Click here to switch to the map view.

The map label for this gene is ilvC

Identifier: 78189857

GI number: 78189857

Start: 2421110

End: 2422102

Strand: Reverse

Name: ilvC

Synonym: Cag_1902

Alternate gene names: 78189857

Gene position: 2422102-2421110 (Counterclockwise)

Preceding gene: 78189858

Following gene: 78189856

Centisome position: 94.17

GC content: 46.22

Gene sequence:

>993_bases
ATGAACGTTTATTACGAAAAGGATGCCGATCTCGCCTATCTGCAAGGAAAAAAGATTGCGGTGCTTGGCTACGGTAGCCA
AGGTCATGCTCACTCTCTTAACCTCCACGAAAGCGGCTTAAATGTTCGCGTTGGTCTTCGCCCCGAAAGCGCTTCATGTG
CGAAAGCTCGCGAAGCTGGGCTTGAGGTTACCTCAGTTGCTGAAGCCACCAAATGGGCTGACATTGTGATGGTGCTTTTA
CCTGACCAAAACCAAAAAGCGGTGTATGAGGCTGAAATTGCGCCAAACCTTGAGCCTGGCAACACCCTTGCATTTGGACA
CGGCTTTAATATTCATTACAAGCAAATTGTACCAGCTTCAAGCGTTAACGTTATTATGATTGCGCCTAAAAGCCCCGGTC
ATTTAGTACGCCGCACCTACACGGAAGGCAACGGTGTTCCATGCTTAATTGCGGTTCATCAAGATCCAACAGGCGAAGCA
AAGCAGCAAGCGCTGGCTTGGGCAAAAGCGCTTGGCGGCACAAAAGCGGGCGTTATTGAAACCAACTTTAAAAATGAAAC
TGAAACCGACCTTTTTGGTGAGCAAGCGGTGCTTTGCGGTGGTTCAGCCGAACTTATTAAAGCTGGTTTTGAAACCCTTG
TAGAAGCAGGCTACCCTGAAGAACTTGCTTACTTTGAATGTATGCACGAGTTGAAACTGATTGTTGATTTGTATTACGAA
GGCGGACTTTCGCGCATGAACTACTCGGTAAGCGATACGGCTGAATATGGTGGCATGACGCGTGGACCTCGTTTAATTAC
TCCTGCGGTTAAAGCTGAAATGAAAAAAATTCTCGAAGAGGTTCAAGATGGACGCTTTGCTAAAGAGTTTATTGATGAGT
GCAATGGTGGTTACCAAAACCTCAGCAAGTTAAGAGAGAGCAACAGCAACCACGCTATCGAAAAAGTTGGTGCAAAGCTT
CGCAACATGATGAGCTGGCTTATTAAAAAATAA

Upstream 100 bases:

>100_bases
GGGGCGACGTATAAGCTTTTTAAGCAAGGCATCTTTTTTAGATGAGGTGCCTTGCTATTGCTAATTTCTTGTATTTCCTC
ACTTTAAACTAATAATAAGA

Downstream 100 bases:

>100_bases
TCTCGGAAAACCTCCATGAACTATAAAATTGTCTCTATTCCGGGTGATGGTATAGGTACCGAAGTTGTTGCTGGCGCTGT
TGCTGTATTACGTCAACTTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNVYYEKDADLAYLQGKKIAVLGYGSQGHAHSLNLHESGLNVRVGLRPESASCAKAREAGLEVTSVAEATKWADIVMVLL
PDQNQKAVYEAEIAPNLEPGNTLAFGHGFNIHYKQIVPASSVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDPTGEA
KQQALAWAKALGGTKAGVIETNFKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNGGYQNLSKLRESNSNHAIEKVGAKL
RNMMSWLIKK

Sequences:

>Translated_330_residues
MNVYYEKDADLAYLQGKKIAVLGYGSQGHAHSLNLHESGLNVRVGLRPESASCAKAREAGLEVTSVAEATKWADIVMVLL
PDQNQKAVYEAEIAPNLEPGNTLAFGHGFNIHYKQIVPASSVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDPTGEA
KQQALAWAKALGGTKAGVIETNFKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNGGYQNLSKLRESNSNHAIEKVGAKL
RNMMSWLIKK
>Mature_330_residues
MNVYYEKDADLAYLQGKKIAVLGYGSQGHAHSLNLHESGLNVRVGLRPESASCAKAREAGLEVTSVAEATKWADIVMVLL
PDQNQKAVYEAEIAPNLEPGNTLAFGHGFNIHYKQIVPASSVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDPTGEA
KQQALAWAKALGGTKAGVIETNFKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNGGYQNLSKLRESNSNHAIEKVGAKL
RNMMSWLIKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=321, Percent_Identity=35.202492211838, Blast_Score=154, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=329, Percent_Identity=32.5227963525836, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CHLCH (Q3APC3)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_380195.1
- ProteinModelPortal:   Q3APC3
- SMR:   Q3APC3
- STRING:   Q3APC3
- GeneID:   3747647
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1902
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   CCHL340177:CAG_1902-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36054; Mature: 36054

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYYEKDADLAYLQGKKIAVLGYGSQGHAHSLNLHESGLNVRVGLRPESASCAKAREAG
CCCEECCCCCEEEECCCEEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHCC
LEVTSVAEATKWADIVMVLLPDQNQKAVYEAEIAPNLEPGNTLAFGHGFNIHYKQIVPAS
CCHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCC
SVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDPTGEAKQQALAWAKALGGTKAGVIE
CCCEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEE
TNFKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
CCCCCCCCHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNGGYQN
CCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHH
LSKLRESNSNHAIEKVGAKLRNMMSWLIKK
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVYYEKDADLAYLQGKKIAVLGYGSQGHAHSLNLHESGLNVRVGLRPESASCAKAREAG
CCCEECCCCCEEEECCCEEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHCC
LEVTSVAEATKWADIVMVLLPDQNQKAVYEAEIAPNLEPGNTLAFGHGFNIHYKQIVPAS
CCHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCC
SVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDPTGEAKQQALAWAKALGGTKAGVIE
CCCEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEE
TNFKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
CCCCCCCCHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAKEFIDECNGGYQN
CCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHH
LSKLRESNSNHAIEKVGAKLRNMMSWLIKK
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA