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The map label for this gene is gmhA

Identifier: 78222140

GI number: 78222140

Start: 1015077

End: 1015646

Strand: Direct

Name: gmhA

Synonym: Gmet_0920

Alternate gene names: 78222140

Gene position: 1015077-1015646 (Clockwise)

Preceding gene: 78222139

Following gene: 78222141

Centisome position: 25.39

GC content: 65.09

Gene sequence:

>570_bases
ATGAATGAGGAAATCATGACCCAGCTCCGGTCCCACCGGGAGGTGATGGAGGCGGTGGAACGGGAGCTGACGCCGCGGAT
CGCCGCCTTTGCCGGGATGCTCGTTGCCGCCCTGAAAGGCGGGAAGAAGCTCCTCGTCATGGGGAACGGAGGCTCTGCCG
CCGATGCCCAGCACTTTGCCGCCGAGATCGTCGGCCGCTTCAAGATGGAGCGCCGGGGGTTGCCGGCCGTGGCCCTCACC
ACCGACACCTCGATCCTGACCGCCATCGGCAATGATTACGGCTTCGACGCCGTTTTCCGCCGCCAGGTGGAGGCCCTGGC
CGACGAGGGGGATGTGGTTGTCGGCCTTTCCACGAGCGGTTCGTCCCGGAACGTGTACGACGCCCTCGCCCTTGCCAATG
ACCGGGGGTGCATCACCGTGGGGCTCCTGGGGCGCGACGGCGGGACCCTCAAGGATATCGTCGATCTCGACGTCACCGTT
CCGAGCGGCGATACCCCCCGTATCCAGGAGGGGCACATCACCATCATCCACATCGTCTGCGATCTCGTGGAGAAGGGGTT
GTTCAAATGA

Upstream 100 bases:

>100_bases
GAGTCCCTGTACCGCCCTGAATCCCCTTGAGTGAAACCGGGTGACACCTCCGGGCGATTCGGATAAATTTGAAGATCATA
CAGATTTCCAGGAGGATGCA

Downstream 100 bases:

>100_bases
AATACCGTCCCGTCGACCTTTCGGGAGTTTCCACCTACCCCCTTGCCGAGCGGAAGAACAAGGTGAGCATCAAAAACGAC
TTCGCCGGCCCGGTTTCCGC

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MNEEIMTQLRSHREVMEAVERELTPRIAAFAGMLVAALKGGKKLLVMGNGGSAADAQHFAAEIVGRFKMERRGLPAVALT
TDTSILTAIGNDYGFDAVFRRQVEALADEGDVVVGLSTSGSSRNVYDALALANDRGCITVGLLGRDGGTLKDIVDLDVTV
PSGDTPRIQEGHITIIHIVCDLVEKGLFK

Sequences:

>Translated_189_residues
MNEEIMTQLRSHREVMEAVERELTPRIAAFAGMLVAALKGGKKLLVMGNGGSAADAQHFAAEIVGRFKMERRGLPAVALT
TDTSILTAIGNDYGFDAVFRRQVEALADEGDVVVGLSTSGSSRNVYDALALANDRGCITVGLLGRDGGTLKDIVDLDVTV
PSGDTPRIQEGHITIIHIVCDLVEKGLFK
>Mature_189_residues
MNEEIMTQLRSHREVMEAVERELTPRIAAFAGMLVAALKGGKKLLVMGNGGSAADAQHFAAEIVGRFKMERRGLPAVALT
TDTSILTAIGNDYGFDAVFRRQVEALADEGDVVVGLSTSGSSRNVYDALALANDRGCITVGLLGRDGGTLKDIVDLDVTV
PSGDTPRIQEGHITIIHIVCDLVEKGLFK

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=158, Percent_Identity=46.2025316455696, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1789539, Length=189, Percent_Identity=41.7989417989418, Blast_Score=145, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_GEOMG (Q39X62)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383887.1
- ProteinModelPortal:   Q39X62
- SMR:   Q39X62
- STRING:   Q39X62
- GeneID:   3740076
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0920
- NMPDR:   fig|269799.3.peg.995
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   QEMHILI
- PhylomeDB:   Q39X62
- ProtClustDB:   PRK13937
- BioCyc:   GMET269799:GMET_0920-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR020620
- InterPro:   IPR001347

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20151; Mature: 20151

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS51464 SIS

Important sites: BINDING 62-62 BINDING 122-122 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEEIMTQLRSHREVMEAVERELTPRIAAFAGMLVAALKGGKKLLVMGNGGSAADAQHFA
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AEIVGRFKMERRGLPAVALTTDTSILTAIGNDYGFDAVFRRQVEALADEGDVVVGLSTSG
HHHHHHHHHHHCCCCEEEEECCCHHEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
SSRNVYDALALANDRGCITVGLLGRDGGTLKDIVDLDVTVPSGDTPRIQEGHITIIHIVC
CCCCHHHHHEEECCCCEEEEEEEECCCCCHHHEEEEEEECCCCCCCCCCCCCEEHHHHHH
DLVEKGLFK
HHHHHCCCC
>Mature Secondary Structure
MNEEIMTQLRSHREVMEAVERELTPRIAAFAGMLVAALKGGKKLLVMGNGGSAADAQHFA
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AEIVGRFKMERRGLPAVALTTDTSILTAIGNDYGFDAVFRRQVEALADEGDVVVGLSTSG
HHHHHHHHHHHCCCCEEEEECCCHHEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
SSRNVYDALALANDRGCITVGLLGRDGGTLKDIVDLDVTVPSGDTPRIQEGHITIIHIVC
CCCCHHHHHEEECCCCEEEEEEEECCCCCHHHEEEEEEECCCCCCCCCCCCCEEHHHHHH
DLVEKGLFK
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA