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The map label for this gene is speA

Identifier: 78222124

GI number: 78222124

Start: 995010

End: 996917

Strand: Direct

Name: speA

Synonym: Gmet_0904

Alternate gene names: 78222124

Gene position: 995010-996917 (Clockwise)

Preceding gene: 78222123

Following gene: 78222125

Centisome position: 24.89

GC content: 58.91

Gene sequence:

>1908_bases
ATGGAACGCTGGTCGATCAACGACTCCGCAAAGATTTACAACCTCCCCAACTGGGGGGCTGACCTCTTCTCCATCAACAA
GAAGGGGAACGTCTGCGTACACCCTTCCCCCACGTCGAAGCACTCCATCGACCTGCGGGCGCTGGTGGACGATCTCATCA
AGCGCAAGATCAAGCCCCCGATCCTGCTACGGTTCATGGATGTCCTCCAGGGGCGGATCGCTGCCATCAACCGCGCCTTC
AAGTACGCCATCGATGAGAACGACTACCCGTCCACGTACCAGACCTTCTACCCCATCAAGGTGAACCAGCAGCGGCAGGT
GGTGGAGGCCATCGCCAAGTTCGGCAAGCGTTACAACATCGGCATCGAGGTGGGCTCCAAGCCGGAGCTGGTGATCGGCA
TCTCCTTCGCCACGGGGAACGGCATCCCGATCATATGCAACGGCTACAAGGACAAGGAGTACATCGAGACGGTCCTCTAC
GCCACCAAGATCGGCTACGACATCACCATCGTCGTGGAGAAGATGTTCGAGCTGGAGAAGATCATCGCCCTCTCCAAAAA
GACCGGCATCAAGCCCAAGCTCGGCATTCGGGTGAAGCTCTCCTCCAAGGGGACCGGCAAATGGGCCACCTCCGGCGGCG
AGGACGCCAAGTTCGGCCTCCGGATGTCGGAGATCATCGCTGCCATCGGGCTTCTGGAGCAGAACGAACTCCTTGATAGC
GTGAAACTGATCCACTTCCACATCGGGAGCCAGATCACCAAGATCGACAAGATCAAGAGCGCCCTCATCGAGGGGACCCG
GGTCTACGCCGAGATGCGGAAGCTGGGGGTCGGCATAGAGTACGTGGACATCGGCGGCGGCCTGGGGGTCGACTACGACG
GCTCCAAGTCCAGCTACTTCTCCAGCGTCAACTACTCCATCGAGGAGTACGCCAACGACGTCATCTACCAAATCAAAAAC
ATCTGCGAGGACGCCGGTGTCGAATGCCCCAATATCATCTCCGAATCGGGCCGGGCCACGGCGGCCCACTACTCGGTGCT
GGTGACGAACCTCCTCAACACCAATACCCAGAACCTGATGCCGGACTTTGAGGAAACCCTCAACGGCGCTGAGAAGCTGG
CCCCCACGGTCAAGAAGCTGGTGGACATCTACAAGAGCATTGACCGCTATTCCCTTCGGGAGGACTACCACGACACGGTA
CAACTCATCCAGGAGGCGGTGAGCCTTTTCAGTCTGGGGTACCTGACCCTTGCCGAACGGGCCATGGCCGAGTGGCTCCA
CGGCAAGATCCTGCGCAAGATCAACGGCATCGTGGAGAAGATTAAACCGATCCCCGAGGAGCTCCAGAACTTCCAGTTGA
GCCTGCGGCAGACCTACTTTGCCAACTTCTCGTTGTTCCAGTCGATTCCCGACTCCTGGGCCATCGACCAGCTCTTTCCC
ATCGTGCCGATTCAGCGGCTCAACCAGAAGCCCGACGTCATGGCCTCCATCGCCGACATAACCTGCGACTCCGACGGGGA
GATAACCAGCTTCGTCGGCGAGAACGGCCGGACGAAGTATCTGCCGCTCCACAAGATCCGCAAGGACGAGGACTACTTCG
TGGGCTTCTTCCTCATCGGCGCCTACCAGGAGATCCTGGGGGACATGCACAACCTCTTCGGCGACACCAACGCCGTGCAT
GTCACTTTCAACAAGAAGACCGGCTACAAGATCGACACGGTCATCAACGGCGACGCCACGTGGGAGAGCCTGAAATACGT
CCAGTACAAGGGACCGGAGATCCTCAAACACGTCCGCGACACCATGGAGAAGGATGTGGCCCTGCGCAAGGTCTCCATCG
AGGAGAGCAGCCACTTCCTGGAACTGCTGGACCGGACCCTCCTGGGGTATACGTACCTGGGGGAATGA

Upstream 100 bases:

>100_bases
GAGAGGAGGAAGGCCCGCAGGCGTAGCAGCGCTACGTAGAGGAGCCTGACGACGAGCCGACGGCGGAAGGGCGCAAATAT
GGCGTCGCCAGGAGACCACT

Downstream 100 bases:

>100_bases
TATCCCGGTGAACAAGCGGATTATGGGAAGGGAAGATGCCCCTGATGCTCCGGGTTCGGATTGTCAGGGGCTTTTTGTTT
CCGGAAACTCGTCCCCAGTG

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MERWSINDSAKIYNLPNWGADLFSINKKGNVCVHPSPTSKHSIDLRALVDDLIKRKIKPPILLRFMDVLQGRIAAINRAF
KYAIDENDYPSTYQTFYPIKVNQQRQVVEAIAKFGKRYNIGIEVGSKPELVIGISFATGNGIPIICNGYKDKEYIETVLY
ATKIGYDITIVVEKMFELEKIIALSKKTGIKPKLGIRVKLSSKGTGKWATSGGEDAKFGLRMSEIIAAIGLLEQNELLDS
VKLIHFHIGSQITKIDKIKSALIEGTRVYAEMRKLGVGIEYVDIGGGLGVDYDGSKSSYFSSVNYSIEEYANDVIYQIKN
ICEDAGVECPNIISESGRATAAHYSVLVTNLLNTNTQNLMPDFEETLNGAEKLAPTVKKLVDIYKSIDRYSLREDYHDTV
QLIQEAVSLFSLGYLTLAERAMAEWLHGKILRKINGIVEKIKPIPEELQNFQLSLRQTYFANFSLFQSIPDSWAIDQLFP
IVPIQRLNQKPDVMASIADITCDSDGEITSFVGENGRTKYLPLHKIRKDEDYFVGFFLIGAYQEILGDMHNLFGDTNAVH
VTFNKKTGYKIDTVINGDATWESLKYVQYKGPEILKHVRDTMEKDVALRKVSIEESSHFLELLDRTLLGYTYLGE

Sequences:

>Translated_635_residues
MERWSINDSAKIYNLPNWGADLFSINKKGNVCVHPSPTSKHSIDLRALVDDLIKRKIKPPILLRFMDVLQGRIAAINRAF
KYAIDENDYPSTYQTFYPIKVNQQRQVVEAIAKFGKRYNIGIEVGSKPELVIGISFATGNGIPIICNGYKDKEYIETVLY
ATKIGYDITIVVEKMFELEKIIALSKKTGIKPKLGIRVKLSSKGTGKWATSGGEDAKFGLRMSEIIAAIGLLEQNELLDS
VKLIHFHIGSQITKIDKIKSALIEGTRVYAEMRKLGVGIEYVDIGGGLGVDYDGSKSSYFSSVNYSIEEYANDVIYQIKN
ICEDAGVECPNIISESGRATAAHYSVLVTNLLNTNTQNLMPDFEETLNGAEKLAPTVKKLVDIYKSIDRYSLREDYHDTV
QLIQEAVSLFSLGYLTLAERAMAEWLHGKILRKINGIVEKIKPIPEELQNFQLSLRQTYFANFSLFQSIPDSWAIDQLFP
IVPIQRLNQKPDVMASIADITCDSDGEITSFVGENGRTKYLPLHKIRKDEDYFVGFFLIGAYQEILGDMHNLFGDTNAVH
VTFNKKTGYKIDTVINGDATWESLKYVQYKGPEILKHVRDTMEKDVALRKVSIEESSHFLELLDRTLLGYTYLGE
>Mature_635_residues
MERWSINDSAKIYNLPNWGADLFSINKKGNVCVHPSPTSKHSIDLRALVDDLIKRKIKPPILLRFMDVLQGRIAAINRAF
KYAIDENDYPSTYQTFYPIKVNQQRQVVEAIAKFGKRYNIGIEVGSKPELVIGISFATGNGIPIICNGYKDKEYIETVLY
ATKIGYDITIVVEKMFELEKIIALSKKTGIKPKLGIRVKLSSKGTGKWATSGGEDAKFGLRMSEIIAAIGLLEQNELLDS
VKLIHFHIGSQITKIDKIKSALIEGTRVYAEMRKLGVGIEYVDIGGGLGVDYDGSKSSYFSSVNYSIEEYANDVIYQIKN
ICEDAGVECPNIISESGRATAAHYSVLVTNLLNTNTQNLMPDFEETLNGAEKLAPTVKKLVDIYKSIDRYSLREDYHDTV
QLIQEAVSLFSLGYLTLAERAMAEWLHGKILRKINGIVEKIKPIPEELQNFQLSLRQTYFANFSLFQSIPDSWAIDQLFP
IVPIQRLNQKPDVMASIADITCDSDGEITSFVGENGRTKYLPLHKIRKDEDYFVGFFLIGAYQEILGDMHNLFGDTNAVH
VTFNKKTGYKIDTVINGDATWESLKYVQYKGPEILKHVRDTMEKDVALRKVSIEESSHFLELLDRTLLGYTYLGE

Specific function: Catalyzes the biosynthesis of agmatine from arginine

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily

Homologues:

Organism=Escherichia coli, GI1789307, Length=628, Percent_Identity=37.7388535031847, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEA_GEOMG (Q39X78)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383871.1
- ProteinModelPortal:   Q39X78
- STRING:   Q39X78
- GeneID:   3738242
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0904
- NMPDR:   fig|269799.3.peg.979
- eggNOG:   COG1166
- HOGENOM:   HBG321436
- OMA:   TCDSDGE
- PhylomeDB:   Q39X78
- ProtClustDB:   PRK05354
- BioCyc:   GMET269799:GMET_0904-MONOMER
- HAMAP:   MF_01417
- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- PANTHER:   PTHR11482:SF3
- PIRSF:   PIRSF001336
- PRINTS:   PR01180
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01273

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.19

Molecular weight: Translated: 71522; Mature: 71522

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERWSINDSAKIYNLPNWGADLFSINKKGNVCVHPSPTSKHSIDLRALVDDLIKRKIKPP
CCCCCCCCCCEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCH
ILLRFMDVLQGRIAAINRAFKYAIDENDYPSTYQTFYPIKVNQQRQVVEAIAKFGKRYNI
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEECCHHHHHHHHHHCCCEEEE
GIEVGSKPELVIGISFATGNGIPIICNGYKDKEYIETVLYATKIGYDITIVVEKMFELEK
EEEECCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
IIALSKKTGIKPKLGIRVKLSSKGTGKWATSGGEDAKFGLRMSEIIAAIGLLEQNELLDS
HHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHH
VKLIHFHIGSQITKIDKIKSALIEGTRVYAEMRKLGVGIEYVDIGGGLGVDYDGSKSSYF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHH
SSVNYSIEEYANDVIYQIKNICEDAGVECPNIISESGRATAAHYSVLVTNLLNTNTQNLM
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHCC
PDFEETLNGAEKLAPTVKKLVDIYKSIDRYSLREDYHDTVQLIQEAVSLFSLGYLTLAER
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAEWLHGKILRKINGIVEKIKPIPEELQNFQLSLRQTYFANFSLFQSIPDSWAIDQLFP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
IVPIQRLNQKPDVMASIADITCDSDGEITSFVGENGRTKYLPLHKIRKDEDYFVGFFLIG
CCCHHHCCCCCHHHHHHHHEECCCCCCCHHHHCCCCCEEECCHHHHCCCCCCEEHHHHHH
AYQEILGDMHNLFGDTNAVHVTFNKKTGYKIDTVINGDATWESLKYVQYKGPEILKHVRD
HHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHEECCCHHHHHHHHH
TMEKDVALRKVSIEESSHFLELLDRTLLGYTYLGE
HHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MERWSINDSAKIYNLPNWGADLFSINKKGNVCVHPSPTSKHSIDLRALVDDLIKRKIKPP
CCCCCCCCCCEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCH
ILLRFMDVLQGRIAAINRAFKYAIDENDYPSTYQTFYPIKVNQQRQVVEAIAKFGKRYNI
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEECCHHHHHHHHHHCCCEEEE
GIEVGSKPELVIGISFATGNGIPIICNGYKDKEYIETVLYATKIGYDITIVVEKMFELEK
EEEECCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
IIALSKKTGIKPKLGIRVKLSSKGTGKWATSGGEDAKFGLRMSEIIAAIGLLEQNELLDS
HHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHH
VKLIHFHIGSQITKIDKIKSALIEGTRVYAEMRKLGVGIEYVDIGGGLGVDYDGSKSSYF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHH
SSVNYSIEEYANDVIYQIKNICEDAGVECPNIISESGRATAAHYSVLVTNLLNTNTQNLM
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHCC
PDFEETLNGAEKLAPTVKKLVDIYKSIDRYSLREDYHDTVQLIQEAVSLFSLGYLTLAER
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAEWLHGKILRKINGIVEKIKPIPEELQNFQLSLRQTYFANFSLFQSIPDSWAIDQLFP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
IVPIQRLNQKPDVMASIADITCDSDGEITSFVGENGRTKYLPLHKIRKDEDYFVGFFLIG
CCCHHHCCCCCHHHHHHHHEECCCCCCCHHHHCCCCCEEECCHHHHCCCCCCEEHHHHHH
AYQEILGDMHNLFGDTNAVHVTFNKKTGYKIDTVINGDATWESLKYVQYKGPEILKHVRD
HHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHEECCCHHHHHHHHH
TMEKDVALRKVSIEESSHFLELLDRTLLGYTYLGE
HHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA