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The map label for this gene is rnc

Identifier: 78189616

GI number: 78189616

Start: 2158016

End: 2158762

Strand: Reverse

Name: rnc

Synonym: Cag_1659

Alternate gene names: 78189616

Gene position: 2158762-2158016 (Counterclockwise)

Preceding gene: 78189617

Following gene: 78189615

Centisome position: 83.93

GC content: 44.71

Gene sequence:

>747_bases
TTGCCACCCGAAACGCTTGCTTATTTGCAAACACTTATTGGCTCGCTTGATGGCAATGCGCGGCTTTATCAAACGGCGTT
AACCCATCGTTCGGTTATTGGTAATACAGCGTTGTCGCATCATAATGAATCAAATCAGCGTCTTGAGTTTCTTGGTGATG
CGGTGCTTGGGCTTCTTATTTCTCACTTCCTTTTTCAAAACTTTCCTGCAAGCGCCGAAGGCGATCTCTCAAAAACTCGC
GCCAAAATTGTTAATAGTAAGTCGTTAGCCTGTTTTGCTCGTTCCATTGGTTTGGGGGAACATTTATTGCTCGGTGAATC
GGCGGCTCATTACAACATTCGTGATAGTGAATCGGCGCTTGCCGATGCCTTTGAATCGCTGATTGGTGCTATCTACCTTG
ATAAAGGGTTAGATGCAGCCTACGGTTTTGTTGATAAACATATTATCCATCACCAGAGTTTTAGCGCCATTGTTGCAAGT
GAGCAGAATTATAAAAGTTGCTTAATTGAATATTCGCAAGCGCACCATGTAGCCGCACCTGTTTATACGGTTATTGCAGA
GCATGGCGCTGAGCACGACAAAGAGTTTACGGTTGAAGTAAGTTGCAACAACATTAAAGGGTGTGGTACGGCACGCCGTA
AAAAAGATGCCGAGCAATTAGCGGCTAAAGAGGCTATGGAGCGCATTATAGCGTTGCAGCCATTACCTCATGAACCAAAA
GATGAAGAGAACAGCACGACAACATGA

Upstream 100 bases:

>100_bases
CTTTCAACGGCATAGTGAGAGCAGTGCCACCTCAGCCGTTGCTGCCGCCATTAGCTCTATCACTCCCGTAACATCATTAC
CATCCACGTACTCTCCGCTG

Downstream 100 bases:

>100_bases
TAATGAGTATTTCATGCTACCTTCTTTTTGAGCTTCTATGCGGCATCTTCTATATTGCCCCTATGCCCCCTCTATGCCTT
AATTCATAGAGCATTTCATT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MPPETLAYLQTLIGSLDGNARLYQTALTHRSVIGNTALSHHNESNQRLEFLGDAVLGLLISHFLFQNFPASAEGDLSKTR
AKIVNSKSLACFARSIGLGEHLLLGESAAHYNIRDSESALADAFESLIGAIYLDKGLDAAYGFVDKHIIHHQSFSAIVAS
EQNYKSCLIEYSQAHHVAAPVYTVIAEHGAEHDKEFTVEVSCNNIKGCGTARRKKDAEQLAAKEAMERIIALQPLPHEPK
DEENSTTT

Sequences:

>Translated_248_residues
MPPETLAYLQTLIGSLDGNARLYQTALTHRSVIGNTALSHHNESNQRLEFLGDAVLGLLISHFLFQNFPASAEGDLSKTR
AKIVNSKSLACFARSIGLGEHLLLGESAAHYNIRDSESALADAFESLIGAIYLDKGLDAAYGFVDKHIIHHQSFSAIVAS
EQNYKSCLIEYSQAHHVAAPVYTVIAEHGAEHDKEFTVEVSCNNIKGCGTARRKKDAEQLAAKEAMERIIALQPLPHEPK
DEENSTTT
>Mature_247_residues
PPETLAYLQTLIGSLDGNARLYQTALTHRSVIGNTALSHHNESNQRLEFLGDAVLGLLISHFLFQNFPASAEGDLSKTRA
KIVNSKSLACFARSIGLGEHLLLGESAAHYNIRDSESALADAFESLIGAIYLDKGLDAAYGFVDKHIIHHQSFSAIVASE
QNYKSCLIEYSQAHHVAAPVYTVIAEHGAEHDKEFTVEVSCNNIKGCGTARRKKDAEQLAAKEAMERIIALQPLPHEPKD
EENSTTT

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=234, Percent_Identity=29.0598290598291, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI155030236, Length=234, Percent_Identity=29.0598290598291, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1788920, Length=222, Percent_Identity=36.9369369369369, Blast_Score=123, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193202651, Length=205, Percent_Identity=28.2926829268293, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506883, Length=205, Percent_Identity=28.2926829268293, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137682, Length=238, Percent_Identity=30.2521008403361, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CHLCH (Q3AQ14)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379954.1
- ProteinModelPortal:   Q3AQ14
- SMR:   Q3AQ14
- STRING:   Q3AQ14
- GeneID:   3747677
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1659
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- BioCyc:   CCHL340177:CAG_1659-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27082; Mature: 26950

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPETLAYLQTLIGSLDGNARLYQTALTHRSVIGNTALSHHNESNQRLEFLGDAVLGLLI
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SHFLFQNFPASAEGDLSKTRAKIVNSKSLACFARSIGLGEHLLLGESAAHYNIRDSESAL
HHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHH
ADAFESLIGAIYLDKGLDAAYGFVDKHIIHHQSFSAIVASEQNYKSCLIEYSQAHHVAAP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VYTVIAEHGAEHDKEFTVEVSCNNIKGCGTARRKKDAEQLAAKEAMERIIALQPLPHEPK
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DEENSTTT
CCCCCCCC
>Mature Secondary Structure 
PPETLAYLQTLIGSLDGNARLYQTALTHRSVIGNTALSHHNESNQRLEFLGDAVLGLLI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SHFLFQNFPASAEGDLSKTRAKIVNSKSLACFARSIGLGEHLLLGESAAHYNIRDSESAL
HHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHH
ADAFESLIGAIYLDKGLDAAYGFVDKHIIHHQSFSAIVASEQNYKSCLIEYSQAHHVAAP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VYTVIAEHGAEHDKEFTVEVSCNNIKGCGTARRKKDAEQLAAKEAMERIIALQPLPHEPK
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DEENSTTT
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA