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The map label for this gene is hldE [H]

Identifier: 78189574

GI number: 78189574

Start: 2114886

End: 2115377

Strand: Reverse

Name: hldE [H]

Synonym: Cag_1616

Alternate gene names: 78189574

Gene position: 2115377-2114886 (Counterclockwise)

Preceding gene: 78189575

Following gene: 78189573

Centisome position: 82.24

GC content: 51.42

Gene sequence:

>492_bases
ATGGCGGCAATTTCTCCTAAAATTTTAAGCTGGCAAAATGCGGCTGAGCAGGTGCAGGCGTGGCGGGCAATGGGCAATAA
GGTGGTTTTTACCAATGGTTGTTTTGATATTCTTCATGCGGGGCATGTGCACTATTTGCAAGCGGCAAAATCGCTGGGGC
AGCGCTTGTGTATTGGTTTAAATAGCGATGCTTCGGTGCAGCGGTTGAAGGGTCCAAAGCGTCCTATTTGTAATGAGGTT
GACCGTGCAACGTTGTTGGCGGCGTTGGAGGTGGTTGATATGGTGGTGCTTTTTGATGAGGATACGCCTGAGCGCTTAAT
TGCGGCGCTGTTGCCCAATGTGTTGGTGAAGGGGGCTGATTGGGCGGTTGAGCAAATTGCGGGGGCTGCAACCGTGCTGC
AACATGGCGGCGAAGTGTTAACCGTGCCGTTGCTTGATGGGCGTTCAACCACTGGCGTTATTGAGCGAATTATTGAACGC
TATAGCTTGTAG

Upstream 100 bases:

>100_bases
CATGTTCTCTAAACTCATTTCCCCTTGAAAATCTGTACTTTAGCGGCATCGTAGCTTTTGAAACAATCTTTATTGATCAA
ATAATTTAGCGTGGGTAAAC

Downstream 100 bases:

>100_bases
CAAAAAAACGGTGCAAAGTTTTAAGCACATAAGCCTTAAAGCGTTAGCTGGGCTACTCTTATCGGTGCTGTTGGTGGCAC
TGATGGCACTTGTGCTGCTT

Product: bifunctional ADP-heptose synthase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MAAISPKILSWQNAAEQVQAWRAMGNKVVFTNGCFDILHAGHVHYLQAAKSLGQRLCIGLNSDASVQRLKGPKRPICNEV
DRATLLAALEVVDMVVLFDEDTPERLIAALLPNVLVKGADWAVEQIAGAATVLQHGGEVLTVPLLDGRSTTGVIERIIER
YSL

Sequences:

>Translated_163_residues
MAAISPKILSWQNAAEQVQAWRAMGNKVVFTNGCFDILHAGHVHYLQAAKSLGQRLCIGLNSDASVQRLKGPKRPICNEV
DRATLLAALEVVDMVVLFDEDTPERLIAALLPNVLVKGADWAVEQIAGAATVLQHGGEVLTVPLLDGRSTTGVIERIIER
YSL
>Mature_162_residues
AAISPKILSWQNAAEQVQAWRAMGNKVVFTNGCFDILHAGHVHYLQAAKSLGQRLCIGLNSDASVQRLKGPKRPICNEVD
RATLLAALEVVDMVVLFDEDTPERLIAALLPNVLVKGADWAVEQIAGAATVLQHGGEVLTVPLLDGRSTTGVIERIIERY
SL

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=140, Percent_Identity=56.4285714285714, Blast_Score=156, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI193209647, Length=72, Percent_Identity=40.2777777777778, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533408, Length=72, Percent_Identity=40.2777777777778, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 17650; Mature: 17518

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAISPKILSWQNAAEQVQAWRAMGNKVVFTNGCFDILHAGHVHYLQAAKSLGQRLCIGL
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHEECC
NSDASVQRLKGPKRPICNEVDRATLLAALEVVDMVVLFDEDTPERLIAALLPNVLVKGAD
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCC
WAVEQIAGAATVLQHGGEVLTVPLLDGRSTTGVIERIIERYSL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAISPKILSWQNAAEQVQAWRAMGNKVVFTNGCFDILHAGHVHYLQAAKSLGQRLCIGL
CCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHEECC
NSDASVQRLKGPKRPICNEVDRATLLAALEVVDMVVLFDEDTPERLIAALLPNVLVKGAD
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCC
WAVEQIAGAATVLQHGGEVLTVPLLDGRSTTGVIERIIERYSL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA