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The map label for this gene is atoC [H]

Identifier: 78221922

GI number: 78221922

Start: 772657

End: 774039

Strand: Direct

Name: atoC [H]

Synonym: Gmet_0702

Alternate gene names: 78221922

Gene position: 772657-774039 (Clockwise)

Preceding gene: 78221921

Following gene: 78221923

Centisome position: 19.33

GC content: 62.55

Gene sequence:

>1383_bases
GTGTCCGAAAACAAGCGCATCATGCTCATCGACAACGAGGAGGGGCTCTGCCGGATGATGGAGGCGGTGCTTCTGGATAG
CGGCTATGGCGTGAAGGGGTACACCCGCTCCTTCGAGGCGGTGGAGGAGTTTCGGCCCGGCGACTGGGATCTGGTGGTCT
CGGACATCAAGATGCCGGGGATGGATGGTCTGGAGGTGCTCCAGCGGATCAAGGCCAAGGAGCCGGCCATTCCGGTCATC
ATGATCACCGCCTACGCCACGGTGGAGATGTCGATCCAGGCCCTGCGCCGGGGCGCCTACGACATGCTGACCAAGCCCTT
CGAGCCCGAGGAGCTCCTCTACCGGGTGAAAAACGCCCTCAAGCACACCGAGCTTCTGGAAGAGAACCGGGAGCTGCGCG
AGAAGCTGGTGGGTAAGTTCCGCTTCGACAACATAATCGGCGCCTCGGACGGGCTCAAGGGGGTTTTGGAGAAGGTGGAG
AAAATCGCCATCCGGGACACGTCGGTGCTCATCACCGGCGAGTCGGGGACCGGCAAGGAGCTCATCGCCCAGGCGATCCA
CTACAACTCGGTCCGCAAGGAAAAGAAGTTCGTTGCCATCAACTGCGGTGCCCTGCCGGAGACGCTCCTGGAGAGCGAGC
TCTTCGGCTACCGCAAGGGGGCCTTCACTGGCGCCAAGGAAAACCGCCAGGGACTTCTGGAGGCGGCCGACGGGGGAACC
CTGTTTCTGGACGAGGTGGGGAACCTCCCCATGAACGTGCAGAAGACGCTTCTCCGTTTCCTCCAGGAGCAGGAGTTTCT
CCGCATTGGCGACACCACCCCCACCAAGGTGGACGTGCGGATCATCTCGGCCACCAACGCCGACCTGCGGGAAGGGGTCA
AGAGCGGCGCCTTCCGGGAGGACCTCTACTACCGCCTCAACGTGGTGAACCTCCATCTCCCGCCGCTGCGGGAGCGCAAG
GGGGATATCCCGCTCCTGGCGGCCCATTTCATTGCCCAGCAGAACAAGAAATTCGACACCGCAATCAAGGGGTTGTCACC
CGACTCCCTGGAAGCGGCCGTTGGCTATGCCTGGCCCGGCAACATCCGCCAGCTCAGGAACGTGATCGAGGCCTGCACAG
CCATGGAGAGCGGCGAATACATTACGCTGTCGGTCCTCTCCCAGTTCATCGAGCTTCCCGAGCCACGGGACGAGCCGGCC
GTGGAGGCGGAAGGGGAGGAGGGTGCCTACGCCCAGGCCCTTTCCCGCTTCGAGATGGACTACATCCGGGGACTGTTGCG
GAAAAACCGTGGCAATGTGGAGGCAGCCGCCCGTGAGGCGGGGATGAACATGGCCACCATCTACCGGAAAATGAAGAAGT
ACAACCTGCGCCGCGAAGAATAG

Upstream 100 bases:

>100_bases
GCGAAGTGGGGAAGGGGTCCGACGTGATTGTGAAGCTGCCGGTGGACCGGGACGAGCTGTGACGGCCGGTAGGAACGAAT
TTTTTTCACAGGGGTAGAGA

Downstream 100 bases:

>100_bases
CTCCAGCTCCCTCTCTCATCTTTGCATTTTTGCAAAACCCCGAAGAATCCCCCTCGCACCCCTGCGAGGGGAAGGGCCGC
AATGTTGCAAATGACAGCAA

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSENKRIMLIDNEEGLCRMMEAVLLDSGYGVKGYTRSFEAVEEFRPGDWDLVVSDIKMPGMDGLEVLQRIKAKEPAIPVI
MITAYATVEMSIQALRRGAYDMLTKPFEPEELLYRVKNALKHTELLEENRELREKLVGKFRFDNIIGASDGLKGVLEKVE
KIAIRDTSVLITGESGTGKELIAQAIHYNSVRKEKKFVAINCGALPETLLESELFGYRKGAFTGAKENRQGLLEAADGGT
LFLDEVGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNADLREGVKSGAFREDLYYRLNVVNLHLPPLRERK
GDIPLLAAHFIAQQNKKFDTAIKGLSPDSLEAAVGYAWPGNIRQLRNVIEACTAMESGEYITLSVLSQFIELPEPRDEPA
VEAEGEEGAYAQALSRFEMDYIRGLLRKNRGNVEAAAREAGMNMATIYRKMKKYNLRREE

Sequences:

>Translated_460_residues
MSENKRIMLIDNEEGLCRMMEAVLLDSGYGVKGYTRSFEAVEEFRPGDWDLVVSDIKMPGMDGLEVLQRIKAKEPAIPVI
MITAYATVEMSIQALRRGAYDMLTKPFEPEELLYRVKNALKHTELLEENRELREKLVGKFRFDNIIGASDGLKGVLEKVE
KIAIRDTSVLITGESGTGKELIAQAIHYNSVRKEKKFVAINCGALPETLLESELFGYRKGAFTGAKENRQGLLEAADGGT
LFLDEVGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNADLREGVKSGAFREDLYYRLNVVNLHLPPLRERK
GDIPLLAAHFIAQQNKKFDTAIKGLSPDSLEAAVGYAWPGNIRQLRNVIEACTAMESGEYITLSVLSQFIELPEPRDEPA
VEAEGEEGAYAQALSRFEMDYIRGLLRKNRGNVEAAAREAGMNMATIYRKMKKYNLRREE
>Mature_459_residues
SENKRIMLIDNEEGLCRMMEAVLLDSGYGVKGYTRSFEAVEEFRPGDWDLVVSDIKMPGMDGLEVLQRIKAKEPAIPVIM
ITAYATVEMSIQALRRGAYDMLTKPFEPEELLYRVKNALKHTELLEENRELREKLVGKFRFDNIIGASDGLKGVLEKVEK
IAIRDTSVLITGESGTGKELIAQAIHYNSVRKEKKFVAINCGALPETLLESELFGYRKGAFTGAKENRQGLLEAADGGTL
FLDEVGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNADLREGVKSGAFREDLYYRLNVVNLHLPPLRERKG
DIPLLAAHFIAQQNKKFDTAIKGLSPDSLEAAVGYAWPGNIRQLRNVIEACTAMESGEYITLSVLSQFIELPEPRDEPAV
EAEGEEGAYAQALSRFEMDYIRGLLRKNRGNVEAAAREAGMNMATIYRKMKKYNLRREE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=42.3245614035088, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=460, Percent_Identity=41.5217391304348, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1788905, Length=454, Percent_Identity=40.7488986784141, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=37.9014989293362, Blast_Score=336, Evalue=1e-93,
Organism=Escherichia coli, GI1789087, Length=352, Percent_Identity=44.0340909090909, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082117, Length=342, Percent_Identity=41.812865497076, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=42.7244582043344, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI87082152, Length=330, Percent_Identity=42.1212121212121, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1786524, Length=336, Percent_Identity=41.3690476190476, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=40.1869158878505, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1787583, Length=323, Percent_Identity=39.0092879256966, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1789828, Length=300, Percent_Identity=31.3333333333333, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081858, Length=288, Percent_Identity=30.9027777777778, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789809, Length=121, Percent_Identity=31.404958677686, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082012, Length=127, Percent_Identity=30.7086614173228, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=26.7241379310345, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=116, Percent_Identity=32.7586206896552, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790860, Length=122, Percent_Identity=26.2295081967213, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789402, Length=118, Percent_Identity=29.6610169491525, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51692; Mature: 51561

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENKRIMLIDNEEGLCRMMEAVLLDSGYGVKGYTRSFEAVEEFRPGDWDLVVSDIKMPG
CCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCC
MDGLEVLQRIKAKEPAIPVIMITAYATVEMSIQALRRGAYDMLTKPFEPEELLYRVKNAL
CCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHH
KHTELLEENRELREKLVGKFRFDNIIGASDGLKGVLEKVEKIAIRDTSVLITGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LIAQAIHYNSVRKEKKFVAINCGALPETLLESELFGYRKGAFTGAKENRQGLLEAADGGT
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCE
LFLDEVGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNADLREGVKSGAFRE
EEEHHHCCCCCCHHHHHHHHHHHHHHEECCCCCCCEEEEEEEECCCHHHHHHHHCCCHHH
DLYYRLNVVNLHLPPLRERKGDIPLLAAHFIAQQNKKFDTAIKGLSPDSLEAAVGYAWPG
HHEEEEEEEEEECCCHHHCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCHHHHCCCCCCC
NIRQLRNVIEACTAMESGEYITLSVLSQFIELPEPRDEPAVEAEGEEGAYAQALSRFEMD
CHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YIRGLLRKNRGNVEAAAREAGMNMATIYRKMKKYNLRREE
HHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SENKRIMLIDNEEGLCRMMEAVLLDSGYGVKGYTRSFEAVEEFRPGDWDLVVSDIKMPG
CCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCC
MDGLEVLQRIKAKEPAIPVIMITAYATVEMSIQALRRGAYDMLTKPFEPEELLYRVKNAL
CCHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHH
KHTELLEENRELREKLVGKFRFDNIIGASDGLKGVLEKVEKIAIRDTSVLITGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LIAQAIHYNSVRKEKKFVAINCGALPETLLESELFGYRKGAFTGAKENRQGLLEAADGGT
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCE
LFLDEVGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNADLREGVKSGAFRE
EEEHHHCCCCCCHHHHHHHHHHHHHHEECCCCCCCEEEEEEEECCCHHHHHHHHCCCHHH
DLYYRLNVVNLHLPPLRERKGDIPLLAAHFIAQQNKKFDTAIKGLSPDSLEAAVGYAWPG
HHEEEEEEEEEECCCHHHCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCHHHHCCCCCCC
NIRQLRNVIEACTAMESGEYITLSVLSQFIELPEPRDEPAVEAEGEEGAYAQALSRFEMD
CHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YIRGLLRKNRGNVEAAAREAGMNMATIYRKMKKYNLRREE
HHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]