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The map label for this gene is hemE

Identifier: 78221244

GI number: 78221244

Start: 23372

End: 24394

Strand: Direct

Name: hemE

Synonym: Gmet_0016

Alternate gene names: 78221244

Gene position: 23372-24394 (Clockwise)

Preceding gene: 78221243

Following gene: 78221245

Centisome position: 0.58

GC content: 64.71

Gene sequence:

>1023_bases
ATGAATAATCGTTTTCTCGACGCCTGCTGGGGCAAGCCCGTTGACCGTACCCCCGTGTGGCTCATGCGGCAGGCCGGGCG
CTACCTCCCCGAATACATGGCGGTGCGCTCCAAGTGCACCTTCCTGGAGCTTTGCAAGACCCCGGAGCTGGCCGCCGAGG
TGACTCTCCAGCCGGTGGATATCCTGGGGGTCGACGCGGCGATCCTCTTTTCCGACATCCTGACGCCGGTGGAGCCCATG
GGGCTCAAGCTCGATTTTGTCCCCGGCCCGGTCTTCGAGACCCCGGTCCGGACCATGGCCGACGTGGAGCGGCTCCGGAT
CCCCAACCCCGAGGAGGATGTCCCCTACGTCCTCGACACCATCAAGATTCTCCGCAAGGAGTTGGCCGGCCGGGTGCCCC
TCATCGGCTTCGGCGGCGCCCCGTTCACCCTGGCCTGCTACATGGTGGAGGGGAAGGGGTCCAAGGACTGGGCCACCATC
AAGCGGATGATGTACGCCGCCCCCGAGGTCTACGCCGCCCTCATGGATAAGGTGACCATGATGGACATGGAGTACCTGAA
CGCCCAGATCCGGGCCGGAGCCCAAGCGATCCAGATCTTCGACACCTGGGGCGGGGTCCTCTCCCCCACCGATTACGAGA
AATTTGTCCTTCCCTACACCCGGAAGCTCATCAATGGCCTGAACCGCCAGAACACTCCCGTCATCCACTTCGTCAAGGGG
GCCGGCACCATGCTGGAGACGGTGCAGAAGGCCGGCGGCGACGTCATGGGGCTCGACTGGCACGTGAACCTGGGGAAAGC
CCGGGACGTGCTTGGCCCGAACATGGCCGTCCAGGGGAACCTGGACCCCACGGTCCTCTACGCTCCCAAGGAGGTGATCG
AGGTGGAGGTGAAGCGGGTTCTCGACGAGAACGCCGGTCGCCCGGGCCACATCTTCAACCTGGGGCACGGCATCCTCCCC
ACGGTGCCGCCCGAGAACGCCATCCACATGGTCGAATGCGTGCACCGGCTGTCACAGAAGTAG

Upstream 100 bases:

>100_bases
TGGGCTACGCCTCCGCCGGGGTTCCTGCGGGTGCACCAATCTGACGTAAATATCACGTTCCTGGTGTTGAAACGCTTTAA
ATCTCCAAGGAGGATTTCCA

Downstream 100 bases:

>100_bases
GAGCAGCGAAGAGATGAACCGGAAAAGGGAGCGAAGGTGGCTCCCTTTTTCTTTTCACCGTTAGGAAAGAGGCCCCCATG
AATAATCGCATCACCGACCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTLQPVDILGVDAAILFSDILTPVEPM
GLKLDFVPGPVFETPVRTMADVERLRIPNPEEDVPYVLDTIKILRKELAGRVPLIGFGGAPFTLACYMVEGKGSKDWATI
KRMMYAAPEVYAALMDKVTMMDMEYLNAQIRAGAQAIQIFDTWGGVLSPTDYEKFVLPYTRKLINGLNRQNTPVIHFVKG
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGPNMAVQGNLDPTVLYAPKEVIEVEVKRVLDENAGRPGHIFNLGHGILP
TVPPENAIHMVECVHRLSQK

Sequences:

>Translated_340_residues
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTLQPVDILGVDAAILFSDILTPVEPM
GLKLDFVPGPVFETPVRTMADVERLRIPNPEEDVPYVLDTIKILRKELAGRVPLIGFGGAPFTLACYMVEGKGSKDWATI
KRMMYAAPEVYAALMDKVTMMDMEYLNAQIRAGAQAIQIFDTWGGVLSPTDYEKFVLPYTRKLINGLNRQNTPVIHFVKG
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGPNMAVQGNLDPTVLYAPKEVIEVEVKRVLDENAGRPGHIFNLGHGILP
TVPPENAIHMVECVHRLSQK
>Mature_340_residues
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTLQPVDILGVDAAILFSDILTPVEPM
GLKLDFVPGPVFETPVRTMADVERLRIPNPEEDVPYVLDTIKILRKELAGRVPLIGFGGAPFTLACYMVEGKGSKDWATI
KRMMYAAPEVYAALMDKVTMMDMEYLNAQIRAGAQAIQIFDTWGGVLSPTDYEKFVLPYTRKLINGLNRQNTPVIHFVKG
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGPNMAVQGNLDPTVLYAPKEVIEVEVKRVLDENAGRPGHIFNLGHGILP
TVPPENAIHMVECVHRLSQK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=44.5402298850575, Blast_Score=278, Evalue=6e-75,
Organism=Escherichia coli, GI2367337, Length=346, Percent_Identity=53.1791907514451, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320252, Length=354, Percent_Identity=36.7231638418079, Blast_Score=236, Evalue=3e-63,
Organism=Drosophila melanogaster, GI221330099, Length=345, Percent_Identity=40.5797101449275, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI19921920, Length=345, Percent_Identity=40.5797101449275, Blast_Score=251, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37774; Mature: 37774

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTLQPVD
CCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHEEECCHH
ILGVDAAILFSDILTPVEPMGLKLDFVPGPVFETPVRTMADVERLRIPNPEEDVPYVLDT
EECCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IKILRKELAGRVPLIGFGGAPFTLACYMVEGKGSKDWATIKRMMYAAPEVYAALMDKVTM
HHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MDMEYLNAQIRAGAQAIQIFDTWGGVLSPTDYEKFVLPYTRKLINGLNRQNTPVIHFVKG
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGPNMAVQGNLDPTVLYAPKEVIEVEVKRV
CCHHHHHHHHCCCCEEEEEEEEECCCHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHH
LDENAGRPGHIFNLGHGILPTVPPENAIHMVECVHRLSQK
HHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTLQPVD
CCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHEEECCHH
ILGVDAAILFSDILTPVEPMGLKLDFVPGPVFETPVRTMADVERLRIPNPEEDVPYVLDT
EECCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IKILRKELAGRVPLIGFGGAPFTLACYMVEGKGSKDWATIKRMMYAAPEVYAALMDKVTM
HHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MDMEYLNAQIRAGAQAIQIFDTWGGVLSPTDYEKFVLPYTRKLINGLNRQNTPVIHFVKG
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGPNMAVQGNLDPTVLYAPKEVIEVEVKRV
CCHHHHHHHHCCCCEEEEEEEEECCCHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHH
LDENAGRPGHIFNLGHGILPTVPPENAIHMVECVHRLSQK
HHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA