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The map label for this gene is hmeD [H]

Identifier: 78189900

GI number: 78189900

Start: 2477545

End: 2479194

Strand: Reverse

Name: hmeD [H]

Synonym: Cag_1947

Alternate gene names: 78189900

Gene position: 2479194-2477545 (Counterclockwise)

Preceding gene: 78189901

Following gene: 78189899

Centisome position: 96.39

GC content: 44.67

Gene sequence:

>1650_bases
ATGTCGAAATACGCACCTAAAGTATCGGAACTCAATGAGGAGTTCGAGAAAAAGAAGCCGAATATTCTTAAAGAGAATTA
TTCAGGTAAGGAGTGGTGGGATTTACCGGTTGAGTTTCGTGATGGTAACTGGTCATTCCCTGCTAAGCCCGAAGTGCTTG
AAGAGCTTCATTTTCCTAATCCACGTAAGTGGATGGCTACCGATGCCGATTGGCAGTTACCTGCTGGATGGGAAAAGACT
ATTAAGGAGGGATTGCGCGATCGTTTAAAGCGCTTCCGCTCGTTTAAGCTTTTTATGGATGCCTGCGTTCGTTGTGGTGC
ATGTGCCGATAAATGCCACTTTTTCCTTGGTACAGGCGATCCTAAAAATATGCCAGTTGTGCGTGCTGAGTTGCTTCGGT
CGGTGTATCGCAACGACTTTCCGCTTGCTGAAAAAATATTTAAAGGTTTTGCTGGGTCGCGTAAGCTTACGCCTGAGGTT
ATTAAAGAGTGGCACATGTACTTTAACCAATGTACTGAGTGTCGCCGTTGTTCCGTTTTTTGCCCAATGGGTATTGATAC
GGCAGAAATTACCATTATGGGGCGTGAGTTGCTGAACCTTATTGGGGTGAACAACAATTGGATTTTGGCACCTGTTGCTA
ATTGTAATCGCACAGGTAACCATCTTGGAATTGAGCCTCATACCTTTGTGCAAAACATTGAGTCGCTTGCCGATGATATT
GAGGATTTAACAGGGGTTACCGTACATCCTACCTTTAACCGAAAAGGTGCAGAAGTACTTTTTGTTACTCCTTCGGGTGA
TGTATTTGGCGATCCGGGTGTTTATACCATGATGGGCTACCTTTTGCTGTTTGAGCATATTGGTTTGGATTACACCATCA
GTACCTATGCTTCTGAAGGTGGAAACTTTGGCTTTTTCACCAACAATGAGATGATGAAAAAGCTCAACGCCAAAATGTAT
CACGAAGCGAAGCGCCTTGGCGTTAAGTGGATACTTGGCGGTGAGTGTGGGCATATGTGGCGCGTTGTGCATCAATATAT
GAACACCATGAATGGTCCTGCTGATTTTCTTGAAGTGCCGATATCGCCCATTACAAAAACAAAGTTTGAACAAGCGGCTG
GCACAAAAATGGTGCACATTGCTGAATTTACGGCTGACCTGATTAAGCATAACAAGCTGAAGCTTGATCCAAAACGTAAC
GACCACTTGCGTACCACCTTCCACGATTCTTGTAACGTGGCGCGTGGTATGGGAATGTTTGATGAGCCTCGCTATGTGCT
TAACAGCGTTTGTAACACCTTCCATGAAATGCCCGAAAACACCATTCGTGAACAAACCTTTTGCTGTGGTTCGGGTAGCG
GTTTAAATCCTGAAGAGTTCATGGATATGCGTATGCGAGGTGGTTTTCCTCGCGCAAATGCCGTGCGTCATGTTAAAGAC
AAGCACAAGGTAAATTCGTTAGTTACCATTTGCGCTATTGACCGCGCTAGCTTACCATCGCTTATGCGCTATTGGAACCC
AGGTATTACCGTGTATGGTTTGCATGAGTTAGTAGGGAATGCCCTTGTTATGAAGGGTGAGAAAAAGAGAACTGAGGATT
TACGAGAAAATCCAATGGCTGGTTTTGAAGATGGAGATGATGATGAGTAA

Upstream 100 bases:

>100_bases
CATGGAACCCTGAAATGAAAATCAGGACATATGCCGAATATGAGGATGATTATCGGGAAAAGATGAAAAAAGCTGGCTTA
CCGGTTGAAAAGCAATAACT

Downstream 100 bases:

>100_bases
ACGGCAATCATTCATTATAGGTGGGGTGCTTATTGCCTTAGTGGCTTCTCTTTGGTCGTTTTGGCCAACCCTTCAAGCTG
AAAAAGTGCCCGATAAACCT

Product: DsrK protein

Products: NA

Alternate protein names: Hme subunit D [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSKYAPKVSELNEEFEKKKPNILKENYSGKEWWDLPVEFRDGNWSFPAKPEVLEELHFPNPRKWMATDADWQLPAGWEKT
IKEGLRDRLKRFRSFKLFMDACVRCGACADKCHFFLGTGDPKNMPVVRAELLRSVYRNDFPLAEKIFKGFAGSRKLTPEV
IKEWHMYFNQCTECRRCSVFCPMGIDTAEITIMGRELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLADDI
EDLTGVTVHPTFNRKGAEVLFVTPSGDVFGDPGVYTMMGYLLLFEHIGLDYTISTYASEGGNFGFFTNNEMMKKLNAKMY
HEAKRLGVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPISPITKTKFEQAAGTKMVHIAEFTADLIKHNKLKLDPKRN
DHLRTTFHDSCNVARGMGMFDEPRYVLNSVCNTFHEMPENTIREQTFCCGSGSGLNPEEFMDMRMRGGFPRANAVRHVKD
KHKVNSLVTICAIDRASLPSLMRYWNPGITVYGLHELVGNALVMKGEKKRTEDLRENPMAGFEDGDDDE

Sequences:

>Translated_549_residues
MSKYAPKVSELNEEFEKKKPNILKENYSGKEWWDLPVEFRDGNWSFPAKPEVLEELHFPNPRKWMATDADWQLPAGWEKT
IKEGLRDRLKRFRSFKLFMDACVRCGACADKCHFFLGTGDPKNMPVVRAELLRSVYRNDFPLAEKIFKGFAGSRKLTPEV
IKEWHMYFNQCTECRRCSVFCPMGIDTAEITIMGRELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLADDI
EDLTGVTVHPTFNRKGAEVLFVTPSGDVFGDPGVYTMMGYLLLFEHIGLDYTISTYASEGGNFGFFTNNEMMKKLNAKMY
HEAKRLGVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPISPITKTKFEQAAGTKMVHIAEFTADLIKHNKLKLDPKRN
DHLRTTFHDSCNVARGMGMFDEPRYVLNSVCNTFHEMPENTIREQTFCCGSGSGLNPEEFMDMRMRGGFPRANAVRHVKD
KHKVNSLVTICAIDRASLPSLMRYWNPGITVYGLHELVGNALVMKGEKKRTEDLRENPMAGFEDGDDDE
>Mature_548_residues
SKYAPKVSELNEEFEKKKPNILKENYSGKEWWDLPVEFRDGNWSFPAKPEVLEELHFPNPRKWMATDADWQLPAGWEKTI
KEGLRDRLKRFRSFKLFMDACVRCGACADKCHFFLGTGDPKNMPVVRAELLRSVYRNDFPLAEKIFKGFAGSRKLTPEVI
KEWHMYFNQCTECRRCSVFCPMGIDTAEITIMGRELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLADDIE
DLTGVTVHPTFNRKGAEVLFVTPSGDVFGDPGVYTMMGYLLLFEHIGLDYTISTYASEGGNFGFFTNNEMMKKLNAKMYH
EAKRLGVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPISPITKTKFEQAAGTKMVHIAEFTADLIKHNKLKLDPKRND
HLRTTFHDSCNVARGMGMFDEPRYVLNSVCNTFHEMPENTIREQTFCCGSGSGLNPEEFMDMRMRGGFPRANAVRHVKDK
HKVNSLVTICAIDRASLPSLMRYWNPGITVYGLHELVGNALVMKGEKKRTEDLRENPMAGFEDGDDDE

Specific function: Has menaquinol-oxidizing activity. The hmeC and hmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 62661; Mature: 62529

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYAPKVSELNEEFEKKKPNILKENYSGKEWWDLPVEFRDGNWSFPAKPEVLEELHFPN
CCCCCCCHHHHHHHHHHCCCCHHHCCCCCCEEECCCEEEECCCCCCCCCHHHHHHCCCCC
PRKWMATDADWQLPAGWEKTIKEGLRDRLKRFRSFKLFMDACVRCGACADKCHFFLGTGD
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEECCC
PKNMPVVRAELLRSVYRNDFPLAEKIFKGFAGSRKLTPEVIKEWHMYFNQCTECRRCSVF
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
CPMGIDTAEITIMGRELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLADDI
CCCCCCCCEEEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EDLTGVTVHPTFNRKGAEVLFVTPSGDVFGDPGVYTMMGYLLLFEHIGLDYTISTYASEG
HHHCCCEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCC
GNFGFFTNNEMMKKLNAKMYHEAKRLGVKWILGGECGHMWRVVHQYMNTMNGPADFLEVP
CCCCEEECHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCC
ISPITKTKFEQAAGTKMVHIAEFTADLIKHNKLKLDPKRNDHLRTTFHDSCNVARGMGMF
CCCHHHHHHHHHCCCCEEEHHHHHHHHHHCCCEEECCCCCCCCEEEHHCCCCHHHCCCCC
DEPRYVLNSVCNTFHEMPENTIREQTFCCGSGSGLNPEEFMDMRMRGGFPRANAVRHVKD
CCCHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
KHKVNSLVTICAIDRASLPSLMRYWNPGITVYGLHELVGNALVMKGEKKRTEDLRENPMA
HHHHHHEEHEEECCHHHHHHHHHHHCCCCEEEEHHHHHCCCEEECCCHHHHHHHHHCCCC
GFEDGDDDE
CCCCCCCCC
>Mature Secondary Structure 
SKYAPKVSELNEEFEKKKPNILKENYSGKEWWDLPVEFRDGNWSFPAKPEVLEELHFPN
CCCCCCHHHHHHHHHHCCCCHHHCCCCCCEEECCCEEEECCCCCCCCCHHHHHHCCCCC
PRKWMATDADWQLPAGWEKTIKEGLRDRLKRFRSFKLFMDACVRCGACADKCHFFLGTGD
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEECCC
PKNMPVVRAELLRSVYRNDFPLAEKIFKGFAGSRKLTPEVIKEWHMYFNQCTECRRCSVF
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
CPMGIDTAEITIMGRELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLADDI
CCCCCCCCEEEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EDLTGVTVHPTFNRKGAEVLFVTPSGDVFGDPGVYTMMGYLLLFEHIGLDYTISTYASEG
HHHCCCEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCC
GNFGFFTNNEMMKKLNAKMYHEAKRLGVKWILGGECGHMWRVVHQYMNTMNGPADFLEVP
CCCCEEECHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCC
ISPITKTKFEQAAGTKMVHIAEFTADLIKHNKLKLDPKRNDHLRTTFHDSCNVARGMGMF
CCCHHHHHHHHHCCCCEEEHHHHHHHHHHCCCEEECCCCCCCCEEEHHCCCCHHHCCCCC
DEPRYVLNSVCNTFHEMPENTIREQTFCCGSGSGLNPEEFMDMRMRGGFPRANAVRHVKD
CCCHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
KHKVNSLVTICAIDRASLPSLMRYWNPGITVYGLHELVGNALVMKGEKKRTEDLRENPMA
HHHHHHEEHEEECCHHHHHHHHHHHCCCCEEEEHHHHHCCCEEECCCHHHHHHHHHCCCC
GFEDGDDDE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA