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The map label for this gene is nuoI1

Identifier: 78221388

GI number: 78221388

Start: 193125

End: 193679

Strand: Direct

Name: nuoI1

Synonym: Gmet_0163

Alternate gene names: 78221388

Gene position: 193125-193679 (Clockwise)

Preceding gene: 78221387

Following gene: 78221389

Centisome position: 4.83

GC content: 66.31

Gene sequence:

>555_bases
ATGCCTCGCCCCTCTGTTGCCACCATGCCCATCATCACCGACTTCAAAGCAATCGCCACCGGGCTCTTTGTCACCTGGAA
GCACATCTTCCGCAGGAGCGTCACGGTGGAATACCCCGAGGTGAAGCGGACCCCCGCTCCCCGCTACCGGGCGAGGATCG
TCCTCACCCGCGACCCCGAGGGGGGAGAGCGGTGCGTGGCCTGCTACCTCTGCTCCGCCGCCTGCCCCGTTGACTGCATC
TCCATGGAGGCGACCGAGGACGGGAACGGCCGCCGGTACGCCCGGTGGTTCCGGATCAACTTCTCCCGCTGCATCTTCTG
CGGCCTCTGCGCCGAGGCCTGCCCCACCCTCGCCATCCAGATGACCCCTGACTACGAGATCTGCGAGCGGGACATCATGG
AACTGGTCTACGAGAAGGAAGACCTCCTCATCGACGGCTGCGGCAAGGACCCCGCCTACAACTTCTACCGCCATGCCGGC
ATCGGCGTCACCCAGCCACGGGGCGCCGGCGAGCGGGAAGAGGAACCGGTTGATGCGCGGGGACTCATGCCGTGA

Upstream 100 bases:

>100_bases
GAACGGACACCCCGACACCCTGGAACTGATAACGAAGGCCCAGCGGGCCAAGGCCGGAAACGCCTGATCCTGCAAGGGTA
CGTTACCGCAGGGGCGGGGG

Downstream 100 bases:

>100_bases
CATCCCCACGCCTGAGCGTCTAACCGGCAGACCGATCCTGCCTCTCCATCCCCGCATTCCGCAAGCCCTCCCCTTCCACA
GCAACAGACTTTATGCCGAA

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 1; NDH-1 subunit I 1

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MPRPSVATMPIITDFKAIATGLFVTWKHIFRRSVTVEYPEVKRTPAPRYRARIVLTRDPEGGERCVACYLCSAACPVDCI
SMEATEDGNGRRYARWFRINFSRCIFCGLCAEACPTLAIQMTPDYEICERDIMELVYEKEDLLIDGCGKDPAYNFYRHAG
IGVTQPRGAGEREEEPVDARGLMP

Sequences:

>Translated_184_residues
MPRPSVATMPIITDFKAIATGLFVTWKHIFRRSVTVEYPEVKRTPAPRYRARIVLTRDPEGGERCVACYLCSAACPVDCI
SMEATEDGNGRRYARWFRINFSRCIFCGLCAEACPTLAIQMTPDYEICERDIMELVYEKEDLLIDGCGKDPAYNFYRHAG
IGVTQPRGAGEREEEPVDARGLMP
>Mature_183_residues
PRPSVATMPIITDFKAIATGLFVTWKHIFRRSVTVEYPEVKRTPAPRYRARIVLTRDPEGGERCVACYLCSAACPVDCIS
MEATEDGNGRRYARWFRINFSRCIFCGLCAEACPTLAIQMTPDYEICERDIMELVYEKEDLLIDGCGKDPAYNFYRHAGI
GVTQPRGAGEREEEPVDARGLMP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=126, Percent_Identity=42.0634920634921, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1788617, Length=175, Percent_Identity=53.7142857142857, Blast_Score=191, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17555194, Length=132, Percent_Identity=40.1515151515151, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17864306, Length=132, Percent_Identity=42.4242424242424, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI1_GEOMG (Q39ZB4)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383135.1
- ProteinModelPortal:   Q39ZB4
- SMR:   Q39ZB4
- STRING:   Q39ZB4
- GeneID:   3739644
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0163
- NMPDR:   fig|269799.3.peg.61
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   DFFRINF
- PhylomeDB:   Q39ZB4
- ProtClustDB:   PRK05888
- BioCyc:   GMET269799:GMET_0163-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 20783; Mature: 20652

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
9.2 %Cys+Met (Translated Protein)
6.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPSVATMPIITDFKAIATGLFVTWKHIFRRSVTVEYPEVKRTPAPRYRARIVLTRDPE
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEEECCC
GGERCVACYLCSAACPVDCISMEATEDGNGRRYARWFRINFSRCIFCGLCAEACPTLAIQ
CCHHEEEEEHHCCCCCCEEEEEECCCCCCCCEEEEEEEECHHHHHHHHHHHHCCCEEEEE
MTPDYEICERDIMELVYEKEDLLIDGCGKDPAYNFYRHAGIGVTQPRGAGEREEEPVDAR
ECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
GLMP
CCCC
>Mature Secondary Structure 
PRPSVATMPIITDFKAIATGLFVTWKHIFRRSVTVEYPEVKRTPAPRYRARIVLTRDPE
CCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEEECCC
GGERCVACYLCSAACPVDCISMEATEDGNGRRYARWFRINFSRCIFCGLCAEACPTLAIQ
CCHHEEEEEHHCCCCCCEEEEEECCCCCCCCEEEEEEEECHHHHHHHHHHHHCCCEEEEE
MTPDYEICERDIMELVYEKEDLLIDGCGKDPAYNFYRHAGIGVTQPRGAGEREEEPVDAR
ECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
GLMP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA