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The map label for this gene is pheA [H]

Identifier: 78222082

GI number: 78222082

Start: 951505

End: 952611

Strand: Direct

Name: pheA [H]

Synonym: Gmet_0862

Alternate gene names: 78222082

Gene position: 951505-952611 (Clockwise)

Preceding gene: 78222081

Following gene: 78222083

Centisome position: 23.8

GC content: 59.44

Gene sequence:

>1107_bases
ATGTCCGCTAACTCCCCACCGGATGGTCCCATACGCACCATGAAAACGCTCCAAGAGCTGCGTCGTGATATCGACGCCAT
TGATGATCAGATCCTGGATCTTCTTAACAGCCGCTCCCGGCTGGCCATAGAGGTCGGCAAGGTCAAAGCGGGAGAGAACC
GCGACTTCCACGTCCCGAGCCGTGAACGGGAAATCTATGAGCGGCTTGCGGCCGGGAATTCTGGACCCTTCCCGAACGAG
GCGGTCCGGAGCGTCTTCCGGGAGATCATTTCTGCTTCCCTTGCCCTCGAATCCCCCATGAAGGTTGCCTTTCTCGGCCC
CAAGGCGACGTTCACTCATCTTGCTTCCCTGCAGCATTTCGGCCTGTCGGCGGAACTCGTCCCCCAGAAGTCTATCCCTG
CTGTTTTCGAGGAGGTCAGCAAGGGGCGTTCCCTCTACGGCGTGGTTCCGGTGGAAAACTCCACCGAGGGGATGGTTTCC
CACACCCTCGACATGTTCATGGAGAGCGATCTCAAAATCAACGCGGAGATACTCCTGGAGGTTTCCCATGATCTCCTCTC
CCGCACCGGCCGCTTGGAGGATGTGAAGAAGGTCTACTCCCACCCCCAGGCCATTGCCCAGTGCCGCAACTGGCTCGACG
AGAATCTGTCGGGCGTGCCGGTGGTGGATGTGGCCTCCACGGCCCTGGCGGCCCAGATCGTCGGGGAGGACTATACCGCC
GCCGCCATTGCCAGCGAGTTTGCTGCGGCGCTGTATGATCTGAAAGTGGTGCGCCACAGGATCGAGGACCAGGTGAACAA
CTTCACCCGCTTCCTGGTTGTGGGGCGGAAAATGGCAGATCGGTGCGGCGACGACAAGACCTCCCTCATGTTTTCGGTCA
AGGACGAGCCGGGAATCCTCCACCGGATGCTGGAGCCCTTTGCCAAACGGGGGGTCAACCTGTCCAAGATCGAGTCGCGC
CCCCTCAAGAAAAAGGCCTGGGAGTACATATTTTTCCTCGATCTGGCCGGCCACATCTCAGATCCGGTGGTGTCCGACGC
GGTCCAGGAACTGAAGAACTACTGCCAGTTTGTCAAGATCCTCGGATCATACCCCCGGGCGAAATAG

Upstream 100 bases:

>100_bases
CATCCACGAGGTCCGCAAGGTTTGTCTGAAATGATGTTTGTGTAAACCAGAAAAGATTTGCATTTTTGCCATCTTTCCTA
TACATTACCCCCTCCACGGC

Downstream 100 bases:

>100_bases
CCGTTGGATACAATGCCCTTCATCCATAGATTAGCCATCATCGGCGTTGGCCTTATCGGCGGCTCCCTGGCCCGCATCCT
GCGAGAGAAGGGGGCGGTGG

Product: prephenate dehydratase/chorismate mutase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSANSPPDGPIRTMKTLQELRRDIDAIDDQILDLLNSRSRLAIEVGKVKAGENRDFHVPSREREIYERLAAGNSGPFPNE
AVRSVFREIISASLALESPMKVAFLGPKATFTHLASLQHFGLSAELVPQKSIPAVFEEVSKGRSLYGVVPVENSTEGMVS
HTLDMFMESDLKINAEILLEVSHDLLSRTGRLEDVKKVYSHPQAIAQCRNWLDENLSGVPVVDVASTALAAQIVGEDYTA
AAIASEFAAALYDLKVVRHRIEDQVNNFTRFLVVGRKMADRCGDDKTSLMFSVKDEPGILHRMLEPFAKRGVNLSKIESR
PLKKKAWEYIFFLDLAGHISDPVVSDAVQELKNYCQFVKILGSYPRAK

Sequences:

>Translated_368_residues
MSANSPPDGPIRTMKTLQELRRDIDAIDDQILDLLNSRSRLAIEVGKVKAGENRDFHVPSREREIYERLAAGNSGPFPNE
AVRSVFREIISASLALESPMKVAFLGPKATFTHLASLQHFGLSAELVPQKSIPAVFEEVSKGRSLYGVVPVENSTEGMVS
HTLDMFMESDLKINAEILLEVSHDLLSRTGRLEDVKKVYSHPQAIAQCRNWLDENLSGVPVVDVASTALAAQIVGEDYTA
AAIASEFAAALYDLKVVRHRIEDQVNNFTRFLVVGRKMADRCGDDKTSLMFSVKDEPGILHRMLEPFAKRGVNLSKIESR
PLKKKAWEYIFFLDLAGHISDPVVSDAVQELKNYCQFVKILGSYPRAK
>Mature_367_residues
SANSPPDGPIRTMKTLQELRRDIDAIDDQILDLLNSRSRLAIEVGKVKAGENRDFHVPSREREIYERLAAGNSGPFPNEA
VRSVFREIISASLALESPMKVAFLGPKATFTHLASLQHFGLSAELVPQKSIPAVFEEVSKGRSLYGVVPVENSTEGMVSH
TLDMFMESDLKINAEILLEVSHDLLSRTGRLEDVKKVYSHPQAIAQCRNWLDENLSGVPVVDVASTALAAQIVGEDYTAA
AIASEFAAALYDLKVVRHRIEDQVNNFTRFLVVGRKMADRCGDDKTSLMFSVKDEPGILHRMLEPFAKRGVNLSKIESRP
LKKKAWEYIFFLDLAGHISDPVVSDAVQELKNYCQFVKILGSYPRAK

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=373, Percent_Identity=31.9034852546917, Blast_Score=175, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324013, Length=349, Percent_Identity=28.6532951289398, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 40924; Mature: 40793

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANSPPDGPIRTMKTLQELRRDIDAIDDQILDLLNSRSRLAIEVGKVKAGENRDFHVPS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCCCCC
REREIYERLAAGNSGPFPNEAVRSVFREIISASLALESPMKVAFLGPKATFTHLASLQHF
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHC
GLSAELVPQKSIPAVFEEVSKGRSLYGVVPVENSTEGMVSHTLDMFMESDLKINAEILLE
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
VSHDLLSRTGRLEDVKKVYSHPQAIAQCRNWLDENLSGVPVVDVASTALAAQIVGEDYTA
HHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHH
AAIASEFAAALYDLKVVRHRIEDQVNNFTRFLVVGRKMADRCGDDKTSLMFSVKDEPGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHH
HRMLEPFAKRGVNLSKIESRPLKKKAWEYIFFLDLAGHISDPVVSDAVQELKNYCQFVKI
HHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHH
LGSYPRAK
HHCCCCCC
>Mature Secondary Structure 
SANSPPDGPIRTMKTLQELRRDIDAIDDQILDLLNSRSRLAIEVGKVKAGENRDFHVPS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCCCCC
REREIYERLAAGNSGPFPNEAVRSVFREIISASLALESPMKVAFLGPKATFTHLASLQHF
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHC
GLSAELVPQKSIPAVFEEVSKGRSLYGVVPVENSTEGMVSHTLDMFMESDLKINAEILLE
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
VSHDLLSRTGRLEDVKKVYSHPQAIAQCRNWLDENLSGVPVVDVASTALAAQIVGEDYTA
HHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHH
AAIASEFAAALYDLKVVRHRIEDQVNNFTRFLVVGRKMADRCGDDKTSLMFSVKDEPGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHH
HRMLEPFAKRGVNLSKIESRPLKKKAWEYIFFLDLAGHISDPVVSDAVQELKNYCQFVKI
HHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHH
LGSYPRAK
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]