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The map label for this gene is metC [H]

Identifier: 78221918

GI number: 78221918

Start: 765466

End: 766641

Strand: Direct

Name: metC [H]

Synonym: Gmet_0698

Alternate gene names: 78221918

Gene position: 765466-766641 (Clockwise)

Preceding gene: 78221917

Following gene: 78221919

Centisome position: 19.15

GC content: 66.07

Gene sequence:

>1176_bases
ATGAACATCGCAACCCAGACAGCACAGATCGGACTTGAGTGGGACACCCGCACCGGCGCGGTGACGGTCCCCATCTACCA
GACGGCCACCTTCCGGCACCCGGGGCTCGGCCAGAGCACCGGCTACGACTATACCCGCTCCGGCAACCCCACCCGGCAGG
CCCTGGAGGAGGGGATCGCCCGCCTGGAGGGAGGCGCCCGGGGCTTCGCCTACGCCTCGGGCATGGCCGCCATCGCCAAT
CTCCTCCTCCTCTTCAAGAAGGGGGACCACTTGGTGGTGACCGAGGATCTCTACGGCGGTACCTGTCGTCTCTTCGACCA
GATCTTCACCCAGTACGAGCTCTCCTTCACCTACGTGGACACGAGCGACATCAAGGCAGTGCGTGCCGCCATCCGCCCAG
AAACGAAGGCCCTCTTCGTGGAGTCCCTCACCAACCCGCTCCTCAAGGTAGCCGACATCGCGGCCCTCTCGGCCCTCTGC
CGGGAGCGGGGGCTTCTCCACATCGTGGACAACACCTTCCTCACCCCCTATCTCCTGCGCCCCTTCGACCATGGGGCCGA
CATCACCGTCTACAGCGCCACCAAGTACCTGGCCGGCCACAACGACACGGTCTCCGGCCTCGTGGCGGTGAAGGACCCGC
AGCTGGCCGAGCGGGTCTACTTCCTCCAGAACTCGGTGGGTGCGGTCCTGGGCCCCCAGGATTCCTGGCTCACCATCCGG
GGGATGAAGACCCTTTCGGTGCGCCTCGACCGACAGCAGGAGAACGCAGGGCGGGTCGCCCAGTGGCTTTCGAATCACCC
GCGGGTGCGGAAGGTCTACTACCCCGGCCTCTCCGGCCACCCCGGCCACCCCGGCCATGAACTCCTCGCCCGCCAGGCAC
GGGGCTTCGGTGCCATGATTGCCTTCGAGGTGGACGAGCATGCGCTCGTGGAGCGTTTGCTTCTGAAGACGGAAGTGATA
TCCTTCGCCGAGAGCCTCGGCGGGGTGGAAACCCTCATTACCTTCCCCCAGGTCCAGACCCATGCCGATATTCCGCCCGA
ACTGCGGCAGCGGCTTGGGATCAACGATGTGCTCCTGCGCCTCTCCGTGGGGATCGAGGACGCGGACGACCTGATCGACG
ACCTGGCCCAGGCGTTTGAAGGCGGGGACCAGGGATCGGGAACCGGGGACCGGTAA

Upstream 100 bases:

>100_bases
AACGTTCCGGGAGATAAGGAAGAGCGTTGCCGCCGTAACGGCGAAAAATCCTCTTCCGCACCCCGGAAGGGGATTTTTTC
ATTCAGGAGGCAAAACCACC

Downstream 100 bases:

>100_bases
AGGCTTTCAAATCGCTTATCGAAAGGAATATTGTATGAAATTCGGCACCCGCATCATCCACACCGGCCACGACATCGACC
CCACCACCGGGGCGGTTTCC

Product: cysteine synthase/cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNIATQTAQIGLEWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYTRSGNPTRQALEEGIARLEGGARGFAYASGMAAIAN
LLLLFKKGDHLVVTEDLYGGTCRLFDQIFTQYELSFTYVDTSDIKAVRAAIRPETKALFVESLTNPLLKVADIAALSALC
RERGLLHIVDNTFLTPYLLRPFDHGADITVYSATKYLAGHNDTVSGLVAVKDPQLAERVYFLQNSVGAVLGPQDSWLTIR
GMKTLSVRLDRQQENAGRVAQWLSNHPRVRKVYYPGLSGHPGHPGHELLARQARGFGAMIAFEVDEHALVERLLLKTEVI
SFAESLGGVETLITFPQVQTHADIPPELRQRLGINDVLLRLSVGIEDADDLIDDLAQAFEGGDQGSGTGDR

Sequences:

>Translated_391_residues
MNIATQTAQIGLEWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYTRSGNPTRQALEEGIARLEGGARGFAYASGMAAIAN
LLLLFKKGDHLVVTEDLYGGTCRLFDQIFTQYELSFTYVDTSDIKAVRAAIRPETKALFVESLTNPLLKVADIAALSALC
RERGLLHIVDNTFLTPYLLRPFDHGADITVYSATKYLAGHNDTVSGLVAVKDPQLAERVYFLQNSVGAVLGPQDSWLTIR
GMKTLSVRLDRQQENAGRVAQWLSNHPRVRKVYYPGLSGHPGHPGHELLARQARGFGAMIAFEVDEHALVERLLLKTEVI
SFAESLGGVETLITFPQVQTHADIPPELRQRLGINDVLLRLSVGIEDADDLIDDLAQAFEGGDQGSGTGDR
>Mature_391_residues
MNIATQTAQIGLEWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYTRSGNPTRQALEEGIARLEGGARGFAYASGMAAIAN
LLLLFKKGDHLVVTEDLYGGTCRLFDQIFTQYELSFTYVDTSDIKAVRAAIRPETKALFVESLTNPLLKVADIAALSALC
RERGLLHIVDNTFLTPYLLRPFDHGADITVYSATKYLAGHNDTVSGLVAVKDPQLAERVYFLQNSVGAVLGPQDSWLTIR
GMKTLSVRLDRQQENAGRVAQWLSNHPRVRKVYYPGLSGHPGHPGHELLARQARGFGAMIAFEVDEHALVERLLLKTEVI
SFAESLGGVETLITFPQVQTHADIPPELRQRLGINDVLLRLSVGIEDADDLIDDLAQAFEGGDQGSGTGDR

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=394, Percent_Identity=44.6700507614213, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI299473759, Length=394, Percent_Identity=41.1167512690355, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI25453487, Length=393, Percent_Identity=40.7124681933842, Blast_Score=268, Evalue=7e-72,
Organism=Escherichia coli, GI1790375, Length=384, Percent_Identity=42.4479166666667, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1789383, Length=345, Percent_Identity=32.1739130434783, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=39.7820163487738, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17538055, Length=367, Percent_Identity=40.0544959128065, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=36.6576819407008, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6319307, Length=388, Percent_Identity=39.6907216494845, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=35.0746268656716, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6321170, Length=335, Percent_Identity=32.2388059701493, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323333, Length=413, Percent_Identity=31.9612590799031, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=387, Percent_Identity=28.4237726098191, Blast_Score=125, Evalue=8e-30,
Organism=Drosophila melanogaster, GI19922554, Length=372, Percent_Identity=43.8172043010753, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42776; Mature: 42776

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIATQTAQIGLEWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYTRSGNPTRQALEEGIA
CCCCCCEEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLEGGARGFAYASGMAAIANLLLLFKKGDHLVVTEDLYGGTCRLFDQIFTQYELSFTYVD
HHCCCCCCHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHEEEEEEEEC
TSDIKAVRAAIRPETKALFVESLTNPLLKVADIAALSALCRERGLLHIVDNTFLTPYLLR
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHCC
PFDHGADITVYSATKYLAGHNDTVSGLVAVKDPQLAERVYFLQNSVGAVLGPQDSWLTIR
CCCCCCCEEEEECHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEECCCCCEEEEE
GMKTLSVRLDRQQENAGRVAQWLSNHPRVRKVYYPGLSGHPGHPGHELLARQARGFGAMI
CCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEE
AFEVDEHALVERLLLKTEVISFAESLGGVETLITFPQVQTHADIPPELRQRLGINDVLLR
EEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCHHHEEEE
LSVGIEDADDLIDDLAQAFEGGDQGSGTGDR
EECCCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNIATQTAQIGLEWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYTRSGNPTRQALEEGIA
CCCCCCEEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLEGGARGFAYASGMAAIANLLLLFKKGDHLVVTEDLYGGTCRLFDQIFTQYELSFTYVD
HHCCCCCCHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHEEEEEEEEC
TSDIKAVRAAIRPETKALFVESLTNPLLKVADIAALSALCRERGLLHIVDNTFLTPYLLR
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHCC
PFDHGADITVYSATKYLAGHNDTVSGLVAVKDPQLAERVYFLQNSVGAVLGPQDSWLTIR
CCCCCCCEEEEECHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEECCCCCEEEEE
GMKTLSVRLDRQQENAGRVAQWLSNHPRVRKVYYPGLSGHPGHPGHELLARQARGFGAMI
CCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEE
AFEVDEHALVERLLLKTEVISFAESLGGVETLITFPQVQTHADIPPELRQRLGINDVLLR
EEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCHHHEEEE
LSVGIEDADDLIDDLAQAFEGGDQGSGTGDR
EECCCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]