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The map label for this gene is tpx [H]

Identifier: 78221407

GI number: 78221407

Start: 213288

End: 213803

Strand: Reverse

Name: tpx [H]

Synonym: Gmet_0183

Alternate gene names: 78221407

Gene position: 213803-213288 (Counterclockwise)

Preceding gene: 78221408

Following gene: 78221401

Centisome position: 5.35

GC content: 65.89

Gene sequence:

>516_bases
ATGCAGGAACGCCCAGGCATCATCACCTTCAAGGGAAACCCCATGACGCTCCTCGGCCCGGCCCTGGCGGTGGGTGACAA
GGCCCCGGCCTTCATCGCCGTGGACACCGGCCTCGCCCCGGTATCCCTGGCCGACTTCGCCGGGAAGGTCAAAATCATCA
GCGCCGTCCCCTCCCTCGACACACCGGTCTGCGACACGGAGACCCGCCGCTTCAACCAGGAAGCGGCAACTCTGCCGGAC
AATGTCGTGCTGCTCACCGTGAGCATGGACCTCCCCTTTGCCCAGAAGCGCTGGTGCGGTGCCGCCGGCATCGACCGGGT
AAAGACCCTCTCCGACTACCGGGACCGCTCCTTCGGCCTCGCCTACGGGGTGGTCATCAAGGAGCTGATGCTCCTCTCCC
GCTCCCTCTTCGTCATCGACGCCACGGACACCATCCGGTACCTCCAGCATGTGCCCGAAGTGACCAGCGAGCCCGACTAC
GCGGCGGTTCTTGCCGCGGCCAAGAGTCTCCTGTAG

Upstream 100 bases:

>100_bases
GCAGCTGGAAGGAAGCTGACGCGGCACGAGGTTCCTCCTTTTCTTTTCGCCCCCATGGAGTAGACTTGTGGGGCAATCAA
CCCGAAAAGGAGGAACACCA

Downstream 100 bases:

>100_bases
CCGACAACCAGTACGCCGGAACGGAAAAGGCCTGCACAAAATGCAGGCCTTTTTTTGTGGTACCGCTATGCAATTGTCGT
CGGGACGCTACCCGTGCCTC

Product: thiol peroxidase (atypical 2-Cys peroxiredoxin)

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MQERPGIITFKGNPMTLLGPALAVGDKAPAFIAVDTGLAPVSLADFAGKVKIISAVPSLDTPVCDTETRRFNQEAATLPD
NVVLLTVSMDLPFAQKRWCGAAGIDRVKTLSDYRDRSFGLAYGVVIKELMLLSRSLFVIDATDTIRYLQHVPEVTSEPDY
AAVLAAAKSLL

Sequences:

>Translated_171_residues
MQERPGIITFKGNPMTLLGPALAVGDKAPAFIAVDTGLAPVSLADFAGKVKIISAVPSLDTPVCDTETRRFNQEAATLPD
NVVLLTVSMDLPFAQKRWCGAAGIDRVKTLSDYRDRSFGLAYGVVIKELMLLSRSLFVIDATDTIRYLQHVPEVTSEPDY
AAVLAAAKSLL
>Mature_171_residues
MQERPGIITFKGNPMTLLGPALAVGDKAPAFIAVDTGLAPVSLADFAGKVKIISAVPSLDTPVCDTETRRFNQEAATLPD
NVVLLTVSMDLPFAQKRWCGAAGIDRVKTLSDYRDRSFGLAYGVVIKELMLLSRSLFVIDATDTIRYLQHVPEVTSEPDY
AAVLAAAKSLL

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=165, Percent_Identity=45.4545454545455, Blast_Score=140, Evalue=6e-35,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18396; Mature: 18396

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERPGIITFKGNPMTLLGPALAVGDKAPAFIAVDTGLAPVSLADFAGKVKIISAVPSLD
CCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCEEHHHHCCCEEEEEECCCCC
TPVCDTETRRFNQEAATLPDNVVLLTVSMDLPFAQKRWCGAAGIDRVKTLSDYRDRSFGL
CCCCCCHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCH
AYGVVIKELMLLSRSLFVIDATDTIRYLQHVPEVTSEPDYAAVLAAAKSLL
HHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQERPGIITFKGNPMTLLGPALAVGDKAPAFIAVDTGLAPVSLADFAGKVKIISAVPSLD
CCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCEEHHHHCCCEEEEEECCCCC
TPVCDTETRRFNQEAATLPDNVVLLTVSMDLPFAQKRWCGAAGIDRVKTLSDYRDRSFGL
CCCCCCHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCH
AYGVVIKELMLLSRSLFVIDATDTIRYLQHVPEVTSEPDYAAVLAAAKSLL
HHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]