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The map label for this gene is gcvPB

Identifier: 78189615

GI number: 78189615

Start: 2156441

End: 2157886

Strand: Reverse

Name: gcvPB

Synonym: Cag_1658

Alternate gene names: 78189615

Gene position: 2157886-2156441 (Counterclockwise)

Preceding gene: 78189616

Following gene: 78189614

Centisome position: 83.9

GC content: 47.93

Gene sequence:

>1446_bases
ATGAAAGAACCCCTCATTTTTGACCTCTCTCGCCCCGGGCGTAAGGGATACAGCTTGTCGCCATGCGACGTGCCTGAAGT
TCCACTTGAATCCATTATTCCAGCATCGTTGCTTCGTAAGGAGGCGGTGGAGTTGCCCGAAGTGGCAGAAAATGAGGTGG
TGCGCCACTTTGTGCGCCTTTCAAACCTCAACTATCATGTTGATAAAAATATGTACCCGTTGGGCAGTTGTACCATGAAG
TACAATCCCAAAGTGAATGATTACACTTGTGATTTGTCGGGCTTTAGCGCGCTCCATCCATTGCAGCCCACCAGCACAAC
GCAAGGTGCTTTGCAGTTGATGTATGAGTTATCCAACATGTTAGCTGAAATTGCTGGCATGGCTGGCGTGAGTTTGCAAC
CAGCCGCAGGTGCACATGGTGAGTTAACGGGCATTTTGCTGATTAAAAAATATCATGAAGTGCGTGGCGATAAGCGCCAT
AAGCTCTTGGTGGTAGATTCAGCGCATGGCACGAACCCCGCTTCTGCCGCACTTGCGGGCTACGAAACCATCTCCGTTAA
AAGCAATGGCGATGGACGTACTGACCTTGAGGATTTACGTAGCAAGTTAGATGGCGATGTTGCAGCGCTTATGCTTACCA
ATCCCAATACGATTGGATTGTTTGAAAAAGAGATTGTGCAAATTGCCGAAATGGTACACGCCAATGGTAGCTTACTTTAT
ATGGATGGCGCCAATATGAATGCGCTGCTTGGTATTACTCGCCCTGGTGATATGGGTTTTGATGTTATGCACTACAATCT
CCATAAAACCTTTGCAGCTCCGCACGGCGGCGGTGGTCCAGGTAGCGGTCCCGTTGGTGTGAATGAAAAACTACTGCCAT
ACCTTCCTGCTCCGCTTGTTGTTAAAGAGGGCGACACTTACCGCTTAACATCGGGTGGCGATGACTCCATTGGGCGTATG
ATGAACTTTTATGGCAACTTTGCTGTCTTGGTGCGTGCCTACACTTACATTCGGATGTTGGGAGCTGAAGGGCTGCGCCG
AGTTTCGGAAAACGCCATTATTAACGCCAACTACCTTTTGAGCAAATTGCTTGAGCGCTACGAGCTGCCTTATCCAAAAC
CTGTGATGCACGAATTTTGCTTGTCGGGTGATAAGCAGAAAAAAGCGCATGGCGTTAAAACGCTTGATATTGCAAAGCGT
TTGCTTGATTATGGGTTCCATGCTCCAACCATTTACTTCCCGCTTATTGTAAGCGAAGCCTTAATGATTGAGCCAACTGA
AACCGAGTCGAAAGAAACGTTAGATATTTTTGCTGATGCGTTGCTTGCTATTGCGCGTGAAGCTGAAGAAAATCCTGATG
TGGTGAAAATGGCGCCATCAACAACCGCCGTTAAGCGCCTTGACGAAGCCACTGCTTCTCGCCAATTGACTATTTGCTGC
ATGTAA

Upstream 100 bases:

>100_bases
GAGCTTCTATGCGGCATCTTCTATATTGCCCCTATGCCCCCTCTATGCCTTAATTCATAGAGCATTTCATTTCTAAACGA
CCTTACAACGCAAATTAGCC

Downstream 100 bases:

>100_bases
GCCGTACATTGTTCTCACCCACAAGAGGAAGCATCACTGTTTGCAGATACTTCCTCTTTTGTTGGGGCATCTCCTTCCTA
CAACTATTGCCGCTGATCTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKEPLIFDLSRPGRKGYSLSPCDVPEVPLESIIPASLLRKEAVELPEVAENEVVRHFVRLSNLNYHVDKNMYPLGSCTMK
YNPKVNDYTCDLSGFSALHPLQPTSTTQGALQLMYELSNMLAEIAGMAGVSLQPAAGAHGELTGILLIKKYHEVRGDKRH
KLLVVDSAHGTNPASAALAGYETISVKSNGDGRTDLEDLRSKLDGDVAALMLTNPNTIGLFEKEIVQIAEMVHANGSLLY
MDGANMNALLGITRPGDMGFDVMHYNLHKTFAAPHGGGGPGSGPVGVNEKLLPYLPAPLVVKEGDTYRLTSGGDDSIGRM
MNFYGNFAVLVRAYTYIRMLGAEGLRRVSENAIINANYLLSKLLERYELPYPKPVMHEFCLSGDKQKKAHGVKTLDIAKR
LLDYGFHAPTIYFPLIVSEALMIEPTETESKETLDIFADALLAIAREAEENPDVVKMAPSTTAVKRLDEATASRQLTICC
M

Sequences:

>Translated_481_residues
MKEPLIFDLSRPGRKGYSLSPCDVPEVPLESIIPASLLRKEAVELPEVAENEVVRHFVRLSNLNYHVDKNMYPLGSCTMK
YNPKVNDYTCDLSGFSALHPLQPTSTTQGALQLMYELSNMLAEIAGMAGVSLQPAAGAHGELTGILLIKKYHEVRGDKRH
KLLVVDSAHGTNPASAALAGYETISVKSNGDGRTDLEDLRSKLDGDVAALMLTNPNTIGLFEKEIVQIAEMVHANGSLLY
MDGANMNALLGITRPGDMGFDVMHYNLHKTFAAPHGGGGPGSGPVGVNEKLLPYLPAPLVVKEGDTYRLTSGGDDSIGRM
MNFYGNFAVLVRAYTYIRMLGAEGLRRVSENAIINANYLLSKLLERYELPYPKPVMHEFCLSGDKQKKAHGVKTLDIAKR
LLDYGFHAPTIYFPLIVSEALMIEPTETESKETLDIFADALLAIAREAEENPDVVKMAPSTTAVKRLDEATASRQLTICC
M
>Mature_481_residues
MKEPLIFDLSRPGRKGYSLSPCDVPEVPLESIIPASLLRKEAVELPEVAENEVVRHFVRLSNLNYHVDKNMYPLGSCTMK
YNPKVNDYTCDLSGFSALHPLQPTSTTQGALQLMYELSNMLAEIAGMAGVSLQPAAGAHGELTGILLIKKYHEVRGDKRH
KLLVVDSAHGTNPASAALAGYETISVKSNGDGRTDLEDLRSKLDGDVAALMLTNPNTIGLFEKEIVQIAEMVHANGSLLY
MDGANMNALLGITRPGDMGFDVMHYNLHKTFAAPHGGGGPGSGPVGVNEKLLPYLPAPLVVKEGDTYRLTSGGDDSIGRM
MNFYGNFAVLVRAYTYIRMLGAEGLRRVSENAIINANYLLSKLLERYELPYPKPVMHEFCLSGDKQKKAHGVKTLDIAKR
LLDYGFHAPTIYFPLIVSEALMIEPTETESKETLDIFADALLAIAREAEENPDVVKMAPSTTAVKRLDEATASRQLTICC
M

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=450, Percent_Identity=39.1111111111111, Blast_Score=276, Evalue=3e-74,
Organism=Escherichia coli, GI1789269, Length=499, Percent_Identity=40.8817635270541, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17535605, Length=444, Percent_Identity=41.2162162162162, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI32564013, Length=384, Percent_Identity=42.7083333333333, Blast_Score=254, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6323843, Length=423, Percent_Identity=44.2080378250591, Blast_Score=308, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24645648, Length=434, Percent_Identity=42.1658986175115, Blast_Score=303, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_CHLCH (Q3AQ15)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379953.1
- ProteinModelPortal:   Q3AQ15
- SMR:   Q3AQ15
- STRING:   Q3AQ15
- GeneID:   3747676
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1658
- eggNOG:   COG1003
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   CCHL340177:CAG_1658-MONOMER
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 52540; Mature: 52540

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEPLIFDLSRPGRKGYSLSPCDVPEVPLESIIPASLLRKEAVELPEVAENEVVRHFVRL
CCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SNLNYHVDKNMYPLGSCTMKYNPKVNDYTCDLSGFSALHPLQPTSTTQGALQLMYELSNM
HCCCEEECCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LAEIAGMAGVSLQPAAGAHGELTGILLIKKYHEVRGDKRHKLLVVDSAHGTNPASAALAG
HHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCC
YETISVKSNGDGRTDLEDLRSKLDGDVAALMLTNPNTIGLFEKEIVQIAEMVHANGSLLY
CEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEE
MDGANMNALLGITRPGDMGFDVMHYNLHKTFAAPHGGGGPGSGPVGVNEKLLPYLPAPLV
ECCCCCCEEEEECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VKEGDTYRLTSGGDDSIGRMMNFYGNFAVLVRAYTYIRMLGAEGLRRVSENAIINANYLL
EECCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
SKLLERYELPYPKPVMHEFCLSGDKQKKAHGVKTLDIAKRLLDYGFHAPTIYFPLIVSEA
HHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCH
LMIEPTETESKETLDIFADALLAIAREAEENPDVVKMAPSTTAVKRLDEATASRQLTICC
HEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEE
M
C
>Mature Secondary Structure
MKEPLIFDLSRPGRKGYSLSPCDVPEVPLESIIPASLLRKEAVELPEVAENEVVRHFVRL
CCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SNLNYHVDKNMYPLGSCTMKYNPKVNDYTCDLSGFSALHPLQPTSTTQGALQLMYELSNM
HCCCEEECCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LAEIAGMAGVSLQPAAGAHGELTGILLIKKYHEVRGDKRHKLLVVDSAHGTNPASAALAG
HHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCC
YETISVKSNGDGRTDLEDLRSKLDGDVAALMLTNPNTIGLFEKEIVQIAEMVHANGSLLY
CEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEE
MDGANMNALLGITRPGDMGFDVMHYNLHKTFAAPHGGGGPGSGPVGVNEKLLPYLPAPLV
ECCCCCCEEEEECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VKEGDTYRLTSGGDDSIGRMMNFYGNFAVLVRAYTYIRMLGAEGLRRVSENAIINANYLL
EECCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
SKLLERYELPYPKPVMHEFCLSGDKQKKAHGVKTLDIAKRLLDYGFHAPTIYFPLIVSEA
HHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCH
LMIEPTETESKETLDIFADALLAIAREAEENPDVVKMAPSTTAVKRLDEATASRQLTICC
HEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEE
M
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA