTTAGTASEMTRFCIITNTDT
HVKMAIVDWRCTPNIAINDPVLMLGKPAPLTAATGMDALTHAVEAYVSTIATPITDACALQAIKLIAEYLSPAVANGDNL
EARDRMAYAEYLAGMAFNNASLGYVHSMAHQLGGFYNLPHGVCNAILLPAVSEFNAIACPKRYADIAVALGEDITGLAPL
DAAAKAIAAIRKLSAAIGIPAGLKELNVKEEDLKVMAENAKKDACQLTNPRKATLEQVIGIFKAAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=409, Percent_Identity=26.8948655256724, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=58.2010582010582, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1789163, Length=361, Percent_Identity=42.6592797783933, Blast_Score=283, Evalue=9e-78,
Organism=Escherichia coli, GI87082107, Length=377, Percent_Identity=37.1352785145889, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1787493, Length=381, Percent_Identity=36.2204724409449, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1789386, Length=388, Percent_Identity=24.7422680412371, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537053, Length=411, Percent_Identity=26.2773722627737, Blast_Score=137, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=381, Percent_Identity=52.49343832021, Blast_Score=396, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24657991, Length=410, Percent_Identity=28.2926829268293, Blast_Score=147, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40371; Mature: 40240

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALADQTFGFFIPTVTLMGVGSSKETGAQVKALGARKALLVTDKGISAMGMADQIKQQVE
CCCCCCCHHHHHHHHHEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHH
AAGVAVVIFDGAEPNPTDTNVHDGVKVYQENGCDSIISLGGGSSHDCAKGVGLVIGNGGH
HCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCHHEECCCCCCCCHHCCCEEEEECCCC
IRDFEGVNKSTKPMPPFVAINTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPNIAIND
EECCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEEECCCCCEECC
PVLMLGKPAPLTAATGMDALTHAVEAYVSTIATPITDACALQAIKLIAEYLSPAVANGDN
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
LEARDRMAYAEYLAGMAFNNASLGYVHSMAHQLGGFYNLPHGVCNAILLPAVSEFNAIAC
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCC
PKRYADIAVALGEDITGLAPLDAAAKAIAAIRKLSAAIGIPAGLKELNVKEEDLKVMAEN
CHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHH
AKKDACQLTNPRKATLEQVIGIFKAAM
CCHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALADQTFGFFIPTVTLMGVGSSKETGAQVKALGARKALLVTDKGISAMGMADQIKQQVE
CCCCCCHHHHHHHHHEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHH
AAGVAVVIFDGAEPNPTDTNVHDGVKVYQENGCDSIISLGGGSSHDCAKGVGLVIGNGGH
HCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCHHEECCCCCCCCHHCCCEEEEECCCC
IRDFEGVNKSTKPMPPFVAINTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPNIAIND
EECCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEEECCCCCEECC
PVLMLGKPAPLTAATGMDALTHAVEAYVSTIATPITDACALQAIKLIAEYLSPAVANGDN
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
LEARDRMAYAEYLAGMAFNNASLGYVHSMAHQLGGFYNLPHGVCNAILLPAVSEFNAIAC
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCC
PKRYADIAVALGEDITGLAPLDAAAKAIAAIRKLSAAIGIPAGLKELNVKEEDLKVMAEN
CHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHH
AKKDACQLTNPRKATLEQVIGIFKAAM
CCHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]