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The map label for this gene is fabF [H]

Identifier: 78189617

GI number: 78189617

Start: 2158919

End: 2160172

Strand: Reverse

Name: fabF [H]

Synonym: Cag_1660

Alternate gene names: 78189617

Gene position: 2160172-2158919 (Counterclockwise)

Preceding gene: 78189618

Following gene: 78189616

Centisome position: 83.99

GC content: 46.97

Gene sequence:

>1254_bases
ATGGCTCAAGAGCAAAAAAGAGTTGTTATTACCGGCATTGGAGTGCTTACTCCAATTGGTCTTACCAAAGAGACCTTCTG
GGAAGCTCTTAAAGCGGGCAAAAGTGGTGCAGCTCCTATCACCTACTTTGATACCACGAACTTTGCAACCACCTTTGCAT
GTGAGTTAAAAGGCTTTTCAGCAGAAAATTATTTAGATAAAAAATCGGCTGATCGCATGGATCCTTACTGCCAATATGCA
GTAGTTGCGGCAACTCATGCGCTTGCTGATTCAGGGCTTGACTTGGCGGCAATTGATCCTATTCGTATTGGTGTTGTTCA
CGGTTCGGGCATTGGTGGTATGACTACCTACGATACACAGTTCCGTCAATTCTTAGATCGCGGGCCTCGCCGTATTAGTC
CCTTCTTTATTCCTATGCTTATCCCCGATATTGCCGCTGGGCAAATTTCGATGAAGCATGGCTTAATGGGTCCAAACTAC
GCAACAGCATCAGCGTGTGCTACTTCGCTTCACGCAATTTTGGATGCAGTGCTGCTGATTCGTGCGGGTATGGCTGATTA
CATGGTGTGTGGTGGCTCCGAAGCACCAATTACCTCAATGAGTGTTGGTGGCTTTAACTCCGCCAAGGCACTCTCTACGG
CAAACGATCGTCCACAACAAGCTTCACGTCCTTATGATCGCGATCGTGATGGCTTTGTAATGGGCGAAGGTGCAGGCTCG
TTAGTGCTTGAAACGTTAGAGTCGGCTAAAGCGCGTGGAGCAAAAATTTATGGTGAAATTGTTGGTTTAGGTGCTACGGC
TGATGCTTACCATTTAACCGCGCCACATCCTGAAGGCAAGGGTGCTGTAAATGCCATGAAAATTGCGCTTTCTATGGCTG
GCATAGCGCTTGAGCAGATTGATTACATCAATACCCACGGCACCGCAACGCCACTTGGTGATATTGCTGAAATTACGGCT
ATTAAGAGCCTTTTTGGTGAACATGCCTACAAACTCAGCATTAGCTCTACCAAATCTATGACGGGGCACTTACTTGGTGC
GGCTGGTGTGGTTGAGTCTATTGCTTGCTTGCTTGCTATGCAAAATCAAACCGTTCCGCCAACGATCAACCTTGACAATC
TTGATGAGCAAATTGATTTGGATGTTACGCCAAATCAGCCAAAAGAGCGCAAGATTGAGTATGCGCTGAACAATGGCTTT
GGCTTTGGTGGGCATAATGGCACCATTATTTTCCGCAACGGCTCTGCACTGTAA

Upstream 100 bases:

>100_bases
TTGTGATGAACAATTTAGAGGTGCTTTCTTTTTTTTAATGGGCAGATGTTGTAACTCATACACGCCCAACCATGTTTAAC
CCTTTAATCTCATTACAGCA

Downstream 100 bases:

>100_bases
GCAAGGTTGCTGGAGTAGCTTGTGGAGCATTTTTGGCAAAAACTGCGCTCATTTACCTTTCAACGGCATAGTGAGAGCAG
TGCCACCTCAGCCGTTGCTG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAQEQKRVVITGIGVLTPIGLTKETFWEALKAGKSGAAPITYFDTTNFATTFACELKGFSAENYLDKKSADRMDPYCQYA
VVAATHALADSGLDLAAIDPIRIGVVHGSGIGGMTTYDTQFRQFLDRGPRRISPFFIPMLIPDIAAGQISMKHGLMGPNY
ATASACATSLHAILDAVLLIRAGMADYMVCGGSEAPITSMSVGGFNSAKALSTANDRPQQASRPYDRDRDGFVMGEGAGS
LVLETLESAKARGAKIYGEIVGLGATADAYHLTAPHPEGKGAVNAMKIALSMAGIALEQIDYINTHGTATPLGDIAEITA
IKSLFGEHAYKLSISSTKSMTGHLLGAAGVVESIACLLAMQNQTVPPTINLDNLDEQIDLDVTPNQPKERKIEYALNNGF
GFGGHNGTIIFRNGSAL

Sequences:

>Translated_417_residues
MAQEQKRVVITGIGVLTPIGLTKETFWEALKAGKSGAAPITYFDTTNFATTFACELKGFSAENYLDKKSADRMDPYCQYA
VVAATHALADSGLDLAAIDPIRIGVVHGSGIGGMTTYDTQFRQFLDRGPRRISPFFIPMLIPDIAAGQISMKHGLMGPNY
ATASACATSLHAILDAVLLIRAGMADYMVCGGSEAPITSMSVGGFNSAKALSTANDRPQQASRPYDRDRDGFVMGEGAGS
LVLETLESAKARGAKIYGEIVGLGATADAYHLTAPHPEGKGAVNAMKIALSMAGIALEQIDYINTHGTATPLGDIAEITA
IKSLFGEHAYKLSISSTKSMTGHLLGAAGVVESIACLLAMQNQTVPPTINLDNLDEQIDLDVTPNQPKERKIEYALNNGF
GFGGHNGTIIFRNGSAL
>Mature_416_residues
AQEQKRVVITGIGVLTPIGLTKETFWEALKAGKSGAAPITYFDTTNFATTFACELKGFSAENYLDKKSADRMDPYCQYAV
VAATHALADSGLDLAAIDPIRIGVVHGSGIGGMTTYDTQFRQFLDRGPRRISPFFIPMLIPDIAAGQISMKHGLMGPNYA
TASACATSLHAILDAVLLIRAGMADYMVCGGSEAPITSMSVGGFNSAKALSTANDRPQQASRPYDRDRDGFVMGEGAGSL
VLETLESAKARGAKIYGEIVGLGATADAYHLTAPHPEGKGAVNAMKIALSMAGIALEQIDYINTHGTATPLGDIAEITAI
KSLFGEHAYKLSISSTKSMTGHLLGAAGVVESIACLLAMQNQTVPPTINLDNLDEQIDLDVTPNQPKERKIEYALNNGFG
FGGHNGTIIFRNGSAL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=42.9594272076372, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=49.7005988023952, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI41872631, Length=424, Percent_Identity=25, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=51.4634146341463, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=38.498789346247, Blast_Score=248, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=33.0900243309002, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=38.9105058365759, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=432, Percent_Identity=25.462962962963, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=390, Percent_Identity=25.3846153846154, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.5470852017937, Blast_Score=252, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=42.8915662650602, Blast_Score=317, Evalue=7e-87,
Organism=Drosophila melanogaster, GI19920632, Length=370, Percent_Identity=24.0540540540541, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221330659, Length=370, Percent_Identity=24.0540540540541, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24581345, Length=387, Percent_Identity=22.9974160206718, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44026; Mature: 43895

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQEQKRVVITGIGVLTPIGLTKETFWEALKAGKSGAAPITYFDTTNFATTFACELKGFS
CCCCCCEEEEEECHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEECCCC
AENYLDKKSADRMDPYCQYAVVAATHALADSGLDLAAIDPIRIGVVHGSGIGGMTTYDTQ
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCCCCCHHHH
FRQFLDRGPRRISPFFIPMLIPDIAAGQISMKHGLMGPNYATASACATSLHAILDAVLLI
HHHHHHCCCCCCCCEEHHHHHCCCCCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RAGMADYMVCGGSEAPITSMSVGGFNSAKALSTANDRPQQASRPYDRDRDGFVMGEGAGS
HCCCHHEEEECCCCCCCCEEECCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEEECCCCH
LVLETLESAKARGAKIYGEIVGLGATADAYHLTAPHPEGKGAVNAMKIALSMAGIALEQI
HHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DYINTHGTATPLGDIAEITAIKSLFGEHAYKLSISSTKSMTGHLLGAAGVVESIACLLAM
HHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
QNQTVPPTINLDNLDEQIDLDVTPNQPKERKIEYALNNGFGFGGHNGTIIFRNGSAL
CCCCCCCCCCCCCCCCEEEEEECCCCCHHHEEEEEECCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
AQEQKRVVITGIGVLTPIGLTKETFWEALKAGKSGAAPITYFDTTNFATTFACELKGFS
CCCCCEEEEEECHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEECCCC
AENYLDKKSADRMDPYCQYAVVAATHALADSGLDLAAIDPIRIGVVHGSGIGGMTTYDTQ
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCCCCCHHHH
FRQFLDRGPRRISPFFIPMLIPDIAAGQISMKHGLMGPNYATASACATSLHAILDAVLLI
HHHHHHCCCCCCCCEEHHHHHCCCCCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RAGMADYMVCGGSEAPITSMSVGGFNSAKALSTANDRPQQASRPYDRDRDGFVMGEGAGS
HCCCHHEEEECCCCCCCCEEECCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEEECCCCH
LVLETLESAKARGAKIYGEIVGLGATADAYHLTAPHPEGKGAVNAMKIALSMAGIALEQI
HHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DYINTHGTATPLGDIAEITAIKSLFGEHAYKLSISSTKSMTGHLLGAAGVVESIACLLAM
HHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
QNQTVPPTINLDNLDEQIDLDVTPNQPKERKIEYALNNGFGFGGHNGTIIFRNGSAL
CCCCCCCCCCCCCCCCEEEEEECCCCCHHHEEEEEECCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]