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The map label for this gene is selA

Identifier: 78221288

GI number: 78221288

Start: 75140

End: 76528

Strand: Reverse

Name: selA

Synonym: Gmet_0061

Alternate gene names: 78221288

Gene position: 76528-75140 (Counterclockwise)

Preceding gene: 78221289

Following gene: 78221287

Centisome position: 1.91

GC content: 64.87

Gene sequence:

>1389_bases
GTGACGCTCTTTGCGCGTATCCCCAAAGTTGACAAAATTCTCGAATGGGATGGGACCAAGGTCCTTCTCGGCATTCATCC
CCGCCCGACCGTCCTCAACGCTGTCAGGTCCGTTCTTGACTCCCTCCGCACCGCTGCCCGCAGCGGCTTTCTCAAGGAAG
AGGAACTGCTCGAAGGTGCGGTAGCGTCGAGAATCGAGCGGGAAGTTGCCCGCTCGACCGCCTTCAGTCTGCGGCGTGTG
GTCAACGGGACCGGCGTCGTGATCCATACGAACCTGGGGCGCTCCCCCCTGTCGAAGCGGGTGAAACCGCTCCTGGACGA
GATCGCCTTCGGCTACTCCAACCTCGAATTCGACCTGGAAAAGGGAGAGCGGGGAAGCCGTTACAGCCACGTGGAACGGC
TTCTCTGCGACCTGACCGGTGCCGAGGCGGCCCTGGTGGTGAACAATAACGCTGCCGCCGTGCTCCTTGCCCTGTCGGCC
CTGGCGGCCGGGAAGGAAGTCGTCGTTTCCCGGGGGGAACTGGTGGAGATTGGGGGGTCCTTCCGCATTCCCGATGTCAT
GGGGCAGGGAGGCGCTATTCTCCGGGAGGTGGGGACCACCAACCGGACCCATCCCCGCGACTACCACCAGGCGGTCTCGG
AGCAGACGGCGCTTCTCCTCAAGGTCCATTCCAGCAATTTTGCCGTGGTCGGCTTTACTGCCGAAGTGTCCGCCACCGAG
CTTGTCGCCATCGGCAAAGAGCATTCCGTGCCGGTCATGGCCGACATCGGGAGTGGATGCCTCCTGGACCTCTCTCCCTT
CGGCATCCGGGGCGAGCCGACGGTTCAGGAATTCGTCAAGGCGGGAGTCGACGTCATCACCTTCAGCGGCGACAAGCTCC
TCGGCGGCCCCCAGGCAGGGATCATCGTCGGCCGCAGGGAATTCATCGCTCCCCTCACGCAGCATCCCCTCCTGCGGGCG
CTGCGGATCGACAAGCTGACCCTGGCTGCACTGGAAGGAACGCTCCGCCTCTACCGGGACGAACGGCTGGCCCTGGCCGA
GATCCCGACCCTCCGGATGCTTACCGCGTCGGCCGCGGAGCTGGCGACCCGTGCCAGGAGCTTTGCGCGACGCATCCGCC
GGGCATCCCCGCCGGACATCCGACTCACCCTCACCAGCGGCATCTCCCAGGTGGGGGGAGGAGCCTATCCCCTCCTCGAA
CTGCCAACGACCCTCATGGCCATGGAGGCCGACGGCATCTCTCCCCAGGAGATGGAAATCCGCCTCCGGGGAATGGAGGT
TCCGGTCACCGGCCGCATCCACAGGGGACGGTTCCTCCTCGATGTCCGCACCCTCCAGGATGACGATATCCCGTTCATAG
CCGCGGCCCTCAGCAGTCTTGCCGACTAG

Upstream 100 bases:

>100_bases
CCTTTTCCCTGTCACGGGGCGGCCTTGACAGGCCGGCATCGATCTGGTAGTGAGGTTTCTCGTTCCACAACCTCCACCTC
CCCAGACAGAGGACGCCCCC

Downstream 100 bases:

>100_bases
GAACTCCTACCGTTGTGGCGCGACTTTTGTCTGGTCTTTTGCCTATCCTTTTGTATAATCGGATAATTCCGGCCGGCTGC
TCCCGCAGCGCACCGGCCCG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTLFARIPKVDKILEWDGTKVLLGIHPRPTVLNAVRSVLDSLRTAARSGFLKEEELLEGAVASRIEREVARSTAFSLRRV
VNGTGVVIHTNLGRSPLSKRVKPLLDEIAFGYSNLEFDLEKGERGSRYSHVERLLCDLTGAEAALVVNNNAAAVLLALSA
LAAGKEVVVSRGELVEIGGSFRIPDVMGQGGAILREVGTTNRTHPRDYHQAVSEQTALLLKVHSSNFAVVGFTAEVSATE
LVAIGKEHSVPVMADIGSGCLLDLSPFGIRGEPTVQEFVKAGVDVITFSGDKLLGGPQAGIIVGRREFIAPLTQHPLLRA
LRIDKLTLAALEGTLRLYRDERLALAEIPTLRMLTASAAELATRARSFARRIRRASPPDIRLTLTSGISQVGGGAYPLLE
LPTTLMAMEADGISPQEMEIRLRGMEVPVTGRIHRGRFLLDVRTLQDDDIPFIAAALSSLAD

Sequences:

>Translated_462_residues
MTLFARIPKVDKILEWDGTKVLLGIHPRPTVLNAVRSVLDSLRTAARSGFLKEEELLEGAVASRIEREVARSTAFSLRRV
VNGTGVVIHTNLGRSPLSKRVKPLLDEIAFGYSNLEFDLEKGERGSRYSHVERLLCDLTGAEAALVVNNNAAAVLLALSA
LAAGKEVVVSRGELVEIGGSFRIPDVMGQGGAILREVGTTNRTHPRDYHQAVSEQTALLLKVHSSNFAVVGFTAEVSATE
LVAIGKEHSVPVMADIGSGCLLDLSPFGIRGEPTVQEFVKAGVDVITFSGDKLLGGPQAGIIVGRREFIAPLTQHPLLRA
LRIDKLTLAALEGTLRLYRDERLALAEIPTLRMLTASAAELATRARSFARRIRRASPPDIRLTLTSGISQVGGGAYPLLE
LPTTLMAMEADGISPQEMEIRLRGMEVPVTGRIHRGRFLLDVRTLQDDDIPFIAAALSSLAD
>Mature_461_residues
TLFARIPKVDKILEWDGTKVLLGIHPRPTVLNAVRSVLDSLRTAARSGFLKEEELLEGAVASRIEREVARSTAFSLRRVV
NGTGVVIHTNLGRSPLSKRVKPLLDEIAFGYSNLEFDLEKGERGSRYSHVERLLCDLTGAEAALVVNNNAAAVLLALSAL
AAGKEVVVSRGELVEIGGSFRIPDVMGQGGAILREVGTTNRTHPRDYHQAVSEQTALLLKVHSSNFAVVGFTAEVSATEL
VAIGKEHSVPVMADIGSGCLLDLSPFGIRGEPTVQEFVKAGVDVITFSGDKLLGGPQAGIIVGRREFIAPLTQHPLLRAL
RIDKLTLAALEGTLRLYRDERLALAEIPTLRMLTASAAELATRARSFARRIRRASPPDIRLTLTSGISQVGGGAYPLLEL
PTTLMAMEADGISPQEMEIRLRGMEVPVTGRIHRGRFLLDVRTLQDDDIPFIAAALSSLAD

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=450, Percent_Identity=46.2222222222222, Blast_Score=357, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_GEOMG (Q39ZL4)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383035.1
- ProteinModelPortal:   Q39ZL4
- STRING:   Q39ZL4
- GeneID:   3739677
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0061
- NMPDR:   fig|269799.3.peg.124
- eggNOG:   COG1921
- HOGENOM:   HBG564950
- OMA:   VFLILNT
- PhylomeDB:   Q39ZL4
- ProtClustDB:   PRK04311
- BioCyc:   GMET269799:GMET_0061-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 49874; Mature: 49743

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFARIPKVDKILEWDGTKVLLGIHPRPTVLNAVRSVLDSLRTAARSGFLKEEELLEGA
CCCHHCCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VASRIEREVARSTAFSLRRVVNGTGVVIHTNLGRSPLSKRVKPLLDEIAFGYSNLEFDLE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEC
KGERGSRYSHVERLLCDLTGAEAALVVNNNAAAVLLALSALAAGKEVVVSRGELVEIGGS
CCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCHHEECCCCEEEECCC
FRIPDVMGQGGAILREVGTTNRTHPRDYHQAVSEQTALLLKVHSSNFAVVGFTAEVSATE
CCCCHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEECCCCEE
LVAIGKEHSVPVMADIGSGCLLDLSPFGIRGEPTVQEFVKAGVDVITFSGDKLLGGPQAG
EEEECCCCCCCEEEECCCCCEEECCCCCCCCCCHHHHHHHCCCEEEEECCCEECCCCCCC
IIVGRREFIAPLTQHPLLRALRIDKLTLAALEGTLRLYRDERLALAEIPTLRMLTASAAE
EEEECHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHH
LATRARSFARRIRRASPPDIRLTLTSGISQVGGGAYPLLELPTTLMAMEADGISPQEMEI
HHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCHHHCCHHHEEEECCCCCCCCEEE
RLRGMEVPVTGRIHRGRFLLDVRTLQDDDIPFIAAALSSLAD
EEECEECCCCCEEECCEEEEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TLFARIPKVDKILEWDGTKVLLGIHPRPTVLNAVRSVLDSLRTAARSGFLKEEELLEGA
CCHHCCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VASRIEREVARSTAFSLRRVVNGTGVVIHTNLGRSPLSKRVKPLLDEIAFGYSNLEFDLE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEC
KGERGSRYSHVERLLCDLTGAEAALVVNNNAAAVLLALSALAAGKEVVVSRGELVEIGGS
CCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCHHEECCCCEEEECCC
FRIPDVMGQGGAILREVGTTNRTHPRDYHQAVSEQTALLLKVHSSNFAVVGFTAEVSATE
CCCCHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEECCCCEE
LVAIGKEHSVPVMADIGSGCLLDLSPFGIRGEPTVQEFVKAGVDVITFSGDKLLGGPQAG
EEEECCCCCCCEEEECCCCCEEECCCCCCCCCCHHHHHHHCCCEEEEECCCEECCCCCCC
IIVGRREFIAPLTQHPLLRALRIDKLTLAALEGTLRLYRDERLALAEIPTLRMLTASAAE
EEEECHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHH
LATRARSFARRIRRASPPDIRLTLTSGISQVGGGAYPLLELPTTLMAMEADGISPQEMEI
HHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCHHHCCHHHEEEECCCCCCCCEEE
RLRGMEVPVTGRIHRGRFLLDVRTLQDDDIPFIAAALSSLAD
EEECEECCCCCEEECCEEEEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA