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The map label for this gene is murC

Identifier: 78221634

GI number: 78221634

Start: 456716

End: 458101

Strand: Direct

Name: murC

Synonym: Gmet_0413

Alternate gene names: 78221634

Gene position: 456716-458101 (Clockwise)

Preceding gene: 78221633

Following gene: 78221635

Centisome position: 11.43

GC content: 63.49

Gene sequence:

>1386_bases
ATGTACGGAAAGATCGAAAAAATCCACTTCGTCGGCATCGGCGGCATCGGTATGAGCGGCATCGCCGAGGTGCTCCTGAA
CCTGGGGTACAAGGTGTCCGGCTCCGACCTGAAACAGTCCGATACCACCGACCGCCTTGCCTCCCTTGGCGGGGACATCC
GTTTTGGCCATGCCCGGGAGAACCTGGCCGACGTGGACGTGGTGGTGACCTCCACGGCGGTCCATGACGACAACCCCGAG
GTGATGGAGGCCAAGCGGCGCATGATCCCGGTGATCCCCCGGGCGGAGATGCTGGCGGAACTGATGCGGATGAAGTACGG
GATCGCCATCGCCGGCACCCACGGCAAGACCACCACCACCTCCATGGTGGCCACGGCCCTCACCCACGGCGGCATTGACC
CCACCATCGTCATCGGCGGCAAACTCAACACCCTCGGCACCAACGCCAAGCTCGGCCAGGGGCAGTTCCTCGTGGCCGAG
GCCGACGAATCCGACGGCTCGTTCCTGAAACTCTCCCCCACCATCGCGGTGGTGACCAACATCGACGCAGACCACCTGGA
CTTCTACACTGGCGGCATCGAGCAGATCAAGGACACCTTCGTCGACTTCATCAACAAGATACCCTTCTACGGTCTTGCGG
TCCTCTGCCTGGAAGATCGGAACATTGCCGAGATCCTGCCGCGGGTGAAGAAGCGCTTCGTCACCTACGGTCTCTCCTCC
CAGGCGGACATCCGGGCAACCCACATCCGCCTCGAAGGGGGAACCACCTCCTTTGTGGCCCACTACAAGGGATACCGGAT
GGGGGAGGTTTCCTTCGCGATGCCCGGTGCCCACAACGTGCTGAACGCCCTCGCGTGTATCGCCGTGGCCATGGAACTCG
ATGTCCCCTTCGCCCAGATCCAGGAGGGGTTTGCCAAGTTTGGCGGCGTTGGGCGGCGCTTTCAGGTAAAGGGCGAGGTG
AATGGTATTACGGTGGTCGACGACTACGGCCACCACCCGGCGGAAATCCGGGCGACCCTGGCCGCGGGCAAGAGTGGCTG
GCCTGATCGGCGGCTCGTGGTGGCCTTCCAGCCCCACCGCTTCAGCAGGACGAAGGAGCTCTTTGCCGAATTCGTCACCT
GCTTCTACGATGCCGATGTGCTGGTGCTCACCGATATCTACTCGGCCGGCGAGGCCCCCATCGAGGGGGTGACGGCGGAA
CGTCTGGCGGAAAATATCCGCAAACACGGACAGCGGGATGTGACGTACATCGCCGATCGGGAGGCGCTCCCCGACCACCT
GCTCCAGATCGTGAGGCCCGGTGACATCGTCCTGACCCTCGGCGCCGGCAACATCTGGCAGACCGGAGAGGCCCTGCTCC
GGAAGCTGGAGACGGCAGAGGGATAG

Upstream 100 bases:

>100_bases
TGAAAAGCGTCGGAGAGGCAGCCCAAGGGCTTGCGCGGCTCGATGCGGCCCAGGTGATCGTTGACGAAATGATGACAAGT
AAAAGGAAAGAAAAATAGAT

Downstream 100 bases:

>100_bases
CTCTTTGAACGACGAACTGTACGCCCGCCTCCGTGCAGAGTTGAGGGGGGAGATTCTGCGGGATGAGCCGATGGCTCGCC
ACACCTCGCTCAAGGTGGGG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGDIRFGHARENLADVDVVVTSTAVHDDNPE
VMEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATALTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAE
ADESDGSFLKLSPTIAVVTNIDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFAMPGAHNVLNALACIAVAMELDVPFAQIQEGFAKFGGVGRRFQVKGEV
NGITVVDDYGHHPAEIRATLAAGKSGWPDRRLVVAFQPHRFSRTKELFAEFVTCFYDADVLVLTDIYSAGEAPIEGVTAE
RLAENIRKHGQRDVTYIADREALPDHLLQIVRPGDIVLTLGAGNIWQTGEALLRKLETAEG

Sequences:

>Translated_461_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGDIRFGHARENLADVDVVVTSTAVHDDNPE
VMEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATALTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAE
ADESDGSFLKLSPTIAVVTNIDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFAMPGAHNVLNALACIAVAMELDVPFAQIQEGFAKFGGVGRRFQVKGEV
NGITVVDDYGHHPAEIRATLAAGKSGWPDRRLVVAFQPHRFSRTKELFAEFVTCFYDADVLVLTDIYSAGEAPIEGVTAE
RLAENIRKHGQRDVTYIADREALPDHLLQIVRPGDIVLTLGAGNIWQTGEALLRKLETAEG
>Mature_461_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGDIRFGHARENLADVDVVVTSTAVHDDNPE
VMEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATALTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAE
ADESDGSFLKLSPTIAVVTNIDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFAMPGAHNVLNALACIAVAMELDVPFAQIQEGFAKFGGVGRRFQVKGEV
NGITVVDDYGHHPAEIRATLAAGKSGWPDRRLVVAFQPHRFSRTKELFAEFVTCFYDADVLVLTDIYSAGEAPIEGVTAE
RLAENIRKHGQRDVTYIADREALPDHLLQIVRPGDIVLTLGAGNIWQTGEALLRKLETAEG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=458, Percent_Identity=47.1615720524017, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1790680, Length=476, Percent_Identity=28.1512605042017, Blast_Score=155, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50013; Mature: 50013

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGDIRFGHARE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCCCEEECCCCC
NLADVDVVVTSTAVHDDNPEVMEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTT
CCCCEEEEEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SMVATALTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAEADESDGSFLKLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEEEEEEE
IDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
CCCHHHHHHCCCHHHHHHHHHHHHHCCCHHCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFAMPGAHNVLNALACIAVAMELDVPFAQI
CCCEEEEEEEEECCCEEEEHHCCCCEECCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHH
QEGFAKFGGVGRRFQVKGEVNGITVVDDYGHHPAEIRATLAAGKSGWPDRRLVVAFQPHR
HHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHEEEECCCCCCCCCEEEEEECCCC
FSRTKELFAEFVTCFYDADVLVLTDIYSAGEAPIEGVTAERLAENIRKHGQRDVTYIADR
CHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC
EALPDHLLQIVRPGDIVLTLGAGNIWQTGEALLRKLETAEG
CCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGDIRFGHARE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCCCEEECCCCC
NLADVDVVVTSTAVHDDNPEVMEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTT
CCCCEEEEEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SMVATALTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAEADESDGSFLKLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEEEEEEE
IDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
CCCHHHHHHCCCHHHHHHHHHHHHHCCCHHCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFAMPGAHNVLNALACIAVAMELDVPFAQI
CCCEEEEEEEEECCCEEEEHHCCCCEECCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHH
QEGFAKFGGVGRRFQVKGEVNGITVVDDYGHHPAEIRATLAAGKSGWPDRRLVVAFQPHR
HHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHEEEECCCCCCCCCEEEEEECCCC
FSRTKELFAEFVTCFYDADVLVLTDIYSAGEAPIEGVTAERLAENIRKHGQRDVTYIADR
CHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC
EALPDHLLQIVRPGDIVLTLGAGNIWQTGEALLRKLETAEG
CCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA