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The map label for this gene is pqqL [C]

Identifier: 78221279

GI number: 78221279

Start: 64386

End: 65684

Strand: Direct

Name: pqqL [C]

Synonym: Gmet_0052

Alternate gene names: 78221279

Gene position: 64386-65684 (Clockwise)

Preceding gene: 78221278

Following gene: 78221282

Centisome position: 1.61

GC content: 65.74

Gene sequence:

>1299_bases
ATGACTACCATCACTCCATCCCTGACAACCCTTCCCAACGGCCTCCGCGTGGTCGCCGTGGAGATGCCCCACCTCAACTC
GGCAGAGATCGCCGTCTACCTCCGGGTGGGGGGCCGCCACGACAGCCGCGAGAAGGCGGGGCTTGCCCACTTCCTGGAGC
ACATGCTCTTCCGGGGTACCGCCGAGCACCCGTCGAGCTTGGAGCTGGAGGCGGACTTCGAGGCCATCGGCGGTTGCATC
AATGCCGCCACCGATGCCGAGACCACCTGCTACTACACCCGGGTCCACCCTGATCACGTGGCCGAGGGGGTGAGGCTTTT
GTCGGTCATGCTCCTCTCACCACTCCTCACGGGGCTCGAGATCGAGAAGAAGATCATCACCGAGGAGGCCCTGGAGGATA
TCAACGAACAGGGGGAAGAGGTCAATCCCGACAACCTGGCGAGCCGGCTCTTGTGGCCCGGCCACGGGATCGGCATGCCC
ACCATCGGCTATCTTGACACCATTGCCGGCTTCACCGAGGAGGATCTCCGGGGGCACATGGCCCGCCACTATGTGCCGGA
AAACGCCGTCGTGGTGGCGGCGGGGAGGGTTTCTGTCGAGGAGGTTTTTGCCGCTGCCGGCCGGGCCTTCGCATCCTGGA
GCGGTCCCCCGGCACCCGTCCAGGAATCGGTCTCCGATGTCCAGGACGCTCCGGTTTCCCTGTTCGTCAAGGACTCCGAC
AGCCAGGTGAACCTCCAGCTTGCCTTCCGGAGCTTTCCCCGGGAGGACCAGCGGCTGGCTGCTGCCCGGCTTATCCGGCG
CATCCTCACCGGCGGCGGGTGCTCCCGGCTCCACCTGAACCTGCGGGAACGGCTCGGCATCGTCTATTCGGTGGACGCCC
AGCTTGCCGCCTACGACGACACCGGCTGCTTCGCTGTGGAACTCTCCACGGCCCCGGAGAACCTGGCCGTGGCAGTGACG
GAAGTGCTGCGCGAGACCCTGCGCCTGGCAACGGAGCCGGTGGGGGATGAGGAACTGGATCGGGTTCGGCAGGGATATTT
CTTCGACCTGGATTACAGCAGGGATTCCACCTTTGACATGCAGGTTCGCTACGGATGGGGTGAGCTCATGGGGATGGTGC
GGAGCATCGAGGAGGATCAGGCCGAGGCCGGCGCCGTGGATGCCGCGGCGGTCATGGCCACGGCCCGGGAGCTCTTCGCG
CCGGCACGGCTCAACCTGGTGGCCGTGGGTCCGGTGAAGGCGGCGGTCAAGCGGGAGATTGCCGGCATTGTCAGGCGGTA
CGAGGCTGAGTTTCGGTAA

Upstream 100 bases:

>100_bases
AGTCGCTCCTGAAGATCCCCCCCGTGGCCCAGGCCATCTCCCAGGACAAGTACGACGCCGTCGTCTTCGACGCCATCCGG
ACCATCAGCGCGGAAGCCCC

Downstream 100 bases:

>100_bases
AAATGCATTAACCTGCAAAAGACAAGTATTCAATAACACGGAGAAACTGAGAGCACGGAGGACTAATAGAGCCCGATTTG
TTGACTCCTCCGTGTTCTCC

Product: peptidase M16-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTTITPSLTTLPNGLRVVAVEMPHLNSAEIAVYLRVGGRHDSREKAGLAHFLEHMLFRGTAEHPSSLELEADFEAIGGCI
NAATDAETTCYYTRVHPDHVAEGVRLLSVMLLSPLLTGLEIEKKIITEEALEDINEQGEEVNPDNLASRLLWPGHGIGMP
TIGYLDTIAGFTEEDLRGHMARHYVPENAVVVAAGRVSVEEVFAAAGRAFASWSGPPAPVQESVSDVQDAPVSLFVKDSD
SQVNLQLAFRSFPREDQRLAAARLIRRILTGGGCSRLHLNLRERLGIVYSVDAQLAAYDDTGCFAVELSTAPENLAVAVT
EVLRETLRLATEPVGDEELDRVRQGYFFDLDYSRDSTFDMQVRYGWGELMGMVRSIEEDQAEAGAVDAAAVMATARELFA
PARLNLVAVGPVKAAVKREIAGIVRRYEAEFR

Sequences:

>Translated_432_residues
MTTITPSLTTLPNGLRVVAVEMPHLNSAEIAVYLRVGGRHDSREKAGLAHFLEHMLFRGTAEHPSSLELEADFEAIGGCI
NAATDAETTCYYTRVHPDHVAEGVRLLSVMLLSPLLTGLEIEKKIITEEALEDINEQGEEVNPDNLASRLLWPGHGIGMP
TIGYLDTIAGFTEEDLRGHMARHYVPENAVVVAAGRVSVEEVFAAAGRAFASWSGPPAPVQESVSDVQDAPVSLFVKDSD
SQVNLQLAFRSFPREDQRLAAARLIRRILTGGGCSRLHLNLRERLGIVYSVDAQLAAYDDTGCFAVELSTAPENLAVAVT
EVLRETLRLATEPVGDEELDRVRQGYFFDLDYSRDSTFDMQVRYGWGELMGMVRSIEEDQAEAGAVDAAAVMATARELFA
PARLNLVAVGPVKAAVKREIAGIVRRYEAEFR
>Mature_431_residues
TTITPSLTTLPNGLRVVAVEMPHLNSAEIAVYLRVGGRHDSREKAGLAHFLEHMLFRGTAEHPSSLELEADFEAIGGCIN
AATDAETTCYYTRVHPDHVAEGVRLLSVMLLSPLLTGLEIEKKIITEEALEDINEQGEEVNPDNLASRLLWPGHGIGMPT
IGYLDTIAGFTEEDLRGHMARHYVPENAVVVAAGRVSVEEVFAAAGRAFASWSGPPAPVQESVSDVQDAPVSLFVKDSDS
QVNLQLAFRSFPREDQRLAAARLIRRILTGGGCSRLHLNLRERLGIVYSVDAQLAAYDDTGCFAVELSTAPENLAVAVTE
VLRETLRLATEPVGDEELDRVRQGYFFDLDYSRDSTFDMQVRYGWGELMGMVRSIEEDQAEAGAVDAAAVMATARELFAP
ARLNLVAVGPVKAAVKREIAGIVRRYEAEFR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=428, Percent_Identity=25.7009345794392, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI24308013, Length=369, Percent_Identity=23.5772357723577, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI46593007, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787770, Length=210, Percent_Identity=27.6190476190476, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=206, Percent_Identity=33.0097087378641, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71994338, Length=169, Percent_Identity=31.9526627218935, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146566, Length=169, Percent_Identity=31.9526627218935, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25146563, Length=169, Percent_Identity=31.9526627218935, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32566665, Length=169, Percent_Identity=31.9526627218935, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72001443, Length=165, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17553678, Length=438, Percent_Identity=25.1141552511416, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71982342, Length=148, Percent_Identity=31.7567567567568, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17557500, Length=145, Percent_Identity=31.7241379310345, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533970, Length=160, Percent_Identity=32.5, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323192, Length=353, Percent_Identity=26.0623229461756, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321813, Length=339, Percent_Identity=24.188790560472, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323421, Length=165, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21357875, Length=216, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646943, Length=216, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921772, Length=370, Percent_Identity=23.2432432432432, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221513245, Length=115, Percent_Identity=33.9130434782609, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667786, Length=270, Percent_Identity=25.5555555555556, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47232; Mature: 47101

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTITPSLTTLPNGLRVVAVEMPHLNSAEIAVYLRVGGRHDSREKAGLAHFLEHMLFRGT
CCCCCCCHHCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
AEHPSSLELEADFEAIGGCINAATDAETTCYYTRVHPDHVAEGVRLLSVMLLSPLLTGLE
CCCCCCEEEEECHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCHH
IEKKIITEEALEDINEQGEEVNPDNLASRLLWPGHGIGMPTIGYLDTIAGFTEEDLRGHM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHH
ARHYVPENAVVVAAGRVSVEEVFAAAGRAFASWSGPPAPVQESVSDVQDAPVSLFVKDSD
HHHCCCCCCEEEEECCCCHHHHHHHHCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCC
SQVNLQLAFRSFPREDQRLAAARLIRRILTGGGCSRLHLNLRERLGIVYSVDAQLAAYDD
CEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCEEEEECCEEEEECC
TGCFAVELSTAPENLAVAVTEVLRETLRLATEPVGDEELDRVRQGYFFDLDYSRDSTFDM
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCEEE
QVRYGWGELMGMVRSIEEDQAEAGAVDAAAVMATARELFAPARLNLVAVGPVKAAVKREI
EEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
AGIVRRYEAEFR
HHHHHHHHHCCC
>Mature Secondary Structure 
TTITPSLTTLPNGLRVVAVEMPHLNSAEIAVYLRVGGRHDSREKAGLAHFLEHMLFRGT
CCCCCCHHCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
AEHPSSLELEADFEAIGGCINAATDAETTCYYTRVHPDHVAEGVRLLSVMLLSPLLTGLE
CCCCCCEEEEECHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCHH
IEKKIITEEALEDINEQGEEVNPDNLASRLLWPGHGIGMPTIGYLDTIAGFTEEDLRGHM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHH
ARHYVPENAVVVAAGRVSVEEVFAAAGRAFASWSGPPAPVQESVSDVQDAPVSLFVKDSD
HHHCCCCCCEEEEECCCCHHHHHHHHCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCC
SQVNLQLAFRSFPREDQRLAAARLIRRILTGGGCSRLHLNLRERLGIVYSVDAQLAAYDD
CEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCEEEEECCEEEEECC
TGCFAVELSTAPENLAVAVTEVLRETLRLATEPVGDEELDRVRQGYFFDLDYSRDSTFDM
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCEEE
QVRYGWGELMGMVRSIEEDQAEAGAVDAAAVMATARELFAPARLNLVAVGPVKAAVKREI
EEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
AGIVRRYEAEFR
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA