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The map label for this gene is ahpC [C]

Identifier: 78189933

GI number: 78189933

Start: 2510734

End: 2511399

Strand: Reverse

Name: ahpC [C]

Synonym: Cag_1980

Alternate gene names: 78189933

Gene position: 2511399-2510734 (Counterclockwise)

Preceding gene: 78189934

Following gene: 78189932

Centisome position: 97.64

GC content: 45.5

Gene sequence:

>666_bases
ATGCACGACGATGAACTGTACTACGATATTTCCATGCCATTGCTTGGCGACGACTTTCCTGAAATGGAAGTGCAAACCAC
TCACGGAGTTATGAACATTCCGGGCGATTTAAAAGGCTCATGGTTTGTGTTGTTTAGCCATCCTGCCGACTTTACCCCTG
TGTGTACCACCGAATTTGTTGCATTCCAAGAGCGTATTGCTGAGTTCGACAAACTTGGCTGTAAGCTTATTGGTATGAGT
GTTGACCAAGTTTTTTCACACATCAAATGGATTGAGTGGATTAAGGATACCTTAAACATTGAAATTACCTTCCCAATTGT
TGCGGCTAACGATCGCATTGCCAATAAGCTTGGCATGTTGCACCCAGGCAAAGGGAGCAACACGGTGCGTGCCGTTTTTG
TGTGCGACCCCAACGGCAAGGTGCGTTTAGTGCTCTACTATCCGCAAGAGATAGGGCGCAACATGGCTGAAATTTTACGC
GCTGTTACGGCTTTGCAAATTTCTGACAACAATAAAGTGGCAATTCCTGCCGACTGGCCTAACAACTCTCTTATTAAGGA
TGAGGTAATTATTCCTCCCGCAAAAGATGTTGCTGAAGCGCAAAAGCGCAAAAACATGGGAGGTTGCTACGATTGGTGGT
TCTGCCATAAACCGCTTGATAAGTAA

Upstream 100 bases:

>100_bases
GCAAGTTAAGAACAGCACTTTCTCCCATCCATCCTTTGGTGTAAGAAGGTGCAATCTTGCTTTTTTACATCCCCCCTATA
ACAACCGATAAGGAGTTTTT

Downstream 100 bases:

>100_bases
AGAGTGCGCAAGTTGCTCTTTTATCAACTTTCTTACTATTATTGCATGTAAAGTAGTGCGCTATTTTGGTGCATCGGCTT
TTTTATTAATTCTTTAGAGA

Product: peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MHDDELYYDISMPLLGDDFPEMEVQTTHGVMNIPGDLKGSWFVLFSHPADFTPVCTTEFVAFQERIAEFDKLGCKLIGMS
VDQVFSHIKWIEWIKDTLNIEITFPIVAANDRIANKLGMLHPGKGSNTVRAVFVCDPNGKVRLVLYYPQEIGRNMAEILR
AVTALQISDNNKVAIPADWPNNSLIKDEVIIPPAKDVAEAQKRKNMGGCYDWWFCHKPLDK

Sequences:

>Translated_221_residues
MHDDELYYDISMPLLGDDFPEMEVQTTHGVMNIPGDLKGSWFVLFSHPADFTPVCTTEFVAFQERIAEFDKLGCKLIGMS
VDQVFSHIKWIEWIKDTLNIEITFPIVAANDRIANKLGMLHPGKGSNTVRAVFVCDPNGKVRLVLYYPQEIGRNMAEILR
AVTALQISDNNKVAIPADWPNNSLIKDEVIIPPAKDVAEAQKRKNMGGCYDWWFCHKPLDK
>Mature_221_residues
MHDDELYYDISMPLLGDDFPEMEVQTTHGVMNIPGDLKGSWFVLFSHPADFTPVCTTEFVAFQERIAEFDKLGCKLIGMS
VDQVFSHIKWIEWIKDTLNIEITFPIVAANDRIANKLGMLHPGKGSNTVRAVFVCDPNGKVRLVLYYPQEIGRNMAEILR
AVTALQISDNNKVAIPADWPNNSLIKDEVIIPPAKDVAEAQKRKNMGGCYDWWFCHKPLDK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=200, Percent_Identity=40.5, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI4505591, Length=157, Percent_Identity=37.5796178343949, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI32455266, Length=157, Percent_Identity=37.5796178343949, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI32455264, Length=157, Percent_Identity=37.5796178343949, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI32189392, Length=157, Percent_Identity=36.3057324840764, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI5802974, Length=157, Percent_Identity=35.031847133758, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI32483377, Length=157, Percent_Identity=35.031847133758, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=32.7044025157233, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI33188454, Length=58, Percent_Identity=51.7241379310345, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786822, Length=169, Percent_Identity=28.9940828402367, Blast_Score=70, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI25153706, Length=195, Percent_Identity=33.8461538461538, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554494, Length=150, Percent_Identity=38, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI193204376, Length=203, Percent_Identity=31.0344827586207, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI32565831, Length=170, Percent_Identity=33.5294117647059, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319407, Length=198, Percent_Identity=43.4343434343434, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323613, Length=155, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320661, Length=171, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24581278, Length=172, Percent_Identity=43.6046511627907, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17975518, Length=198, Percent_Identity=40.9090909090909, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652436, Length=198, Percent_Identity=40.9090909090909, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652434, Length=198, Percent_Identity=40.9090909090909, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17738015, Length=176, Percent_Identity=35.2272727272727, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17157991, Length=146, Percent_Identity=35.6164383561644, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24641739, Length=146, Percent_Identity=35.6164383561644, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357347, Length=146, Percent_Identity=34.9315068493151, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24656348, Length=143, Percent_Identity=33.5664335664336, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17864676, Length=143, Percent_Identity=33.5664335664336, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 25040; Mature: 25040

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDDELYYDISMPLLGDDFPEMEVQTTHGVMNIPGDLKGSWFVLFSHPADFTPVCTTEFV
CCCCEEEEEEECCCCCCCCCCCEEEECCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHH
AFQERIAEFDKLGCKLIGMSVDQVFSHIKWIEWIKDTLNIEITFPIVAANDRIANKLGML
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCHHHHHHCCC
HPGKGSNTVRAVFVCDPNGKVRLVLYYPQEIGRNMAEILRAVTALQISDNNKVAIPADWP
CCCCCCCCEEEEEEECCCCCEEEEEECCHHHCCHHHHHHHHHHEEEECCCCEEEEECCCC
NNSLIKDEVIIPPAKDVAEAQKRKNMGGCYDWWFCHKPLDK
CCCEECCCEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MHDDELYYDISMPLLGDDFPEMEVQTTHGVMNIPGDLKGSWFVLFSHPADFTPVCTTEFV
CCCCEEEEEEECCCCCCCCCCCEEEECCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHH
AFQERIAEFDKLGCKLIGMSVDQVFSHIKWIEWIKDTLNIEITFPIVAANDRIANKLGML
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCHHHHHHCCC
HPGKGSNTVRAVFVCDPNGKVRLVLYYPQEIGRNMAEILRAVTALQISDNNKVAIPADWP
CCCCCCCCEEEEEEECCCCCEEEEEECCHHHCCHHHHHHHHHHEEEECCCCEEEEECCCC
NNSLIKDEVIIPPAKDVAEAQKRKNMGGCYDWWFCHKPLDK
CCCEECCCEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]