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The map label for this gene is dapA

Identifier: 78189690

GI number: 78189690

Start: 2253168

End: 2254058

Strand: Reverse

Name: dapA

Synonym: Cag_1734

Alternate gene names: 78189690

Gene position: 2254058-2253168 (Counterclockwise)

Preceding gene: 78189691

Following gene: 78189686

Centisome position: 87.64

GC content: 45.9

Gene sequence:

>891_bases
ATGCCAACCCCATATCTTTCAGGCTCTGCTGTTGCGTTAGTTACTCCATTTAAGAGCGATAGCTCCATTGATTTTGAAGC
AATTGCTCGACTTACCGAGTTTCACGTTGCGGCGGGCACCAACATTATTATTCCTTGTGGCACCACAGGCGAATCGCCAA
CGCTTGCTGAAGAGGAGCAAGTTGCCATTATTAAAACTGTTGTTGAAGCTGCTCAGGGAAAATTGATGGTGGCAGCAGGT
GCTGGTACCAATAATACGCACCATGCGGTAGAGTTAGCTAAAAATGCTGAAAAAGCAGGTGCCGCAGCCATTCTTTCCGT
TGCGCCTTACTACAACAAGCCGTCGCAGGAGGGATTTTACCAACACTATCGCCACATTGCTGAAGCTGTGGCGGTGCCAA
TTATTATTTACAATGTGCCGGGACGCACGGGGTGCAATGTAGCTGCTTCTACTATTTTACGCTTAGCTCGTGATTTTGAT
AATGTATTAGCGGTAAAAGAGGCTTCGGAGAATTTTACGCAAATTTCGGAGTTGCTCGAAGAGCGCCCAAGCAATTTTGC
GGTGCTTACGGGTGAGGATTCGCTTATTTTGCCATTTATGGCAATGGGTGGAAATGGCGTTATTTCTGTAGCGGCTAATG
AAATTCCAGCCCAAATTCGCCAATTAGTAGAAAGTGCTGGTAGTGGCGATCTTGTAACAGCTCGTACACTGTACAGCCGT
TATCGTAAGCTGCTTAAGTTGAATTTTATTGAGAGCAATCCTGTGCCTGTTAAGTATGCTTTAGCGCGTATGGGAATGAT
TGAAGAAAATTATCGTTTGCCGCTTGTGCCGCTTTCAGCCGAAAGTAAGCGTGCAATGGATGAGGAGTTAACGCTCTTGG
GATTAGTCTAA

Upstream 100 bases:

>100_bases
GATGCTTTTGCATTATATTGCTGGTAAGGTGGCACGTGCTTAAACCTCAAAAGCATAGCGTAGCACTCATATTTATTATT
TTTTAAACCCCATTGAACTC

Downstream 100 bases:

>100_bases
AGCGCCTTTCTCCTTTTTTCAGTCCTAAACCAAAAAGTCCGATCATGTAACAATCGGACTTTTTGGTTTACACGAATGTA
TAGGAAGTGTTTACAAGCGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPTPYLSGSAVALVTPFKSDSSIDFEAIARLTEFHVAAGTNIIIPCGTTGESPTLAEEEQVAIIKTVVEAAQGKLMVAAG
AGTNNTHHAVELAKNAEKAGAAAILSVAPYYNKPSQEGFYQHYRHIAEAVAVPIIIYNVPGRTGCNVAASTILRLARDFD
NVLAVKEASENFTQISELLEERPSNFAVLTGEDSLILPFMAMGGNGVISVAANEIPAQIRQLVESAGSGDLVTARTLYSR
YRKLLKLNFIESNPVPVKYALARMGMIEENYRLPLVPLSAESKRAMDEELTLLGLV

Sequences:

>Translated_296_residues
MPTPYLSGSAVALVTPFKSDSSIDFEAIARLTEFHVAAGTNIIIPCGTTGESPTLAEEEQVAIIKTVVEAAQGKLMVAAG
AGTNNTHHAVELAKNAEKAGAAAILSVAPYYNKPSQEGFYQHYRHIAEAVAVPIIIYNVPGRTGCNVAASTILRLARDFD
NVLAVKEASENFTQISELLEERPSNFAVLTGEDSLILPFMAMGGNGVISVAANEIPAQIRQLVESAGSGDLVTARTLYSR
YRKLLKLNFIESNPVPVKYALARMGMIEENYRLPLVPLSAESKRAMDEELTLLGLV
>Mature_295_residues
PTPYLSGSAVALVTPFKSDSSIDFEAIARLTEFHVAAGTNIIIPCGTTGESPTLAEEEQVAIIKTVVEAAQGKLMVAAGA
GTNNTHHAVELAKNAEKAGAAAILSVAPYYNKPSQEGFYQHYRHIAEAVAVPIIIYNVPGRTGCNVAASTILRLARDFDN
VLAVKEASENFTQISELLEERPSNFAVLTGEDSLILPFMAMGGNGVISVAANEIPAQIRQLVESAGSGDLVTARTLYSRY
RKLLKLNFIESNPVPVKYALARMGMIEENYRLPLVPLSAESKRAMDEELTLLGLV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=299, Percent_Identity=24.4147157190635, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13540533, Length=240, Percent_Identity=25.8333333333333, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=38.013698630137, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=31.0810810810811, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1786463, Length=223, Percent_Identity=26.9058295964126, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789620, Length=245, Percent_Identity=29.3877551020408, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CHLCH (Q3APU0)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_380028.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q3APU0
- SMR:   Q3APU0
- STRING:   Q3APU0
- GeneID:   3746517
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1734
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   TVEFAKG
- ProtClustDB:   PRK03170
- BioCyc:   CCHL340177:CAG_1734-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31733; Mature: 31602

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPYLSGSAVALVTPFKSDSSIDFEAIARLTEFHVAAGTNIIIPCGTTGESPTLAEEEQ
CCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCHHH
VAIIKTVVEAAQGKLMVAAGAGTNNTHHAVELAKNAEKAGAAAILSVAPYYNKPSQEGFY
HHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHH
QHYRHIAEAVAVPIIIYNVPGRTGCNVAASTILRLARDFDNVLAVKEASENFTQISELLE
HHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERPSNFAVLTGEDSLILPFMAMGGNGVISVAANEIPAQIRQLVESAGSGDLVTARTLYSR
HCCCCEEEEECCCCEEEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCEEHHHHHHHH
YRKLLKLNFIESNPVPVKYALARMGMIEENYRLPLVPLSAESKRAMDEELTLLGLV
HHHHHEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHEEECC
>Mature Secondary Structure 
PTPYLSGSAVALVTPFKSDSSIDFEAIARLTEFHVAAGTNIIIPCGTTGESPTLAEEEQ
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCHHH
VAIIKTVVEAAQGKLMVAAGAGTNNTHHAVELAKNAEKAGAAAILSVAPYYNKPSQEGFY
HHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHH
QHYRHIAEAVAVPIIIYNVPGRTGCNVAASTILRLARDFDNVLAVKEASENFTQISELLE
HHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERPSNFAVLTGEDSLILPFMAMGGNGVISVAANEIPAQIRQLVESAGSGDLVTARTLYSR
HCCCCEEEEECCCCEEEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCEEHHHHHHHH
YRKLLKLNFIESNPVPVKYALARMGMIEENYRLPLVPLSAESKRAMDEELTLLGLV
HHHHHEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA