Click here to switch to the map view.

The map label for this gene is dapA

Identifier: 78221435

GI number: 78221435

Start: 244750

End: 245622

Strand: Direct

Name: dapA

Synonym: Gmet_0211

Alternate gene names: 78221435

Gene position: 244750-245622 (Clockwise)

Preceding gene: 78221434

Following gene: 78221436

Centisome position: 6.12

GC content: 60.71

Gene sequence:

>873_bases
ATGTTCAAGGGAAGCATCGTCGCCATCGTCACCCCGTTCAATAACGGCCAGGTGGATTTTGAGAAACTGCGGGAACTGGT
CGAATTCCAGATCTCCAACGGTACCGACGCCATCGTCCCCTGCGGCACCACCGGCGAGGCTTCGACCCTGGACTACGACG
AGCACATGGATGTGGTGAAGACCGTCATCGAGCAGGTCAACAAGCGGGTTCCGGTCATTGCCGGCACCGGCTCCAACTCC
ACCGCCGAGGCCATCGAGCTTTCCCAGAAGGCCAAGGAGGTCGGGGCCGACGGCGTGCTGCTCGTCACCCCTTACTACAA
CAAGCCGACCCAGGAGGGGCTCGTTCGCCACTACACCGCCATCGCCGATGCCGTGGCCATACCCCAGATCCTTTACAACG
TGCCGGGACGCACCGGCGTCAACATGCTCCCCGAAACCGTGGCCCGGCTGGCGCCCCACAAAAACATCGTCGCCATCAAG
GAGGCCACCGGCTCGCTCCAGCAGGCATCTGAGATTCTGGCGCTTTGCGGCGATAAGATCGACGTTCTCTGCGGCGACGA
CTTCATCACCTTTCCCATGATGGCCTGCGGCGCCAAGGGGGTCATCTCGGTGCTGGCCAACATCATGCCCAAGACCGTGG
CCGAACTGACAGATGCCTTTTACGCCGGGGACATGGAGAAGGCCCGTCAGCTCCACCTGCAAACCCTCAAGATCGGCAAT
GCCATGTTCATCGAGTCGAACCCGATTCCGGTGAAAACCGCCCTCGGCCTTATGGGCAAGTGCTCCGACGAGGTGCGGCT
CCCGCTTTGCCCCATGGGTGCGGCCAACAAAGAGAAGCTTGCGGCCATCATGAAAGAGTACGAACTAATCTAA

Upstream 100 bases:

>100_bases
AATGAAACACCTTTTTATACATTGGGCAAGCTGAGGATTACTGACAGATTTTTTGCAAAACGGGCTATCACAAAGATCGC
CCCCACATAGGAGGTTTCAT

Downstream 100 bases:

>100_bases
ATTCAAAGTCCGCCACAGAGGCACAGAGAAACGGAGAAAGCTGTGTTTGCCAGGCATTGACGCTGAGGTTTTTCTCTGTG
TCTCCGTGTCCCTGTGGCGG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MFKGSIVAIVTPFNNGQVDFEKLRELVEFQISNGTDAIVPCGTTGEASTLDYDEHMDVVKTVIEQVNKRVPVIAGTGSNS
TAEAIELSQKAKEVGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIK
EATGSLQQASEILALCGDKIDVLCGDDFITFPMMACGAKGVISVLANIMPKTVAELTDAFYAGDMEKARQLHLQTLKIGN
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMGAANKEKLAAIMKEYELI

Sequences:

>Translated_290_residues
MFKGSIVAIVTPFNNGQVDFEKLRELVEFQISNGTDAIVPCGTTGEASTLDYDEHMDVVKTVIEQVNKRVPVIAGTGSNS
TAEAIELSQKAKEVGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIK
EATGSLQQASEILALCGDKIDVLCGDDFITFPMMACGAKGVISVLANIMPKTVAELTDAFYAGDMEKARQLHLQTLKIGN
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMGAANKEKLAAIMKEYELI
>Mature_290_residues
MFKGSIVAIVTPFNNGQVDFEKLRELVEFQISNGTDAIVPCGTTGEASTLDYDEHMDVVKTVIEQVNKRVPVIAGTGSNS
TAEAIELSQKAKEVGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIK
EATGSLQQASEILALCGDKIDVLCGDDFITFPMMACGAKGVISVLANIMPKTVAELTDAFYAGDMEKARQLHLQTLKIGN
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMGAANKEKLAAIMKEYELI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=277, Percent_Identity=29.9638989169675, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI13540533, Length=238, Percent_Identity=27.3109243697479, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788823, Length=294, Percent_Identity=46.9387755102041, Blast_Score=268, Evalue=2e-73,
Organism=Escherichia coli, GI1786463, Length=285, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI87082415, Length=242, Percent_Identity=35.1239669421488, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789620, Length=283, Percent_Identity=31.4487632508834, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_GEOMG (Q39Z67)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383182.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q39Z67
- SMR:   Q39Z67
- STRING:   Q39Z67
- GeneID:   3739673
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0211
- NMPDR:   fig|269799.3.peg.242
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- PhylomeDB:   Q39Z67
- ProtClustDB:   PRK03170
- BioCyc:   GMET269799:GMET_0211-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31126; Mature: 31126

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 160-160 BINDING 105-105

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKGSIVAIVTPFNNGQVDFEKLRELVEFQISNGTDAIVPCGTTGEASTLDYDEHMDVVK
CCCCCEEEEEECCCCCCCCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCHHHHHHHHH
TVIEQVNKRVPVIAGTGSNSTAEAIELSQKAKEVGADGVLLVTPYYNKPTQEGLVRHYTA
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
IADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIKEATGSLQQASEILALCGDKI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCE
DVLCGDDFITFPMMACGAKGVISVLANIMPKTVAELTDAFYAGDMEKARQLHLQTLKIGN
EEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMGAANKEKLAAIMKEYELI
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKGSIVAIVTPFNNGQVDFEKLRELVEFQISNGTDAIVPCGTTGEASTLDYDEHMDVVK
CCCCCEEEEEECCCCCCCCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCHHHHHHHHH
TVIEQVNKRVPVIAGTGSNSTAEAIELSQKAKEVGADGVLLVTPYYNKPTQEGLVRHYTA
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
IADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIKEATGSLQQASEILALCGDKI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCE
DVLCGDDFITFPMMACGAKGVISVLANIMPKTVAELTDAFYAGDMEKARQLHLQTLKIGN
EEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
AMFIESNPIPVKTALGLMGKCSDEVRLPLCPMGAANKEKLAAIMKEYELI
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA