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The map label for this gene is moeB [H]

Identifier: 78222261

GI number: 78222261

Start: 1158038

End: 1158880

Strand: Reverse

Name: moeB [H]

Synonym: Gmet_1043

Alternate gene names: 78222261

Gene position: 1158880-1158038 (Counterclockwise)

Preceding gene: 78222262

Following gene: 78222260

Centisome position: 28.99

GC content: 64.77

Gene sequence:

>843_bases
ATGGAGCTGTACGACTTCATCACGGCAGCGGCGCCAGCGGGCCTTTTTCCCTGGACGGCCCAGGTGGAGGCCGCCGAGCG
GTTCGGCCTCACCCTCGGCCGCGTGGAGGAGGCGGCTCTCGAACAGGGCATCATGCCGGCTCGCTACCAGCGCAACCGCC
AGACCATCACCGTCGGCAACCAGCTCCGCCTCTGCCGTAGCTGTGCGGTCATCATCGGCAGCGGCGGCCTCGGAGGGTAC
CTGATCGAGGAACTGGCCCGCCTCGGGGTGGGAAACCTCGTGGTGGTGGACCCCGACATCTTCGAGGAGCACAACCTGAA
CCGCCAGATCCTTTCCTCCCCTGCCTTCCTCGGCCATCCAAAGGTTGAGGTCGCCGCGGCGCGCGTCGGTGAGATCAACC
CTGCGGTCACCGTTACCCCGCTTCAGCTTTCATTTTCCCGGGAAAACGGTCAAGGGATACTGGCGGGGTCCGATGTGGTG
ATGGACGGCCTGGACAGCATCGCCACACGCATTGAACTGGCGGAATGCTGCCGAGGGCTTTCCATTCCCCTCGTGCATGG
CGCCATAGGCGGCTGGTACGGGCAAGTGGCCTCCCAACTTCCCGGGGACGACATCGTCCCATCCCTCTTCGGCAACTGGT
CGGAGCCGAAGGGAGTTGAATCGCAGCTCGGCAACCCCTCCTTCACCCCGGCGGTGGTGGCAAGCCTCCAGGTGGCAGAA
GCCTGCAAGATCCTCTTGGGTGAGGGGGAATCGCTCCGCCACCGGATGATCTACGTGAACCTCCTCCACATGGAATTCGA
CGAGGTGCTGCTGGAACCGCCACTGGCGGCGGTGGGGGAATGA

Upstream 100 bases:

>100_bases
GTGGGCATCGTCCTGGTCAATAGCCGGCACGCCAAACTGGACCATCGGCTGTTCGAGGGTGATACCCTGTCGCTGTTCCC
CCTCGTAGGAGGGGGGTAAG

Downstream 100 bases:

>100_bases
ACCGTCATAACGTCTGAACAGACCCCTTCCGTTTGGTAATAATCAGCATATTTCATTTTATCAGTTGACACGCATCCCCT
AAATTGGTATTTAAGTACCA

Product: UBA/THIF-type NAD/FAD binding fold:MoeZ/MoeB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MELYDFITAAAPAGLFPWTAQVEAAERFGLTLGRVEEAALEQGIMPARYQRNRQTITVGNQLRLCRSCAVIIGSGGLGGY
LIEELARLGVGNLVVVDPDIFEEHNLNRQILSSPAFLGHPKVEVAAARVGEINPAVTVTPLQLSFSRENGQGILAGSDVV
MDGLDSIATRIELAECCRGLSIPLVHGAIGGWYGQVASQLPGDDIVPSLFGNWSEPKGVESQLGNPSFTPAVVASLQVAE
ACKILLGEGESLRHRMIYVNLLHMEFDEVLLEPPLAAVGE

Sequences:

>Translated_280_residues
MELYDFITAAAPAGLFPWTAQVEAAERFGLTLGRVEEAALEQGIMPARYQRNRQTITVGNQLRLCRSCAVIIGSGGLGGY
LIEELARLGVGNLVVVDPDIFEEHNLNRQILSSPAFLGHPKVEVAAARVGEINPAVTVTPLQLSFSRENGQGILAGSDVV
MDGLDSIATRIELAECCRGLSIPLVHGAIGGWYGQVASQLPGDDIVPSLFGNWSEPKGVESQLGNPSFTPAVVASLQVAE
ACKILLGEGESLRHRMIYVNLLHMEFDEVLLEPPLAAVGE
>Mature_280_residues
MELYDFITAAAPAGLFPWTAQVEAAERFGLTLGRVEEAALEQGIMPARYQRNRQTITVGNQLRLCRSCAVIIGSGGLGGY
LIEELARLGVGNLVVVDPDIFEEHNLNRQILSSPAFLGHPKVEVAAARVGEINPAVTVTPLQLSFSRENGQGILAGSDVV
MDGLDSIATRIELAECCRGLSIPLVHGAIGGWYGQVASQLPGDDIVPSLFGNWSEPKGVESQLGNPSFTPAVVASLQVAE
ACKILLGEGESLRHRMIYVNLLHMEFDEVLLEPPLAAVGE

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=151, Percent_Identity=35.7615894039735, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI38045948, Length=164, Percent_Identity=32.3170731707317, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787048, Length=233, Percent_Identity=33.9055793991416, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082356, Length=151, Percent_Identity=37.0860927152318, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789177, Length=141, Percent_Identity=34.0425531914894, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17540406, Length=179, Percent_Identity=29.0502793296089, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193203301, Length=141, Percent_Identity=29.0780141843972, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=227, Percent_Identity=27.7533039647577, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24582879, Length=219, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28573937, Length=163, Percent_Identity=30.6748466257669, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24660640, Length=132, Percent_Identity=28.7878787878788, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 29924; Mature: 29924

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYDFITAAAPAGLFPWTAQVEAAERFGLTLGRVEEAALEQGIMPARYQRNRQTITVGN
CCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHCCCCEEEECH
QLRLCRSCAVIIGSGGLGGYLIEELARLGVGNLVVVDPDIFEEHNLNRQILSSPAFLGHP
HHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCEEEECCCHHHHCCCCHHHHCCCCCCCCC
KVEVAAARVGEINPAVTVTPLQLSFSRENGQGILAGSDVVMDGLDSIATRIELAECCRGL
CCEEHHHHHCCCCCCEEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
SIPLVHGAIGGWYGQVASQLPGDDIVPSLFGNWSEPKGVESQLGNPSFTPAVVASLQVAE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHH
ACKILLGEGESLRHRMIYVNLLHMEFDEVLLEPPLAAVGE
HHHHHHCCCHHHHEEEEEEEEEHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MELYDFITAAAPAGLFPWTAQVEAAERFGLTLGRVEEAALEQGIMPARYQRNRQTITVGN
CCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHCCCCEEEECH
QLRLCRSCAVIIGSGGLGGYLIEELARLGVGNLVVVDPDIFEEHNLNRQILSSPAFLGHP
HHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCEEEECCCHHHHCCCCHHHHCCCCCCCCC
KVEVAAARVGEINPAVTVTPLQLSFSRENGQGILAGSDVVMDGLDSIATRIELAECCRGL
CCEEHHHHHCCCCCCEEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
SIPLVHGAIGGWYGQVASQLPGDDIVPSLFGNWSEPKGVESQLGNPSFTPAVVASLQVAE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHH
ACKILLGEGESLRHRMIYVNLLHMEFDEVLLEPPLAAVGE
HHHHHHCCCHHHHEEEEEEEEEHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA