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The map label for this gene is nuoF [H]

Identifier: 78221382

GI number: 78221382

Start: 187117

End: 188385

Strand: Direct

Name: nuoF [H]

Synonym: Gmet_0157

Alternate gene names: 78221382

Gene position: 187117-188385 (Clockwise)

Preceding gene: 78221381

Following gene: 78221383

Centisome position: 4.68

GC content: 68.16

Gene sequence:

>1269_bases
ATGGAACAGCTCCTCTTCCGACATAACCGCCCCGGCCGGTGCGTGACCTTTGCCGAGTACCGGGCCGAGGGGGGCTTCGC
GGCGCTGGAGAAAGCCCTTGCCGGCATGTCCCCCAACGACGTCCAGCAGGTCGTGATCGACTCGGGCCTGCGCGGCCGCG
GCGGCGCCGGCTTCCCCACGGGGAAGAAGTGGTCCTTCGTCCCCCGGGACATCCCCGGCCCCCGTTACCTCATCTGCAAC
TGCGACGAGATGGAGCCGGGGACCTACAAGGACCGGGTGCTCCTGGAGGCGAACCCCTATTCCCTCGTGGAGGGGATGAC
CCTGGCCGCCTACGCCATCGGTGTGGCCCACGCCTTCATCTTCATCCGGCGGGGGTACGAGGAGGCGGCGGAGAACTGCC
GCCGGGCCATCGCCGAGGCGAAAGCGGCGGGGCTTCTGGGGGAGAACATCCTCGGCACCGGCTTCTCCCTGGAGCTGGAC
GTCCACCAGTCCGCCGGGCGCTACATCTGCGGCGAGGAAACCGCTCTCATGAACGCCCTGGAGGGGAAGCGGGCCAATCC
GCGGAGCAAGCCCCCCTTCCCGGCGGTGAAGGGGCTCTGGGGGCGCCCCACGGTGGTGAACAACGTGGAGACCCTGGCAA
ACATCCCGGCCATCGTGGCCAACGGGGCCGCCTGGTTCAAGGGGCTGGCACGGATCCCCGAGGCGGCGGGGATGAAGCTC
TTCTGCGTGAGCGGCCATGTGAACAACACCGCCTGCTTCGAGTTGCCGCTCGGGATGACCCTGGGCGAGATCATCGACGG
CCCCTGCGGCGGGATGCTCCCGGGACGGGAGTTCAAGGCGTGCATCCCCGGTGGGGCGTCGACGCCGTTCTTCACGAAGG
AGCACTGGCACGTTCCCATGGATTTCGACACCGTGGCCAAGGCCGGGTCCCGGCTCGGCACCGGCGGCATCGTGGTCTTC
GACCGGGACACCTGCATGGTGGCGGCAACCCTGAACCTAATCGTCTTCTACGCCCGGGAATCGTGCGGCTGGTGCACCCC
CTGCCGGGAGGGGCTCCCCTTCGTGCAGGACGTCCTGGCCCGGATCGAGGCGGGGGAGGGACGGGAGGAGCACATCGGCA
TCCTCCGGGAGCATATCCAATACCTCAACTACTCCTTCTGTCCCCTGGCCCCGGGCGCCATGGGGCCGGTGGAGGGACTG
TTGCGGCTCTTCGAGGGCGAGATCCGGGAGCATATTGTTCTGGGGCGCTGCCCCTTTGGAGGGAAATGA

Upstream 100 bases:

>100_bases
TCGGACTCTTGTCGGCAAGGGAACGGTAACGCTCCTCTTTGCGGCCAAGGATGAAGAGCACAACAACGCGGTGGTTTTGA
AGGAAATGCTCGATTAGCCC

Downstream 100 bases:

>100_bases
TGGCACCACCGGTGGATGATTTCGGCGGCCTCGTCACCCGGGCCACACGGCTCTGGACAGGGAACTTCGGCAACCTGCTC
ATTCTCTCCCTGGTCTTCGT

Product: respiratory-chain NADH dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F; NUO6 [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MEQLLFRHNRPGRCVTFAEYRAEGGFAALEKALAGMSPNDVQQVVIDSGLRGRGGAGFPTGKKWSFVPRDIPGPRYLICN
CDEMEPGTYKDRVLLEANPYSLVEGMTLAAYAIGVAHAFIFIRRGYEEAAENCRRAIAEAKAAGLLGENILGTGFSLELD
VHQSAGRYICGEETALMNALEGKRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARIPEAAGMKL
FCVSGHVNNTACFELPLGMTLGEIIDGPCGGMLPGREFKACIPGGASTPFFTKEHWHVPMDFDTVAKAGSRLGTGGIVVF
DRDTCMVAATLNLIVFYARESCGWCTPCREGLPFVQDVLARIEAGEGREEHIGILREHIQYLNYSFCPLAPGAMGPVEGL
LRLFEGEIREHIVLGRCPFGGK

Sequences:

>Translated_422_residues
MEQLLFRHNRPGRCVTFAEYRAEGGFAALEKALAGMSPNDVQQVVIDSGLRGRGGAGFPTGKKWSFVPRDIPGPRYLICN
CDEMEPGTYKDRVLLEANPYSLVEGMTLAAYAIGVAHAFIFIRRGYEEAAENCRRAIAEAKAAGLLGENILGTGFSLELD
VHQSAGRYICGEETALMNALEGKRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARIPEAAGMKL
FCVSGHVNNTACFELPLGMTLGEIIDGPCGGMLPGREFKACIPGGASTPFFTKEHWHVPMDFDTVAKAGSRLGTGGIVVF
DRDTCMVAATLNLIVFYARESCGWCTPCREGLPFVQDVLARIEAGEGREEHIGILREHIQYLNYSFCPLAPGAMGPVEGL
LRLFEGEIREHIVLGRCPFGGK
>Mature_422_residues
MEQLLFRHNRPGRCVTFAEYRAEGGFAALEKALAGMSPNDVQQVVIDSGLRGRGGAGFPTGKKWSFVPRDIPGPRYLICN
CDEMEPGTYKDRVLLEANPYSLVEGMTLAAYAIGVAHAFIFIRRGYEEAAENCRRAIAEAKAAGLLGENILGTGFSLELD
VHQSAGRYICGEETALMNALEGKRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARIPEAAGMKL
FCVSGHVNNTACFELPLGMTLGEIIDGPCGGMLPGREFKACIPGGASTPFFTKEHWHVPMDFDTVAKAGSRLGTGGIVVF
DRDTCMVAATLNLIVFYARESCGWCTPCREGLPFVQDVLARIEAGEGREEHIGILREHIQYLNYSFCPLAPGAMGPVEGL
LRLFEGEIREHIVLGRCPFGGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=379, Percent_Identity=45.646437994723, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI260656005, Length=379, Percent_Identity=45.646437994723, Blast_Score=307, Evalue=1e-83,
Organism=Escherichia coli, GI1788620, Length=412, Percent_Identity=52.1844660194175, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17531727, Length=369, Percent_Identity=43.9024390243902, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI19920794, Length=371, Percent_Identity=46.0916442048518, Blast_Score=311, Evalue=4e-85,
Organism=Drosophila melanogaster, GI45550452, Length=372, Percent_Identity=44.8924731182796, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24653819, Length=382, Percent_Identity=37.434554973822, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24653817, Length=358, Percent_Identity=36.0335195530726, Blast_Score=221, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45651; Mature: 45651

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLLFRHNRPGRCVTFAEYRAEGGFAALEKALAGMSPNDVQQVVIDSGLRGRGGAGFPT
CCCCHHHCCCCCCEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
GKKWSFVPRDIPGPRYLICNCDEMEPGTYKDRVLLEANPYSLVEGMTLAAYAIGVAHAFI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FIRRGYEEAAENCRRAIAEAKAAGLLGENILGTGFSLELDVHQSAGRYICGEETALMNAL
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEECCCHHHHHHHH
EGKRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARIPEAAGMKL
CCCCCCCCCCCCCHHHCCCCCCCCHHHCHHHHHHCCHHHCCCHHHHHHHHHCHHHCCCEE
FCVSGHVNNTACFELPLGMTLGEIIDGPCGGMLPGREFKACIPGGASTPFFTKEHWHVPM
EEEECCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCC
DFDTVAKAGSRLGTGGIVVFDRDTCMVAATLNLIVFYARESCGWCTPCREGLPFVQDVLA
CHHHHHHCCCCCCCCCEEEEECCCEEHHHHHHHHEEEECCCCCCCCHHHCCCCHHHHHHH
RIEAGEGREEHIGILREHIQYLNYSFCPLAPGAMGPVEGLLRLFEGEIREHIVLGRCPFG
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCC
GK
CC
>Mature Secondary Structure
MEQLLFRHNRPGRCVTFAEYRAEGGFAALEKALAGMSPNDVQQVVIDSGLRGRGGAGFPT
CCCCHHHCCCCCCEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
GKKWSFVPRDIPGPRYLICNCDEMEPGTYKDRVLLEANPYSLVEGMTLAAYAIGVAHAFI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FIRRGYEEAAENCRRAIAEAKAAGLLGENILGTGFSLELDVHQSAGRYICGEETALMNAL
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEECCCHHHHHHHH
EGKRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARIPEAAGMKL
CCCCCCCCCCCCCHHHCCCCCCCCHHHCHHHHHHCCHHHCCCHHHHHHHHHCHHHCCCEE
FCVSGHVNNTACFELPLGMTLGEIIDGPCGGMLPGREFKACIPGGASTPFFTKEHWHVPM
EEEECCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCC
DFDTVAKAGSRLGTGGIVVFDRDTCMVAATLNLIVFYARESCGWCTPCREGLPFVQDVLA
CHHHHHHCCCCCCCCCEEEEECCCEEHHHHHHHHEEEECCCCCCCCHHHCCCCHHHHHHH
RIEAGEGREEHIGILREHIQYLNYSFCPLAPGAMGPVEGLLRLFEGEIREHIVLGRCPFG
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCC
GK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7690854; 8157582; 9205837; 9278503; 8366049 [H]