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The map label for this gene is rnhA

Identifier: 78222155

GI number: 78222155

Start: 1038344

End: 1038802

Strand: Direct

Name: rnhA

Synonym: Gmet_0935

Alternate gene names: 78222155

Gene position: 1038344-1038802 (Clockwise)

Preceding gene: 78222154

Following gene: 78222156

Centisome position: 25.98

GC content: 63.18

Gene sequence:

>459_bases
ATGTCAACAAGGGTTGAACTTTTCTGCGACGGTGCCTGCAGCGGTAATCCGGGCGTCGGCGGTTGGGGGGGCATCCTTCG
GTGTGGCGCTACGGAAAAGGAATTATCGGGCGCCGAGTGGGAGACCACCAACAACCGGATGGAGATGACCGCCGCCATCC
GGGGGCTGGAGGCCCTGACGCGTCCCTGTGAGGTGGTCGTCACCACCGACTCCCAGTATCTGGTAAAGGGAATGACCGAA
TGGCTTTCGGGGTGGATCCGGCGGGGGTGGGTCAACAGCAAGAAGGAGCCGGTGCTGAACCGGGATCTCTGGGAACGGCT
CCTGGAACTCTCCAAGACTCACCGGATCCAGTGGACCTGGATTCGGGGGCACAACGGCCATGCCGAGAACGAGCGCTGTG
ACGCCCTGGCTCGGGGGGCCATTGACGAGCTCAGAAAGAAGGGGCAGGGACGGCGGTGA

Upstream 100 bases:

>100_bases
GCAGACCTGTATGGCCGCGAAGACAACAAGGAAACTCACCAGTTGATTGTCGGGCGTGTCATGACAGCCATAGCTGATCT
TCTGAAGACGGAAGGGGCCT

Downstream 100 bases:

>100_bases
ACTACTTCATCGTTGAGGTGTCGGAGCAGGAGGTGAAGCGGGAGAAGGAAAAGGCCCGGGAGCTTCGCCGAAGCCAGTGG
TGGAAGAACCGGATTGCCCG

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MSTRVELFCDGACSGNPGVGGWGGILRCGATEKELSGAEWETTNNRMEMTAAIRGLEALTRPCEVVVTTDSQYLVKGMTE
WLSGWIRRGWVNSKKEPVLNRDLWERLLELSKTHRIQWTWIRGHNGHAENERCDALARGAIDELRKKGQGRR

Sequences:

>Translated_152_residues
MSTRVELFCDGACSGNPGVGGWGGILRCGATEKELSGAEWETTNNRMEMTAAIRGLEALTRPCEVVVTTDSQYLVKGMTE
WLSGWIRRGWVNSKKEPVLNRDLWERLLELSKTHRIQWTWIRGHNGHAENERCDALARGAIDELRKKGQGRR
>Mature_151_residues
STRVELFCDGACSGNPGVGGWGGILRCGATEKELSGAEWETTNNRMEMTAAIRGLEALTRPCEVVVTTDSQYLVKGMTEW
LSGWIRRGWVNSKKEPVLNRDLWERLLELSKTHRIQWTWIRGHNGHAENERCDALARGAIDELRKKGQGRR

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=149, Percent_Identity=34.8993288590604, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786408, Length=140, Percent_Identity=54.2857142857143, Blast_Score=164, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI115532542, Length=137, Percent_Identity=35.036496350365, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45552509, Length=141, Percent_Identity=32.6241134751773, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137476, Length=141, Percent_Identity=32.6241134751773, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_GEOMG (Q39X47)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383902.1
- HSSP:   P0A7Y4
- ProteinModelPortal:   Q39X47
- STRING:   Q39X47
- GeneID:   3740091
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0935
- NMPDR:   fig|269799.3.peg.1010
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- PhylomeDB:   Q39X47
- ProtClustDB:   PRK00203
- BioCyc:   GMET269799:GMET_0935-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 17169; Mature: 17038

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRVELFCDGACSGNPGVGGWGGILRCGATEKELSGAEWETTNNRMEMTAAIRGLEALT
CCCEEEEEECCCCCCCCCCCCCCHHEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
RPCEVVVTTDSQYLVKGMTEWLSGWIRRGWVNSKKEPVLNRDLWERLLELSKTHRIQWTW
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEE
IRGHNGHAENERCDALARGAIDELRKKGQGRR
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STRVELFCDGACSGNPGVGGWGGILRCGATEKELSGAEWETTNNRMEMTAAIRGLEALT
CCEEEEEECCCCCCCCCCCCCCHHEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
RPCEVVVTTDSQYLVKGMTEWLSGWIRRGWVNSKKEPVLNRDLWERLLELSKTHRIQWTW
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEE
IRGHNGHAENERCDALARGAIDELRKKGQGRR
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA