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The map label for this gene is metC [H]

Identifier: 78221919

GI number: 78221919

Start: 766676

End: 767812

Strand: Direct

Name: metC [H]

Synonym: Gmet_0699

Alternate gene names: 78221919

Gene position: 766676-767812 (Clockwise)

Preceding gene: 78221918

Following gene: 78221920

Centisome position: 19.18

GC content: 66.75

Gene sequence:

>1137_bases
ATGAAATTCGGCACCCGCATCATCCACACCGGCCACGACATCGACCCCACCACCGGGGCGGTTTCCATCCCCATCTACCA
GACCTCTACCTTTCGTCAGGAGTCGGTGGATCACTTCGGCAAGTATGACTATGCCCGTTCCGACAATCCCACTCGGGAGG
CCCTGGAGGAGACCATTGCCCAGCTGGAGGGAGGAACTCGCGGGTTTGCCTACGCCTCGGGGATGGCGGCCATCTCGTCG
GTGCTGCTTCTCTTCTCGCCGGGGGATCACCTGGTGGTCTGCGAGGATGTGTACGGGGGGACGTTCCGGGTCCTGACCCA
GCTCTTCAGCCGCCTCGGCATCACCTCCACCTTCGTGGATGCCACCGATCTGGACGCCATCGCCGCTGCGTTCCGGCCCG
AGACCAAGGGGCTCTTCCTGGAGAGCCCGTCGAACCCGCTTCTCAAGATCACCGACCTGGAAGGCGCGGCCCGCATCGCC
CGGGAGCGGGGCGCCATAACGCTGGTGGACAACACCTTCATGACTCCCTACCTCCAGAGGCCCCTGGAGGTGGGGTGCGA
CATCGTCCTCCACAGCGGGACCAAGTTCCTGAACGGCCACAGCGACGTCATCTGCGGCTTTGCCGTGGTGAAGGACCCCG
AGTTGGGGAAGCGGATCCGCTTCATTCAGAATGCCTTCGGCGCCATCCTCGGCCCCCAGGATTCGTGGCTCGTGCTCCGG
GGGCTCAAGACCCTTCGGGTGCGGATGGAGGAGAGCCAGCGGAGCGCGACCCGCATCGCCTCGTGGCTGGCGGGAGAGAA
GCGGGTGACCCGGGTGCTGTACCCCGGCCTTCCGAGCCACCCCGGCCATGCAATCCATGCCCGCCAGAGCTCGGGTCCCG
GCGCGGTTCTCTCCTTTGCCCTCGACTCCCTGGAGGTTACCCGCCGGCTCCTGGAGGGGATGAAGCTGGCCGCCTTCGCC
GTGAGCCTCGGCGGGGTGGAGAGCATCATCTCCTACCCGGCCAGGATGTCCCATGCGGCCATGCCCCCCGAGGAGCGGGC
CGCCCGCGGCATCGGCGACACGCTCGTGCGCCTCTCGGTGGGGCTGGAGGAGGCCGACGACCTCATCGCGGAGATGGACC
GGCTCATCAACGGCTGA

Upstream 100 bases:

>100_bases
CTGATCGACGACCTGGCCCAGGCGTTTGAAGGCGGGGACCAGGGATCGGGAACCGGGGACCGGTAAAGGCTTTCAAATCG
CTTATCGAAAGGAATATTGT

Downstream 100 bases:

>100_bases
ACCCATTCAGGCAGCACGGTTCTCGCCCCGGGATCCTCGGTATGCTCCGACGGTTCCGGGGCGTTTTGCGTCATGGTCAG
ACCATCGGGGCATTGGCAAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKFGTRIIHTGHDIDPTTGAVSIPIYQTSTFRQESVDHFGKYDYARSDNPTREALEETIAQLEGGTRGFAYASGMAAISS
VLLLFSPGDHLVVCEDVYGGTFRVLTQLFSRLGITSTFVDATDLDAIAAAFRPETKGLFLESPSNPLLKITDLEGAARIA
RERGAITLVDNTFMTPYLQRPLEVGCDIVLHSGTKFLNGHSDVICGFAVVKDPELGKRIRFIQNAFGAILGPQDSWLVLR
GLKTLRVRMEESQRSATRIASWLAGEKRVTRVLYPGLPSHPGHAIHARQSSGPGAVLSFALDSLEVTRRLLEGMKLAAFA
VSLGGVESIISYPARMSHAAMPPEERAARGIGDTLVRLSVGLEEADDLIAEMDRLING

Sequences:

>Translated_378_residues
MKFGTRIIHTGHDIDPTTGAVSIPIYQTSTFRQESVDHFGKYDYARSDNPTREALEETIAQLEGGTRGFAYASGMAAISS
VLLLFSPGDHLVVCEDVYGGTFRVLTQLFSRLGITSTFVDATDLDAIAAAFRPETKGLFLESPSNPLLKITDLEGAARIA
RERGAITLVDNTFMTPYLQRPLEVGCDIVLHSGTKFLNGHSDVICGFAVVKDPELGKRIRFIQNAFGAILGPQDSWLVLR
GLKTLRVRMEESQRSATRIASWLAGEKRVTRVLYPGLPSHPGHAIHARQSSGPGAVLSFALDSLEVTRRLLEGMKLAAFA
VSLGGVESIISYPARMSHAAMPPEERAARGIGDTLVRLSVGLEEADDLIAEMDRLING
>Mature_378_residues
MKFGTRIIHTGHDIDPTTGAVSIPIYQTSTFRQESVDHFGKYDYARSDNPTREALEETIAQLEGGTRGFAYASGMAAISS
VLLLFSPGDHLVVCEDVYGGTFRVLTQLFSRLGITSTFVDATDLDAIAAAFRPETKGLFLESPSNPLLKITDLEGAARIA
RERGAITLVDNTFMTPYLQRPLEVGCDIVLHSGTKFLNGHSDVICGFAVVKDPELGKRIRFIQNAFGAILGPQDSWLVLR
GLKTLRVRMEESQRSATRIASWLAGEKRVTRVLYPGLPSHPGHAIHARQSSGPGAVLSFALDSLEVTRRLLEGMKLAAFA
VSLGGVESIISYPARMSHAAMPPEERAARGIGDTLVRLSVGLEEADDLIAEMDRLING

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=362, Percent_Identity=43.646408839779, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI299473759, Length=362, Percent_Identity=40.3314917127072, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=37.3961218836565, Blast_Score=244, Evalue=7e-65,
Organism=Escherichia coli, GI1790375, Length=375, Percent_Identity=44.8, Blast_Score=314, Evalue=7e-87,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=30.5912596401028, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17560056, Length=366, Percent_Identity=42.896174863388, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17538055, Length=366, Percent_Identity=40.9836065573771, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71980708, Length=364, Percent_Identity=36.8131868131868, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI193202265, Length=104, Percent_Identity=39.4230769230769, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319307, Length=382, Percent_Identity=40.3141361256544, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6321254, Length=397, Percent_Identity=36.272040302267, Blast_Score=242, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6321170, Length=335, Percent_Identity=31.6417910447761, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323333, Length=429, Percent_Identity=30.5361305361305, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321904, Length=388, Percent_Identity=28.6082474226804, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI19922554, Length=376, Percent_Identity=44.6808510638298, Blast_Score=333, Evalue=8e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41039; Mature: 41039

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGTRIIHTGHDIDPTTGAVSIPIYQTSTFRQESVDHFGKYDYARSDNPTREALEETIA
CCCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
QLEGGTRGFAYASGMAAISSVLLLFSPGDHLVVCEDVYGGTFRVLTQLFSRLGITSTFVD
HHCCCCCCHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECC
ATDLDAIAAAFRPETKGLFLESPSNPLLKITDLEGAARIARERGAITLVDNTFMTPYLQR
CHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCCHHHHHHHHCCCEEEECCCCCCHHHHC
PLEVGCDIVLHSGTKFLNGHSDVICGFAVVKDPELGKRIRFIQNAFGAILGPQDSWLVLR
HHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
GLKTLRVRMEESQRSATRIASWLAGEKRVTRVLYPGLPSHPGHAIHARQSSGPGAVLSFA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCEEEECCCCCCCHHHHHH
LDSLEVTRRLLEGMKLAAFAVSLGGVESIISYPARMSHAAMPPEERAARGIGDTLVRLSV
HHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHCHHHHHHCCCCCHHHHHCCCHHHHHHHHC
GLEEADDLIAEMDRLING
CHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFGTRIIHTGHDIDPTTGAVSIPIYQTSTFRQESVDHFGKYDYARSDNPTREALEETIA
CCCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
QLEGGTRGFAYASGMAAISSVLLLFSPGDHLVVCEDVYGGTFRVLTQLFSRLGITSTFVD
HHCCCCCCHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECC
ATDLDAIAAAFRPETKGLFLESPSNPLLKITDLEGAARIARERGAITLVDNTFMTPYLQR
CHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCCHHHHHHHHCCCEEEECCCCCCHHHHC
PLEVGCDIVLHSGTKFLNGHSDVICGFAVVKDPELGKRIRFIQNAFGAILGPQDSWLVLR
HHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
GLKTLRVRMEESQRSATRIASWLAGEKRVTRVLYPGLPSHPGHAIHARQSSGPGAVLSFA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCEEEECCCCCCCHHHHHH
LDSLEVTRRLLEGMKLAAFAVSLGGVESIISYPARMSHAAMPPEERAARGIGDTLVRLSV
HHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHCHHHHHHCCCCCHHHHHCCCHHHHHHHHC
GLEEADDLIAEMDRLING
CHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]