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The map label for this gene is asd [H]

Identifier: 78221824

GI number: 78221824

Start: 674045

End: 675145

Strand: Direct

Name: asd [H]

Synonym: Gmet_0603

Alternate gene names: 78221824

Gene position: 674045-675145 (Clockwise)

Preceding gene: 78221823

Following gene: 78221825

Centisome position: 16.86

GC content: 63.31

Gene sequence:

>1101_bases
ATGAAAGTAGGAATCGTCGGTTGGCGCGGTATGGTCGGTTCGGTTCTCCTCCAGCGGATGGTGGAGGAGGGGGATTTCAA
CACCGGCATCGAGCCGGTTTTCTTCAGCACCTCCCAGGCGGGGCAGCCTGCCCCCATGAATGCAGGCACCCTCAAGAGTG
CCGATGACATTGAAGAACTGAAAAAGCTCGACATCATCGTTACCTGCCAGGGTGGCGACTACACCAAGGCCGTCCACCCG
GAACTCCGCAAGCAAGGGTGGCAGGGATACTGGATCGACGCGGCCTCCACCCTCCGGATGGAGCCGAATGCGGTCATCAT
CCTCGACCCGGTGAACCGCAACGTCATCGACGCGGCCCTGGCCAAGGGGCAAAAGGATTTCATCGGCGGCAACTGCACCG
TGAGCCTCATGCTCATGGCCTTGGGAGGGCTTTTTCGGGCCGGCCTCGTGGAGTGGCTCACCTCCATGACCTACCAGGCT
GCTTCCGGCGCCGGTGCCCCCAACATGCGCGAACTCCTCTCCCAGATGGGAACCCTCCACGGTTCCGTGGCTGACCTCCT
CAAGAATCCCTCGTCGGCCATCCTCGACATCGACCGGGATGTGACCGCCACCCTGCGCGGCGACGCCCTGCCGACGAAAG
AGTTCGGCTTCCCCCTGGCTGGCAGCGTCCTTCCCTGGATCGACCGGGAGGTGGAGGACGGCCAGAGCCGGGAGGAGTGG
AAGGGCTTCGCCGAGACCAACAAGATCCTCGGCACAACCACCCCGATCCCGGTGGACGGCATCTGCGTCCGCGTCGGCGC
CATGCGCTGTCACAGCCAGGCCCTGACCATCAAGCTGAACAAGGACGTCCCCCTGGGCGATATTGAAGAGCTGATCAAGA
ACGACAACCAGTGGGTCAAGTTCGTCCCCAACACCAAGGCCGACACCTTGGCCGACCTGACCCCCGCCGCGGTATCCGGG
CTTCTCACAGTCCCTATCGGCCGGGTCCGCAAGATGAAGATGGGCCCCCAGTACATGCAGGCCTTCACCTGCGGCGATCA
ACTCCTCTGGGGGGCTGCCGAGCCCCTGCGCCGGATGCTCCGTATCCTCGTGGAGAAATAA

Upstream 100 bases:

>100_bases
GAAGCCGGGCGAAAAGCTCGTCAACACCAAAGAGATGGGTGACGCGATCATCGTGGCCCTGTAACGGATTTACCTTATTC
CCGAAAAAGGAGTTCTGCCC

Downstream 100 bases:

>100_bases
GTAATGGCAAAACTGTGGAACGTGGCCGTCGTCGGCGCCACTGGCGCCGTCGGTGGCCAGATGATCGAATGCCTCGAAGA
GCGCAACTTCCCTGTGGGGA

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKVGIVGWRGMVGSVLLQRMVEEGDFNTGIEPVFFSTSQAGQPAPMNAGTLKSADDIEELKKLDIIVTCQGGDYTKAVHP
ELRKQGWQGYWIDAASTLRMEPNAVIILDPVNRNVIDAALAKGQKDFIGGNCTVSLMLMALGGLFRAGLVEWLTSMTYQA
ASGAGAPNMRELLSQMGTLHGSVADLLKNPSSAILDIDRDVTATLRGDALPTKEFGFPLAGSVLPWIDREVEDGQSREEW
KGFAETNKILGTTTPIPVDGICVRVGAMRCHSQALTIKLNKDVPLGDIEELIKNDNQWVKFVPNTKADTLADLTPAAVSG
LLTVPIGRVRKMKMGPQYMQAFTCGDQLLWGAAEPLRRMLRILVEK

Sequences:

>Translated_366_residues
MKVGIVGWRGMVGSVLLQRMVEEGDFNTGIEPVFFSTSQAGQPAPMNAGTLKSADDIEELKKLDIIVTCQGGDYTKAVHP
ELRKQGWQGYWIDAASTLRMEPNAVIILDPVNRNVIDAALAKGQKDFIGGNCTVSLMLMALGGLFRAGLVEWLTSMTYQA
ASGAGAPNMRELLSQMGTLHGSVADLLKNPSSAILDIDRDVTATLRGDALPTKEFGFPLAGSVLPWIDREVEDGQSREEW
KGFAETNKILGTTTPIPVDGICVRVGAMRCHSQALTIKLNKDVPLGDIEELIKNDNQWVKFVPNTKADTLADLTPAAVSG
LLTVPIGRVRKMKMGPQYMQAFTCGDQLLWGAAEPLRRMLRILVEK
>Mature_366_residues
MKVGIVGWRGMVGSVLLQRMVEEGDFNTGIEPVFFSTSQAGQPAPMNAGTLKSADDIEELKKLDIIVTCQGGDYTKAVHP
ELRKQGWQGYWIDAASTLRMEPNAVIILDPVNRNVIDAALAKGQKDFIGGNCTVSLMLMALGGLFRAGLVEWLTSMTYQA
ASGAGAPNMRELLSQMGTLHGSVADLLKNPSSAILDIDRDVTATLRGDALPTKEFGFPLAGSVLPWIDREVEDGQSREEW
KGFAETNKILGTTTPIPVDGICVRVGAMRCHSQALTIKLNKDVPLGDIEELIKNDNQWVKFVPNTKADTLADLTPAAVSG
LLTVPIGRVRKMKMGPQYMQAFTCGDQLLWGAAEPLRRMLRILVEK

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=365, Percent_Identity=65.7534246575342, Blast_Score=497, Evalue=1e-142,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 39767; Mature: 39767

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGIVGWRGMVGSVLLQRMVEEGDFNTGIEPVFFSTSQAGQPAPMNAGTLKSADDIEEL
CCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHH
KKLDIIVTCQGGDYTKAVHPELRKQGWQGYWIDAASTLRMEPNAVIILDPVNRNVIDAAL
HHCCEEEEECCCCCCCCCCHHHHHCCCCEEEEECCCEEEECCCEEEEECCCCCHHHHHHH
AKGQKDFIGGNCTVSLMLMALGGLFRAGLVEWLTSMTYQAASGAGAPNMRELLSQMGTLH
HCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GSVADLLKNPSSAILDIDRDVTATLRGDALPTKEFGFPLAGSVLPWIDREVEDGQSREEW
HHHHHHHCCCCCCEEECCCCCEEEECCCCCCCHHCCCCCCCCHHHHHCCHHCCCCCHHHH
KGFAETNKILGTTTPIPVDGICVRVGAMRCHSQALTIKLNKDVPLGDIEELIKNDNQWVK
CCHHHHCCEECCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCCEEE
FVPNTKADTLADLTPAAVSGLLTVPIGRVRKMKMGPQYMQAFTCGDQLLWGAAEPLRRML
ECCCCCCHHHHHCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCHHHHHCCHHHHHHHH
RILVEK
HHHHCC
>Mature Secondary Structure
MKVGIVGWRGMVGSVLLQRMVEEGDFNTGIEPVFFSTSQAGQPAPMNAGTLKSADDIEEL
CCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHH
KKLDIIVTCQGGDYTKAVHPELRKQGWQGYWIDAASTLRMEPNAVIILDPVNRNVIDAAL
HHCCEEEEECCCCCCCCCCHHHHHCCCCEEEEECCCEEEECCCEEEEECCCCCHHHHHHH
AKGQKDFIGGNCTVSLMLMALGGLFRAGLVEWLTSMTYQAASGAGAPNMRELLSQMGTLH
HCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GSVADLLKNPSSAILDIDRDVTATLRGDALPTKEFGFPLAGSVLPWIDREVEDGQSREEW
HHHHHHHCCCCCCEEECCCCCEEEECCCCCCCHHCCCCCCCCHHHHHCCHHCCCCCHHHH
KGFAETNKILGTTTPIPVDGICVRVGAMRCHSQALTIKLNKDVPLGDIEELIKNDNQWVK
CCHHHHCCEECCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCCEEE
FVPNTKADTLADLTPAAVSGLLTVPIGRVRKMKMGPQYMQAFTCGDQLLWGAAEPLRRML
ECCCCCCHHHHHCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCHHHHHCCHHHHHHHH
RILVEK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]