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The map label for this gene is zwf [H]

Identifier: 78189625

GI number: 78189625

Start: 2165968

End: 2167404

Strand: Reverse

Name: zwf [H]

Synonym: Cag_1668

Alternate gene names: 78189625

Gene position: 2167404-2165968 (Counterclockwise)

Preceding gene: 78189626

Following gene: 78189624

Centisome position: 84.27

GC content: 46.83

Gene sequence:

>1437_bases
ATGCAACCTAAGCCCGATAACTGTACCATTGTCATTTTTGGAGCGAGCGGCGACCTTGCAGCCCGCAAACTTTTTCCCTC
CCTTTTTGATCTTGCGTTATGGGGTCATCTTTCTGAAGAACACCATATTGTTGGCGTAGGGCGAGCACCCTTAACGCAGG
AGCAGTTCCGAGCAATGGTTGCGAGCAAAATGGAAGAGCTTTTTCCTGAACGAACGGCACAACACGAGGCGTTTCAGCGC
TTTCTTGCAAATCTCCATTACAGTGTTGTTGATCTTGCGCAACCTGAAGATTACATCAAATTGCGGCAGCATATTGAGCA
ATTGCCCAACGGTGGCGGCATCTCTAACAATCTTCTCTTTTACCTTGCCATTCCACCAACACTTGCCCCACAAATTGTAC
AATCATTGCACACCGCAGGTTTGGGTGAAGCCGATGGCTGCCCACATGGATGGCGCAAAATTATGGTTGAAAAACCTTAC
GGTACCAACCTTGAAAGCGCTCGTGAGTTGAATCAAGTGATTGGTAATGTGTTTCGTGAAAAGCAGGTGTATCGCATTGA
TCACTACCTTGCAAAAGAGACGGTGCAAAACATTATGGTCTTTCGCTTTTCCAACGGCATGTTTGAGCCACTTTGGAACC
GCCAGCATATTGCCAATGTTACAATAACCATTGCCGAAAACTTCGGTATTCGCGATCGAGGTGCTTTTTATGAAGACGCG
GGGCTGTTGCGTGACATTATGCAAAACCACGCCTTGCAGTTACTTGCGGCTGTGGCTATGGAGCCACCGGTAGATTTTTC
AGCCGATGCCGTGCGCGATGAAAAGGCAAAAGTACTCCGTTCCATTCGCCCCTTTACTGCTGAGCAGGTTGCAAAAACCG
TTGTGCTGGGGCAGTACGAAGGGTACCGCCAAGAGAAAAACGTTGCGCCCAATTCCACGGTTGAAACCTTTGCTGCCATT
AAGTTTTTTATTGATAATTGGCGCTGGAAAGATGTACCCTTTTACATTCGAGCAGGCAAAAATTTAGCCCAAACACTCAC
GGAAATTGTTATCACCTTTCAATGCCCGCCACAAAATTACTTTGGACCAACGGGTAGCGAAGTGTGTACCGCCAATCAAG
TGATTTTGCGTATTCAACCCGAAGAGACCATTGCAGTACGTTTTGGCGCAAAACGTCCGGGCGAATCGGTTATTACCGAT
CCCGTTTCCATGACGTTTGATTACAAAACCTCTTTTGTTGAATCAGGCTTAACTCCATACCATCGTTTATTGCTTGATGC
TATGGCGGGTGAGCAAATGAATTTTATTCGCCAAGATAGCGTCGAATATTCATGGGGAATTATTGATGCCATTCGTCAAG
CAGTTGCAGGACAACAGCCTGAAAGCTATCCCGTCCATTCCTATGGACCCGCAGGTATAAGCCGATTGTATGAGTAA

Upstream 100 bases:

>100_bases
GCAACCTCTCCGACCGCACAGTAGCAGCCTTGCGCCATGAGTTTGGCGGACATGGATTTAGTGAAAAAAAGTAAACTTGA
TAACCACTTATTCTAACCCC

Downstream 100 bases:

>100_bases
TGGTTGAACGAAAGGCAGGGATGTTCTCAGTTCCTTTGTTGTAATGGAGGGCGGTGGGGGAGAGAAACCTCTTATTGGTA
GTACTTCCTCTTTACAAGAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MQPKPDNCTIVIFGASGDLAARKLFPSLFDLALWGHLSEEHHIVGVGRAPLTQEQFRAMVASKMEELFPERTAQHEAFQR
FLANLHYSVVDLAQPEDYIKLRQHIEQLPNGGGISNNLLFYLAIPPTLAPQIVQSLHTAGLGEADGCPHGWRKIMVEKPY
GTNLESARELNQVIGNVFREKQVYRIDHYLAKETVQNIMVFRFSNGMFEPLWNRQHIANVTITIAENFGIRDRGAFYEDA
GLLRDIMQNHALQLLAAVAMEPPVDFSADAVRDEKAKVLRSIRPFTAEQVAKTVVLGQYEGYRQEKNVAPNSTVETFAAI
KFFIDNWRWKDVPFYIRAGKNLAQTLTEIVITFQCPPQNYFGPTGSEVCTANQVILRIQPEETIAVRFGAKRPGESVITD
PVSMTFDYKTSFVESGLTPYHRLLLDAMAGEQMNFIRQDSVEYSWGIIDAIRQAVAGQQPESYPVHSYGPAGISRLYE

Sequences:

>Translated_478_residues
MQPKPDNCTIVIFGASGDLAARKLFPSLFDLALWGHLSEEHHIVGVGRAPLTQEQFRAMVASKMEELFPERTAQHEAFQR
FLANLHYSVVDLAQPEDYIKLRQHIEQLPNGGGISNNLLFYLAIPPTLAPQIVQSLHTAGLGEADGCPHGWRKIMVEKPY
GTNLESARELNQVIGNVFREKQVYRIDHYLAKETVQNIMVFRFSNGMFEPLWNRQHIANVTITIAENFGIRDRGAFYEDA
GLLRDIMQNHALQLLAAVAMEPPVDFSADAVRDEKAKVLRSIRPFTAEQVAKTVVLGQYEGYRQEKNVAPNSTVETFAAI
KFFIDNWRWKDVPFYIRAGKNLAQTLTEIVITFQCPPQNYFGPTGSEVCTANQVILRIQPEETIAVRFGAKRPGESVITD
PVSMTFDYKTSFVESGLTPYHRLLLDAMAGEQMNFIRQDSVEYSWGIIDAIRQAVAGQQPESYPVHSYGPAGISRLYE
>Mature_478_residues
MQPKPDNCTIVIFGASGDLAARKLFPSLFDLALWGHLSEEHHIVGVGRAPLTQEQFRAMVASKMEELFPERTAQHEAFQR
FLANLHYSVVDLAQPEDYIKLRQHIEQLPNGGGISNNLLFYLAIPPTLAPQIVQSLHTAGLGEADGCPHGWRKIMVEKPY
GTNLESARELNQVIGNVFREKQVYRIDHYLAKETVQNIMVFRFSNGMFEPLWNRQHIANVTITIAENFGIRDRGAFYEDA
GLLRDIMQNHALQLLAAVAMEPPVDFSADAVRDEKAKVLRSIRPFTAEQVAKTVVLGQYEGYRQEKNVAPNSTVETFAAI
KFFIDNWRWKDVPFYIRAGKNLAQTLTEIVITFQCPPQNYFGPTGSEVCTANQVILRIQPEETIAVRFGAKRPGESVITD
PVSMTFDYKTSFVESGLTPYHRLLLDAMAGEQMNFIRQDSVEYSWGIIDAIRQAVAGQQPESYPVHSYGPAGISRLYE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=35.966735966736, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=35.966735966736, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI52145310, Length=497, Percent_Identity=28.9738430583501, Blast_Score=186, Evalue=6e-47,
Organism=Escherichia coli, GI1788158, Length=480, Percent_Identity=37.7083333333333, Blast_Score=316, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17538218, Length=479, Percent_Identity=34.2379958246347, Blast_Score=293, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=481, Percent_Identity=34.3035343035343, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24643350, Length=489, Percent_Identity=34.560327198364, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24643352, Length=489, Percent_Identity=34.560327198364, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI221513548, Length=481, Percent_Identity=29.7297297297297, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 53879; Mature: 53879

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPKPDNCTIVIFGASGDLAARKLFPSLFDLALWGHLSEEHHIVGVGRAPLTQEQFRAMV
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
ASKMEELFPERTAQHEAFQRFLANLHYSVVDLAQPEDYIKLRQHIEQLPNGGGISNNLLF
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
YLAIPPTLAPQIVQSLHTAGLGEADGCPHGWRKIMVEKPYGTNLESARELNQVIGNVFRE
EEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHH
KQVYRIDHYLAKETVQNIMVFRFSNGMFEPLWNRQHIANVTITIAENFGIRDRGAFYEDA
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEECEEEEEEECCCCCCCCCCCHHHH
GLLRDIMQNHALQLLAAVAMEPPVDFSADAVRDEKAKVLRSIRPFTAEQVAKTVVLGQYE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
GYRQEKNVAPNSTVETFAAIKFFIDNWRWKDVPFYIRAGKNLAQTLTEIVITFQCPPQNY
CCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHEEEEECCCCCC
FGPTGSEVCTANQVILRIQPEETIAVRFGAKRPGESVITDPVSMTFDYKTSFVESGLTPY
CCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEECHHHHHHHCCCCHH
HRLLLDAMAGEQMNFIRQDSVEYSWGIIDAIRQAVAGQQPESYPVHSYGPAGISRLYE
HHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MQPKPDNCTIVIFGASGDLAARKLFPSLFDLALWGHLSEEHHIVGVGRAPLTQEQFRAMV
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
ASKMEELFPERTAQHEAFQRFLANLHYSVVDLAQPEDYIKLRQHIEQLPNGGGISNNLLF
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
YLAIPPTLAPQIVQSLHTAGLGEADGCPHGWRKIMVEKPYGTNLESARELNQVIGNVFRE
EEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHH
KQVYRIDHYLAKETVQNIMVFRFSNGMFEPLWNRQHIANVTITIAENFGIRDRGAFYEDA
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEECEEEEEEECCCCCCCCCCCHHHH
GLLRDIMQNHALQLLAAVAMEPPVDFSADAVRDEKAKVLRSIRPFTAEQVAKTVVLGQYE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
GYRQEKNVAPNSTVETFAAIKFFIDNWRWKDVPFYIRAGKNLAQTLTEIVITFQCPPQNY
CCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHEEEEECCCCCC
FGPTGSEVCTANQVILRIQPEETIAVRFGAKRPGESVITDPVSMTFDYKTSFVESGLTPY
CCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEECHHHHHHHCCCCHH
HRLLLDAMAGEQMNFIRQDSVEYSWGIIDAIRQAVAGQQPESYPVHSYGPAGISRLYE
HHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]