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The map label for this gene is fabD [H]

Identifier: 78189620

GI number: 78189620

Start: 2161622

End: 2162533

Strand: Reverse

Name: fabD [H]

Synonym: Cag_1663

Alternate gene names: 78189620

Gene position: 2162533-2161622 (Counterclockwise)

Preceding gene: 78189621

Following gene: 78189619

Centisome position: 84.08

GC content: 48.9

Gene sequence:

>912_bases
ATGAAAGCATTTGTTTTTCCGGGACAAGGTTCCCAATACTGCGGCATGGGGCGCGATTTATTTGAGAGCTTTCCAGAAGC
ACGCGCTTTAATGGAGCAAGCAAACGAGATATTAGGTTACTCCATTACCGATATTATGTTTACGGGTAGTGAAGAGGAGC
TTCGCCAAACGAAGTTTACCCAGCCCGCTATTTTTCTCCATAGCATGGTGCTTGCTACACTGCTTGGCAACAACGGGGTG
AGCATGTGTGCTGGGCATAGCTTAGGCGAATACAGCGCTCTGTGTTTTGCTGGAGCAATGAGTTTTGAGGATGCCCTTCG
CATTGTGGCTAAGCGTGGTAATTTAATGCAGGAGGCAGGTACGCAAAACCCCGGCACAATGGCGGCGATTATTGGTATGG
CTGATGAGGCGCTCGAAGGGTTACTTGCTGAAGCGCAAAGCGATGGCATTGTGCAAGCTGCTAACTTTAATTCACCCGGA
CAAATTGTTATTTCGGGTGATGTTGCTGCGGTTAAAAAAGCGGTTGCGCTTGCACCAAGCAAAGGAGCACGTATGGCTAA
AGAGTTAGTGGTGTCGGGTGCATTTCACTCGCCGCTTATGAAGCCTGCCGAAGAGGAGCTTGCCGCTGCACTTGCTCAGG
TGGAAATTAAGGAGGCGCGTATTCCTGTTTGCATGAACGCTGTTGCCAAAGCGGTAACAAGCGCGGCTGAAATTCGTTGT
AACTTAGTGCTGCAATTAACCAGCTCCGTGTTGTGGACGCAATCAATTGAAGCAATGGCACAAGCGGGAGTTACCACTTT
TGTAGAGGTTGGACCGCAAAAGGTGCTGCAAGGCTTAATAAAGCGCATTGTAAAAAACGTTACCATTCAAACGGTGGATA
CAGCGGCTGAATTGCAAGGCATGTTGCCGTAA

Upstream 100 bases:

>100_bases
AAACAATAAACTGAAACATGGTGATAACCTTGTGTTAGTCAGTTTTGGAGCAGGTTATACATGGGGTGGCATTTACGTTA
AATGGCAATAAGCAACAAGC

Downstream 100 bases:

>100_bases
GATTGTTAGCTTATCCACTTATAACCATCTTTATTTATTATGCTTACAGGAAAAATTGCTGTTGTTACAGGTGCCGCACG
AGGCATTGGTCAGGCGATTG

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKAFVFPGQGSQYCGMGRDLFESFPEARALMEQANEILGYSITDIMFTGSEEELRQTKFTQPAIFLHSMVLATLLGNNGV
SMCAGHSLGEYSALCFAGAMSFEDALRIVAKRGNLMQEAGTQNPGTMAAIIGMADEALEGLLAEAQSDGIVQAANFNSPG
QIVISGDVAAVKKAVALAPSKGARMAKELVVSGAFHSPLMKPAEEELAAALAQVEIKEARIPVCMNAVAKAVTSAAEIRC
NLVLQLTSSVLWTQSIEAMAQAGVTTFVEVGPQKVLQGLIKRIVKNVTIQTVDTAAELQGMLP

Sequences:

>Translated_303_residues
MKAFVFPGQGSQYCGMGRDLFESFPEARALMEQANEILGYSITDIMFTGSEEELRQTKFTQPAIFLHSMVLATLLGNNGV
SMCAGHSLGEYSALCFAGAMSFEDALRIVAKRGNLMQEAGTQNPGTMAAIIGMADEALEGLLAEAQSDGIVQAANFNSPG
QIVISGDVAAVKKAVALAPSKGARMAKELVVSGAFHSPLMKPAEEELAAALAQVEIKEARIPVCMNAVAKAVTSAAEIRC
NLVLQLTSSVLWTQSIEAMAQAGVTTFVEVGPQKVLQGLIKRIVKNVTIQTVDTAAELQGMLP
>Mature_303_residues
MKAFVFPGQGSQYCGMGRDLFESFPEARALMEQANEILGYSITDIMFTGSEEELRQTKFTQPAIFLHSMVLATLLGNNGV
SMCAGHSLGEYSALCFAGAMSFEDALRIVAKRGNLMQEAGTQNPGTMAAIIGMADEALEGLLAEAQSDGIVQAANFNSPG
QIVISGDVAAVKKAVALAPSKGARMAKELVVSGAFHSPLMKPAEEELAAALAQVEIKEARIPVCMNAVAKAVTSAAEIRC
NLVLQLTSSVLWTQSIEAMAQAGVTTFVEVGPQKVLQGLIKRIVKNVTIQTVDTAAELQGMLP

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=296, Percent_Identity=34.1216216216216, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI27477045, Length=107, Percent_Identity=41.1214953271028, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI41872631, Length=299, Percent_Identity=28.0936454849498, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1787334, Length=289, Percent_Identity=45.3287197231834, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71984332, Length=286, Percent_Identity=30.0699300699301, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=292, Percent_Identity=28.7671232876712, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24665753, Length=298, Percent_Identity=36.241610738255, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 31985; Mature: 31985

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFVFPGQGSQYCGMGRDLFESFPEARALMEQANEILGYSITDIMFTGSEEELRQTKFT
CCEEEECCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHCC
QPAIFLHSMVLATLLGNNGVSMCAGHSLGEYSALCFAGAMSFEDALRIVAKRGNLMQEAG
CHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCC
TQNPGTMAAIIGMADEALEGLLAEAQSDGIVQAANFNSPGQIVISGDVAAVKKAVALAPS
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHHHHHHHHCCCC
KGARMAKELVVSGAFHSPLMKPAEEELAAALAQVEIKEARIPVCMNAVAKAVTSAAEIRC
CHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
NLVLQLTSSVLWTQSIEAMAQAGVTTFVEVGPQKVLQGLIKRIVKNVTIQTVDTAAELQG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
MLP
CCC
>Mature Secondary Structure
MKAFVFPGQGSQYCGMGRDLFESFPEARALMEQANEILGYSITDIMFTGSEEELRQTKFT
CCEEEECCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHCC
QPAIFLHSMVLATLLGNNGVSMCAGHSLGEYSALCFAGAMSFEDALRIVAKRGNLMQEAG
CHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCC
TQNPGTMAAIIGMADEALEGLLAEAQSDGIVQAANFNSPGQIVISGDVAAVKKAVALAPS
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHHHHHHHHCCCC
KGARMAKELVVSGAFHSPLMKPAEEELAAALAQVEIKEARIPVCMNAVAKAVTSAAEIRC
CHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
NLVLQLTSSVLWTQSIEAMAQAGVTTFVEVGPQKVLQGLIKRIVKNVTIQTVDTAAELQG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
MLP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]