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The map label for this gene is atoC [H]

Identifier: 78221776

GI number: 78221776

Start: 592626

End: 593999

Strand: Direct

Name: atoC [H]

Synonym: Gmet_0555

Alternate gene names: 78221776

Gene position: 592626-593999 (Clockwise)

Preceding gene: 78221775

Following gene: 78221777

Centisome position: 14.83

GC content: 59.32

Gene sequence:

>1374_bases
GTGAGAAAGACGAAGATTCTGGTTGTCGACGACGAGCACCTTATCCGCTGGTCCCTGGAGCAGAATCTGAAAAAACAGGG
ATACGAGGTGGTTTCGGCCGGCAACGGCGAGGATGCCCTGCGGCTCGTCCGGGATGAACAACCGGACCTGGTGCTGCTCG
ATATCCAGCTCCCCGGCATCAGTGGCCTGGATGTCCTGGAGAAGATCAAGGAGCACGACGAGGAGATCATCGTGATCATG
GTCACGGCCCACGGAGCGCTGGAGACGGCGGTTCATGCCATGCGGCTCGGGGCCTTCGACTATATCAACAAGCCCTTTAA
CCTGGACGAGATGGCCATCGTCATCCGCAAGGCCCTGGAAACCTCCGATCTCCGGCGGGAGGTCCAGCGGCTGCGGGGTG
AGCAGGCGAAGAAGTTCGGTACGCCCGATATCATCGGAGCGAGCCGCCACATGAAGAACGTCCTCGACATGATGGAGAAG
GTGGCCAAGAGCGACGCCTCCACTGTCCTCGTTCAGGGAGAGTCGGGGACCGGCAAGGAGCTGGTCGCCAAGTGGATCCA
CTATAAATCCGCCCGGGCCGAACGCCCCTTTGTCGCCATAAACTGCGCTGCTGTCCCGGCGACACTCCTCGAAAGCGAGC
TCTTCGGTCATGAAAAAGGGGCCTTCACCGACGCCAAGGCGATGAAAAAGGGGCTTTTCGAGCTGGCCGACGGTGGCACG
GTCTTTCTTGACGAGATCGGCGACATGGAGTTGGGGATGCAGGCGAAGCTCCTCCGCTTCCTGGAGGAACGGACCTTCCG
CCGCATCGGCGGCACCAAGTCGTTTTCCGTCGATGTCCGGATCATCTCCGCCACCAACCGCGACCTCATCAAGGCGATCG
AGGAAAAGAGCTTCCGCAACGATCTCTACTATCGCCTCCAGGTGATCCCCATCTATCTCCCCCCCCTGCGGGAGCGGCGG
GAAGACATCCTCACCCTGACCAGCCATTTCATCGAGCTGTTCAACGCCGAGTTCAACAAGCATGTCACCGGCATCTCCAA
GATGGCGGAGAAACTCTTGCTCGACTACACCTGGCCCGGCAATATCCGCGAATTGAAGAACGTCATCGAGCGCGCCATCA
TTCTCGGCAATGACGAGACGCTCCTCCTTGAGCACCTGCCGCTGGAAATCGTCGCCAAGGCCTCCTCCCAGTCCGTGGGG
CTCACCACCTTCAAGCTTCCCCCCGAGGGGATAGACATTGAAGAGGTGGAAAAGGAGCTTATCCGCCAGGCCCTGGAGAT
CTCGGACTGGAACCAGTCCAAGGCGGCCAGGAAGCTTAATCTCGGCATTGACGCCTTCCGTTACCGGATGAAGAAATTCG
GGTATTTGAAGTAG

Upstream 100 bases:

>100_bases
GTCGGTCAGGTTTTATTCTGGATTCTGGCTCCTGTATTCTGTATTCTTTTTTCATTCGGTAATTTCCAGATATCCGCTTG
GTTACGATAAAGGAGCAGAT

Downstream 100 bases:

>100_bases
AAGTAACCTTCCCCTTCATCGCAGCGTTGTCATTTGACGGATTCCCGGAACCTTTCCGAAGTTGCCGGGAACCTCATTCC
TTCCCTTTTCCCGCGAAATT

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MRKTKILVVDDEHLIRWSLEQNLKKQGYEVVSAGNGEDALRLVRDEQPDLVLLDIQLPGISGLDVLEKIKEHDEEIIVIM
VTAHGALETAVHAMRLGAFDYINKPFNLDEMAIVIRKALETSDLRREVQRLRGEQAKKFGTPDIIGASRHMKNVLDMMEK
VAKSDASTVLVQGESGTGKELVAKWIHYKSARAERPFVAINCAAVPATLLESELFGHEKGAFTDAKAMKKGLFELADGGT
VFLDEIGDMELGMQAKLLRFLEERTFRRIGGTKSFSVDVRIISATNRDLIKAIEEKSFRNDLYYRLQVIPIYLPPLRERR
EDILTLTSHFIELFNAEFNKHVTGISKMAEKLLLDYTWPGNIRELKNVIERAIILGNDETLLLEHLPLEIVAKASSQSVG
LTTFKLPPEGIDIEEVEKELIRQALEISDWNQSKAARKLNLGIDAFRYRMKKFGYLK

Sequences:

>Translated_457_residues
MRKTKILVVDDEHLIRWSLEQNLKKQGYEVVSAGNGEDALRLVRDEQPDLVLLDIQLPGISGLDVLEKIKEHDEEIIVIM
VTAHGALETAVHAMRLGAFDYINKPFNLDEMAIVIRKALETSDLRREVQRLRGEQAKKFGTPDIIGASRHMKNVLDMMEK
VAKSDASTVLVQGESGTGKELVAKWIHYKSARAERPFVAINCAAVPATLLESELFGHEKGAFTDAKAMKKGLFELADGGT
VFLDEIGDMELGMQAKLLRFLEERTFRRIGGTKSFSVDVRIISATNRDLIKAIEEKSFRNDLYYRLQVIPIYLPPLRERR
EDILTLTSHFIELFNAEFNKHVTGISKMAEKLLLDYTWPGNIRELKNVIERAIILGNDETLLLEHLPLEIVAKASSQSVG
LTTFKLPPEGIDIEEVEKELIRQALEISDWNQSKAARKLNLGIDAFRYRMKKFGYLK
>Mature_457_residues
MRKTKILVVDDEHLIRWSLEQNLKKQGYEVVSAGNGEDALRLVRDEQPDLVLLDIQLPGISGLDVLEKIKEHDEEIIVIM
VTAHGALETAVHAMRLGAFDYINKPFNLDEMAIVIRKALETSDLRREVQRLRGEQAKKFGTPDIIGASRHMKNVLDMMEK
VAKSDASTVLVQGESGTGKELVAKWIHYKSARAERPFVAINCAAVPATLLESELFGHEKGAFTDAKAMKKGLFELADGGT
VFLDEIGDMELGMQAKLLRFLEERTFRRIGGTKSFSVDVRIISATNRDLIKAIEEKSFRNDLYYRLQVIPIYLPPLRERR
EDILTLTSHFIELFNAEFNKHVTGISKMAEKLLLDYTWPGNIRELKNVIERAIILGNDETLLLEHLPLEIVAKASSQSVG
LTTFKLPPEGIDIEEVEKELIRQALEISDWNQSKAARKLNLGIDAFRYRMKKFGYLK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=44.8577680525164, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790437, Length=440, Percent_Identity=45, Blast_Score=342, Evalue=4e-95,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=40.0423728813559, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=38.9140271493213, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI87082117, Length=338, Percent_Identity=44.3786982248521, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1789087, Length=359, Percent_Identity=44.5682451253482, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=43.167701863354, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=41.6403785488959, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=40.5660377358491, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786524, Length=323, Percent_Identity=39.3188854489164, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI1787583, Length=262, Percent_Identity=42.3664122137405, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1789828, Length=266, Percent_Identity=34.2105263157895, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081858, Length=286, Percent_Identity=29.7202797202797, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789809, Length=184, Percent_Identity=33.695652173913, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=36.7521367521368, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786784, Length=115, Percent_Identity=33.0434782608696, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789402, Length=108, Percent_Identity=36.1111111111111, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788394, Length=130, Percent_Identity=32.3076923076923, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790863, Length=140, Percent_Identity=30, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788222, Length=113, Percent_Identity=34.5132743362832, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=31.304347826087, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1787229, Length=145, Percent_Identity=27.5862068965517, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=28.0373831775701, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51781; Mature: 51781

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTKILVVDDEHLIRWSLEQNLKKQGYEVVSAGNGEDALRLVRDEQPDLVLLDIQLPGI
CCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCC
SGLDVLEKIKEHDEEIIVIMVTAHGALETAVHAMRLGAFDYINKPFNLDEMAIVIRKALE
CCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TSDLRREVQRLRGEQAKKFGTPDIIGASRHMKNVLDMMEKVAKSDASTVLVQGESGTGKE
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
LVAKWIHYKSARAERPFVAINCAAVPATLLESELFGHEKGAFTDAKAMKKGLFELADGGT
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCE
VFLDEIGDMELGMQAKLLRFLEERTFRRIGGTKSFSVDVRIISATNRDLIKAIEEKSFRN
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHHC
DLYYRLQVIPIYLPPLRERREDILTLTSHFIELFNAEFNKHVTGISKMAEKLLLDYTWPG
CEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
NIRELKNVIERAIILGNDETLLLEHLPLEIVAKASSQSVGLTTFKLPPEGIDIEEVEKEL
CHHHHHHHHHHHEEECCCCEEEEECCCHHHEECCCCCCCCEEEEECCCCCCCHHHHHHHH
IRQALEISDWNQSKAARKLNLGIDAFRYRMKKFGYLK
HHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRKTKILVVDDEHLIRWSLEQNLKKQGYEVVSAGNGEDALRLVRDEQPDLVLLDIQLPGI
CCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCC
SGLDVLEKIKEHDEEIIVIMVTAHGALETAVHAMRLGAFDYINKPFNLDEMAIVIRKALE
CCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TSDLRREVQRLRGEQAKKFGTPDIIGASRHMKNVLDMMEKVAKSDASTVLVQGESGTGKE
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
LVAKWIHYKSARAERPFVAINCAAVPATLLESELFGHEKGAFTDAKAMKKGLFELADGGT
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCE
VFLDEIGDMELGMQAKLLRFLEERTFRRIGGTKSFSVDVRIISATNRDLIKAIEEKSFRN
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHHC
DLYYRLQVIPIYLPPLRERREDILTLTSHFIELFNAEFNKHVTGISKMAEKLLLDYTWPG
CEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
NIRELKNVIERAIILGNDETLLLEHLPLEIVAKASSQSVGLTTFKLPPEGIDIEEVEKEL
CHHHHHHHHHHHEEECCCCEEEEECCCHHHEECCCCCCCCEEEEECCCCCCCHHHHHHHH
IRQALEISDWNQSKAARKLNLGIDAFRYRMKKFGYLK
HHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]