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The map label for this gene is hisG

Identifier: 78221604

GI number: 78221604

Start: 427795

End: 428433

Strand: Direct

Name: hisG

Synonym: Gmet_0383

Alternate gene names: 78221604

Gene position: 427795-428433 (Clockwise)

Preceding gene: 78221603

Following gene: 78221605

Centisome position: 10.7

GC content: 60.88

Gene sequence:

>639_bases
ATGAGCGACTTTCTTACCATCGCCATCCCCAAGGGGCGGATTCTCGAAGAGTCCGTTGCCCTGTTCGGCAAGATCGGAAT
CCACTGCGACGAGCTTCTCTCCAACACCCGCAAGCTCATCTTCGAGAACCGCGAGCAGCGGATGCGGTACATGATTGTCC
GGGCCACTGACGTCCCCACCTACGTGGAGTATGGTTGCGCCGATCTCGGTATCGTGGGGAAGGACACCCTCATGGAGCAG
GAGAAGGACCTCTACGAGCCCCTGGACCTCAAGTTCGGTTACTGCCGGATGATGGTGGCGGAGCCAGCGGGGCTTGCCAG
GGACGACGACCCCTCCAGTTGGAGCAACATCCGGATCGCCACCAAGTACCCCAACGTGACCGAGAAGTACTTCGCCAAAA
AGGGGGTGCAGGTGGAGATCATCAAGCTCTACGGCTCCATCGAGTTGGCGCCGCTGGTGGGGCTCTCCGAGCGGATCGTG
GACTTAGTCTCCACCGGCGAGACCCTGCGGCAGAACGGCCTCGTGGAGGTGGAGACCATCGCCGAGATCACCACGCGCCT
CATCGTCAACCGGGCGAGCCTCAAGACCAAGCACCCCCGGATCACCGAGATCATCGAAGGGTTGGAGAAGCACGTATGA

Upstream 100 bases:

>100_bases
CGGCCTCGGGGCCGACATCAAACGTGTAAAGGAGTGAGCCGGCGGCGGGAGCGGGTGCCATTGTTGGTCCCCGGTCCCTG
GTCCCCGGTCCCTTAGTTTT

Downstream 100 bases:

>100_bases
AATTCCTCGATATCAGGGATACGAACTTCGACATGGAATTCGCCGCCATCCTCGCCCGGGGCGAGGAGACCGGCCGCGAG
GTGGAACAGGTGGTCCTCGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT 2; ATP-PRTase 2 [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSDFLTIAIPKGRILEESVALFGKIGIHCDELLSNTRKLIFENREQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQ
EKDLYEPLDLKFGYCRMMVAEPAGLARDDDPSSWSNIRIATKYPNVTEKYFAKKGVQVEIIKLYGSIELAPLVGLSERIV
DLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV

Sequences:

>Translated_212_residues
MSDFLTIAIPKGRILEESVALFGKIGIHCDELLSNTRKLIFENREQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQ
EKDLYEPLDLKFGYCRMMVAEPAGLARDDDPSSWSNIRIATKYPNVTEKYFAKKGVQVEIIKLYGSIELAPLVGLSERIV
DLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV
>Mature_211_residues
SDFLTIAIPKGRILEESVALFGKIGIHCDELLSNTRKLIFENREQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQE
KDLYEPLDLKFGYCRMMVAEPAGLARDDDPSSWSNIRIATKYPNVTEKYFAKKGVQVEIIKLYGSIELAPLVGLSERIVD
LVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=186, Percent_Identity=39.247311827957, Blast_Score=105, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320896, Length=209, Percent_Identity=32.5358851674641, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23963; Mature: 23832

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFLTIAIPKGRILEESVALFGKIGIHCDELLSNTRKLIFENREQRMRYMIVRATDVPT
CCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHEEEEEEEECCCCH
YVEYGCADLGIVGKDTLMEQEKDLYEPLDLKFGYCRMMVAEPAGLARDDDPSSWSNIRIA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHEEEEECCCCCCCCCCCCCCCCEEEE
TKYPNVTEKYFAKKGVQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETI
ECCCCHHHHHHHHCCCEEEEEEEECCEEEEHHCCHHHHHHHHHHCCHHHHHCCCEEHHHH
AEITTRLIVNRASLKTKHPRITEIIEGLEKHV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SDFLTIAIPKGRILEESVALFGKIGIHCDELLSNTRKLIFENREQRMRYMIVRATDVPT
CCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHEEEEEEEECCCCH
YVEYGCADLGIVGKDTLMEQEKDLYEPLDLKFGYCRMMVAEPAGLARDDDPSSWSNIRIA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHEEEEECCCCCCCCCCCCCCCCEEEE
TKYPNVTEKYFAKKGVQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETI
ECCCCHHHHHHHHCCCEEEEEEEECCEEEEHHCCHHHHHHHHHHCCHHHHHCCCEEHHHH
AEITTRLIVNRASLKTKHPRITEIIEGLEKHV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA