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The map label for this gene is ctaB

Identifier: 78221476

GI number: 78221476

Start: 283347

End: 284162

Strand: Direct

Name: ctaB

Synonym: Gmet_0253

Alternate gene names: 78221476

Gene position: 283347-284162 (Clockwise)

Preceding gene: 78221475

Following gene: 78221478

Centisome position: 7.09

GC content: 66.54

Gene sequence:

>816_bases
ATGATTGCGGAGGCCAGTCGGCTGCTTCGACCCCGTCTCGCGCTGCTGAACGGCATCGCGGCAGTGGCGGGGTGTCTCCT
CGCCCCGGAGGGAGCGGCGATGTCACTCATCGTCGCATCCCTGGCGGGGGTGACGCTTCTTGCTGCCGGGGGATCGGCCC
TCAACCAGGTGATGGAACGGGACCTGGATCTCCTCATGGAGCGGACCCGGCAGCGCCCCCTCCCCACGGGAGAGCTCTCT
CCTCGGGCGGCAACGGCCATCGGCGGCATCAGCATCATCGCCGGCCTCGTTGTGCTTGCCGGGACCGGGGGGATATTCCC
CCCCCTCATCGGTGTCGGCGCCCTGGCCTGGTACCTGGGGATCTACACCCCCCTCAAGCGCCGCACTTCCTGCTCCCTCC
TGGCCGGAGCCGTGAGCGGAGCTGTTCCACCCCTTGTGGGCTGGACCATAACCGGCGGGAGTCTCGTCGATTTCCGGATT
GTACTCGTGGCAGGCCTTCTCTATCTCTGGCAGATCCCCCACTTCTGGTTGCTCCAGTGTCGCCACGCAGAAGACTACCG
GCGGGCGGGGCTCCCGCTCTTCGCTCCCGGCGTTACGGCCGGCTCACCCGTCTTCAGGGTCTGGATCGGGGCATTCGCGG
CAGGGACGCTCCTGCTGCCGCTGTTCGGCATCATCGGAGGCAGTGCCGCACCCGGTTTTTGCGCTTTCCCTCTCCTCCTG
GTCCTCCTCGCATTCTCCCGAGCCGAGGGTGCCCTCTTCTCCAGCCTTAACCTCTTCCCGCTTCTGATGGTCCTGGCTCT
CTATCTCCAGCGGTAA

Upstream 100 bases:

>100_bases
GGGCCGATGTGGTCAAGGGATACCCGCCAGTCATGCCCCCCTATTCAGCCCTCTCCGATAAGGATATCGAGGAAATTATG
GATTTCCTGAAGGATCTCAA

Downstream 100 bases:

>100_bases
ATTCCATCAGCTCCTTCATCATATTGCGCGACGCTCATGCGTTTCGCTCGCCCCCGGCCCGGGGGAGGGACCAGTTGTAG
CGGATGGCCAGGAGCCGCAC

Product: UbiA prenyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MIAEASRLLRPRLALLNGIAAVAGCLLAPEGAAMSLIVASLAGVTLLAAGGSALNQVMERDLDLLMERTRQRPLPTGELS
PRAATAIGGISIIAGLVVLAGTGGIFPPLIGVGALAWYLGIYTPLKRRTSCSLLAGAVSGAVPPLVGWTITGGSLVDFRI
VLVAGLLYLWQIPHFWLLQCRHAEDYRRAGLPLFAPGVTAGSPVFRVWIGAFAAGTLLLPLFGIIGGSAAPGFCAFPLLL
VLLAFSRAEGALFSSLNLFPLLMVLALYLQR

Sequences:

>Translated_271_residues
MIAEASRLLRPRLALLNGIAAVAGCLLAPEGAAMSLIVASLAGVTLLAAGGSALNQVMERDLDLLMERTRQRPLPTGELS
PRAATAIGGISIIAGLVVLAGTGGIFPPLIGVGALAWYLGIYTPLKRRTSCSLLAGAVSGAVPPLVGWTITGGSLVDFRI
VLVAGLLYLWQIPHFWLLQCRHAEDYRRAGLPLFAPGVTAGSPVFRVWIGAFAAGTLLLPLFGIIGGSAAPGFCAFPLLL
VLLAFSRAEGALFSSLNLFPLLMVLALYLQR
>Mature_271_residues
MIAEASRLLRPRLALLNGIAAVAGCLLAPEGAAMSLIVASLAGVTLLAAGGSALNQVMERDLDLLMERTRQRPLPTGELS
PRAATAIGGISIIAGLVVLAGTGGIFPPLIGVGALAWYLGIYTPLKRRTSCSLLAGAVSGAVPPLVGWTITGGSLVDFRI
VLVAGLLYLWQIPHFWLLQCRHAEDYRRAGLPLFAPGVTAGSPVFRVWIGAFAAGTLLLPLFGIIGGSAAPGFCAFPLLL
VLLAFSRAEGALFSSLNLFPLLMVLALYLQR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=187, Percent_Identity=35.8288770053476, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786631, Length=230, Percent_Identity=30.8695652173913, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71998235, Length=185, Percent_Identity=36.2162162162162, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=191, Percent_Identity=30.8900523560209, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921064, Length=195, Percent_Identity=35.3846153846154, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_GEOMG (Q39Z26)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383223.1
- STRING:   Q39Z26
- GeneID:   3739716
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0253
- NMPDR:   fig|269799.3.peg.283
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   AKMARTR
- PhylomeDB:   Q39Z26
- ProtClustDB:   CLSK743077
- BioCyc:   GMET269799:GMET_0253-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 28248; Mature: 28248

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00943 UBIA; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x960bd74)-; HASH(0xb808c0c)-; HASH(0x9529bd4)-; HASH(0x105f0980)-; HASH(0x105ee094)-; HASH(0x952cc8c)-; HASH(0x101be0e4)-; HASH(0xd0934d0)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAEASRLLRPRLALLNGIAAVAGCLLAPEGAAMSLIVASLAGVTLLAAGGSALNQVMER
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLDLLMERTRQRPLPTGELSPRAATAIGGISIIAGLVVLAGTGGIFPPLIGVGALAWYLG
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IYTPLKRRTSCSLLAGAVSGAVPPLVGWTITGGSLVDFRIVLVAGLLYLWQIPHFWLLQC
HHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
RHAEDYRRAGLPLFAPGVTAGSPVFRVWIGAFAAGTLLLPLFGIIGGSAAPGFCAFPLLL
HCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VLLAFSRAEGALFSSLNLFPLLMVLALYLQR
HHHHHHHHCHHHHHHCCHHHHHHHHHHHHCH
>Mature Secondary Structure
MIAEASRLLRPRLALLNGIAAVAGCLLAPEGAAMSLIVASLAGVTLLAAGGSALNQVMER
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLDLLMERTRQRPLPTGELSPRAATAIGGISIIAGLVVLAGTGGIFPPLIGVGALAWYLG
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IYTPLKRRTSCSLLAGAVSGAVPPLVGWTITGGSLVDFRIVLVAGLLYLWQIPHFWLLQC
HHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
RHAEDYRRAGLPLFAPGVTAGSPVFRVWIGAFAAGTLLLPLFGIIGGSAAPGFCAFPLLL
HCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VLLAFSRAEGALFSSLNLFPLLMVLALYLQR
HHHHHHHHCHHHHHHCCHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA