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The map label for this gene is arsB [H]

Identifier: 78221741

GI number: 78221741

Start: 557767

End: 558819

Strand: Reverse

Name: arsB [H]

Synonym: Gmet_0520

Alternate gene names: 78221741

Gene position: 558819-557767 (Counterclockwise)

Preceding gene: 78221742

Following gene: 78221740

Centisome position: 13.98

GC content: 61.35

Gene sequence:

>1053_bases
ATGAGTGAGCATGTATCCCGCAACCTATCCTTCCTCGACCGCTGGCTCACCCTCTGGATCTTCGCCGCCATGGCCCTCGG
CGTCGGCCTGGGGTACTTCATCCCGGGCGTGGAGCAGTTCATCAACCGTTTCCAGGTGGGGACAACGAACATCCCCATCG
CCGCCGGCCTCATCCTCATGATGTATCCCCCCTTTGCCAAGGTGAAGTACGAGGAGATGCCCGAAGTCTTCAGGAACAAG
AAAATCCTCGGCCTCTCCCTCGCCCAGAACTGGCTCATCGGGCCGGCGCTCATGTTCGTCCTGGCCATTGCCTTCCTCCC
CGACAAGCCTGAGTACATGGTGGGGCTCATCATGATCGGCCTGGCCCGCTGCATCGCCATGGTCATCGTCTGGAACGAGC
TGGCCAAGGGGAACACCGAGTACGCCGCCGGGCTTGTGGCTTTCAACAGCATCTTCCAGGTCCTTTTCTACAGCGTCTAC
GCCTGGTTCTTCATTACGGTGCTCCCGCCCCTCTTCGGCCTTTCGGGGAGCGTGGTGGAAGTGAGCATCCGCCAGATCGC
CGAGAGCGTCTTCATCTACCTGGGAATCCCCTGCATCGCCGGGGCACTGACGCGCCTCGTCGGCGTGAAGCTCATGGGGA
AGGAACGCTACCACCGGGAGGTGGTGCCACGCATCGGCCCCATCACCCTCGTGGCGCTCCTCTTCACCATCGTGGTGATG
TTCAGCCTCAAGGGTAACCTCATCGTTCAGTTGCCGCTGGACGTGGTGCGGATCGCCATCCCGCTCCTCATCTACTTCAT
CGTCATGTTCCTAATTTCTTTCTGGATGGGGAAACGGCTTGGCGCCGACTACACAAAAACCACCACGTTGGCCTTCACGG
CGGCCAGCAACAACTTCGAACTGGCCATCGCCGTGGCGGTGGCGGTCTTCGGGCTCAACTCGGGAGCGGCCTTCGCGGCG
GTCATCGGCCCCCTTGTTGAGGTACCGGTTATGATCGGGCTGGTGAACGTGGCGTTCTGGTTCCGGCGCCGCTGGTTCGC
CACCACTGCCTGA

Upstream 100 bases:

>100_bases
TCACGGGCCACTGGCACCGAAGGGGAAATCATGGCCGAATTTCGTCGGGTCCGGGATGAGATGCGACAGGAGCTGACTGC
CCACCTGAGCGGAGGAACCC

Downstream 100 bases:

>100_bases
GGGGAGAGATTCGCGTGTTCAAACCCTTCGCCGACTATCTAGTATTCGATCTCTTCGGCCTCTCCCCGGTGAGCCATCTG
GGGGAGGCCCTCGATTTCTT

Product: arsenical-resistance protein ACR3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSEHVSRNLSFLDRWLTLWIFAAMALGVGLGYFIPGVEQFINRFQVGTTNIPIAAGLILMMYPPFAKVKYEEMPEVFRNK
KILGLSLAQNWLIGPALMFVLAIAFLPDKPEYMVGLIMIGLARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSVY
AWFFITVLPPLFGLSGSVVEVSIRQIAESVFIYLGIPCIAGALTRLVGVKLMGKERYHREVVPRIGPITLVALLFTIVVM
FSLKGNLIVQLPLDVVRIAIPLLIYFIVMFLISFWMGKRLGADYTKTTTLAFTAASNNFELAIAVAVAVFGLNSGAAFAA
VIGPLVEVPVMIGLVNVAFWFRRRWFATTA

Sequences:

>Translated_350_residues
MSEHVSRNLSFLDRWLTLWIFAAMALGVGLGYFIPGVEQFINRFQVGTTNIPIAAGLILMMYPPFAKVKYEEMPEVFRNK
KILGLSLAQNWLIGPALMFVLAIAFLPDKPEYMVGLIMIGLARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSVY
AWFFITVLPPLFGLSGSVVEVSIRQIAESVFIYLGIPCIAGALTRLVGVKLMGKERYHREVVPRIGPITLVALLFTIVVM
FSLKGNLIVQLPLDVVRIAIPLLIYFIVMFLISFWMGKRLGADYTKTTTLAFTAASNNFELAIAVAVAVFGLNSGAAFAA
VIGPLVEVPVMIGLVNVAFWFRRRWFATTA
>Mature_349_residues
SEHVSRNLSFLDRWLTLWIFAAMALGVGLGYFIPGVEQFINRFQVGTTNIPIAAGLILMMYPPFAKVKYEEMPEVFRNKK
ILGLSLAQNWLIGPALMFVLAIAFLPDKPEYMVGLIMIGLARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSVYA
WFFITVLPPLFGLSGSVVEVSIRQIAESVFIYLGIPCIAGALTRLVGVKLMGKERYHREVVPRIGPITLVALLFTIVVMF
SLKGNLIVQLPLDVVRIAIPLLIYFIVMFLISFWMGKRLGADYTKTTTLAFTAASNNFELAIAVAVAVFGLNSGAAFAAV
IGPLVEVPVMIGLVNVAFWFRRRWFATTA

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=320, Percent_Identity=34.375, Blast_Score=170, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38768; Mature: 38637

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEHVSRNLSFLDRWLTLWIFAAMALGVGLGYFIPGVEQFINRFQVGTTNIPIAAGLILM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
MYPPFAKVKYEEMPEVFRNKKILGLSLAQNWLIGPALMFVLAIAFLPDKPEYMVGLIMIG
HCCCHHHCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSVYAWFFITVLPPLFGLSGSVVE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VSIRQIAESVFIYLGIPCIAGALTRLVGVKLMGKERYHREVVPRIGPITLVALLFTIVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FSLKGNLIVQLPLDVVRIAIPLLIYFIVMFLISFWMGKRLGADYTKTTTLAFTAASNNFE
HHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCCH
LAIAVAVAVFGLNSGAAFAAVIGPLVEVPVMIGLVNVAFWFRRRWFATTA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]