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The map label for this gene is lspA

Identifier: 78221573

GI number: 78221573

Start: 393644

End: 394132

Strand: Direct

Name: lspA

Synonym: Gmet_0352

Alternate gene names: 78221573

Gene position: 393644-394132 (Clockwise)

Preceding gene: 78221572

Following gene: 78221575

Centisome position: 9.85

GC content: 61.15

Gene sequence:

>489_bases
ATGAAGCCCAACTACCGCATTTTCTCAATCGTCACGGCGGTGTCCCTGGTAATCGACCAGGCGACCAAGATTCTCGTGGA
CCGGACCCTGGAGCTCTACCAGTCCATTCCGGTGGTCCCCGGGCTCTTCAGCATCACCTACATGCGGAACAAGGGGGCGG
CGTTCAGCTTCCTCTCGAACTTCGATTACCGCCGCCCCTTTTTCATCGCAGTCACGCTGGTGGCCATGGCGGCCATCGCC
ATCACCTTCCGCAAGCTCCGGGACGACCAGCGACTGGCGGCAGTTTCCCTTTCCCTCATCTTCTCCGGTGCTGTCGGCAA
TCTCATCGACCGGGTGCGGCTCGGCGAGGTGATCGACTTCCTCGACGTCTACTGGAAAACCCACCACTGGCCCGCCTTCA
ACGTGGCCGACTCCGCCATCTGCGTTGGCGTGGCGCTCCTCGCCCTCGACATGATCCGCGACGAGCGGCGCCAGTCCAAA
GATAATTAA

Upstream 100 bases:

>100_bases
GACAAGTGCGAGCGGTGCTGGCACTATGACGAGGAAATCGGTGGCGATGCCGAGCATCCGACCCTCTGCCCCAAGTGCGT
TGCGGCGGTCAAATAGGACC

Downstream 100 bases:

>100_bases
AACCGCTGCCGTAGCGCCAGGTGGAAGTTCACGTCCGGCGAGGTTTTCACGTTCAGATCCTCGGAAAGAGCGATGTCGAA
GAAGGTCCGCTCCGTGAAGG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKPNYRIFSIVTAVSLVIDQATKILVDRTLELYQSIPVVPGLFSITYMRNKGAAFSFLSNFDYRRPFFIAVTLVAMAAIA
ITFRKLRDDQRLAAVSLSLIFSGAVGNLIDRVRLGEVIDFLDVYWKTHHWPAFNVADSAICVGVALLALDMIRDERRQSK
DN

Sequences:

>Translated_162_residues
MKPNYRIFSIVTAVSLVIDQATKILVDRTLELYQSIPVVPGLFSITYMRNKGAAFSFLSNFDYRRPFFIAVTLVAMAAIA
ITFRKLRDDQRLAAVSLSLIFSGAVGNLIDRVRLGEVIDFLDVYWKTHHWPAFNVADSAICVGVALLALDMIRDERRQSK
DN
>Mature_162_residues
MKPNYRIFSIVTAVSLVIDQATKILVDRTLELYQSIPVVPGLFSITYMRNKGAAFSFLSNFDYRRPFFIAVTLVAMAAIA
ITFRKLRDDQRLAAVSLSLIFSGAVGNLIDRVRLGEVIDFLDVYWKTHHWPAFNVADSAICVGVALLALDMIRDERRQSK
DN

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=148, Percent_Identity=36.4864864864865, Blast_Score=100, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_GEOMG (Q39YS9)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383320.1
- STRING:   Q39YS9
- MEROPS:   A08.001
- GeneID:   3739718
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0352
- NMPDR:   fig|269799.3.peg.364
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   FFYITSH
- PhylomeDB:   Q39YS9
- ProtClustDB:   PRK00376
- BioCyc:   GMET269799:GMET_0352-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18289; Mature: 18289

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 110-110 ACT_SITE 137-137

Signals:

None

Transmembrane regions:

HASH(0xfd93ee8)-; HASH(0x10787a50)-; HASH(0x102e2658)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNYRIFSIVTAVSLVIDQATKILVDRTLELYQSIPVVPGLFSITYMRNKGAAFSFLSN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCHHHHHHC
FDYRRPFFIAVTLVAMAAIAITFRKLRDDQRLAAVSLSLIFSGAVGNLIDRVRLGEVIDF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVYWKTHHWPAFNVADSAICVGVALLALDMIRDERRQSKDN
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MKPNYRIFSIVTAVSLVIDQATKILVDRTLELYQSIPVVPGLFSITYMRNKGAAFSFLSN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCHHHHHHC
FDYRRPFFIAVTLVAMAAIAITFRKLRDDQRLAAVSLSLIFSGAVGNLIDRVRLGEVIDF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVYWKTHHWPAFNVADSAICVGVALLALDMIRDERRQSKDN
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA