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The map label for this gene is adcA [H]

Identifier: 78221712

GI number: 78221712

Start: 537175

End: 538131

Strand: Direct

Name: adcA [H]

Synonym: Gmet_0491

Alternate gene names: 78221712

Gene position: 537175-538131 (Clockwise)

Preceding gene: 78221708

Following gene: 78221713

Centisome position: 13.44

GC content: 64.89

Gene sequence:

>957_bases
ATGAGACGCATTGCATTCATGGTTTTGGTGCTGGTCCTGGCGGCGCTCGCTTCCGGGTGCCGGAAAACGGAGGAAAAGGG
TGCCGGCGGGAGCGGCAAGCTGCGGATCGTCGCCACCATCTTCCCGGTCTACGAATTTGCCCGCGCCGTGGCAGGGGACA
AGGCCGAGGTGACGCTCCTCCTTCCTCCCGGCATGGAGCCCCACAGCTTCGAGCCCCAGCCGGGCGATATCGTGCGGGTA
AGCAACGCCGATCTCTTTATCTACACGAACCGGTACATGGAGCCGTGGGCCGGCGAGATCGTCAAGGGGGCCGGCGGCAG
GAAGCTCACCGTGGTCGATGCGAGCCGGGGGGCAAAATTCCTTAAGGCAGGCGAGGGGAATAATCACGACGACCATGGCC
ACGGAGGGCACAACCATGGCGGCGAGGGGATGGACCCCCACCTCTGGCTCGATTTCACCAACTCTCAGCTCATGGTGGAC
AACATCGCCGCGGCCTTGGCCGAGCGGGACCCGGCGAACCGGTCCGTCTACCTTGCCAATGCCGCCGCCTACCGCGCCAG
GCTGGCCGACCTGGACGAACGGTACCGCAAGGGGCTCGCTTCGTGCGCCACGCGAACCATCCTCCATGGCGGGCACTACG
CCTTCGGCTACCTGGCCAACCGCTACGGTCTCCGCTACCTGTCGGCCTACGCCGTTTCCGCCGACGCCGAGCCGACCCCG
GCGAAGCTGGCGCAACTCGTGAATCAGGTGCGGGCCGAGGGACTGAAGTACATCTTCACCGAGGAGCTTCTCGATCCCCG
CACCGCAGAGACCATCGCCCGGGAAACCGGCGCCTCCATCCTCATGCTCCACGGCGCCCATACCGTCTCGAAGGCCGATC
TGGACAGGGGAGTCACCTTTATGGAGCTCATGGAGAAGAACCTGAAGAATCTGCGGGAGGGGCTCCAATGTCGGTAG

Upstream 100 bases:

>100_bases
CCCCCTTGACAAGCACCGGGCGGGGGGTATTTTAGAGCGGCAACCACCGCTTGTTATTCCTGCTTCGGCTGCCCCGTTCG
CGGGCGAAAAAAGAGGGTTC

Downstream 100 bases:

>100_bases
GGGTGGTCACGGTCCAGGGGCTTTCCCATGCCTACCAGGGGGTCGACGCCTTGCTCGACGTATCGTTTGCCGTGGAAAAG
GGGAGCTACGTGGGGATTGT

Product: periplasmic solute binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRRIAFMVLVLVLAALASGCRKTEEKGAGGSGKLRIVATIFPVYEFARAVAGDKAEVTLLLPPGMEPHSFEPQPGDIVRV
SNADLFIYTNRYMEPWAGEIVKGAGGRKLTVVDASRGAKFLKAGEGNNHDDHGHGGHNHGGEGMDPHLWLDFTNSQLMVD
NIAAALAERDPANRSVYLANAAAYRARLADLDERYRKGLASCATRTILHGGHYAFGYLANRYGLRYLSAYAVSADAEPTP
AKLAQLVNQVRAEGLKYIFTEELLDPRTAETIARETGASILMLHGAHTVSKADLDRGVTFMELMEKNLKNLREGLQCR

Sequences:

>Translated_318_residues
MRRIAFMVLVLVLAALASGCRKTEEKGAGGSGKLRIVATIFPVYEFARAVAGDKAEVTLLLPPGMEPHSFEPQPGDIVRV
SNADLFIYTNRYMEPWAGEIVKGAGGRKLTVVDASRGAKFLKAGEGNNHDDHGHGGHNHGGEGMDPHLWLDFTNSQLMVD
NIAAALAERDPANRSVYLANAAAYRARLADLDERYRKGLASCATRTILHGGHYAFGYLANRYGLRYLSAYAVSADAEPTP
AKLAQLVNQVRAEGLKYIFTEELLDPRTAETIARETGASILMLHGAHTVSKADLDRGVTFMELMEKNLKNLREGLQCR
>Mature_318_residues
MRRIAFMVLVLVLAALASGCRKTEEKGAGGSGKLRIVATIFPVYEFARAVAGDKAEVTLLLPPGMEPHSFEPQPGDIVRV
SNADLFIYTNRYMEPWAGEIVKGAGGRKLTVVDASRGAKFLKAGEGNNHDDHGHGGHNHGGEGMDPHLWLDFTNSQLMVD
NIAAALAERDPANRSVYLANAAAYRARLADLDERYRKGLASCATRTILHGGHYAFGYLANRYGLRYLSAYAVSADAEPTP
AKLAQLVNQVRAEGLKYIFTEELLDPRTAETIARETGASILMLHGAHTVSKADLDRGVTFMELMEKNLKNLREGLQCR

Specific function: Part of the high-affinity ABC transporter complex AdcABC involved in zinc import (Probable) [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=267, Percent_Identity=26.2172284644195, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 34680; Mature: 34680

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIAFMVLVLVLAALASGCRKTEEKGAGGSGKLRIVATIFPVYEFARAVAGDKAEVTLL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEEE
LPPGMEPHSFEPQPGDIVRVSNADLFIYTNRYMEPWAGEIVKGAGGRKLTVVDASRGAKF
ECCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCHHHHHCCCCCCEEEEEECCCCCCE
LKAGEGNNHDDHGHGGHNHGGEGMDPHLWLDFTNSQLMVDNIAAALAERDPANRSVYLAN
EECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCCCCEEEEEH
AAAYRARLADLDERYRKGLASCATRTILHGGHYAFGYLANRYGLRYLSAYAVSADAEPTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCH
AKLAQLVNQVRAEGLKYIFTEELLDPRTAETIARETGASILMLHGAHTVSKADLDRGVTF
HHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHH
MELMEKNLKNLREGLQCR
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRIAFMVLVLVLAALASGCRKTEEKGAGGSGKLRIVATIFPVYEFARAVAGDKAEVTLL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEEE
LPPGMEPHSFEPQPGDIVRVSNADLFIYTNRYMEPWAGEIVKGAGGRKLTVVDASRGAKF
ECCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCHHHHHCCCCCCEEEEEECCCCCCE
LKAGEGNNHDDHGHGGHNHGGEGMDPHLWLDFTNSQLMVDNIAAALAERDPANRSVYLAN
EECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCCCCEEEEEH
AAAYRARLADLDERYRKGLASCATRTILHGGHYAFGYLANRYGLRYLSAYAVSADAEPTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCH
AKLAQLVNQVRAEGLKYIFTEELLDPRTAETIARETGASILMLHGAHTVSKADLDRGVTF
HHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHH
MELMEKNLKNLREGLQCR
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9811636 [H]