Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 78221996

GI number: 78221996

Start: 852328

End: 853692

Strand: Reverse

Name: atoC [H]

Synonym: Gmet_0776

Alternate gene names: 78221996

Gene position: 853692-852328 (Counterclockwise)

Preceding gene: 78221997

Following gene: 78221994

Centisome position: 21.36

GC content: 63.88

Gene sequence:

>1365_bases
ATGAACGAAACAATACTCGTCGTCGATGACGAACAGAACATCCGCACGGCCCTGGCCGGCATCCTCGAAGACGAGGGATA
CCGCCCCGTCTTCGCCAAGGACGGCCTGGAAGCCCTCGACATGGCCAAGAAGGAGAACCCCGACCTGGTGCTCCTCGACA
TCTGGATGCCGCGGCTTGACGGCCTGGAGACCCTTCAGGCCCTCAAGGAGTTCCACCCCCTCCTGACCGTAGTGATGATG
TCGGGCCACGGCACCATCGAAACGGCGGTGAAGTCCACGAAGCTCGGGGCCTATGACTTCATCGAGAAACCCCTCTCCCT
GGAAAAGGTTCTCGTCACCGTAAAAAACGGCCTCGACGTGGGGCGCCTCAAGGCCGAGAACGACACCCTGCGCACCGTGG
CTTTCAAGGGACACGACATGGTGGGGAACACCCCGGCCATTCTCCAGCTCCAGGAGCAGGTGAGGCGCGTGGCGGCCACC
AACGCCTCGGTGCTCATCACCGGCGAGAACGGCACCGGCAAGGAGCTGGTGGCCCGGGCCATCCACCACTGGAGCCCCCG
CAAGGAGAAGCCCTTTGTGGAGATCAACTGCGCCGCCCTCCCCGAGGAGCTCATCGAAAGCGAGCTTTTCGGCCACGAAA
AAGGAGCCTTCACCGGCGCCGTGGCCCAGAAGAAGGGGAAATTCGACCTGGCCGACGGCGGCACCATCTTCCTGGACGAG
ATCGGCGACATGTCCCTGAAGACCCAGGCCAAGGTGCTCCGCATCCTCCAGGAGCGGAAATTCGAGCGGGTGGGAGGGAC
AAAGACCATCGAGGTGGATGTGCGGGTGGTGGCGGCCACCAACAAGGACCTCCCCGGCGAGATCCGCGGCGGCACCTTCC
GCGAAGACCTCTTCTATCGCCTCAACGTGGTCCCCTTCACGGTGCCGCCGCTCAGGGAGCGGCGGGATGACATCCCGCTC
CTGGTGGAGCATTTCCTCGCCATCTTCGCCCAGCGGGAGGGACAGGAGCGCAAGAAGATGCTCCCGGAGACGGTGGAACT
CCTCAAGGGGTACGACTGGCCCGGCAACGTGCGGGAGCTGCGCAACATCATCGAGCGGCTCGTCATCATGACGCCGGGAA
AGGTCATCACCCCCGACCAGGTCCCTGACACCATCGGCAGCGCAGCCGGCGAGGCGCACCGCCCCGGAGCTCCCCTTGAG
CTCAACTCCCTCCGGGAAGCCCGGGAGGGGTTCGAGCGGGAATTCATCCTCCAGAAGCTGGAGGAGAACGGCTGGAACAT
CTCCCGCACCGCCGAGGCAATCGAGCTGGAACGGAGCAATCTCTACCGGAAGATGAAGAGCTACGGGATCGACGCCAGGA
AATGA

Upstream 100 bases:

>100_bases
TCATTTCTGGTAGCCTCTCTGTTTTTTTCTCTTGGTTTCTCCGTGCTCTCCGTCTCTCCGTGTTATTGAATCACTGCTTT
CAATACAAGAGGATCCACCC

Downstream 100 bases:

>100_bases
GCTTTGGGTATCCCACCAAGAGAAAAGGCCGTCCCCCACTAGGGAGACGGCCTTTTCTCTTGAAGAAGAGAGTTTATTTC
TTACTTCTGCTGCAACACGC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNETILVVDDEQNIRTALAGILEDEGYRPVFAKDGLEALDMAKKENPDLVLLDIWMPRLDGLETLQALKEFHPLLTVVMM
SGHGTIETAVKSTKLGAYDFIEKPLSLEKVLVTVKNGLDVGRLKAENDTLRTVAFKGHDMVGNTPAILQLQEQVRRVAAT
NASVLITGENGTGKELVARAIHHWSPRKEKPFVEINCAALPEELIESELFGHEKGAFTGAVAQKKGKFDLADGGTIFLDE
IGDMSLKTQAKVLRILQERKFERVGGTKTIEVDVRVVAATNKDLPGEIRGGTFREDLFYRLNVVPFTVPPLRERRDDIPL
LVEHFLAIFAQREGQERKKMLPETVELLKGYDWPGNVRELRNIIERLVIMTPGKVITPDQVPDTIGSAAGEAHRPGAPLE
LNSLREAREGFEREFILQKLEENGWNISRTAEAIELERSNLYRKMKSYGIDARK

Sequences:

>Translated_454_residues
MNETILVVDDEQNIRTALAGILEDEGYRPVFAKDGLEALDMAKKENPDLVLLDIWMPRLDGLETLQALKEFHPLLTVVMM
SGHGTIETAVKSTKLGAYDFIEKPLSLEKVLVTVKNGLDVGRLKAENDTLRTVAFKGHDMVGNTPAILQLQEQVRRVAAT
NASVLITGENGTGKELVARAIHHWSPRKEKPFVEINCAALPEELIESELFGHEKGAFTGAVAQKKGKFDLADGGTIFLDE
IGDMSLKTQAKVLRILQERKFERVGGTKTIEVDVRVVAATNKDLPGEIRGGTFREDLFYRLNVVPFTVPPLRERRDDIPL
LVEHFLAIFAQREGQERKKMLPETVELLKGYDWPGNVRELRNIIERLVIMTPGKVITPDQVPDTIGSAAGEAHRPGAPLE
LNSLREAREGFEREFILQKLEENGWNISRTAEAIELERSNLYRKMKSYGIDARK
>Mature_454_residues
MNETILVVDDEQNIRTALAGILEDEGYRPVFAKDGLEALDMAKKENPDLVLLDIWMPRLDGLETLQALKEFHPLLTVVMM
SGHGTIETAVKSTKLGAYDFIEKPLSLEKVLVTVKNGLDVGRLKAENDTLRTVAFKGHDMVGNTPAILQLQEQVRRVAAT
NASVLITGENGTGKELVARAIHHWSPRKEKPFVEINCAALPEELIESELFGHEKGAFTGAVAQKKGKFDLADGGTIFLDE
IGDMSLKTQAKVLRILQERKFERVGGTKTIEVDVRVVAATNKDLPGEIRGGTFREDLFYRLNVVPFTVPPLRERRDDIPL
LVEHFLAIFAQREGQERKKMLPETVELLKGYDWPGNVRELRNIIERLVIMTPGKVITPDQVPDTIGSAAGEAHRPGAPLE
LNSLREAREGFEREFILQKLEENGWNISRTAEAIELERSNLYRKMKSYGIDARK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=44.273127753304, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=44.1964285714286, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=39.5744680851064, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1788905, Length=448, Percent_Identity=39.2857142857143, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI87082152, Length=322, Percent_Identity=46.8944099378882, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI87082117, Length=331, Percent_Identity=44.7129909365559, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789087, Length=359, Percent_Identity=43.7325905292479, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=44.7204968944099, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1787583, Length=354, Percent_Identity=38.135593220339, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786524, Length=356, Percent_Identity=38.7640449438202, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87081872, Length=329, Percent_Identity=40.4255319148936, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI87081858, Length=399, Percent_Identity=28.5714285714286, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789828, Length=284, Percent_Identity=32.7464788732394, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790860, Length=116, Percent_Identity=32.7586206896552, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=35.042735042735, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788192, Length=104, Percent_Identity=36.5384615384615, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=24.4541484716157, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50817; Mature: 50817

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETILVVDDEQNIRTALAGILEDEGYRPVFAKDGLEALDMAKKENPDLVLLDIWMPRLD
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCCEEEEEECCCCCC
GLETLQALKEFHPLLTVVMMSGHGTIETAVKSTKLGAYDFIEKPLSLEKVLVTVKNGLDV
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCC
GRLKAENDTLRTVAFKGHDMVGNTPAILQLQEQVRRVAATNASVLITGENGTGKELVARA
CEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
IHHWSPRKEKPFVEINCAALPEELIESELFGHEKGAFTGAVAQKKGKFDLADGGTIFLDE
HHHCCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCHHHHHHCCCCEEECCCCEEEEEC
IGDMSLKTQAKVLRILQERKFERVGGTKTIEVDVRVVAATNKDLPGEIRGGTFREDLFYR
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHEE
LNVVPFTVPPLRERRDDIPLLVEHFLAIFAQREGQERKKMLPETVELLKGYDWPGNVREL
EEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHCCCCCCCHHHH
RNIIERLVIMTPGKVITPDQVPDTIGSAAGEAHRPGAPLELNSLREAREGFEREFILQKL
HHHHHHHHHCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EENGWNISRTAEAIELERSNLYRKMKSYGIDARK
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNETILVVDDEQNIRTALAGILEDEGYRPVFAKDGLEALDMAKKENPDLVLLDIWMPRLD
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCCEEEEEECCCCCC
GLETLQALKEFHPLLTVVMMSGHGTIETAVKSTKLGAYDFIEKPLSLEKVLVTVKNGLDV
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCC
GRLKAENDTLRTVAFKGHDMVGNTPAILQLQEQVRRVAATNASVLITGENGTGKELVARA
CEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
IHHWSPRKEKPFVEINCAALPEELIESELFGHEKGAFTGAVAQKKGKFDLADGGTIFLDE
HHHCCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCHHHHHHCCCCEEECCCCEEEEEC
IGDMSLKTQAKVLRILQERKFERVGGTKTIEVDVRVVAATNKDLPGEIRGGTFREDLFYR
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHEE
LNVVPFTVPPLRERRDDIPLLVEHFLAIFAQREGQERKKMLPETVELLKGYDWPGNVREL
EEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHCCCCCCCHHHH
RNIIERLVIMTPGKVITPDQVPDTIGSAAGEAHRPGAPLELNSLREAREGFEREFILQKL
HHHHHHHHHCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EENGWNISRTAEAIELERSNLYRKMKSYGIDARK
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]